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The map label for this gene is tadA [H]

Identifier: 114330609

GI number: 114330609

Start: 601339

End: 601842

Strand: Direct

Name: tadA [H]

Synonym: Neut_0594

Alternate gene names: 114330609

Gene position: 601339-601842 (Clockwise)

Preceding gene: 114330607

Following gene: 114330610

Centisome position: 22.6

GC content: 50.2

Gene sequence:

>504_bases
ATGAAAGTACAGGTTATCCGGGTGCCGGTTCAGGCAGAAGATGAGTATTTCATGCGTCAGGCGCTGGATCTTGCCCGTGT
AGCGGGCGACTCAGGGGAGGTTCCAGTCGGTGCGGTTGTGGTCAGAAATAGCCAGATTGCAGGTTACGGATATAACTGTC
CTGTTACGTTAATGGATCCGACGGCACATGCTGAAATCATGGCCTTGCGTGATGCTGCCAACAAACTGGGAAATTACCGG
CTGCCAGAATGTACGCTGTATGTCACACTTGAGCCTTGTGTGATGTGTATCGGTTCAATGTTTCATGCCAGAATCAAACG
GCTGGTTTATGCTGCGGAGGATCCAAAAACCGGTGTGTGTGGCAGTTTGCTTGATTTGCCTGCTGATACCCGGCTTAATC
ATCACTTGGTGGTTAGTCAGGGTGTTCTGGCGGATGAAGCGAGTACCTTGCTGAAACAGTTTTTCATTATCCGGCGCAGT
ACAAAAGAGCGCGATACACCATGA

Upstream 100 bases:

>100_bases
TCTTCCCCTGCCTGGAGGATGGTAGTGTTATTGGGCTGTCTGGTATAAGTCATGATTCAATCCGAGTTTCTCCGGAAAGC
AATTTAGCATAAAAAAACTG

Downstream 100 bases:

>100_bases
AAATTATCGTTGATATTTCGTTGCAACAAATGACTCTACAGGATGTAACAGGACATATTGTCAGGTGTTACCCAATCTCT
TCCGCAAAAAATGGTACTGG

Product: CMP/dCMP deaminase, zinc-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MKVQVIRVPVQAEDEYFMRQALDLARVAGDSGEVPVGAVVVRNSQIAGYGYNCPVTLMDPTAHAEIMALRDAANKLGNYR
LPECTLYVTLEPCVMCIGSMFHARIKRLVYAAEDPKTGVCGSLLDLPADTRLNHHLVVSQGVLADEASTLLKQFFIIRRS
TKERDTP

Sequences:

>Translated_167_residues
MKVQVIRVPVQAEDEYFMRQALDLARVAGDSGEVPVGAVVVRNSQIAGYGYNCPVTLMDPTAHAEIMALRDAANKLGNYR
LPECTLYVTLEPCVMCIGSMFHARIKRLVYAAEDPKTGVCGSLLDLPADTRLNHHLVVSQGVLADEASTLLKQFFIIRRS
TKERDTP
>Mature_167_residues
MKVQVIRVPVQAEDEYFMRQALDLARVAGDSGEVPVGAVVVRNSQIAGYGYNCPVTLMDPTAHAEIMALRDAANKLGNYR
LPECTLYVTLEPCVMCIGSMFHARIKRLVYAAEDPKTGVCGSLLDLPADTRLNHHLVVSQGVLADEASTLLKQFFIIRRS
TKERDTP

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=154, Percent_Identity=32.4675324675325, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI145693172, Length=150, Percent_Identity=54, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17541138, Length=149, Percent_Identity=35.5704697986577, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554608, Length=99, Percent_Identity=37.3737373737374, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555996, Length=85, Percent_Identity=40, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322425, Length=152, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355527, Length=145, Percent_Identity=35.1724137931034, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 18406; Mature: 18406

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQVIRVPVQAEDEYFMRQALDLARVAGDSGEVPVGAVVVRNSQIAGYGYNCPVTLMDP
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCEEEECC
TAHAEIMALRDAANKLGNYRLPECTLYVTLEPCVMCIGSMFHARIKRLVYAAEDPKTGVC
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSLLDLPADTRLNHHLVVSQGVLADEASTLLKQFFIIRRSTKERDTP
CHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVQVIRVPVQAEDEYFMRQALDLARVAGDSGEVPVGAVVVRNSQIAGYGYNCPVTLMDP
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCEEEECC
TAHAEIMALRDAANKLGNYRLPECTLYVTLEPCVMCIGSMFHARIKRLVYAAEDPKTGVC
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GSLLDLPADTRLNHHLVVSQGVLADEASTLLKQFFIIRRSTKERDTP
CHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]