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The map label for this gene is hisD [H]

Identifier: 114331204

GI number: 114331204

Start: 1260356

End: 1261654

Strand: Direct

Name: hisD [H]

Synonym: Neut_1206

Alternate gene names: 114331204

Gene position: 1260356-1261654 (Clockwise)

Preceding gene: 114331203

Following gene: 114331205

Centisome position: 47.36

GC content: 48.96

Gene sequence:

>1299_bases
ATGATTCAAATCAGGCGGCTGTCGTCCTCAGATATTGATTTCCAAGAAGAACTTAGATCACTATTGAGTTTTGAGATATC
TCTTGATGACGAGATTGATCGGACAGTGATTCATATCCTGAATCAGATCAGGAAATACGGAGATGAAGCGTTACTTGAGC
TGACACGCCGGTTTGATAATCTAGATATAACTCGGATTGATCAGGTTGAATTACCTCGGAATCAATGGCAATCTGCTCTG
GAAGCCTTGAGTCGTGATCAACGCGAGGCCCTGGAACAGGCTGCTTCCCATATACATCTCTACCATGAAAAACAGCTAGC
CCAGTCATGGGATTATGTTGAGCCAGACGGCACACGACTGGGACAGAAAATTACTGCGCTGGATCGTGTCGGGCTCTATG
TGCCCGGTGGTAAGGCAGCCTACCCATCATCAGTGCTGATGAACGCAATTCCTGCCCGGGTAGCCGGTGTCAATGAACTG
ATTATGGTAACCCCAACACCAGGAGGAGAAAAAAATCCGCTGGTACTGGCGGCAGCTGCAATCTGCGAAGTAGATCGTGT
TTTCACTATTGGGGGGGCACAGGCAATTGCTGCCTTGGCTTATGGCACGGCAACCATTCCGAAAGTAGATAAAATTGTTG
GTCCGGGCAATGCCTATGTGGCAACGGCAAAGCGGCATGTATTCGGGGAGGTTGGAATTGATATGCTGGCAGGGCCATCG
GAAATTCTGGTTATTTGCGACGGAAAGACCGACCCTGACTGGATTGCGATGGATCTGTTTTCGCAGGCAGAACATGACGA
GCAGGCACAATCAATTCTGCTTTGCCCAGATGAAACTTTTTTGGATACAGTAGCAAAAAGTATGGCCAGATTAATCAATA
CACTGCCACGCCGGGAGGTTATTCGTACCTCATTGGAAAATCGTGGTGCATTGATCAAAGTGCGTGATCTGGAGGAAGCC
TGTCTGATTGCAAACCGGATTGCACCTGAACATTTGGAGTTATCCGTTGATCAGCCAGAACAATGGGTAGACAGTATTCG
GCACGCTGGCGCAATTTTCCTTGGGCGATATACCTGTGAGGCACTGGGAGATTATTGTGCTGGCCCCAACCATGTACTTC
CCACTTCCGGTACGGCTCGTTTTTCCTCTCCACTGGGTGTTTATGATTTCCAGAAGCGTACCAGCCTGATTCAAGTTTCA
GCCGAGGGAGCATCCAGGTTAGGCAAGATTGCATCTATTCTGGCAAAGGGGGAGGGGCTTGAGGCACACGCCAGATCTGC
TGAGTTCCGTTATCGATAG

Upstream 100 bases:

>100_bases
GGCGGCGCTGAAGCTGAAAAATCCCACAATACAACCTTTGTTAGAAGCGTTTAATGCAGCAATCCCCGCAAATGTGTAGT
CCTCTCAACTCTTAATTACT

Downstream 100 bases:

>100_bases
ATCACAAGTCCAAATGTCTGTGATCAATCTGTCTGCATGATTCTATTGCTTATATGAACGGTCATGATTGATCAGCAATT
CGATATTGTCATTGTTGGAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MIQIRRLSSSDIDFQEELRSLLSFEISLDDEIDRTVIHILNQIRKYGDEALLELTRRFDNLDITRIDQVELPRNQWQSAL
EALSRDQREALEQAASHIHLYHEKQLAQSWDYVEPDGTRLGQKITALDRVGLYVPGGKAAYPSSVLMNAIPARVAGVNEL
IMVTPTPGGEKNPLVLAAAAICEVDRVFTIGGAQAIAALAYGTATIPKVDKIVGPGNAYVATAKRHVFGEVGIDMLAGPS
EILVICDGKTDPDWIAMDLFSQAEHDEQAQSILLCPDETFLDTVAKSMARLINTLPRREVIRTSLENRGALIKVRDLEEA
CLIANRIAPEHLELSVDQPEQWVDSIRHAGAIFLGRYTCEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRTSLIQVS
AEGASRLGKIASILAKGEGLEAHARSAEFRYR

Sequences:

>Translated_432_residues
MIQIRRLSSSDIDFQEELRSLLSFEISLDDEIDRTVIHILNQIRKYGDEALLELTRRFDNLDITRIDQVELPRNQWQSAL
EALSRDQREALEQAASHIHLYHEKQLAQSWDYVEPDGTRLGQKITALDRVGLYVPGGKAAYPSSVLMNAIPARVAGVNEL
IMVTPTPGGEKNPLVLAAAAICEVDRVFTIGGAQAIAALAYGTATIPKVDKIVGPGNAYVATAKRHVFGEVGIDMLAGPS
EILVICDGKTDPDWIAMDLFSQAEHDEQAQSILLCPDETFLDTVAKSMARLINTLPRREVIRTSLENRGALIKVRDLEEA
CLIANRIAPEHLELSVDQPEQWVDSIRHAGAIFLGRYTCEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRTSLIQVS
AEGASRLGKIASILAKGEGLEAHARSAEFRYR
>Mature_432_residues
MIQIRRLSSSDIDFQEELRSLLSFEISLDDEIDRTVIHILNQIRKYGDEALLELTRRFDNLDITRIDQVELPRNQWQSAL
EALSRDQREALEQAASHIHLYHEKQLAQSWDYVEPDGTRLGQKITALDRVGLYVPGGKAAYPSSVLMNAIPARVAGVNEL
IMVTPTPGGEKNPLVLAAAAICEVDRVFTIGGAQAIAALAYGTATIPKVDKIVGPGNAYVATAKRHVFGEVGIDMLAGPS
EILVICDGKTDPDWIAMDLFSQAEHDEQAQSILLCPDETFLDTVAKSMARLINTLPRREVIRTSLENRGALIKVRDLEEA
CLIANRIAPEHLELSVDQPEQWVDSIRHAGAIFLGRYTCEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRTSLIQVS
AEGASRLGKIASILAKGEGLEAHARSAEFRYR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=419, Percent_Identity=41.2887828162291, Blast_Score=302, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=35.3348729792148, Blast_Score=249, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47550; Mature: 47550

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIRRLSSSDIDFQEELRSLLSFEISLDDEIDRTVIHILNQIRKYGDEALLELTRRFDN
CEEEEECCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDITRIDQVELPRNQWQSALEALSRDQREALEQAASHIHLYHEKQLAQSWDYVEPDGTRL
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GQKITALDRVGLYVPGGKAAYPSSVLMNAIPARVAGVNELIMVTPTPGGEKNPLVLAAAA
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHH
ICEVDRVFTIGGAQAIAALAYGTATIPKVDKIVGPGNAYVATAKRHVFGEVGIDMLAGPS
HHHHHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEHHHHHHHHCCHHHCCCCC
EILVICDGKTDPDWIAMDLFSQAEHDEQAQSILLCPDETFLDTVAKSMARLINTLPRREV
EEEEEECCCCCCCHHHHHHHHHCCCCHHHCEEEECCCHHHHHHHHHHHHHHHHHCCHHHH
IRTSLENRGALIKVRDLEEACLIANRIAPEHLELSVDQPEQWVDSIRHAGAIFLGRYTCE
HHHHHHCCCCEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCEEHHHHHH
ALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRTSLIQVSAEGASRLGKIASILAKGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCC
EAHARSAEFRYR
CHHCCCCCCCCC
>Mature Secondary Structure
MIQIRRLSSSDIDFQEELRSLLSFEISLDDEIDRTVIHILNQIRKYGDEALLELTRRFDN
CEEEEECCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDITRIDQVELPRNQWQSALEALSRDQREALEQAASHIHLYHEKQLAQSWDYVEPDGTRL
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GQKITALDRVGLYVPGGKAAYPSSVLMNAIPARVAGVNELIMVTPTPGGEKNPLVLAAAA
HHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHH
ICEVDRVFTIGGAQAIAALAYGTATIPKVDKIVGPGNAYVATAKRHVFGEVGIDMLAGPS
HHHHHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEHHHHHHHHCCHHHCCCCC
EILVICDGKTDPDWIAMDLFSQAEHDEQAQSILLCPDETFLDTVAKSMARLINTLPRREV
EEEEEECCCCCCCHHHHHHHHHCCCCHHHCEEEECCCHHHHHHHHHHHHHHHHHCCHHHH
IRTSLENRGALIKVRDLEEACLIANRIAPEHLELSVDQPEQWVDSIRHAGAIFLGRYTCE
HHHHHHCCCCEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCEEHHHHHH
ALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRTSLIQVSAEGASRLGKIASILAKGEGL
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCC
EAHARSAEFRYR
CHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]