Click here to switch to the map view.

The map label for this gene is pyrC' [H]

Identifier: 114330472

GI number: 114330472

Start: 461463

End: 462734

Strand: Direct

Name: pyrC' [H]

Synonym: Neut_0452

Alternate gene names: 114330472

Gene position: 461463-462734 (Clockwise)

Preceding gene: 114330471

Following gene: 114330473

Centisome position: 17.34

GC content: 51.49

Gene sequence:

>1272_bases
ATGCATATTTGTATCCAAAATGGCCGTCTGATTGACCCTGACAGCGGTATGGATCGTATTGGCGATCTTTATCTGGCTGA
AGGCAGGATTATATCAATCGATTCCCGGCCTGAACATTTTCATGACGATCGGGAGATTGATGCAAGCGGATTGGTTGTAT
GCCCCGGTTTGGTTGATTTATCCGCACGTTTGCGCGAACCTGGGCTTGAGTATATGGCCACCCTGGAGTCGGAGCTGGAA
GCCGCAGTAGCGGGAGGAGTAACCAGCCTCGCGTGCCCCCCGGATACAGATCCACCATTGGATGAACCGGGTCTGGTGGA
GATGCTGAAGCATCGTGCGCGTAATCTTGATCGGGCACGAGTCTACCCGGTAGGAGCGCTGACTCAAGGACTTAAAGGTG
AACGATTAACGGAAATGGTTGAGTTGCATGATGCCGGGTGTGTTGCTTTTAGCCAGGCAGATGCACCGATTGCCAACCTG
CATGTATTGATGCGAGCCATGCAGTATGCTGCCACTTTCGGTTTCAAAGTCTGGTTGCGCCCTCAGGATATGTATCTGGC
CAATCATGGTGTTGCCCATGATGGGGAGGTTGCCACTCGTTTAGGATTGCCAGCAATACCTGTATGTGCGGAGACAATTG
CGCTCACGGATATTTTGTCCCTGATGAAAGAAACTGGTGCCAGCGCACATCTATGCCGTATTTCCAGTGCCGAGGGCGTA
GCGCTGGTACGTGCAGCCAAGCAGCAAGGTTTGCCGCTAACTTGTGATGTTTCCATCCACCATGTACATCTGGTTGATAT
GGATATTGGCTTTTTTGATGCGAACTGTCATCTTATGCCACCACTCAGAGGTCTGGCGGACAGGGATGCATTACGCGCAG
GGCTGATGGATGGGGCGATTGATACGATCTGCTCGGATCATGCACCCGTGGATGATGATGCCAAGCTGCTACCCTTTGCC
CAGGCCGAAACTGGCGCAACCGGATTGGAGCTGTTGCTGCCGCTTACGCTGAAATGGGCAATGGAAAGCAGATTATCATT
ACCAGAAGCGCTGGCAAGAATTACATCGTATCCGGCTCGTATACTGGGAATTGATGCCGGGCGATTGGTGGCAGGTGCTC
CAGCTGATTTATGTATTTTTGATCCTGATGCGTACTGGGTTGTCAGTAATGCTGAGTTGAAAAGTCAGGGCAAGAATACA
CCTTTTCTTGGAATGGAGCTATGTGGTCGCACCCGGTTTACGTTGATTAGCGGGCATGTTGTGTATGGCTAG

Upstream 100 bases:

>100_bases
ACGGTTCTCAATCGGTCATTCTACCCCAGGTAGGTTTTGGTATTGCTGTTCGCATGGCAGTCATGTCGATTCTCGCTGGA
AATTAACGCTCGTATCCTCT

Downstream 100 bases:

>100_bases
TAGCACATATGCCTGAAGCCTATAGATTTCATCCAGATCATATTGAAATCAGGATGATTCGATAACTAACAAAATACCCT
GAGACCGCACATTAATAATA

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MHICIQNGRLIDPDSGMDRIGDLYLAEGRIISIDSRPEHFHDDREIDASGLVVCPGLVDLSARLREPGLEYMATLESELE
AAVAGGVTSLACPPDTDPPLDEPGLVEMLKHRARNLDRARVYPVGALTQGLKGERLTEMVELHDAGCVAFSQADAPIANL
HVLMRAMQYAATFGFKVWLRPQDMYLANHGVAHDGEVATRLGLPAIPVCAETIALTDILSLMKETGASAHLCRISSAEGV
ALVRAAKQQGLPLTCDVSIHHVHLVDMDIGFFDANCHLMPPLRGLADRDALRAGLMDGAIDTICSDHAPVDDDAKLLPFA
QAETGATGLELLLPLTLKWAMESRLSLPEALARITSYPARILGIDAGRLVAGAPADLCIFDPDAYWVVSNAELKSQGKNT
PFLGMELCGRTRFTLISGHVVYG

Sequences:

>Translated_423_residues
MHICIQNGRLIDPDSGMDRIGDLYLAEGRIISIDSRPEHFHDDREIDASGLVVCPGLVDLSARLREPGLEYMATLESELE
AAVAGGVTSLACPPDTDPPLDEPGLVEMLKHRARNLDRARVYPVGALTQGLKGERLTEMVELHDAGCVAFSQADAPIANL
HVLMRAMQYAATFGFKVWLRPQDMYLANHGVAHDGEVATRLGLPAIPVCAETIALTDILSLMKETGASAHLCRISSAEGV
ALVRAAKQQGLPLTCDVSIHHVHLVDMDIGFFDANCHLMPPLRGLADRDALRAGLMDGAIDTICSDHAPVDDDAKLLPFA
QAETGATGLELLLPLTLKWAMESRLSLPEALARITSYPARILGIDAGRLVAGAPADLCIFDPDAYWVVSNAELKSQGKNT
PFLGMELCGRTRFTLISGHVVYG
>Mature_423_residues
MHICIQNGRLIDPDSGMDRIGDLYLAEGRIISIDSRPEHFHDDREIDASGLVVCPGLVDLSARLREPGLEYMATLESELE
AAVAGGVTSLACPPDTDPPLDEPGLVEMLKHRARNLDRARVYPVGALTQGLKGERLTEMVELHDAGCVAFSQADAPIANL
HVLMRAMQYAATFGFKVWLRPQDMYLANHGVAHDGEVATRLGLPAIPVCAETIALTDILSLMKETGASAHLCRISSAEGV
ALVRAAKQQGLPLTCDVSIHHVHLVDMDIGFFDANCHLMPPLRGLADRDALRAGLMDGAIDTICSDHAPVDDDAKLLPFA
QAETGATGLELLLPLTLKWAMESRLSLPEALARITSYPARILGIDAGRLVAGAPADLCIFDPDAYWVVSNAELKSQGKNT
PFLGMELCGRTRFTLISGHVVYG

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=382, Percent_Identity=28.0104712041885, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786722, Length=443, Percent_Identity=27.313769751693, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=21.923937360179, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=414, Percent_Identity=25.3623188405797, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=420, Percent_Identity=24.5238095238095, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=25.7894736842105, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859883, Length=207, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 45548; Mature: 45548

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHICIQNGRLIDPDSGMDRIGDLYLAEGRIISIDSRPEHFHDDREIDASGLVVCPGLVDL
CEEEECCCEEECCCCCHHHHCCEEEECCEEEEECCCCCCCCCCCCCCCCCEEECCCHHHH
SARLREPGLEYMATLESELEAAVAGGVTSLACPPDTDPPLDEPGLVEMLKHRARNLDRAR
HHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
VYPVGALTQGLKGERLTEMVELHDAGCVAFSQADAPIANLHVLMRAMQYAATFGFKVWLR
EEEHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEC
PQDMYLANHGVAHDGEVATRLGLPAIPVCAETIALTDILSLMKETGASAHLCRISSAEGV
CCCEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
ALVRAAKQQGLPLTCDVSIHHVHLVDMDIGFFDANCHLMPPLRGLADRDALRAGLMDGAI
HHHHHHHHCCCCEEEEEEEEEEEEEEEECEEEECCCEECCCHHCCCHHHHHHHHHHHHHH
DTICSDHAPVDDDAKLLPFAQAETGATGLELLLPLTLKWAMESRLSLPEALARITSYPAR
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
ILGIDAGRLVAGAPADLCIFDPDAYWVVSNAELKSQGKNTPFLGMELCGRTRFTLISGHV
EEECCCCCEEECCCCCEEEECCCCEEEEECCHHHHCCCCCCEEHHHHCCCCEEEEEECEE
VYG
ECC
>Mature Secondary Structure
MHICIQNGRLIDPDSGMDRIGDLYLAEGRIISIDSRPEHFHDDREIDASGLVVCPGLVDL
CEEEECCCEEECCCCCHHHHCCEEEECCEEEEECCCCCCCCCCCCCCCCCEEECCCHHHH
SARLREPGLEYMATLESELEAAVAGGVTSLACPPDTDPPLDEPGLVEMLKHRARNLDRAR
HHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
VYPVGALTQGLKGERLTEMVELHDAGCVAFSQADAPIANLHVLMRAMQYAATFGFKVWLR
EEEHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEC
PQDMYLANHGVAHDGEVATRLGLPAIPVCAETIALTDILSLMKETGASAHLCRISSAEGV
CCCEEEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
ALVRAAKQQGLPLTCDVSIHHVHLVDMDIGFFDANCHLMPPLRGLADRDALRAGLMDGAI
HHHHHHHHCCCCEEEEEEEEEEEEEEEECEEEECCCEECCCHHCCCHHHHHHHHHHHHHH
DTICSDHAPVDDDAKLLPFAQAETGATGLELLLPLTLKWAMESRLSLPEALARITSYPAR
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
ILGIDAGRLVAGAPADLCIFDPDAYWVVSNAELKSQGKNTPFLGMELCGRTRFTLISGHV
EEECCCCCEEECCCCCEEEECCCCEEEEECCHHHHCCCCCCEEHHHHCCCCEEEEEECEE
VYG
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]