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The map label for this gene is hslU

Identifier: 114330626

GI number: 114330626

Start: 622054

End: 623385

Strand: Reverse

Name: hslU

Synonym: Neut_0611

Alternate gene names: 114330626

Gene position: 623385-622054 (Counterclockwise)

Preceding gene: 114330627

Following gene: 114330625

Centisome position: 23.43

GC content: 50.98

Gene sequence:

>1332_bases
ATGTCACATATGACGCCACAGGAAATTGTCCACGAACTGGACAAACATATCATCGGGCAGGAAGCCGCTAAACGATCCGT
CGCCATTGCATTGAGAAATCGCTGGCGCAGGCAACAAGTGGGTGAGCCACTGCGCCACGAAATCACCCCTAAAAATATCC
TCATGATCGGCCCGACTGGTGTCGGCAAGACTGAAATTGCCAGGCGACTTGCCAGGCTGGCTGATGCGCCTTTCATCAAG
ATCGAGGCGACCAAGTTTACCGAGGTGGGTTATGTCGGTCGGGATGTCGATTCCATTATTCGCGACCTGGTGGAATCTGC
CATCAAACAGGCTCGCGAGCACGAGATCAGGAAGAATAAGCCTCTGGCTGAAGATCGCGCGGAGGAACGGATACTTGACG
CCCTGCTACCATCGGCACGTGATTCAGGCTTTGATGCCAACCCTAGCGAAGAAAATAACGCAACCCGCCAGAAATTCCGC
AAGAAACTGCGCGAAGGTGAGCTTGACGACAAGGAAATCGATATCGAAATTACCATGTCACAAGCCAGCATGGAAATTTT
TGCCCCGCCAGGCATGGAAGAACTAACTTCCCAGATTCAGGGTATGTTTCAGAACATGGGTGCCAGCAAGAAAAAGTCAC
GCAAGTTGCGTATCCGTGAAGCCAGAAAACTACTGACTGAAGAAGAAGCCGCCCGCCTGATCAATGATGAGGAATTGAAA
CTGAATGCAGTGCAGAATGTCGAGCAAAACGGCATCGTGTTTCTTGATGAAATTGACAAGATTACCAGCCGCTCAGAAGT
ATCCAGTTCCGATATTTCACGCCAGGGCGTTCAGCGCGATTTGCTGCCGCTGGTAGAGGGCACGACCATTTCCACAAAGT
ACGGCATGATCCGTACCGACCACATCCTGTTTATCGCCAGCGGGGCTTTTCATCTGGCCAAACCATCGGACCTAATCCCC
GAACTCCAGGGACGTTTCCCCATTCGGGTGGAACTGGACAGCCTCAGCGCGGATGATTTCAAGCAAATTCTCACCAACAC
CGATGCCTGCCTGATTCGCCAGTATCAGGCACTACTGAAAACAGAGGGGATTGAACTGAATTTTTCAGAAGACGCCATCG
AGCGACTGGCCGAGATTGCCTTTTCGGTCAATGAAATAACCGAGAACATTGGCGCCAGAAGGCTACATACCGTGATGGAA
AAATTGCTGGAAGACATTTCATTCAATGCCACTCGCTACAGCGGAAGCACACATGTCATTGATGCTGCGTATGTTGATGA
ACGTCTTGGCAAACTCTCGCAGAGCGAAGATCTGGCTCGCTACGTACTGTAA

Upstream 100 bases:

>100_bases
CTGACCATCGCCGGTGATATCTGCATCTATACCAATCAGGTGCATGTCATTGAGCAGCTCGATTAACACCAGGAATTAAT
CCAAGCCAGGAAAACCTATC

Downstream 100 bases:

>100_bases
CCATTTTCAATGCGCAACGTTGTCATTCTGAGTGGCACAAGAACCGCAATCGGTGATTACGGCAGCGCACTGAAGGATCT
GGCGCCCACCACGCTGGCCG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSHMTPQEIVHELDKHIIGQEAAKRSVAIALRNRWRRQQVGEPLRHEITPKNILMIGPTGVGKTEIARRLARLADAPFIK
IEATKFTEVGYVGRDVDSIIRDLVESAIKQAREHEIRKNKPLAEDRAEERILDALLPSARDSGFDANPSEENNATRQKFR
KKLREGELDDKEIDIEITMSQASMEIFAPPGMEELTSQIQGMFQNMGASKKKSRKLRIREARKLLTEEEAARLINDEELK
LNAVQNVEQNGIVFLDEIDKITSRSEVSSSDISRQGVQRDLLPLVEGTTISTKYGMIRTDHILFIASGAFHLAKPSDLIP
ELQGRFPIRVELDSLSADDFKQILTNTDACLIRQYQALLKTEGIELNFSEDAIERLAEIAFSVNEITENIGARRLHTVME
KLLEDISFNATRYSGSTHVIDAAYVDERLGKLSQSEDLARYVL

Sequences:

>Translated_443_residues
MSHMTPQEIVHELDKHIIGQEAAKRSVAIALRNRWRRQQVGEPLRHEITPKNILMIGPTGVGKTEIARRLARLADAPFIK
IEATKFTEVGYVGRDVDSIIRDLVESAIKQAREHEIRKNKPLAEDRAEERILDALLPSARDSGFDANPSEENNATRQKFR
KKLREGELDDKEIDIEITMSQASMEIFAPPGMEELTSQIQGMFQNMGASKKKSRKLRIREARKLLTEEEAARLINDEELK
LNAVQNVEQNGIVFLDEIDKITSRSEVSSSDISRQGVQRDLLPLVEGTTISTKYGMIRTDHILFIASGAFHLAKPSDLIP
ELQGRFPIRVELDSLSADDFKQILTNTDACLIRQYQALLKTEGIELNFSEDAIERLAEIAFSVNEITENIGARRLHTVME
KLLEDISFNATRYSGSTHVIDAAYVDERLGKLSQSEDLARYVL
>Mature_442_residues
SHMTPQEIVHELDKHIIGQEAAKRSVAIALRNRWRRQQVGEPLRHEITPKNILMIGPTGVGKTEIARRLARLADAPFIKI
EATKFTEVGYVGRDVDSIIRDLVESAIKQAREHEIRKNKPLAEDRAEERILDALLPSARDSGFDANPSEENNATRQKFRK
KLREGELDDKEIDIEITMSQASMEIFAPPGMEELTSQIQGMFQNMGASKKKSRKLRIREARKLLTEEEAARLINDEELKL
NAVQNVEQNGIVFLDEIDKITSRSEVSSSDISRQGVQRDLLPLVEGTTISTKYGMIRTDHILFIASGAFHLAKPSDLIPE
LQGRFPIRVELDSLSADDFKQILTNTDACLIRQYQALLKTEGIELNFSEDAIERLAEIAFSVNEITENIGARRLHTVMEK
LLEDISFNATRYSGSTHVIDAAYVDERLGKLSQSEDLARYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=443, Percent_Identity=65.0112866817156, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=48.0769230769231, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648289, Length=235, Percent_Identity=29.7872340425532, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648291, Length=235, Percent_Identity=29.7872340425532, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_NITEC (Q0AD37)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746848.1
- ProteinModelPortal:   Q0AD37
- SMR:   Q0AD37
- STRING:   Q0AD37
- GeneID:   4272505
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0611
- NMPDR:   fig|335283.3.peg.1484
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q0AD37
- ProtClustDB:   PRK05201
- BioCyc:   NEUT335283:NEUT_0611-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 50068; Mature: 49936

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 256-256 BINDING 321-321 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHMTPQEIVHELDKHIIGQEAAKRSVAIALRNRWRRQQVGEPLRHEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCC
VGKTEIARRLARLADAPFIKIEATKFTEVGYVGRDVDSIIRDLVESAIKQAREHEIRKNK
CCHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLAEDRAEERILDALLPSARDSGFDANPSEENNATRQKFRKKLREGELDDKEIDIEITMS
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEC
QASMEIFAPPGMEELTSQIQGMFQNMGASKKKSRKLRIREARKLLTEEEAARLINDEELK
CCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LNAVQNVEQNGIVFLDEIDKITSRSEVSSSDISRQGVQRDLLPLVEGTTISTKYGMIRTD
HHHHHCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSADDFKQILTNTDACLIRQYQALLK
EEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHH
TEGIELNFSEDAIERLAEIAFSVNEITENIGARRLHTVMEKLLEDISFNATRYSGSTHVI
HCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEE
DAAYVDERLGKLSQSEDLARYVL
HHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
SHMTPQEIVHELDKHIIGQEAAKRSVAIALRNRWRRQQVGEPLRHEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCC
VGKTEIARRLARLADAPFIKIEATKFTEVGYVGRDVDSIIRDLVESAIKQAREHEIRKNK
CCHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PLAEDRAEERILDALLPSARDSGFDANPSEENNATRQKFRKKLREGELDDKEIDIEITMS
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEC
QASMEIFAPPGMEELTSQIQGMFQNMGASKKKSRKLRIREARKLLTEEEAARLINDEELK
CCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LNAVQNVEQNGIVFLDEIDKITSRSEVSSSDISRQGVQRDLLPLVEGTTISTKYGMIRTD
HHHHHCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSADDFKQILTNTDACLIRQYQALLK
EEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHH
TEGIELNFSEDAIERLAEIAFSVNEITENIGARRLHTVMEKLLEDISFNATRYSGSTHVI
HCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEE
DAAYVDERLGKLSQSEDLARYVL
HHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA