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The map label for this gene is prlC [H]

Identifier: 114330473

GI number: 114330473

Start: 462858

End: 464963

Strand: Direct

Name: prlC [H]

Synonym: Neut_0453

Alternate gene names: 114330473

Gene position: 462858-464963 (Clockwise)

Preceding gene: 114330472

Following gene: 114330474

Centisome position: 17.39

GC content: 47.77

Gene sequence:

>2106_bases
ATGAAGAACCCGTTACTTGATTTTTCCACGTTGCCACATTATGAGGAAATCCGAAATGAACATATTGCGCCAGCCATAGA
TGAGCTATTGCGTGATTGCCGTGCAGTGATGAATGCAGTCAAAAATACATCGGAAGTCCCGAATTGGCAGGATTTTGTGC
AACCAATGGTGGATGTGAATGAACGTCTGTCGCGTGCATGGGGGCAGGTGACACATTTGAATGCAGTCATGAATAATCCG
GAGTTGCGTGAAATCTATAATGCCAATCTGCCGCGTGTTACGCAGTACTATGCTGAGTTATCACAAGACCCAGTATTATT
TGAGAAATTTAAGCAATTGCGAACAGATTCGGCGTTCAATAATTTGAGTCAGGCACGCAGGAAAATTGTAGAAAACCAAT
TGCGAGATTTTCGGTTGGGGGGGGCTGAATTATCACCTGAAGATAAAGCACGGTTTATGCAAATTCAAGAAGAGCTGTCA
GCATTGAGTGCAAAATTCAGTGATAACCTGCTTGATGCAACCAATGCATTTTTCTTGTTGATAGAAAACCGGAGTGAGCT
GGCCGGGATTCCGGAAGATATATTGCAGGCAGCCAGTGAAGCAGCAGCTAAAGATACCTTAATTACTGTGCCGAGCTGGA
AATTTACGCTACATGCTCCATCCTATCTGCCGGTTATGCAGTACGCAGATAACCGTAGTTTGCGCGAACAGATGTACCGG
GCATATACAACGCGAGCCAGTGAGCTTGAAGTCAGTCCAGATCAGACTGTGAAGCGTGACAACATGCCTTTGATCGAACA
GATCCTGCGTTTGCGTCAGGAAGAAGCCAAATTGCTAGGTTATGATTGCTATGCGCAGGTATCTCTTGCCCCCAAGATGG
CAGAAACACCGCAGCAGGTGCTGGATTTTTTGAATGAACTGGCTGCTAAAGCGAGACCCTATGCGGAAAGAGATCTGGTG
GAACTACGTCAGTTTGCAGCTGATAAACTAAAGCTGACCCAACTTGAGGCGTGGGATATTGCCTATGTTAGTGAAAAGCT
GCGGATCGAGCGTTATGCTTTTTCTGATCAGGAAGTCAAGCAATATTTTCCAGAAAACAAGGTGTTATCCGGTATGTTCG
GGTTGGTGGAAACGCTGTACGGGATACATATCAGTGAAGCAGAGCAGGCGCGTAATGTTCAGCGTTGGCACCAGGATGTA
AGGTTTTTCGATATTACTGACGGTGAAGGCGATGTGTTGGGACAATTCTATCTGGATCTTTATGCTCGTCCTGGCAAGCG
TGGAGGAGCGTGGATGGATGATGCCGTAACGCGGCGACGAATTGAGGTGCCAGAAATCGGCCGTTCTGAAATCCAGGTGC
CAGTTGCTTACCTCACCTGTAATTTTTCTGCGCCGGTGACGATCAATGGCCATTTGCGCCCTGCGTTGTTTACGCATGAT
GAGGTCATTACACTGTTTCACGAGTTTGGTCATGGATTGCACCACTTGCTGACGCAGATGGATGAACTGGGGGTTTCCGG
TATTAACGGCGTCGAGTGGGATGCGGTCGAACTGCCAAGCCAGTTCATGGAGAACTTTTGCTGGGAATGGGAGGTGTTGC
GCGATATGGCTGCGCATGTGGAAACTGGTGATTCGTTACCGCGCACATTATTCGACAAGATGCTCGCAGCCAAGAATTTT
CAGAGCGGTCTTCAAACTTTACGTCAGATCGAATTTGCCTTGTTTGACATGCATCTGCACACTGATTTTGATCCGCTGGG
CAGCGAGACCGTGTTGCAGCGTCTGGATAAAATCCGTCAGCAGGTAGCAGTTATTATTCCGCCAGCTTTCCACCGGTTTC
CGAGCAGCTTTGGACATATATTTGCTGGGGGTTATGCAGCTGGTTATTACAGCTATAAATGGGCAGAAGTATTGTCTGCC
GATGCTTATAGCCTGTTTGAGGAAAATGGTGTTGGCCAAGTGGTTAATGCGAAGACTGGCGAGCGTTTCTGGCATGAAAT
TCTTGCTGTAGGCGGTAGCCGTCCTGCGCTTGAGTCATTTGTTGCGTTTCGCGGACGCGAGCCAAAAATTGATGCGCTAT
TGCGCCATCATGGGATGGTGGTTTGA

Upstream 100 bases:

>100_bases
AGATTTCATCCAGATCATATTGAAATCAGGATGATTCGATAACTAACAAAATACCCTGAGACCGCACATTAATAATAAAC
CCTTTGAATATATAACTGAT

Downstream 100 bases:

>100_bases
GTAATTTTTGTATCTTTGGCGTGTTCAATATTGTTGTCAAATAATCTAGTGAGAAGCTTTGCCGAAAACAGTAGTGCTAT
TTCTCTGACAGGTAGCGCAA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MKNPLLDFSTLPHYEEIRNEHIAPAIDELLRDCRAVMNAVKNTSEVPNWQDFVQPMVDVNERLSRAWGQVTHLNAVMNNP
ELREIYNANLPRVTQYYAELSQDPVLFEKFKQLRTDSAFNNLSQARRKIVENQLRDFRLGGAELSPEDKARFMQIQEELS
ALSAKFSDNLLDATNAFFLLIENRSELAGIPEDILQAASEAAAKDTLITVPSWKFTLHAPSYLPVMQYADNRSLREQMYR
AYTTRASELEVSPDQTVKRDNMPLIEQILRLRQEEAKLLGYDCYAQVSLAPKMAETPQQVLDFLNELAAKARPYAERDLV
ELRQFAADKLKLTQLEAWDIAYVSEKLRIERYAFSDQEVKQYFPENKVLSGMFGLVETLYGIHISEAEQARNVQRWHQDV
RFFDITDGEGDVLGQFYLDLYARPGKRGGAWMDDAVTRRRIEVPEIGRSEIQVPVAYLTCNFSAPVTINGHLRPALFTHD
EVITLFHEFGHGLHHLLTQMDELGVSGINGVEWDAVELPSQFMENFCWEWEVLRDMAAHVETGDSLPRTLFDKMLAAKNF
QSGLQTLRQIEFALFDMHLHTDFDPLGSETVLQRLDKIRQQVAVIIPPAFHRFPSSFGHIFAGGYAAGYYSYKWAEVLSA
DAYSLFEENGVGQVVNAKTGERFWHEILAVGGSRPALESFVAFRGREPKIDALLRHHGMVV

Sequences:

>Translated_701_residues
MKNPLLDFSTLPHYEEIRNEHIAPAIDELLRDCRAVMNAVKNTSEVPNWQDFVQPMVDVNERLSRAWGQVTHLNAVMNNP
ELREIYNANLPRVTQYYAELSQDPVLFEKFKQLRTDSAFNNLSQARRKIVENQLRDFRLGGAELSPEDKARFMQIQEELS
ALSAKFSDNLLDATNAFFLLIENRSELAGIPEDILQAASEAAAKDTLITVPSWKFTLHAPSYLPVMQYADNRSLREQMYR
AYTTRASELEVSPDQTVKRDNMPLIEQILRLRQEEAKLLGYDCYAQVSLAPKMAETPQQVLDFLNELAAKARPYAERDLV
ELRQFAADKLKLTQLEAWDIAYVSEKLRIERYAFSDQEVKQYFPENKVLSGMFGLVETLYGIHISEAEQARNVQRWHQDV
RFFDITDGEGDVLGQFYLDLYARPGKRGGAWMDDAVTRRRIEVPEIGRSEIQVPVAYLTCNFSAPVTINGHLRPALFTHD
EVITLFHEFGHGLHHLLTQMDELGVSGINGVEWDAVELPSQFMENFCWEWEVLRDMAAHVETGDSLPRTLFDKMLAAKNF
QSGLQTLRQIEFALFDMHLHTDFDPLGSETVLQRLDKIRQQVAVIIPPAFHRFPSSFGHIFAGGYAAGYYSYKWAEVLSA
DAYSLFEENGVGQVVNAKTGERFWHEILAVGGSRPALESFVAFRGREPKIDALLRHHGMVV
>Mature_701_residues
MKNPLLDFSTLPHYEEIRNEHIAPAIDELLRDCRAVMNAVKNTSEVPNWQDFVQPMVDVNERLSRAWGQVTHLNAVMNNP
ELREIYNANLPRVTQYYAELSQDPVLFEKFKQLRTDSAFNNLSQARRKIVENQLRDFRLGGAELSPEDKARFMQIQEELS
ALSAKFSDNLLDATNAFFLLIENRSELAGIPEDILQAASEAAAKDTLITVPSWKFTLHAPSYLPVMQYADNRSLREQMYR
AYTTRASELEVSPDQTVKRDNMPLIEQILRLRQEEAKLLGYDCYAQVSLAPKMAETPQQVLDFLNELAAKARPYAERDLV
ELRQFAADKLKLTQLEAWDIAYVSEKLRIERYAFSDQEVKQYFPENKVLSGMFGLVETLYGIHISEAEQARNVQRWHQDV
RFFDITDGEGDVLGQFYLDLYARPGKRGGAWMDDAVTRRRIEVPEIGRSEIQVPVAYLTCNFSAPVTINGHLRPALFTHD
EVITLFHEFGHGLHHLLTQMDELGVSGINGVEWDAVELPSQFMENFCWEWEVLRDMAAHVETGDSLPRTLFDKMLAAKNF
QSGLQTLRQIEFALFDMHLHTDFDPLGSETVLQRLDKIRQQVAVIIPPAFHRFPSSFGHIFAGGYAAGYYSYKWAEVLSA
DAYSLFEENGVGQVVNAKTGERFWHEILAVGGSRPALESFVAFRGREPKIDALLRHHGMVV

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=621, Percent_Identity=31.5619967793881, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI14149738, Length=693, Percent_Identity=29.7258297258297, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI156105687, Length=640, Percent_Identity=24.84375, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1789913, Length=699, Percent_Identity=49.7854077253219, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=711, Percent_Identity=30.379746835443, Blast_Score=281, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71999758, Length=690, Percent_Identity=23.9130434782609, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565901, Length=667, Percent_Identity=20.9895052473763, Blast_Score=99, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319793, Length=700, Percent_Identity=29.8571428571429, Blast_Score=303, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=608, Percent_Identity=24.8355263157895, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=27.9600570613409, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129717, Length=589, Percent_Identity=24.6179966044143, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80146; Mature: 80146

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPLLDFSTLPHYEEIRNEHIAPAIDELLRDCRAVMNAVKNTSEVPNWQDFVQPMVDVN
CCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ERLSRAWGQVTHLNAVMNNPELREIYNANLPRVTQYYAELSQDPVLFEKFKQLRTDSAFN
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NLSQARRKIVENQLRDFRLGGAELSPEDKARFMQIQEELSALSAKFSDNLLDATNAFFLL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEE
IENRSELAGIPEDILQAASEAAAKDTLITVPSWKFTLHAPSYLPVMQYADNRSLREQMYR
EECCHHHCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCHHHHHHCCHHHHHHHHH
AYTTRASELEVSPDQTVKRDNMPLIEQILRLRQEEAKLLGYDCYAQVSLAPKMAETPQQV
HHHCCCCCEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHEEEECCCHHHCCHHHH
LDFLNELAAKARPYAERDLVELRQFAADKLKLTQLEAWDIAYVSEKLRIERYAFSDQEVK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
QYFPENKVLSGMFGLVETLYGIHISEAEQARNVQRWHQDVRFFDITDGEGDVLGQFYLDL
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
YARPGKRGGAWMDDAVTRRRIEVPEIGRSEIQVPVAYLTCNFSAPVTINGHLRPALFTHD
HCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHEEEEEEEEECCCCCEEECCCCCCCCCCHH
EVITLFHEFGHGLHHLLTQMDELGVSGINGVEWDAVELPSQFMENFCWEWEVLRDMAAHV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETGDSLPRTLFDKMLAAKNFQSGLQTLRQIEFALFDMHLHTDFDPLGSETVLQRLDKIRQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QVAVIIPPAFHRFPSSFGHIFAGGYAAGYYSYKWAEVLSADAYSLFEENGVGQVVNAKTG
HHEEEECHHHHHCCHHHCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHH
ERFWHEILAVGGSRPALESFVAFRGREPKIDALLRHHGMVV
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MKNPLLDFSTLPHYEEIRNEHIAPAIDELLRDCRAVMNAVKNTSEVPNWQDFVQPMVDVN
CCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ERLSRAWGQVTHLNAVMNNPELREIYNANLPRVTQYYAELSQDPVLFEKFKQLRTDSAFN
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NLSQARRKIVENQLRDFRLGGAELSPEDKARFMQIQEELSALSAKFSDNLLDATNAFFLL
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEE
IENRSELAGIPEDILQAASEAAAKDTLITVPSWKFTLHAPSYLPVMQYADNRSLREQMYR
EECCHHHCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCHHHHHHCCHHHHHHHHH
AYTTRASELEVSPDQTVKRDNMPLIEQILRLRQEEAKLLGYDCYAQVSLAPKMAETPQQV
HHHCCCCCEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHEEEECCCHHHCCHHHH
LDFLNELAAKARPYAERDLVELRQFAADKLKLTQLEAWDIAYVSEKLRIERYAFSDQEVK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
QYFPENKVLSGMFGLVETLYGIHISEAEQARNVQRWHQDVRFFDITDGEGDVLGQFYLDL
HHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHH
YARPGKRGGAWMDDAVTRRRIEVPEIGRSEIQVPVAYLTCNFSAPVTINGHLRPALFTHD
HCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHEEEEEEEEECCCCCEEECCCCCCCCCCHH
EVITLFHEFGHGLHHLLTQMDELGVSGINGVEWDAVELPSQFMENFCWEWEVLRDMAAHV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETGDSLPRTLFDKMLAAKNFQSGLQTLRQIEFALFDMHLHTDFDPLGSETVLQRLDKIRQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
QVAVIIPPAFHRFPSSFGHIFAGGYAAGYYSYKWAEVLSADAYSLFEENGVGQVVNAKTG
HHEEEECHHHHHCCHHHCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHH
ERFWHEILAVGGSRPALESFVAFRGREPKIDALLRHHGMVV
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]