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The map label for this gene is pepA

Identifier: 114330614

GI number: 114330614

Start: 606689

End: 608182

Strand: Direct

Name: pepA

Synonym: Neut_0599

Alternate gene names: 114330614

Gene position: 606689-608182 (Clockwise)

Preceding gene: 114330611

Following gene: 114330615

Centisome position: 22.8

GC content: 51.14

Gene sequence:

>1494_bases
ATGGACTTCGCAATCCAAGCGGGCGATCTGGGGAAATATTATGGTGACTGTATCGTGGCGGGTGTGTTCGAGTCCCGTAA
GTTGACTGAGGCGGCCAAAGCTTTGGACGAAATGTGCAGAGGTTATCTAACCAAGGTGCTTGACCAGGGAGACATGGACG
GTAGAGCAAATACAACTTTACTGCTGCACAACGTCCCGGCTATTGGAAGCAAGCGAGTGTTGCTGGTCGGGCTGGGCAAG
GAGGAAGAATACGTAGAAAAGGTATTCCTGGAGGCCATTCGTGCAGCTTTTAAAGCACTGCATCAGACAGGGGTCAAAGA
TGTCGGTTTGTGTGTGGCGGATTTGATTGTAAAAGGAAGAGATACTGCCTGGAGCGTACTGCAGTCAACCCTCCTGGTAG
AAGAAAGTGTGTACCGCTTTGATCGGCTCAAAAGTAAACGTGAGGAACGTCAGCCATCCCTGCAGAAAATTATCTTTCTT
ATCGGGGATGAAGCTGCAAGGGCAGGCGCAGAACAAGCATTTAAGCAGGGAGCAGCTATTGCGTGTGGTATGAATGTAAC
GAAAGATTTGGGTAATCTTGCGCCCAATATCTGTACTCCGACCTATTTGGCCGAACAGGCTGGCGAAATGGCCAAAACAT
ACAATCTCAAACTTTCCGTGCTGGAAGAAAAAGATATGGAAGCGCTCGGAATGGGTGCATTGCTGGCTGTGGCACGTGGC
AGCCATCAGCCGGCCAAGCTGATCGTACTGGAGTATCATGGCCGGGAAGGCATCGAGAAACCAGTTGTACTGGTTGGGAA
AGGTGTCACCTTTGATACCGGCGGTATTTCACTGAAACCGGCAGTTGATCTTGATGAAATGAAATACGATATGGGCGGCG
CAGCAAGTGTTTTCGGTACGCTGACTGCTGTAGCGGAAATGAAGTTGCCTATCAATGTAACAGCCATCATTCCCACAACC
GAAAATATGCCAGGTGGCAATGCAACCAAACCCGGGGATGTTGTTACCAGTTTGTCCGGGCAGACAATCGAGATATTGAA
TACCGACGCAGAGGGACGATTGATTCTGTGTGACGCGCTGACATACGCCGAACGTTACAATCCGGATGTGGTGATTGATA
TTGCCACGCTAACGGGGGCCTGTGTGGTCGCCCTGGGGCATGTGGTCAGTGGCCTGATGGGTACCGATGAGCCGCTTGTT
CAGGAACTGCTTCAGGCTGGGGAAAAGGCATCTGATCGTGCCTGGCAGCTACCACTGGGAGAGGAATATCAGGAACTGCT
CAAAAGTAATTTTGCCGATATGGCCAATATCGGCGGTCGCTGGGGAGGAGCGATTACCGCGGCCTGCTTTCTTTCACGTT
TTACCAGGAAATACCGCTGGGCGCACCTTGATATTGCTGGAACAGCGTGGAAATCCGGCAAGGAGAAGGGTGCGACCGGA
CGTCCGGTTCCGCTACTAACACAATTTCTGATCGATCGTGCACAACAGCATTAA

Upstream 100 bases:

>100_bases
TATGGCAGGGAATTCGGTTTTTTAATTTTAAATCAGAGACATGACCATAGTCCGGTTCATATTTATTGTCAAAAATAAAC
AAATAAAACAGGAGTAAAGC

Downstream 100 bases:

>100_bases
TCAGCTGGTATTCTAATTTCTGCGGGCAGGTGTGACACAGATTGATTTTTACACGGGCGCAACCGACAGATTGCTGATCG
CCTGTCGTTTGTGTTCGAAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MDFAIQAGDLGKYYGDCIVAGVFESRKLTEAAKALDEMCRGYLTKVLDQGDMDGRANTTLLLHNVPAIGSKRVLLVGLGK
EEEYVEKVFLEAIRAAFKALHQTGVKDVGLCVADLIVKGRDTAWSVLQSTLLVEESVYRFDRLKSKREERQPSLQKIIFL
IGDEAARAGAEQAFKQGAAIACGMNVTKDLGNLAPNICTPTYLAEQAGEMAKTYNLKLSVLEEKDMEALGMGALLAVARG
SHQPAKLIVLEYHGREGIEKPVVLVGKGVTFDTGGISLKPAVDLDEMKYDMGGAASVFGTLTAVAEMKLPINVTAIIPTT
ENMPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDALTYAERYNPDVVIDIATLTGACVVALGHVVSGLMGTDEPLV
QELLQAGEKASDRAWQLPLGEEYQELLKSNFADMANIGGRWGGAITAACFLSRFTRKYRWAHLDIAGTAWKSGKEKGATG
RPVPLLTQFLIDRAQQH

Sequences:

>Translated_497_residues
MDFAIQAGDLGKYYGDCIVAGVFESRKLTEAAKALDEMCRGYLTKVLDQGDMDGRANTTLLLHNVPAIGSKRVLLVGLGK
EEEYVEKVFLEAIRAAFKALHQTGVKDVGLCVADLIVKGRDTAWSVLQSTLLVEESVYRFDRLKSKREERQPSLQKIIFL
IGDEAARAGAEQAFKQGAAIACGMNVTKDLGNLAPNICTPTYLAEQAGEMAKTYNLKLSVLEEKDMEALGMGALLAVARG
SHQPAKLIVLEYHGREGIEKPVVLVGKGVTFDTGGISLKPAVDLDEMKYDMGGAASVFGTLTAVAEMKLPINVTAIIPTT
ENMPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDALTYAERYNPDVVIDIATLTGACVVALGHVVSGLMGTDEPLV
QELLQAGEKASDRAWQLPLGEEYQELLKSNFADMANIGGRWGGAITAACFLSRFTRKYRWAHLDIAGTAWKSGKEKGATG
RPVPLLTQFLIDRAQQH
>Mature_497_residues
MDFAIQAGDLGKYYGDCIVAGVFESRKLTEAAKALDEMCRGYLTKVLDQGDMDGRANTTLLLHNVPAIGSKRVLLVGLGK
EEEYVEKVFLEAIRAAFKALHQTGVKDVGLCVADLIVKGRDTAWSVLQSTLLVEESVYRFDRLKSKREERQPSLQKIIFL
IGDEAARAGAEQAFKQGAAIACGMNVTKDLGNLAPNICTPTYLAEQAGEMAKTYNLKLSVLEEKDMEALGMGALLAVARG
SHQPAKLIVLEYHGREGIEKPVVLVGKGVTFDTGGISLKPAVDLDEMKYDMGGAASVFGTLTAVAEMKLPINVTAIIPTT
ENMPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDALTYAERYNPDVVIDIATLTGACVVALGHVVSGLMGTDEPLV
QELLQAGEKASDRAWQLPLGEEYQELLKSNFADMANIGGRWGGAITAACFLSRFTRKYRWAHLDIAGTAWKSGKEKGATG
RPVPLLTQFLIDRAQQH

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=506, Percent_Identity=35.9683794466403, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI47155554, Length=277, Percent_Identity=32.8519855595668, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=53.1187122736419, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI87082123, Length=303, Percent_Identity=38.2838283828383, Blast_Score=184, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=282, Percent_Identity=34.7517730496454, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=261, Percent_Identity=32.5670498084291, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20129969, Length=513, Percent_Identity=31.3840155945419, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24661038, Length=326, Percent_Identity=36.1963190184049, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21355725, Length=326, Percent_Identity=35.5828220858896, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24662227, Length=495, Percent_Identity=28.6868686868687, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161077148, Length=502, Percent_Identity=30.2788844621514, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20130057, Length=502, Percent_Identity=30.2788844621514, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355645, Length=501, Percent_Identity=28.1437125748503, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24662223, Length=501, Percent_Identity=28.1437125748503, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI19922386, Length=488, Percent_Identity=27.8688524590164, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129963, Length=503, Percent_Identity=27.4353876739563, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357381, Length=294, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379063, Length=294, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221379062, Length=294, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646701, Length=230, Percent_Identity=33.0434782608696, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646703, Length=230, Percent_Identity=33.0434782608696, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358201, Length=230, Percent_Identity=33.0434782608696, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_NITEC (Q0AIF5)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746836.1
- ProteinModelPortal:   Q0AIF5
- SMR:   Q0AIF5
- STRING:   Q0AIF5
- MEROPS:   M17.003
- GeneID:   4272682
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0599
- NMPDR:   fig|335283.3.peg.1473
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- PhylomeDB:   Q0AIF5
- ProtClustDB:   PRK00913
- BioCyc:   NEUT335283:NEUT_0599-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53522; Mature: 53522

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 279-279 ACT_SITE 353-353

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAIQAGDLGKYYGDCIVAGVFESRKLTEAAKALDEMCRGYLTKVLDQGDMDGRANTTL
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LLHNVPAIGSKRVLLVGLGKEEEYVEKVFLEAIRAAFKALHQTGVKDVGLCVADLIVKGR
EEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DTAWSVLQSTLLVEESVYRFDRLKSKREERQPSLQKIIFLIGDEAARAGAEQAFKQGAAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEHEECCHHHHCCHHHHHHCCCEE
ACGMNVTKDLGNLAPNICTPTYLAEQAGEMAKTYNLKLSVLEEKDMEALGMGALLAVARG
EECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCC
SHQPAKLIVLEYHGREGIEKPVVLVGKGVTFDTGGISLKPAVDLDEMKYDMGGAASVFGT
CCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCHHHHHHH
LTAVAEMKLPINVTAIIPTTENMPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDAL
HHHHHHEECCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHH
TYAERYNPDVVIDIATLTGACVVALGHVVSGLMGTDEPLVQELLQAGEKASDRAWQLPLG
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCCC
EEYQELLKSNFADMANIGGRWGGAITAACFLSRFTRKYRWAHLDIAGTAWKSGKEKGATG
HHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCC
RPVPLLTQFLIDRAQQH
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFAIQAGDLGKYYGDCIVAGVFESRKLTEAAKALDEMCRGYLTKVLDQGDMDGRANTTL
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
LLHNVPAIGSKRVLLVGLGKEEEYVEKVFLEAIRAAFKALHQTGVKDVGLCVADLIVKGR
EEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DTAWSVLQSTLLVEESVYRFDRLKSKREERQPSLQKIIFLIGDEAARAGAEQAFKQGAAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEHEECCHHHHCCHHHHHHCCCEE
ACGMNVTKDLGNLAPNICTPTYLAEQAGEMAKTYNLKLSVLEEKDMEALGMGALLAVARG
EECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCC
SHQPAKLIVLEYHGREGIEKPVVLVGKGVTFDTGGISLKPAVDLDEMKYDMGGAASVFGT
CCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCHHHHHHH
LTAVAEMKLPINVTAIIPTTENMPGGNATKPGDVVTSLSGQTIEILNTDAEGRLILCDAL
HHHHHHEECCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHH
TYAERYNPDVVIDIATLTGACVVALGHVVSGLMGTDEPLVQELLQAGEKASDRAWQLPLG
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEECCCC
EEYQELLKSNFADMANIGGRWGGAITAACFLSRFTRKYRWAHLDIAGTAWKSGKEKGATG
HHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCC
RPVPLLTQFLIDRAQQH
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA