Click here to switch to the map view.

The map label for this gene is holC [H]

Identifier: 114330615

GI number: 114330615

Start: 608214

End: 608642

Strand: Direct

Name: holC [H]

Synonym: Neut_0600

Alternate gene names: 114330615

Gene position: 608214-608642 (Clockwise)

Preceding gene: 114330614

Following gene: 114330616

Centisome position: 22.86

GC content: 47.55

Gene sequence:

>429_bases
GTGACACAGATTGATTTTTACACGGGCGCAACCGACAGATTGCTGATCGCCTGTCGTTTGTGTTCGAAAGCAGTACAGCA
GGGATTGAAAACAGTTGTTTATATTCCGGATGCAGAATTGGCAAACCGGTTTGATAAGTTGCTCTGGACGTTTTCTCCAA
CCAGTTTTGTCCCACACTGCCAGGCAGATGACAAACTGGCGGGGGTGACGCCAGTGATCCTGAATAATCAGCTAGAAATG
CCGGAAGTGGCTTACTTCGATGTGTTGCTTAATCTGGATGCGGCAATTCCATCCGGATTTGAACATTTTAAGCGGGTCGT
TGAAATTGTTGATGAAATAGAGGACAGCAAGCTGCATGCACGCAAACGGTACCGGCGCTACCAAGAGTTGGGACACGACA
TTCGCCATCATCGGCTTGAGGAAAATTAA

Upstream 100 bases:

>100_bases
AAGGGTGCGACCGGACGTCCGGTTCCGCTACTAACACAATTTCTGATCGATCGTGCACAACAGCATTAATCAGCTGGTAT
TCTAATTTCTGCGGGCAGGT

Downstream 100 bases:

>100_bases
CTGATTCCGAGCTATGCAGAAGCTCTCTGTATTCTCGGACTTTGAGTTTACTATCTGATCAGGAGCAATCTGGTGGCGGA
TGATCAACCCGATATAACGC

Product: DNA polymerase III chi subunit, HolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MTQIDFYTGATDRLLIACRLCSKAVQQGLKTVVYIPDAELANRFDKLLWTFSPTSFVPHCQADDKLAGVTPVILNNQLEM
PEVAYFDVLLNLDAAIPSGFEHFKRVVEIVDEIEDSKLHARKRYRRYQELGHDIRHHRLEEN

Sequences:

>Translated_142_residues
MTQIDFYTGATDRLLIACRLCSKAVQQGLKTVVYIPDAELANRFDKLLWTFSPTSFVPHCQADDKLAGVTPVILNNQLEM
PEVAYFDVLLNLDAAIPSGFEHFKRVVEIVDEIEDSKLHARKRYRRYQELGHDIRHHRLEEN
>Mature_141_residues
TQIDFYTGATDRLLIACRLCSKAVQQGLKTVVYIPDAELANRFDKLLWTFSPTSFVPHCQADDKLAGVTPVILNNQLEMP
EVAYFDVLLNLDAAIPSGFEHFKRVVEIVDEIEDSKLHARKRYRRYQELGHDIRHHRLEEN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 16400; Mature: 16269

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIDFYTGATDRLLIACRLCSKAVQQGLKTVVYIPDAELANRFDKLLWTFSPTSFVPHC
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
QADDKLAGVTPVILNNQLEMPEVAYFDVLLNLDAAIPSGFEHFKRVVEIVDEIEDSKLHA
CCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
RKRYRRYQELGHDIRHHRLEEN
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQIDFYTGATDRLLIACRLCSKAVQQGLKTVVYIPDAELANRFDKLLWTFSPTSFVPHC
CEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
QADDKLAGVTPVILNNQLEMPEVAYFDVLLNLDAAIPSGFEHFKRVVEIVDEIEDSKLHA
CCCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
RKRYRRYQELGHDIRHHRLEEN
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9864319; 10984043 [H]