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The map label for this gene is fabH

Identifier: 114330490

GI number: 114330490

Start: 485372

End: 486334

Strand: Reverse

Name: fabH

Synonym: Neut_0470

Alternate gene names: 114330490

Gene position: 486334-485372 (Counterclockwise)

Preceding gene: 114330491

Following gene: 114330489

Centisome position: 18.28

GC content: 49.01

Gene sequence:

>963_bases
ATGGCTATGTATTCACGCATAATTGGTACCGGAAGCTATCTGCCGGAAAAAATCCTGACCAACCTGGAGCTTGAATCCAT
GGTTGATACCAGTGATGAATGGATACAGGCACGGACTGGCATCAAACAACGTCATATTGCTGCGCCGGGCCAGATGGCCA
GCGACCTTGCTTTGGAGGCCAGTCGAAATGCCATCGAGGCTGCAGGTATTCAGGCAAGTGATATTGATCTGGTAATTGTT
GCAACCACAACGCCGGATATGATTTTCCCAAGCACAGCTTGTATTCTGCAAAATAAACTCGGCATATCTGGTAGCCCTGC
ATTTGATGTTCAGGCCGTCTGTAGTGGGTTTATTTATGCCTTGGCTACAGCGGATATGTTCGTCAGCTCCGGAAAATCCC
GTAACGCACTGATAGTTGGCAGCGAAGTATATTCCCGGATTATGGATTGGAACGACCGCAGCACTTGTGTTCTGTTTGGA
GATGGCGCAGGTGCGGTAGTTCTTACCCGGGATCAAAAACCGGGAATTCTCTCATCCCATTTACACGCAGATGGAAGCTA
TAGTCAGGTTCTTTCAGCCCCTGCCTCTATTCATTCCGGAAAGATACAAGGCACACCCTTCATCACAATGGAAGGCAGCA
CGGTATTCAAATTTGCCGTTAAAGTCCTGGAAGAAGCGGTACTAGAAGCATTGCATGCAAATGATCTACAATCTTCCGAT
ATCGACTGGCTGATCCCTCATCAGGCCAATATCCGTATTATCACCTCAACAGCGAAAAAGCTGGGTATACCTGAAGAGAA
GGTAGTAGTGACTGTTACACAACATGGCAATACTTCAGCTGCTTCTGTGCCGCTGGCACTGGATCAGGCAGTTCGAGACG
GGCGTGTCCAGTCAGGCCAGCATGTTGTGCTGGAAGGTGTGGGAGGTGGATTCACCTGGGGATCAGTTCTGGTACGCTGG
TAA

Upstream 100 bases:

>100_bases
GGTGGCACCTTGCGACGCATTGTCGAACATATTGAAACACTGCGATACAACATTGAGCAAAACATTACACAACCGGCATC
AGTAGAGTGAGCAACTGAAC

Downstream 100 bases:

>100_bases
AACATGAAGATTGCTTTTATTTTTCCCGGGCAGGGATCTCAGTCAGTCGGTATGATGGATGGTTATTCAGAACTTCCATC
AATACGTGAGACGTTCAATG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MAMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEASRNAIEAAGIQASDIDLVIV
ATTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYALATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFG
DGAGAVVLTRDQKPGILSSHLHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSD
IDWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQHVVLEGVGGGFTWGSVLVRW

Sequences:

>Translated_320_residues
MAMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEASRNAIEAAGIQASDIDLVIV
ATTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYALATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFG
DGAGAVVLTRDQKPGILSSHLHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSD
IDWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQHVVLEGVGGGFTWGSVLVRW
>Mature_319_residues
AMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEASRNAIEAAGIQASDIDLVIVA
TTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYALATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFGD
GAGAVVLTRDQKPGILSSHLHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSDI
DWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQHVVLEGVGGGFTWGSVLVRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=57.5471698113208, Blast_Score=380, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_NITEC (Q0AIS4)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746712.1
- ProteinModelPortal:   Q0AIS4
- SMR:   Q0AIS4
- STRING:   Q0AIS4
- GeneID:   4272364
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0470
- NMPDR:   fig|335283.3.peg.1176
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q0AIS4
- ProtClustDB:   PRK09352
- BioCyc:   NEUT335283:NEUT_0470-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34038; Mature: 33907

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 247-247 ACT_SITE 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEA
CCCHHHHHCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHH
SRNAIEAAGIQASDIDLVIVATTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYA
CCCHHHHCCCEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFGDGAGAVVLTRDQKPGILSSH
HHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCHHHH
LHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSD
CCCCCCHHHHHHCCCHHCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQ
CCEECCCCCCEEEEEECHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
HVVLEGVGGGFTWGSVLVRW
EEEEEECCCCEEHHHEEEEC
>Mature Secondary Structure 
AMYSRIIGTGSYLPEKILTNLELESMVDTSDEWIQARTGIKQRHIAAPGQMASDLALEA
CCHHHHHCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHH
SRNAIEAAGIQASDIDLVIVATTTPDMIFPSTACILQNKLGISGSPAFDVQAVCSGFIYA
CCCHHHHCCCEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LATADMFVSSGKSRNALIVGSEVYSRIMDWNDRSTCVLFGDGAGAVVLTRDQKPGILSSH
HHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCHHHH
LHADGSYSQVLSAPASIHSGKIQGTPFITMEGSTVFKFAVKVLEEAVLEALHANDLQSSD
CCCCCCHHHHHHCCCHHCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDWLIPHQANIRIITSTAKKLGIPEEKVVVTVTQHGNTSAASVPLALDQAVRDGRVQSGQ
CCEECCCCCCEEEEEECHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCC
HVVLEGVGGGFTWGSVLVRW
EEEEEECCCCEEHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA