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The map label for this gene is pntB [H]

Identifier: 114331191

GI number: 114331191

Start: 1248451

End: 1249830

Strand: Direct

Name: pntB [H]

Synonym: Neut_1193

Alternate gene names: 114331191

Gene position: 1248451-1249830 (Clockwise)

Preceding gene: 114331190

Following gene: 114331195

Centisome position: 46.92

GC content: 45.51

Gene sequence:

>1380_bases
ATGTCTGTTAACTTCATCGCGCTGGCCTATCTGGTAGCGGCTGTATTTTTTATTCTTTCACTCAAGGGATTAAGTTCGCC
CACTGCTGCACGTCGTGGCAATCTACTTGGTATGTTGGGGATGGGTATTGCTGTAAGTACAACCCTGACCATTACTGGAA
ACTGGGTGCTGATTTTAAGCTGTATTGCTGTGGGTGCAATCATCGGTTCAATTGTGGCGCAGCGTATTCAGATGACTGCA
ATGCCTGAACTCATTGCGTTCATGCATTCGCTTGTTGGACTTGCTGCGGTATTTATTGCAATTGCCGCTGTCAATAATCC
GGTTTCATTCGGTTTGCCGGAAATATTACCTGCTGGTAATAAACTTGAGCTTTTTCTGGGGACTTTCATCGGTGCCATGA
CATGGTCTGGATCCGTTATTGCTTTCCTTAAGTTATCCGGGCGCATGAGTGGCGCACCGATTATCTTTAGTGGCCAGCAT
ATGGTTAATTTGTTGCTGGCAATTGTCATGATCAGTTTTGGCTTATGGTTTTTCTTTAGCGAAACAACGAACTGGACTGC
ATTTTCTACAATGACAGCGGTTGCCTTCCTGTTGGGTTTTCTCATTATTATTCCAATCGGTGGTGCAGACATGCCGGTTG
TGATTTCCATGTTGAACTCATATTCGGGATGGGCTGCAGCAGGAATTGGTTTTTCGCTTGGGAATCCGATGTTGATTATC
GCCGGATCTCTGGTAGGTAGCTCTGGCGCAATTCTCTCTTACATTATGTGTAAGGCCATGAACCGACCATTTCTTTCTGT
GATTCTTGGTGGTTTTGGCAGTGATGGAGGAAGCCAGAGTACTAGCGATGGGGCACAGAAAACCTACCGTAGCGGTAGTG
CAGATGATGCTGCATTTTTGTTGGGGAATTCGGACAGTGTTATTATCATTCCCGGATATGGACTGGCCGTGGCACGTGCT
CAGCATGCCGTTAAAGAATTAGCATTGGCACTGCATAAAAAAGGAATCAATATTCGTTTTGCCATTCATCCTGTCGCAGG
TCGTATGCCTGGCCATATGAATGTACTGCTTGCAGAGGCTGAGATTCCCTATGAGATGGTTCAGGAAATGGAAGAGATCA
ACAGTGATTTTCCGAATACCGATGTCGTACTGGTATTAGGCGCAAATGACGTAGTCAATCCGGCAGCAAATGTTCCAGGA
AGTCCTATTTACGGAATGCCAATCCTGGAGGCATATAAGGCACGTACAGTAATGGTTGTCAAACGCAGTATGGCTGCTGG
CTATGCGGGCTTGGACAATGATCTCTTTTATATGGATAAGACCATGATGGTATTTGGTGATGCCAAGAAAGTCGTGGAAG
ATATGGTTAAAGCACTTTAA

Upstream 100 bases:

>100_bases
AGCCGTGGTCTTGGCATCCATCAATGTATTCGGTGGATTTCTCGTTACCCAGCGTATGCTGGAAATGTTTAAGAAAAAAG
ATAAAAAAGGACAAGCCTAA

Downstream 100 bases:

>100_bases
TTAAGTCGTAGTGTTATTACTCTAATAGCCCGATAGCTGTTTCTCAGATTTATTTCTGGAATCCAGCCACTCTCGGGCTG
TTTTTTGTGCTGATGTAAGT

Product: NAD(P) transhydrogenase, beta subunit

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSVNFIALAYLVAAVFFILSLKGLSSPTAARRGNLLGMLGMGIAVSTTLTITGNWVLILSCIAVGAIIGSIVAQRIQMTA
MPELIAFMHSLVGLAAVFIAIAAVNNPVSFGLPEILPAGNKLELFLGTFIGAMTWSGSVIAFLKLSGRMSGAPIIFSGQH
MVNLLLAIVMISFGLWFFFSETTNWTAFSTMTAVAFLLGFLIIIPIGGADMPVVISMLNSYSGWAAAGIGFSLGNPMLII
AGSLVGSSGAILSYIMCKAMNRPFLSVILGGFGSDGGSQSTSDGAQKTYRSGSADDAAFLLGNSDSVIIIPGYGLAVARA
QHAVKELALALHKKGINIRFAIHPVAGRMPGHMNVLLAEAEIPYEMVQEMEEINSDFPNTDVVLVLGANDVVNPAANVPG
SPIYGMPILEAYKARTVMVVKRSMAAGYAGLDNDLFYMDKTMMVFGDAKKVVEDMVKAL

Sequences:

>Translated_459_residues
MSVNFIALAYLVAAVFFILSLKGLSSPTAARRGNLLGMLGMGIAVSTTLTITGNWVLILSCIAVGAIIGSIVAQRIQMTA
MPELIAFMHSLVGLAAVFIAIAAVNNPVSFGLPEILPAGNKLELFLGTFIGAMTWSGSVIAFLKLSGRMSGAPIIFSGQH
MVNLLLAIVMISFGLWFFFSETTNWTAFSTMTAVAFLLGFLIIIPIGGADMPVVISMLNSYSGWAAAGIGFSLGNPMLII
AGSLVGSSGAILSYIMCKAMNRPFLSVILGGFGSDGGSQSTSDGAQKTYRSGSADDAAFLLGNSDSVIIIPGYGLAVARA
QHAVKELALALHKKGINIRFAIHPVAGRMPGHMNVLLAEAEIPYEMVQEMEEINSDFPNTDVVLVLGANDVVNPAANVPG
SPIYGMPILEAYKARTVMVVKRSMAAGYAGLDNDLFYMDKTMMVFGDAKKVVEDMVKAL
>Mature_458_residues
SVNFIALAYLVAAVFFILSLKGLSSPTAARRGNLLGMLGMGIAVSTTLTITGNWVLILSCIAVGAIIGSIVAQRIQMTAM
PELIAFMHSLVGLAAVFIAIAAVNNPVSFGLPEILPAGNKLELFLGTFIGAMTWSGSVIAFLKLSGRMSGAPIIFSGQHM
VNLLLAIVMISFGLWFFFSETTNWTAFSTMTAVAFLLGFLIIIPIGGADMPVVISMLNSYSGWAAAGIGFSLGNPMLIIA
GSLVGSSGAILSYIMCKAMNRPFLSVILGGFGSDGGSQSTSDGAQKTYRSGSADDAAFLLGNSDSVIIIPGYGLAVARAQ
HAVKELALALHKKGINIRFAIHPVAGRMPGHMNVLLAEAEIPYEMVQEMEEINSDFPNTDVVLVLGANDVVNPAANVPGS
PIYGMPILEAYKARTVMVVKRSMAAGYAGLDNDLFYMDKTMMVFGDAKKVVEDMVKAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=459, Percent_Identity=45.3159041394335, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI122939153, Length=459, Percent_Identity=45.3159041394335, Blast_Score=368, Evalue=1e-102,
Organism=Escherichia coli, GI1787886, Length=466, Percent_Identity=53.2188841201717, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17550456, Length=460, Percent_Identity=43.4782608695652, Blast_Score=348, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48314; Mature: 48183

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNFIALAYLVAAVFFILSLKGLSSPTAARRGNLLGMLGMGIAVSTTLTITGNWVLILS
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEHHHCCEEEEEEEEECCCHHHHHH
CIAVGAIIGSIVAQRIQMTAMPELIAFMHSLVGLAAVFIAIAAVNNPVSFGLPEILPAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
KLELFLGTFIGAMTWSGSVIAFLKLSGRMSGAPIIFSGQHMVNLLLAIVMISFGLWFFFS
EEHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHEEE
ETTNWTAFSTMTAVAFLLGFLIIIPIGGADMPVVISMLNSYSGWAAAGIGFSLGNPMLII
CCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEECCCCCCCCCCEEEE
AGSLVGSSGAILSYIMCKAMNRPFLSVILGGFGSDGGSQSTSDGAQKTYRSGSADDAAFL
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEE
LGNSDSVIIIPGYGLAVARAQHAVKELALALHKKGINIRFAIHPVAGRMPGHMNVLLAEA
ECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEC
EIPYEMVQEMEEINSDFPNTDVVLVLGANDVVNPAANVPGSPIYGMPILEAYKARTVMVV
CCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEE
KRSMAAGYAGLDNDLFYMDKTMMVFGDAKKVVEDMVKAL
HHHHHCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHC
>Mature Secondary Structure 
SVNFIALAYLVAAVFFILSLKGLSSPTAARRGNLLGMLGMGIAVSTTLTITGNWVLILS
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEHHHCCEEEEEEEEECCCHHHHHH
CIAVGAIIGSIVAQRIQMTAMPELIAFMHSLVGLAAVFIAIAAVNNPVSFGLPEILPAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
KLELFLGTFIGAMTWSGSVIAFLKLSGRMSGAPIIFSGQHMVNLLLAIVMISFGLWFFFS
EEHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHEEE
ETTNWTAFSTMTAVAFLLGFLIIIPIGGADMPVVISMLNSYSGWAAAGIGFSLGNPMLII
CCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEECCCCCCCCCCEEEE
AGSLVGSSGAILSYIMCKAMNRPFLSVILGGFGSDGGSQSTSDGAQKTYRSGSADDAAFL
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEE
LGNSDSVIIIPGYGLAVARAQHAVKELALALHKKGINIRFAIHPVAGRMPGHMNVLLAEA
ECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEC
EIPYEMVQEMEEINSDFPNTDVVLVLGANDVVNPAANVPGSPIYGMPILEAYKARTVMVV
CCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEE
KRSMAAGYAGLDNDLFYMDKTMMVFGDAKKVVEDMVKAL
HHHHHCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]