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The map label for this gene is gltT [H]

Identifier: 114330850

GI number: 114330850

Start: 862825

End: 864045

Strand: Reverse

Name: gltT [H]

Synonym: Neut_0844

Alternate gene names: 114330850

Gene position: 864045-862825 (Counterclockwise)

Preceding gene: 114330851

Following gene: 114330847

Centisome position: 32.47

GC content: 52.17

Gene sequence:

>1221_bases
ATGGGATTAGGCACGATCACTGGGCTTGCATTATCCCCTGGTGGCTTTGCATTGCTGGAAAATGAAACCGCGCTCACTGC
GGCAGAATGGATTGCCCTGCCCGGTACCGTATTTCTGGAAATCCTGAAAATGGTAGTAATTCCGCTAATCATCTGCTCCA
TCGTACTGGGCATTCTGAGCAGCGGCTCACCCCGGCAACTAAAGAAGATGGGGGCATTTATCGTGCCCTATTTCATAGCA
ACTTCTTTTGTAGCAGTCACAATCGGCCTGTCACTCTCTCTTTTTATCCAGCCAGGACACATGATGAGTGCCGGTGCCCA
TGCAATGGTAACGGATGCAATATCGACCGCCAGTGCACCGATACTGGATGAACTGACTGTTCCACAACGCATTACCCGTC
TGATTCCTTCCAATTTTGTCGAAGCAGCTTTGCACGTCGACATGCTCAAAATTGTGATCATCGCCATCTTTTTTGGTGTT
GCCGCGCTGACCATGCCGCGCGAGATCGTAAAACCATTTGAGGCACTATGTCTGTTCGGGCAAGGCGCCGCGATGCAAAT
TATCGACTGGGCCATGGCATTGGCACCTTATGCCGTATTTGGCCTGATGACCGACGCCATGATTCACCTGGGCTTTGACG
CCCTCAGCGCCATTGGCTGGTATATGACCTCTGTACTATCGGGGCTGGCCATTATTCTCAGTTTGTATCTGTTCGGAGCA
ACCGTATTTGGTGGCCATTCACCAACTACTTTTTTACGAGCGATCCGTGAAGTGCAACTGCTGGCCTTTTCAACCTCCAG
CTCGGCAGCTGTGATGCCAGTATCCATCCGTACCGCAGAAAACAACCTGGGTGTCAGTGAAGATATCAGCCGCTTCGTCA
TCCCCATTGGTGCAACCATCAACATGGACGGCACCGGACTTTATCAGGCCGTAGCTGCTATTTTCCTGTGTCAGATCTTC
GGCGTGGATCTGAGTTTTACCGAGATGGCCTTGCTGATGTGCGTCATCGTGGGTGCATCAATCGGCACTCCCGCCACCCC
TGGCGTTGGCATTGTCGTGCTGGCCACCATTTTATCCGGCATCGGCGTACCTCCCGCCGGCATCGGTATTATTTTCGGCG
TTGACCGTATCCTTGACATGTGCCGCACGACTATCAACGTCACAGGCGATCTCACCGCTGTCGTCATTATGGAGCGCTGG
ATGAAAAGCAGATCTGCTTAA

Upstream 100 bases:

>100_bases
TCTTTGCAAGCTAGCCGTGACATTTTTCAGATACCAGCAAATATTCACATCTGTGCGCTCTTTGCTTGCCCAGCAGCTAT
GGGCAAGGATCTTATTGGGT

Downstream 100 bases:

>100_bases
AAAGTAGGCGAGAATCACCGTGCAGAGATTCCCTAAACACCCGAAGCGGCACGCCAAAGCGATCCAGCAACTTCAGAGCT
TTCTTTATCTCCGCCCGTGC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MGLGTITGLALSPGGFALLENETALTAAEWIALPGTVFLEILKMVVIPLIICSIVLGILSSGSPRQLKKMGAFIVPYFIA
TSFVAVTIGLSLSLFIQPGHMMSAGAHAMVTDAISTASAPILDELTVPQRITRLIPSNFVEAALHVDMLKIVIIAIFFGV
AALTMPREIVKPFEALCLFGQGAAMQIIDWAMALAPYAVFGLMTDAMIHLGFDALSAIGWYMTSVLSGLAIILSLYLFGA
TVFGGHSPTTFLRAIREVQLLAFSTSSSAAVMPVSIRTAENNLGVSEDISRFVIPIGATINMDGTGLYQAVAAIFLCQIF
GVDLSFTEMALLMCVIVGASIGTPATPGVGIVVLATILSGIGVPPAGIGIIFGVDRILDMCRTTINVTGDLTAVVIMERW
MKSRSA

Sequences:

>Translated_406_residues
MGLGTITGLALSPGGFALLENETALTAAEWIALPGTVFLEILKMVVIPLIICSIVLGILSSGSPRQLKKMGAFIVPYFIA
TSFVAVTIGLSLSLFIQPGHMMSAGAHAMVTDAISTASAPILDELTVPQRITRLIPSNFVEAALHVDMLKIVIIAIFFGV
AALTMPREIVKPFEALCLFGQGAAMQIIDWAMALAPYAVFGLMTDAMIHLGFDALSAIGWYMTSVLSGLAIILSLYLFGA
TVFGGHSPTTFLRAIREVQLLAFSTSSSAAVMPVSIRTAENNLGVSEDISRFVIPIGATINMDGTGLYQAVAAIFLCQIF
GVDLSFTEMALLMCVIVGASIGTPATPGVGIVVLATILSGIGVPPAGIGIIFGVDRILDMCRTTINVTGDLTAVVIMERW
MKSRSA
>Mature_405_residues
GLGTITGLALSPGGFALLENETALTAAEWIALPGTVFLEILKMVVIPLIICSIVLGILSSGSPRQLKKMGAFIVPYFIAT
SFVAVTIGLSLSLFIQPGHMMSAGAHAMVTDAISTASAPILDELTVPQRITRLIPSNFVEAALHVDMLKIVIIAIFFGVA
ALTMPREIVKPFEALCLFGQGAAMQIIDWAMALAPYAVFGLMTDAMIHLGFDALSAIGWYMTSVLSGLAIILSLYLFGAT
VFGGHSPTTFLRAIREVQLLAFSTSSSAAVMPVSIRTAENNLGVSEDISRFVIPIGATINMDGTGLYQAVAAIFLCQIFG
VDLSFTEMALLMCVIVGASIGTPATPGVGIVVLATILSGIGVPPAGIGIIFGVDRILDMCRTTINVTGDLTAVVIMERWM
KSRSA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI194239697, Length=450, Percent_Identity=27.3333333333333, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI5032093, Length=412, Percent_Identity=31.3106796116505, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI66773030, Length=463, Percent_Identity=29.1576673866091, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI169790839, Length=451, Percent_Identity=28.3813747228381, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI21314632, Length=410, Percent_Identity=28.2926829268293, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI40254478, Length=412, Percent_Identity=28.1553398058252, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=32.3529411764706, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4827012, Length=299, Percent_Identity=30.7692307692308, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI262359914, Length=387, Percent_Identity=27.1317829457364, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI301601644, Length=168, Percent_Identity=35.1190476190476, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1790514, Length=374, Percent_Identity=32.0855614973262, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1789947, Length=375, Percent_Identity=29.6, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788024, Length=396, Percent_Identity=27.2727272727273, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983106, Length=441, Percent_Identity=30.1587301587302, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983099, Length=441, Percent_Identity=30.1587301587302, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71996953, Length=458, Percent_Identity=29.4759825327511, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17537407, Length=391, Percent_Identity=31.7135549872123, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=27.9279279279279, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=444, Percent_Identity=25.6756756756757, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=27.363184079602, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24583025, Length=415, Percent_Identity=28.433734939759, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17137668, Length=415, Percent_Identity=28.433734939759, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583023, Length=415, Percent_Identity=28.433734939759, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281360481, Length=461, Percent_Identity=27.765726681128, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI281360483, Length=461, Percent_Identity=27.765726681128, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17137666, Length=461, Percent_Identity=27.765726681128, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42661; Mature: 42530

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLGTITGLALSPGGFALLENETALTAAEWIALPGTVFLEILKMVVIPLIICSIVLGILS
CCCCCCCCEEECCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SGSPRQLKKMGAFIVPYFIATSFVAVTIGLSLSLFIQPGHMMSAGAHAMVTDAISTASAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCC
ILDELTVPQRITRLIPSNFVEAALHVDMLKIVIIAIFFGVAALTMPREIVKPFEALCLFG
HHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
QGAAMQIIDWAMALAPYAVFGLMTDAMIHLGFDALSAIGWYMTSVLSGLAIILSLYLFGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVFGGHSPTTFLRAIREVQLLAFSTSSSAAVMPVSIRTAENNLGVSEDISRFVIPIGATI
HHCCCCCHHHHHHHHHHHHHHEEECCCCCEEEEEEEEECCCCCCCHHHHHHHEEECCCEE
NMDGTGLYQAVAAIFLCQIFGVDLSFTEMALLMCVIVGASIGTPATPGVGIVVLATILSG
ECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
IGVPPAGIGIIFGVDRILDMCRTTINVTGDLTAVVIMERWMKSRSA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLGTITGLALSPGGFALLENETALTAAEWIALPGTVFLEILKMVVIPLIICSIVLGILS
CCCCCCCEEECCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SGSPRQLKKMGAFIVPYFIATSFVAVTIGLSLSLFIQPGHMMSAGAHAMVTDAISTASAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCHHHHHHHHHHCCCC
ILDELTVPQRITRLIPSNFVEAALHVDMLKIVIIAIFFGVAALTMPREIVKPFEALCLFG
HHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
QGAAMQIIDWAMALAPYAVFGLMTDAMIHLGFDALSAIGWYMTSVLSGLAIILSLYLFGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVFGGHSPTTFLRAIREVQLLAFSTSSSAAVMPVSIRTAENNLGVSEDISRFVIPIGATI
HHCCCCCHHHHHHHHHHHHHHEEECCCCCEEEEEEEEECCCCCCCHHHHHHHEEECCCEE
NMDGTGLYQAVAAIFLCQIFGVDLSFTEMALLMCVIVGASIGTPATPGVGIVVLATILSG
ECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
IGVPPAGIGIIFGVDRILDMCRTTINVTGDLTAVVIMERWMKSRSA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]