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The map label for this gene is hemH [H]

Identifier: 114330783

GI number: 114330783

Start: 786407

End: 787504

Strand: Direct

Name: hemH [H]

Synonym: Neut_0770

Alternate gene names: 114330783

Gene position: 786407-787504 (Clockwise)

Preceding gene: 114330782

Following gene: 114330784

Centisome position: 29.55

GC content: 48.63

Gene sequence:

>1098_bases
ATGTCACGAATAATATTACCGGAGCCGGCTTATCAACACGGTTCAATTGATAGAGTCGGTGTTCTGCTGATTAATCTGGG
TACGCCAGATGCTCCGAATGCCAAGTCCCTGCGAACCTATCTAAGACAATTTCTGAGTGAGCCTCGTATTGTGGAGTTCC
CGCGCTGGTTGTGGTGGCTTATTCTGAACGGTATTATTTTGAATATCCGGCCAGGTAAATCAGCAAAGAAGTATGCGCAA
ATCTGGACGCCAGAAGGTTCTCCACTGAAAATACATACCGAGCGTCAGACAGAACTTGTCGCAGCTTTACTGAAGAAACA
GCTCAATTCGGTTCCGATAGTTGAATATGCAATGATTGTCGGCAATCCATCTATCGCAGAGAGGTTACAGCGGATGAGAG
AGCAGGGTTGCAGCCGGATTTTGGTGCTGTCATTATTTCCCCAGTATGCTGCCAGTAGCGCCGGTTGTGCATTGGATAGT
GTTTTTACTGAGTTGGGAAAGATGCGTAATATCCCTGATATTCGCACCGTCAAGCACTACCACGATGATCCGGGCTATAT
TGCAGCATTGGCGCAGAATGTTCGTGATTACTGGGAGAAACACGGGAGGCCTGACAAGCTGGTTATCAGCTTTCACGGTG
TGCCGCGTAAAACTCTGGAGATGGGCGATCCTTATCATTGTGAATGTCAAAAAACCGGGCGATTACTGGCTGAGGCACTG
GAACTAACGAATGACCAGTATCAAGTATGCTTCCAGTCGCGTTTTGGCTTTTCTCAGTGGTTGAGTCCCTATACTTCAGA
AGTTCTAAAAGAATTAGGCAAACAGGAAACCGGGCGGGTGGATGTTGTCTGCCCAGGATTCGTCTCGGACTGTCTGGAAA
CACTCGAGGAAATCGCAATGGAAGGTAAAACAACCTTTACCGAGGCCGGAGGGGGGGAATTTCACTACATTCCCAGCCTC
AATGAACATCCGGAGTGGATTAAAGCGATGAGAGACATGATTCAAACACACTTAGCAGGCTGGGTTGTCCGGCAACCTTC
CGAAGAGGATGCTGAGCAGTCGCGTAAACGGGCGCTGGAGCTGGGAGCAGAAGAATGA

Upstream 100 bases:

>100_bases
GGTCCACGACGTATGGCTTATGAGCGCATTATCCCTATTGTTGATATAACTGCCCGCCTGCTTTCAAATAATCTGTCGTA
ATATCCCGCCCTCTATTTTT

Downstream 100 bases:

>100_bases
TTAGTGCATCCATTTGTATTCTTGTTGATTGATAATCCGCGCAGGGGATTTGCTCTGAATTGGGGCTGAACATATGATCG
ATTTATATCTGGTTATGGTC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSRIILPEPAYQHGSIDRVGVLLINLGTPDAPNAKSLRTYLRQFLSEPRIVEFPRWLWWLILNGIILNIRPGKSAKKYAQ
IWTPEGSPLKIHTERQTELVAALLKKQLNSVPIVEYAMIVGNPSIAERLQRMREQGCSRILVLSLFPQYAASSAGCALDS
VFTELGKMRNIPDIRTVKHYHDDPGYIAALAQNVRDYWEKHGRPDKLVISFHGVPRKTLEMGDPYHCECQKTGRLLAEAL
ELTNDQYQVCFQSRFGFSQWLSPYTSEVLKELGKQETGRVDVVCPGFVSDCLETLEEIAMEGKTTFTEAGGGEFHYIPSL
NEHPEWIKAMRDMIQTHLAGWVVRQPSEEDAEQSRKRALELGAEE

Sequences:

>Translated_365_residues
MSRIILPEPAYQHGSIDRVGVLLINLGTPDAPNAKSLRTYLRQFLSEPRIVEFPRWLWWLILNGIILNIRPGKSAKKYAQ
IWTPEGSPLKIHTERQTELVAALLKKQLNSVPIVEYAMIVGNPSIAERLQRMREQGCSRILVLSLFPQYAASSAGCALDS
VFTELGKMRNIPDIRTVKHYHDDPGYIAALAQNVRDYWEKHGRPDKLVISFHGVPRKTLEMGDPYHCECQKTGRLLAEAL
ELTNDQYQVCFQSRFGFSQWLSPYTSEVLKELGKQETGRVDVVCPGFVSDCLETLEEIAMEGKTTFTEAGGGEFHYIPSL
NEHPEWIKAMRDMIQTHLAGWVVRQPSEEDAEQSRKRALELGAEE
>Mature_364_residues
SRIILPEPAYQHGSIDRVGVLLINLGTPDAPNAKSLRTYLRQFLSEPRIVEFPRWLWWLILNGIILNIRPGKSAKKYAQI
WTPEGSPLKIHTERQTELVAALLKKQLNSVPIVEYAMIVGNPSIAERLQRMREQGCSRILVLSLFPQYAASSAGCALDSV
FTELGKMRNIPDIRTVKHYHDDPGYIAALAQNVRDYWEKHGRPDKLVISFHGVPRKTLEMGDPYHCECQKTGRLLAEALE
LTNDQYQVCFQSRFGFSQWLSPYTSEVLKELGKQETGRVDVVCPGFVSDCLETLEEIAMEGKTTFTEAGGGEFHYIPSLN
EHPEWIKAMRDMIQTHLAGWVVRQPSEEDAEQSRKRALELGAEE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=262, Percent_Identity=27.8625954198473, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI60499021, Length=262, Percent_Identity=27.8625954198473, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=41.5625, Blast_Score=268, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6324750, Length=330, Percent_Identity=24.5454545454545, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17864156, Length=338, Percent_Identity=26.9230769230769, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=26.3940520446097, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552018, Length=186, Percent_Identity=29.5698924731183, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 41433; Mature: 41302

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIILPEPAYQHGSIDRVGVLLINLGTPDAPNAKSLRTYLRQFLSEPRIVEFPRWLWWL
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILNGIILNIRPGKSAKKYAQIWTPEGSPLKIHTERQTELVAALLKKQLNSVPIVEYAMIV
HHCCEEEEECCCCCHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHH
GNPSIAERLQRMREQGCSRILVLSLFPQYAASSAGCALDSVFTELGKMRNIPDIRTVKHY
CCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHC
HDDPGYIAALAQNVRDYWEKHGRPDKLVISFHGVPRKTLEMGDPYHCECQKTGRLLAEAL
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCEECHHHHHHHHHHHH
ELTNDQYQVCFQSRFGFSQWLSPYTSEVLKELGKQETGRVDVVCPGFVSDCLETLEEIAM
HHCCHHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHH
EGKTTFTEAGGGEFHYIPSLNEHPEWIKAMRDMIQTHLAGWVVRQPSEEDAEQSRKRALE
CCCCEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGAEE
CCCCC
>Mature Secondary Structure 
SRIILPEPAYQHGSIDRVGVLLINLGTPDAPNAKSLRTYLRQFLSEPRIVEFPRWLWWL
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
ILNGIILNIRPGKSAKKYAQIWTPEGSPLKIHTERQTELVAALLKKQLNSVPIVEYAMIV
HHCCEEEEECCCCCHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHH
GNPSIAERLQRMREQGCSRILVLSLFPQYAASSAGCALDSVFTELGKMRNIPDIRTVKHY
CCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHC
HDDPGYIAALAQNVRDYWEKHGRPDKLVISFHGVPRKTLEMGDPYHCECQKTGRLLAEAL
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCEECHHHHHHHHHHHH
ELTNDQYQVCFQSRFGFSQWLSPYTSEVLKELGKQETGRVDVVCPGFVSDCLETLEEIAM
HHCCHHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHH
EGKTTFTEAGGGEFHYIPSLNEHPEWIKAMRDMIQTHLAGWVVRQPSEEDAEQSRKRALE
CCCCEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGAEE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]