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The map label for this gene is phoR [H]

Identifier: 114330963

GI number: 114330963

Start: 990472

End: 991788

Strand: Direct

Name: phoR [H]

Synonym: Neut_0960

Alternate gene names: 114330963

Gene position: 990472-991788 (Clockwise)

Preceding gene: 114330962

Following gene: 114330964

Centisome position: 37.22

GC content: 48.52

Gene sequence:

>1317_bases
GTGAATACCTTTTGGCTCAGTCTTGCTCCCATTTTATGGCTGACTATTATTGCTGCATTGACGGGGATGATATTTGATAT
AGCAATCGTACTGGGTCTGTACAGCGTCATCCTGCTCGGGATTGTTATTTATCATCTTTATACATTATATTGCCTGGATC
AATGGTTACGCCACTCGGATTATTCCTATTCGACAGTGCCCGATAGATCTGGTTTGTGGGGAGTCGTTTTTGCCAGATTG
GCACGTTTCGTCAGGCGTAGCGATAAGGAACGCCTGGGACTGAATCTCTCGCTGGAGCGACTGCAGCGCGCGACATCTGC
TTTACCGGAAGGAATTGTCATCCTGGGCGACAAAGATCAGATCGAGTGGTGCAATTCGTCTGCCGAGTTGCACCTGGGCC
TCAATCTTGGGATGGATGCCGGCCAGCATATTACTCGCATGGTACGTCAGGTGCGATTTGTGGCTTATCTTGATGCGGGA
GATTTCAGCAAGCCTTTTCTACTCAATCAGACACGTTTTCGCGATACGCTGCTTTCTATTCAGATAGTGCCTTATGGTGA
CAGGGAAAAATTACTGATCAGCCGGGATGTAACACGTTTTGAAAAACTTGAAATTATGCGGCGTGATTTTGTCGCGAATG
TCTCGCATGAATTGCGTACACCCTTGACAGTAATTGGAGGGTTTCTTGAAACGCTGCTGGAAGAAAACAAGGTATCCGGT
GACATGGAGAAAAATGCACTGCGACTGATGTTTGACCAGGCTACCCGCATGCGCCGTCTGGTAGAGGATTTGCTGACGCT
ATCCCGACTGGAGAATGCCGGAAATAATCTGGCTGAAGAAAAGGTAGATATCGTTAAGCTGTTACAGGGACTTTATCAGG
AAGCCCAATCATTAAGCGCTGGCCGCCATACTATTTCCCTTGATCTTGCCAGCCATGCCATGCTGCTTGGCAGTGAAGAT
GAGCTGCGCAGCGCATTTGAAAACCTCATCAGTAATGCTGTGCGGTACACCCCTGAAAATGGGGTGATTTCCCTGAACTG
GACGGTGGAAAATGGGAAAGGATTGTTTTACGTTCAGGACAGCGGGATAGGCATTGAGCCGAATCATATTCCCCGGTTGA
CAGAACGTTTTTATCGGGTGGATCGTAGTCGTTCTCGCGAAACCGGTGGCACCGGTCTCGGACTTGCTATCGTCAAGCAT
GTTCTGAACCGCCATCAGGCGAGTATGGAAATTACCAGTCAGCCTGGGGCAGGCAGTATTTTTAGGATGTGGTTCCCTGA
AAGCCGAGTATTGCCTGCTGAAAATGTGACTGAGTAA

Upstream 100 bases:

>100_bases
ATAAGATCCGGATAATATTCCAAGGTGAAGGCTGAAGTTGGAAAAACGGATACTGCTGGAGCTGTACTGAAAAATCAATC
CTGTCACTGCTCATAATTAC

Downstream 100 bases:

>100_bases
TATCTGGGTGTGTAGAGTAAGCTTTTCTGGTCAGGGACTTGTTCGACGTTCCATGTCGTCTGATATTAGCTCGCTGTTGT
TTTTATTCCACTCCTTAAAC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNTFWLSLAPILWLTIIAALTGMIFDIAIVLGLYSVILLGIVIYHLYTLYCLDQWLRHSDYSYSTVPDRSGLWGVVFARL
ARFVRRSDKERLGLNLSLERLQRATSALPEGIVILGDKDQIEWCNSSAELHLGLNLGMDAGQHITRMVRQVRFVAYLDAG
DFSKPFLLNQTRFRDTLLSIQIVPYGDREKLLISRDVTRFEKLEIMRRDFVANVSHELRTPLTVIGGFLETLLEENKVSG
DMEKNALRLMFDQATRMRRLVEDLLTLSRLENAGNNLAEEKVDIVKLLQGLYQEAQSLSAGRHTISLDLASHAMLLGSED
ELRSAFENLISNAVRYTPENGVISLNWTVENGKGLFYVQDSGIGIEPNHIPRLTERFYRVDRSRSRETGGTGLGLAIVKH
VLNRHQASMEITSQPGAGSIFRMWFPESRVLPAENVTE

Sequences:

>Translated_438_residues
MNTFWLSLAPILWLTIIAALTGMIFDIAIVLGLYSVILLGIVIYHLYTLYCLDQWLRHSDYSYSTVPDRSGLWGVVFARL
ARFVRRSDKERLGLNLSLERLQRATSALPEGIVILGDKDQIEWCNSSAELHLGLNLGMDAGQHITRMVRQVRFVAYLDAG
DFSKPFLLNQTRFRDTLLSIQIVPYGDREKLLISRDVTRFEKLEIMRRDFVANVSHELRTPLTVIGGFLETLLEENKVSG
DMEKNALRLMFDQATRMRRLVEDLLTLSRLENAGNNLAEEKVDIVKLLQGLYQEAQSLSAGRHTISLDLASHAMLLGSED
ELRSAFENLISNAVRYTPENGVISLNWTVENGKGLFYVQDSGIGIEPNHIPRLTERFYRVDRSRSRETGGTGLGLAIVKH
VLNRHQASMEITSQPGAGSIFRMWFPESRVLPAENVTE
>Mature_438_residues
MNTFWLSLAPILWLTIIAALTGMIFDIAIVLGLYSVILLGIVIYHLYTLYCLDQWLRHSDYSYSTVPDRSGLWGVVFARL
ARFVRRSDKERLGLNLSLERLQRATSALPEGIVILGDKDQIEWCNSSAELHLGLNLGMDAGQHITRMVRQVRFVAYLDAG
DFSKPFLLNQTRFRDTLLSIQIVPYGDREKLLISRDVTRFEKLEIMRRDFVANVSHELRTPLTVIGGFLETLLEENKVSG
DMEKNALRLMFDQATRMRRLVEDLLTLSRLENAGNNLAEEKVDIVKLLQGLYQEAQSLSAGRHTISLDLASHAMLLGSED
ELRSAFENLISNAVRYTPENGVISLNWTVENGKGLFYVQDSGIGIEPNHIPRLTERFYRVDRSRSRETGGTGLGLAIVKH
VLNRHQASMEITSQPGAGSIFRMWFPESRVLPAENVTE

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=412, Percent_Identity=41.504854368932, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=31.640625, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=29.1666666666667, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=30.0429184549356, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=28.3261802575107, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=30.0411522633745, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=373, Percent_Identity=25.7372654155496, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI48994928, Length=268, Percent_Identity=29.4776119402985, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081816, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=229, Percent_Identity=31.4410480349345, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=31.1475409836066, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=32.2175732217573, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=278, Percent_Identity=26.2589928057554, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=27.8969957081545, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=25.5506607929515, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=27.4336283185841, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790551, Length=224, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=25.1082251082251, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49610; Mature: 49610

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFWLSLAPILWLTIIAALTGMIFDIAIVLGLYSVILLGIVIYHLYTLYCLDQWLRHSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YSYSTVPDRSGLWGVVFARLARFVRRSDKERLGLNLSLERLQRATSALPEGIVILGDKDQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCH
IEWCNSSAELHLGLNLGMDAGQHITRMVRQVRFVAYLDAGDFSKPFLLNQTRFRDTLLSI
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCEECCHHHHHHEEEEE
QIVPYGDREKLLISRDVTRFEKLEIMRRDFVANVSHELRTPLTVIGGFLETLLEENKVSG
EEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
DMEKNALRLMFDQATRMRRLVEDLLTLSRLENAGNNLAEEKVDIVKLLQGLYQEAQSLSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GRHTISLDLASHAMLLGSEDELRSAFENLISNAVRYTPENGVISLNWTVENGKGLFYVQD
CCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCEEEEEEC
SGIGIEPNHIPRLTERFYRVDRSRSRETGGTGLGLAIVKHVLNRHQASMEITSQPGAGSI
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCE
FRMWFPESRVLPAENVTE
EEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNTFWLSLAPILWLTIIAALTGMIFDIAIVLGLYSVILLGIVIYHLYTLYCLDQWLRHSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YSYSTVPDRSGLWGVVFARLARFVRRSDKERLGLNLSLERLQRATSALPEGIVILGDKDQ
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCH
IEWCNSSAELHLGLNLGMDAGQHITRMVRQVRFVAYLDAGDFSKPFLLNQTRFRDTLLSI
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCEECCHHHHHHEEEEE
QIVPYGDREKLLISRDVTRFEKLEIMRRDFVANVSHELRTPLTVIGGFLETLLEENKVSG
EEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
DMEKNALRLMFDQATRMRRLVEDLLTLSRLENAGNNLAEEKVDIVKLLQGLYQEAQSLSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GRHTISLDLASHAMLLGSEDELRSAFENLISNAVRYTPENGVISLNWTVENGKGLFYVQD
CCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCEEEEEEC
SGIGIEPNHIPRLTERFYRVDRSRSRETGGTGLGLAIVKHVLNRHQASMEITSQPGAGSI
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCE
FRMWFPESRVLPAENVTE
EEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]