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The map label for this gene is pepA [H]

Identifier: 114331022

GI number: 114331022

Start: 1055529

End: 1057025

Strand: Direct

Name: pepA [H]

Synonym: Neut_1022

Alternate gene names: 114331022

Gene position: 1055529-1057025 (Clockwise)

Preceding gene: 114331019

Following gene: 114331023

Centisome position: 39.67

GC content: 49.57

Gene sequence:

>1497_bases
ATGCTCGCAACTCTTACTCAAAACGACGATACTTTTGACGAATCGACTCAGGCTTCTCACTTACTGATCATCTTTCCCAA
GACAGAGAAAATACCCGGGAAATACCCATTGCCTGCTGAGCAGGTGCTCAATGATTTACTGCAGCGGCAAGGCGCATCGC
CAGGCCGGTTGGCGGAAACACCGTTATCTGTCAACCTGCAGAGTGGTGCGCTTTATGCCTGGACGATGGTGGATACCGGC
AAATCGGTATTTGAACAACAAACCGGAATTCGCAAGGCAATGCAACTGCTGCTGAATGAGAACCCGGTTGAAATTCATCT
GGCTGTTTATGGAGATGAGACACAAAGACGACATCTGGCCGAACTCGCAGTTTATATCGCCTGGATTAACGGGGCAATAC
TACCGATACGTAAACAGCGTAAGGCGGATGACAAGCCACTGGAGAGAATTTATTTGCATGGCGCGGCTGATTCCACTGGA
TTTGCCATACAGTGCGCACAGGCAGAGGGAAATTTTCTTGCCAGAGGATTGACTATCCTGCCTCCCAACGAGCTGACTCC
CAAGACTTACCGTGAACAAATAAAAAAGCTGGCTGCCAGTGAAAACTGGCAATACCAGGAATATGAATTATCCCGGTTGC
GCGAGATGGGGGCAGGTGCATTTACAGCCGTCGCGCAGGGCAGCTTGACGGATGATGCGGCAATTGTTTATTTACGTAGA
ACGGCAAAAAACAGTGAAACTAACAGAACAATCGCCCTGGTGGGAAAGGGTATCTGCTTTGATACAGGCGGACATAATCT
TAAATCGGCGCGCTATATGTATGGCATGCATGAGGATATGAATGGTTCAGCGGTAGCGCTTGGGGCACTTCTGGCTGCAA
CCCGGGCCGATCTGCCAATCAACATAGATTGCTGGCTTGCTATTGCCCAGAACCACGTGAGCCCCGATGCGTTCAAGCAA
AATGATGTGATTACTGCTCTGAATGGTATGACGGTAGAAGTCGTTCATACGGATGCGGAAGGGCGACTGGTACTGGCGGA
TACGCTGACACTTGCTGCCAGAGAAAAACCTGATCTGATTATCGACTATGCTACGTTGACAGGCAGCCTGATTACCGCAC
TGGGCACTCGCTACAGCGGTGTTTTTACCAACCGTGATTATCTGGCGCAAAATGCGGTGGCAGTGGGCAGAACAAGTGGC
GAACGGGTATGCGTGTTTCCGGTGGACAATGATTATGAAGCTGATCTCGAAAGCAAAATTGCCGACATCAAGCAGTGCTC
CATAGAAAGTGAGGCAGACCATATTCTTGCCGCCTGTTTCCTGCGACATTTTGTGAATGATATTCCCTGGTTGCATATGG
ATCTTTCTGCTTCCCGTCATCAGGATGGATTGGGCGCGGTCAGTACGGATGTTACCGGGTTCGGCGTTACCTGGTCGATT
CATTTTTTGCAGGAAATGCTCAAAATTTTGCAGAAAAGAACAGGGAGAACTCGCTGA

Upstream 100 bases:

>100_bases
TGAATAATCCTGAAAGTATGAATCAAGCAGATATAATAGAGCGCTATATCAATTGAATAGTACAGGTGGCTTTTTTAAAG
CCAGTTTACTTAAAAAAATA

Downstream 100 bases:

>100_bases
TTATCAACCTTATTTCACTGGTATTTTCTCCATGAATGATGAAGTAAAACAACGTTTGCAAAATACTGAAACCTGGACCC
GGGTACTTTTTATGCTGTTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MLATLTQNDDTFDESTQASHLLIIFPKTEKIPGKYPLPAEQVLNDLLQRQGASPGRLAETPLSVNLQSGALYAWTMVDTG
KSVFEQQTGIRKAMQLLLNENPVEIHLAVYGDETQRRHLAELAVYIAWINGAILPIRKQRKADDKPLERIYLHGAADSTG
FAIQCAQAEGNFLARGLTILPPNELTPKTYREQIKKLAASENWQYQEYELSRLREMGAGAFTAVAQGSLTDDAAIVYLRR
TAKNSETNRTIALVGKGICFDTGGHNLKSARYMYGMHEDMNGSAVALGALLAATRADLPINIDCWLAIAQNHVSPDAFKQ
NDVITALNGMTVEVVHTDAEGRLVLADTLTLAAREKPDLIIDYATLTGSLITALGTRYSGVFTNRDYLAQNAVAVGRTSG
ERVCVFPVDNDYEADLESKIADIKQCSIESEADHILAACFLRHFVNDIPWLHMDLSASRHQDGLGAVSTDVTGFGVTWSI
HFLQEMLKILQKRTGRTR

Sequences:

>Translated_498_residues
MLATLTQNDDTFDESTQASHLLIIFPKTEKIPGKYPLPAEQVLNDLLQRQGASPGRLAETPLSVNLQSGALYAWTMVDTG
KSVFEQQTGIRKAMQLLLNENPVEIHLAVYGDETQRRHLAELAVYIAWINGAILPIRKQRKADDKPLERIYLHGAADSTG
FAIQCAQAEGNFLARGLTILPPNELTPKTYREQIKKLAASENWQYQEYELSRLREMGAGAFTAVAQGSLTDDAAIVYLRR
TAKNSETNRTIALVGKGICFDTGGHNLKSARYMYGMHEDMNGSAVALGALLAATRADLPINIDCWLAIAQNHVSPDAFKQ
NDVITALNGMTVEVVHTDAEGRLVLADTLTLAAREKPDLIIDYATLTGSLITALGTRYSGVFTNRDYLAQNAVAVGRTSG
ERVCVFPVDNDYEADLESKIADIKQCSIESEADHILAACFLRHFVNDIPWLHMDLSASRHQDGLGAVSTDVTGFGVTWSI
HFLQEMLKILQKRTGRTR
>Mature_498_residues
MLATLTQNDDTFDESTQASHLLIIFPKTEKIPGKYPLPAEQVLNDLLQRQGASPGRLAETPLSVNLQSGALYAWTMVDTG
KSVFEQQTGIRKAMQLLLNENPVEIHLAVYGDETQRRHLAELAVYIAWINGAILPIRKQRKADDKPLERIYLHGAADSTG
FAIQCAQAEGNFLARGLTILPPNELTPKTYREQIKKLAASENWQYQEYELSRLREMGAGAFTAVAQGSLTDDAAIVYLRR
TAKNSETNRTIALVGKGICFDTGGHNLKSARYMYGMHEDMNGSAVALGALLAATRADLPINIDCWLAIAQNHVSPDAFKQ
NDVITALNGMTVEVVHTDAEGRLVLADTLTLAAREKPDLIIDYATLTGSLITALGTRYSGVFTNRDYLAQNAVAVGRTSG
ERVCVFPVDNDYEADLESKIADIKQCSIESEADHILAACFLRHFVNDIPWLHMDLSASRHQDGLGAVSTDVTGFGVTWSI
HFLQEMLKILQKRTGRTR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=338, Percent_Identity=34.6153846153846, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI47155554, Length=343, Percent_Identity=31.7784256559767, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1790710, Length=290, Percent_Identity=35.1724137931034, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87082123, Length=302, Percent_Identity=36.0927152317881, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17556903, Length=284, Percent_Identity=32.3943661971831, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17565172, Length=145, Percent_Identity=37.2413793103448, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355725, Length=310, Percent_Identity=30.6451612903226, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24661038, Length=300, Percent_Identity=30.6666666666667, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI221379063, Length=304, Percent_Identity=31.25, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI221379062, Length=304, Percent_Identity=31.25, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357381, Length=304, Percent_Identity=31.25, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24662227, Length=336, Percent_Identity=26.1904761904762, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077148, Length=372, Percent_Identity=27.4193548387097, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI20130057, Length=372, Percent_Identity=27.4193548387097, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI19922386, Length=318, Percent_Identity=28.3018867924528, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129969, Length=304, Percent_Identity=26.3157894736842, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129963, Length=354, Percent_Identity=26.8361581920904, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355645, Length=309, Percent_Identity=25.5663430420712, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24662223, Length=309, Percent_Identity=25.5663430420712, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646701, Length=251, Percent_Identity=27.4900398406374, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646703, Length=251, Percent_Identity=27.4900398406374, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358201, Length=251, Percent_Identity=27.4900398406374, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54830; Mature: 54830

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLATLTQNDDTFDESTQASHLLIIFPKTEKIPGKYPLPAEQVLNDLLQRQGASPGRLAET
CEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECC
PLSVNLQSGALYAWTMVDTGKSVFEQQTGIRKAMQLLLNENPVEIHLAVYGDETQRRHLA
CEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHH
ELAVYIAWINGAILPIRKQRKADDKPLERIYLHGAADSTGFAIQCAQAEGNFLARGLTIL
HHHHHHHHHCCCEEECHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCEEECCEEEE
PPNELTPKTYREQIKKLAASENWQYQEYELSRLREMGAGAFTAVAQGSLTDDAAIVYLRR
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHCCCCCCCCEEEEEEEE
TAKNSETNRTIALVGKGICFDTGGHNLKSARYMYGMHEDMNGSAVALGALLAATRADLPI
CCCCCCCCCEEEEEECCEEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCE
NIDCWLAIAQNHVSPDAFKQNDVITALNGMTVEVVHTDAEGRLVLADTLTLAAREKPDLI
EEHEEEEEECCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCEEEEEEEEECCCCCCCEE
IDYATLTGSLITALGTRYSGVFTNRDYLAQNAVAVGRTSGERVCVFPVDNDYEADLESKI
EEEHHHHHHHHHHHCCCCCEEECCCHHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHH
ADIKQCSIESEADHILAACFLRHFVNDIPWLHMDLSASRHQDGLGAVSTDVTGFGVTWSI
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEECCCCCCCEEEEH
HFLQEMLKILQKRTGRTR
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLATLTQNDDTFDESTQASHLLIIFPKTEKIPGKYPLPAEQVLNDLLQRQGASPGRLAET
CEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECC
PLSVNLQSGALYAWTMVDTGKSVFEQQTGIRKAMQLLLNENPVEIHLAVYGDETQRRHLA
CEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHH
ELAVYIAWINGAILPIRKQRKADDKPLERIYLHGAADSTGFAIQCAQAEGNFLARGLTIL
HHHHHHHHHCCCEEECHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCEEECCEEEE
PPNELTPKTYREQIKKLAASENWQYQEYELSRLREMGAGAFTAVAQGSLTDDAAIVYLRR
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHCCCCCCCCEEEEEEEE
TAKNSETNRTIALVGKGICFDTGGHNLKSARYMYGMHEDMNGSAVALGALLAATRADLPI
CCCCCCCCCEEEEEECCEEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCE
NIDCWLAIAQNHVSPDAFKQNDVITALNGMTVEVVHTDAEGRLVLADTLTLAAREKPDLI
EEHEEEEEECCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCEEEEEEEEECCCCCCCEE
IDYATLTGSLITALGTRYSGVFTNRDYLAQNAVAVGRTSGERVCVFPVDNDYEADLESKI
EEEHHHHHHHHHHHCCCCCEEECCCHHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHH
ADIKQCSIESEADHILAACFLRHFVNDIPWLHMDLSASRHQDGLGAVSTDVTGFGVTWSI
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEECCCCCCCEEEEH
HFLQEMLKILQKRTGRTR
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA