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The map label for this gene is 114330847

Identifier: 114330847

GI number: 114330847

Start: 859102

End: 861222

Strand: Reverse

Name: 114330847

Synonym: Neut_0841

Alternate gene names: NA

Gene position: 861222-859102 (Counterclockwise)

Preceding gene: 114330850

Following gene: 114330846

Centisome position: 32.36

GC content: 53.61

Gene sequence:

>2121_bases
ATGTCAAATGCAAGATCAATTCATTCGCCATTTTCAGATCACTTATATCATTGCTTCAGTTTTTCAATTCTTCTGTTTCT
CCTGATCATCTTCTCCAGCAATAGCCATGCCAATCCAGGCAAGGATATCCGGGAAGCTGCCAGATCTGAATCAACCAGTA
AAACCGCCGCTTCTCCCTCCCATTGGAAAAAAGGTCGTCTGCTGCTCATTCCGCGTGCCGGGTTGACCGCAAAAGAGTTT
GATAAGGCCATCAGACCGCATGGCGTCAAATCCAAACGTAAACTCAGCAGGCTAAGTGCGCATATTTACGAATTGCCCGA
TGGCGTGGATGAAATCAAGGTCATGAACAAGCTCAAAAAAGATCGCCGTTTCAAGGCGGTTGAGCTGGATCAACTGGTTG
GCCCAGCGCAAATGGTTTCTGATCCCGCATTCAACAGCAGTTGGGCGCTACCCAAAATCCAGGCACCTGTCGCCTGGGAT
ATTGCTACTGGCGATGGCGTAACCATTGCTGTTCTTGATACCGGGGTGGACAGTAACCATCCTGATCTGGCCGCCAACAT
GGTTCCCGGCTGGAATATTTACAATGGTAACGACGATGCCAGCGATGTACATGGCCACGGCACCAAAGTGGCCGGTTCAG
CGGCAGCAGCGGCCAATAACGGTATTGGCAGCGCCGGGGTAGCCTGGAATGCACGCATCATGCCAATACGCATTGCCAAT
CCCAACGCTTACGCCTATTTCAGCGCCATGGCAGATGGCATTCGCTGGGCGGCTGATCACGGCGCGCGTGTTGCCAACAT
CAGCTATGAAGGCGCAGCCGGTAGCTTGACCGTGCAATCCGCTGCCAACTATATGCGTAGCAAGGGAGGAGTGGTGGTCG
TCGCCGCAGGCAATTCCAGCGGATATATCAGTTATGCCCCCAGTGATGCGCTGATCGTTGCCTCAGCAACAGGCAGTAAC
GATACACGCGCCAGCTGGTCCAGCTACGGCCCCGCAGTGGATGTTGCTGCACCGGGAGCAAGTATTTACACCACTACGCG
CGGCGGCGGGTACGGCTCCGTTTCCGGCACGTCCTTCTCCAGCCCGATTGTCGCCGCCACCGCTGCACTGATGTTCTCTG
CCAATCCGGATCTGGCCCCGGCAGATGTCGATCAGATACTCAAAAACACCTCTCTCGATCTCGGCGATCCCGGCCATGAT
GCCTACTACGGCCACGGGCGTATTAATGCTGCCGGTGCGGTGAATGCTGCTCATGCACAATTTAACGTGGATAACATTGC
GCCGGTTATCAGCATCACCTCCCCCACTGGTGGCACAGTGTTGGGAGATGTGTTGGTGGATGTCAATTATTCCGACAACA
AGGGCGTGGTGCGTGTAGAGCTGTACGTCAACGGCAGAAAAGCGATCGAAGATACCCAGCCGCCTTTCGCCTTCGCCTGG
GATACCAGCACACTGGCGGACGGCAGCTACACCCTGGTAGCGTATGCGTTTGATACTGCCGGTAACCAGGGTACCTCTGC
CCCGGTTAAAATCACCGTAAAAAATACGGCGGCAGATACCACACCGCCGACCATCAGCATCACCTCTCCCACTGGTGGCA
CAGTCTCCGGTAACGTATCCGTAAGTGTAAATTTTTCCGACAACATCGGCGTGGCGCGTACAGAACTGCACATTAACGGT
AAGCAGGCGATGGAAGACACCGAACCGGGCAACCGTTTTACCTGGAATACCACCACGCTGGCCGATGGCAGCTATACCCT
GGTGACGTATGCGTTTGATGCTGCCGGTAATCTGGGCACTTCCTCACCGGTGGTGGTCAGTGTAAAAAATTCCGACAACA
ATCCACAGAAAGCGCCTTTACCCAAAATTAACCAGTTCAATCTCAAGGATGGACAGAAAGTCAGCCTTTTTGAGAACGTC
AAAGTGAAAGCCGACAACAACACCCGCAAAATCAACCTGAAAGTGAATGGCAACATCCTTACCACTATTGACGGCAACTC
GTTGAATTACCGCTGGAATACATGGGATAGCGCCCCGCGCGGCAGCACGCTTACCGTTACCGTGGAAGCCGGTAACGTGG
ATGGTGAATTTGTCAGCCAAACTGTCAGCGTCAGAAATTAG

Upstream 100 bases:

>100_bases
AAAGCGGGACTGCCGAAGTTCGCATCCACTCCCTTTCTTCATACAGGTATGCGTACTGCGGGTCGGCTTCGTTATAACCT
ATCTTTCCAAGGAGCCGCGC

Downstream 100 bases:

>100_bases
GGAGGCTGTATAACCTTGATCCTGTCCTGACACAATCTGCAGGATTAAGGCAATCCGGCGCCGCTACTATCGTCTTTGTG
ACTGCGAGCGCAGAGAAGCA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MSNARSIHSPFSDHLYHCFSFSILLFLLIIFSSNSHANPGKDIREAARSESTSKTAASPSHWKKGRLLLIPRAGLTAKEF
DKAIRPHGVKSKRKLSRLSAHIYELPDGVDEIKVMNKLKKDRRFKAVELDQLVGPAQMVSDPAFNSSWALPKIQAPVAWD
IATGDGVTIAVLDTGVDSNHPDLAANMVPGWNIYNGNDDASDVHGHGTKVAGSAAAAANNGIGSAGVAWNARIMPIRIAN
PNAYAYFSAMADGIRWAADHGARVANISYEGAAGSLTVQSAANYMRSKGGVVVVAAGNSSGYISYAPSDALIVASATGSN
DTRASWSSYGPAVDVAAPGASIYTTTRGGGYGSVSGTSFSSPIVAATAALMFSANPDLAPADVDQILKNTSLDLGDPGHD
AYYGHGRINAAGAVNAAHAQFNVDNIAPVISITSPTGGTVLGDVLVDVNYSDNKGVVRVELYVNGRKAIEDTQPPFAFAW
DTSTLADGSYTLVAYAFDTAGNQGTSAPVKITVKNTAADTTPPTISITSPTGGTVSGNVSVSVNFSDNIGVARTELHING
KQAMEDTEPGNRFTWNTTTLADGSYTLVTYAFDAAGNLGTSSPVVVSVKNSDNNPQKAPLPKINQFNLKDGQKVSLFENV
KVKADNNTRKINLKVNGNILTTIDGNSLNYRWNTWDSAPRGSTLTVTVEAGNVDGEFVSQTVSVRN

Sequences:

>Translated_706_residues
MSNARSIHSPFSDHLYHCFSFSILLFLLIIFSSNSHANPGKDIREAARSESTSKTAASPSHWKKGRLLLIPRAGLTAKEF
DKAIRPHGVKSKRKLSRLSAHIYELPDGVDEIKVMNKLKKDRRFKAVELDQLVGPAQMVSDPAFNSSWALPKIQAPVAWD
IATGDGVTIAVLDTGVDSNHPDLAANMVPGWNIYNGNDDASDVHGHGTKVAGSAAAAANNGIGSAGVAWNARIMPIRIAN
PNAYAYFSAMADGIRWAADHGARVANISYEGAAGSLTVQSAANYMRSKGGVVVVAAGNSSGYISYAPSDALIVASATGSN
DTRASWSSYGPAVDVAAPGASIYTTTRGGGYGSVSGTSFSSPIVAATAALMFSANPDLAPADVDQILKNTSLDLGDPGHD
AYYGHGRINAAGAVNAAHAQFNVDNIAPVISITSPTGGTVLGDVLVDVNYSDNKGVVRVELYVNGRKAIEDTQPPFAFAW
DTSTLADGSYTLVAYAFDTAGNQGTSAPVKITVKNTAADTTPPTISITSPTGGTVSGNVSVSVNFSDNIGVARTELHING
KQAMEDTEPGNRFTWNTTTLADGSYTLVTYAFDAAGNLGTSSPVVVSVKNSDNNPQKAPLPKINQFNLKDGQKVSLFENV
KVKADNNTRKINLKVNGNILTTIDGNSLNYRWNTWDSAPRGSTLTVTVEAGNVDGEFVSQTVSVRN
>Mature_705_residues
SNARSIHSPFSDHLYHCFSFSILLFLLIIFSSNSHANPGKDIREAARSESTSKTAASPSHWKKGRLLLIPRAGLTAKEFD
KAIRPHGVKSKRKLSRLSAHIYELPDGVDEIKVMNKLKKDRRFKAVELDQLVGPAQMVSDPAFNSSWALPKIQAPVAWDI
ATGDGVTIAVLDTGVDSNHPDLAANMVPGWNIYNGNDDASDVHGHGTKVAGSAAAAANNGIGSAGVAWNARIMPIRIANP
NAYAYFSAMADGIRWAADHGARVANISYEGAAGSLTVQSAANYMRSKGGVVVVAAGNSSGYISYAPSDALIVASATGSND
TRASWSSYGPAVDVAAPGASIYTTTRGGGYGSVSGTSFSSPIVAATAALMFSANPDLAPADVDQILKNTSLDLGDPGHDA
YYGHGRINAAGAVNAAHAQFNVDNIAPVISITSPTGGTVLGDVLVDVNYSDNKGVVRVELYVNGRKAIEDTQPPFAFAWD
TSTLADGSYTLVAYAFDTAGNQGTSAPVKITVKNTAADTTPPTISITSPTGGTVSGNVSVSVNFSDNIGVARTELHINGK
QAMEDTEPGNRFTWNTTTLADGSYTLVTYAFDAAGNLGTSSPVVVSVKNSDNNPQKAPLPKINQFNLKDGQKVSLFENVK
VKADNNTRKINLKVNGNILTTIDGNSLNYRWNTWDSAPRGSTLTVTVEAGNVDGEFVSQTVSVRN

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505577, Length=370, Percent_Identity=27.8378378378378, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI20336180, Length=370, Percent_Identity=27.8378378378378, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI20336190, Length=370, Percent_Identity=27.2972972972973, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI27894285, Length=370, Percent_Identity=27.2972972972973, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI20336188, Length=370, Percent_Identity=27.2972972972973, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4505579, Length=304, Percent_Identity=29.6052631578947, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI20336182, Length=370, Percent_Identity=27.8378378378378, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI20336184, Length=370, Percent_Identity=27.8378378378378, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI20336186, Length=333, Percent_Identity=27.9279279279279, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI295424143, Length=348, Percent_Identity=28.448275862069, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI20336242, Length=348, Percent_Identity=28.448275862069, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI76443679, Length=363, Percent_Identity=26.1707988980716, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI299523015, Length=339, Percent_Identity=27.1386430678466, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI20336246, Length=335, Percent_Identity=25.0746268656716, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI20336244, Length=351, Percent_Identity=27.0655270655271, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=318, Percent_Identity=27.9874213836478, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141268, Length=318, Percent_Identity=27.9874213836478, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988308, Length=294, Percent_Identity=26.8707482993197, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988315, Length=294, Percent_Identity=26.8707482993197, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=294, Percent_Identity=26.8707482993197, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=294, Percent_Identity=26.8707482993197, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=294, Percent_Identity=26.8707482993197, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=294, Percent_Identity=26.8707482993197, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324576, Length=237, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320775, Length=290, Percent_Identity=29.3103448275862, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319893, Length=240, Percent_Identity=26.25, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281360987, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24642494, Length=298, Percent_Identity=28.1879194630872, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24642490, Length=298, Percent_Identity=28.1879194630872, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45555723, Length=298, Percent_Identity=28.1879194630872, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24642492, Length=298, Percent_Identity=28.1879194630872, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24642488, Length=301, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642484, Length=301, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642486, Length=301, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650056, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17864552, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650058, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24650060, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45553513, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45553515, Length=403, Percent_Identity=25.3101736972705, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.66 [H]

Molecular weight: Translated: 74188; Mature: 74057

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNARSIHSPFSDHLYHCFSFSILLFLLIIFSSNSHANPGKDIREAARSESTSKTAASPS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
HWKKGRLLLIPRAGLTAKEFDKAIRPHGVKSKRKLSRLSAHIYELPDGVDEIKVMNKLKK
CCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DRRFKAVELDQLVGPAQMVSDPAFNSSWALPKIQAPVAWDIATGDGVTIAVLDTGVDSNH
HCCCEEEEHHHHCCCHHHHCCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEECCCCCCC
PDLAANMVPGWNIYNGNDDASDVHGHGTKVAGSAAAAANNGIGSAGVAWNARIMPIRIAN
CCCEEECCCCCEEECCCCCCCCCCCCCCEECCCHHHHCCCCCCCCCEEECEEEEEEEEEC
PNAYAYFSAMADGIRWAADHGARVANISYEGAAGSLTVQSAANYMRSKGGVVVVAAGNSS
CCCEEEEEHHHCCEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCC
GYISYAPSDALIVASATGSNDTRASWSSYGPAVDVAAPGASIYTTTRGGGYGSVSGTSFS
CEEEECCCCEEEEEECCCCCCCCCCHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCC
SPIVAATAALMFSANPDLAPADVDQILKNTSLDLGDPGHDAYYGHGRINAAGAVNAAHAQ
CCHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCEEECCCCCEEEEEE
FNVDNIAPVISITSPTGGTVLGDVLVDVNYSDNKGVVRVELYVNGRKAIEDTQPPFAFAW
EECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEE
DTSTLADGSYTLVAYAFDTAGNQGTSAPVKITVKNTAADTTPPTISITSPTGGTVSGNVS
CCCEECCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEECEEE
VSVNFSDNIGVARTELHINGKQAMEDTEPGNRFTWNTTTLADGSYTLVTYAFDAAGNLGT
EEEEECCCCCEEEEEEEECCHHHCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCC
SSPVVVSVKNSDNNPQKAPLPKINQFNLKDGQKVSLFENVKVKADNNTRKINLKVNGNIL
CCCEEEEEECCCCCCCCCCCCCCCEECCCCCCEEEEEEEEEEEECCCEEEEEEEECCEEE
TTIDGNSLNYRWNTWDSAPRGSTLTVTVEAGNVDGEFVSQTVSVRN
EEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHCEEECCC
>Mature Secondary Structure 
SNARSIHSPFSDHLYHCFSFSILLFLLIIFSSNSHANPGKDIREAARSESTSKTAASPS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
HWKKGRLLLIPRAGLTAKEFDKAIRPHGVKSKRKLSRLSAHIYELPDGVDEIKVMNKLKK
CCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DRRFKAVELDQLVGPAQMVSDPAFNSSWALPKIQAPVAWDIATGDGVTIAVLDTGVDSNH
HCCCEEEEHHHHCCCHHHHCCCCCCCCCCCCEECCCEEEEEECCCCEEEEEEECCCCCCC
PDLAANMVPGWNIYNGNDDASDVHGHGTKVAGSAAAAANNGIGSAGVAWNARIMPIRIAN
CCCEEECCCCCEEECCCCCCCCCCCCCCEECCCHHHHCCCCCCCCCEEECEEEEEEEEEC
PNAYAYFSAMADGIRWAADHGARVANISYEGAAGSLTVQSAANYMRSKGGVVVVAAGNSS
CCCEEEEEHHHCCEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCC
GYISYAPSDALIVASATGSNDTRASWSSYGPAVDVAAPGASIYTTTRGGGYGSVSGTSFS
CEEEECCCCEEEEEECCCCCCCCCCHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCC
SPIVAATAALMFSANPDLAPADVDQILKNTSLDLGDPGHDAYYGHGRINAAGAVNAAHAQ
CCHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCEECCCEEECCCCCEEEEEE
FNVDNIAPVISITSPTGGTVLGDVLVDVNYSDNKGVVRVELYVNGRKAIEDTQPPFAFAW
EECCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEE
DTSTLADGSYTLVAYAFDTAGNQGTSAPVKITVKNTAADTTPPTISITSPTGGTVSGNVS
CCCEECCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEECEEE
VSVNFSDNIGVARTELHINGKQAMEDTEPGNRFTWNTTTLADGSYTLVTYAFDAAGNLGT
EEEEECCCCCEEEEEEEECCHHHCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCC
SSPVVVSVKNSDNNPQKAPLPKINQFNLKDGQKVSLFENVKVKADNNTRKINLKVNGNIL
CCCEEEEEECCCCCCCCCCCCCCCEECCCCCCEEEEEEEEEEEECCCEEEEEEEECCEEE
TTIDGNSLNYRWNTWDSAPRGSTLTVTVEAGNVDGEFVSQTVSVRN
EEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2647518; 2689655; 2196375; 1993669 [H]