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The map label for this gene is copA [H]

Identifier: 114330338

GI number: 114330338

Start: 317933

End: 319732

Strand: Direct

Name: copA [H]

Synonym: Neut_0311

Alternate gene names: 114330338

Gene position: 317933-319732 (Clockwise)

Preceding gene: 114330337

Following gene: 114330339

Centisome position: 11.95

GC content: 52.5

Gene sequence:

>1800_bases
ATGAAGGACTCAATTTCAAGACGCGCCTTTCTGAAAAAATCAGGCACACTGGGAACCCTTACTGCTCTGGACGGGATGCT
GCCGACCTATGCCTGGTCTAATTTCTTAAGTGCTGTTACGCCGGCTATGCAGCTAAGCGGAGATGTTATCAATCTCACTA
TCGCCAGAACGCCGTTTCGTATCGATCATCGCACTACAACCGCCACAACTGTCAATGGTACCGTTCCAGGGCCTTTACTT
CGTTTGCGCGAAGGGCAGGATGTTACCCTGAATGTGACTAACCGCCTGGACGAAACGTCTTCAATACATTGGCACGGCAT
TCTCCTGCCACCTGAAATGGATGGTGTGCCTGGTGTCAGTTTCCCGGGTATTGAGCCGGGAACAACCTTTTCCTATCGCT
TCACGATCAGGCAGTACGGCACGTACTGGTTTCACAGTCATTCAGGCGGCCAGGAGCAGGCAGGCGTGTATGCACCAATG
ATTATTGATCCGCTTGAACCAGACCCGATCCAGTACGATCGCGAATATGTGATCATGCTTTCGGACTGGAGCTTTTCTTC
AGTGGATGCAATGATCGGAAAGCTCAAGAAGCAGCCCGGCTACTTCAACTTTCAAAAGCGCACGCTGGGTGATTTTATTA
AGGACGTCATGCAGGATGGCTGGCTCCCGGCATTTGACAATTACTTGATGTGGGCCCGGATGCGAATGGATCCGACAGAC
TTGGCAGACGTAACGGGTTATGCCTACACCTACCTCATGAATGGATTGACCTCGGCCGCAAATTGGACGGGGATTTTCCG
TCCGGGTGAACGCGTACGATTGCGCTTTATTCAAGCAGGGGCTATGACATTTCAGGACATCCGGATTCCCGGACTCAGGA
TGACCGTAGTGCAAGCGGATGGTCAGAATGTACAACCTGTTGAAGTGGATGAGTTCCGCATCGGTCCGGCTGAAACCTAC
GATATTATCGTGGAACCTAAAGAGGATCGTGCTTACACGATTTTTGCAGAGACACTGGATCGAAGTGGTTTCGCACGCGG
CACCCTGGCACCGCGCCCTGGAATGACGGCAGAGATTCCGCCGCGCCGCTCCCGTCCGCTTCTCACCATGGCAGATATGG
GCATGCGACACATGAACGCCGAGAGCCATGGTGACCACGAATCTCACGATGCAGCTAGAGGTGAACCGACAAAAGGGATG
CAGCTCGACGACACGCATGGAGAGCATGATCGGCCCGGGCATCTCGATACCAAGCCAGTCAGGCATGCTGCTGACGATCA
TGGTCCTGGCAATCAGTTCATTCCGGATTTCACACAGAGTCGTATGGATGAACCGGGCATCGGGCTGGGAAATGATGGCC
GCCGGGTGTTAGTCTATACCGATTTAAAGAGCCTCAAGCCCTATCCTGATCAGCGCAAACCTGAGCGTGAGCTCGAAATT
CACCTTACCGGTCATATGGAACGCTTCATATGGTCGTTCGATGGCAAGAAATATTCAGATGCCAGGGAGCCGATCCTTTT
CCATCATGGAGAGCGGTTACGCTGGATTTTTGTTAACGATACGATGATGGACCACACGATGCATCTGCATGGCATGTGGA
TGTATCTGGAAAATGGCGCTGGCGCATACCTTCCGCGTAAGCACACGGTTCTTGTCAAGCCCGCTGAACGCATTTCTGTT
GCCATTACTGCTGATGCACCTGGTCCTTGGGCCTTTCACTGCCACTTGCTCTTGCATATGGAAACAGGAATGTTTCGTGT
GGTTGAGACCCTGGATGCAGTTCCCGGAACAGAACCGTGA

Upstream 100 bases:

>100_bases
GGGCGAAGGTTTTTGAATGACTTGCTGGAGATTTTTCTGCCAGAATCCAGGCAAACGACAACTTCCTGAACTTAAAATAG
CGGGGGGGGGGGAGATCGGA

Downstream 100 bases:

>100_bases
AATTCTTTCTGCAACTTGGGGCTGGCATTGTTGCGATTCTGTTCTTAGGTGCGGGTAGCAGCCTGCCGGCAGCAAGCGCA
GAAATACTGTCAGACAAAGC

Product: copper-resistance protein, CopA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MKDSISRRAFLKKSGTLGTLTALDGMLPTYAWSNFLSAVTPAMQLSGDVINLTIARTPFRIDHRTTTATTVNGTVPGPLL
RLREGQDVTLNVTNRLDETSSIHWHGILLPPEMDGVPGVSFPGIEPGTTFSYRFTIRQYGTYWFHSHSGGQEQAGVYAPM
IIDPLEPDPIQYDREYVIMLSDWSFSSVDAMIGKLKKQPGYFNFQKRTLGDFIKDVMQDGWLPAFDNYLMWARMRMDPTD
LADVTGYAYTYLMNGLTSAANWTGIFRPGERVRLRFIQAGAMTFQDIRIPGLRMTVVQADGQNVQPVEVDEFRIGPAETY
DIIVEPKEDRAYTIFAETLDRSGFARGTLAPRPGMTAEIPPRRSRPLLTMADMGMRHMNAESHGDHESHDAARGEPTKGM
QLDDTHGEHDRPGHLDTKPVRHAADDHGPGNQFIPDFTQSRMDEPGIGLGNDGRRVLVYTDLKSLKPYPDQRKPERELEI
HLTGHMERFIWSFDGKKYSDAREPILFHHGERLRWIFVNDTMMDHTMHLHGMWMYLENGAGAYLPRKHTVLVKPAERISV
AITADAPGPWAFHCHLLLHMETGMFRVVETLDAVPGTEP

Sequences:

>Translated_599_residues
MKDSISRRAFLKKSGTLGTLTALDGMLPTYAWSNFLSAVTPAMQLSGDVINLTIARTPFRIDHRTTTATTVNGTVPGPLL
RLREGQDVTLNVTNRLDETSSIHWHGILLPPEMDGVPGVSFPGIEPGTTFSYRFTIRQYGTYWFHSHSGGQEQAGVYAPM
IIDPLEPDPIQYDREYVIMLSDWSFSSVDAMIGKLKKQPGYFNFQKRTLGDFIKDVMQDGWLPAFDNYLMWARMRMDPTD
LADVTGYAYTYLMNGLTSAANWTGIFRPGERVRLRFIQAGAMTFQDIRIPGLRMTVVQADGQNVQPVEVDEFRIGPAETY
DIIVEPKEDRAYTIFAETLDRSGFARGTLAPRPGMTAEIPPRRSRPLLTMADMGMRHMNAESHGDHESHDAARGEPTKGM
QLDDTHGEHDRPGHLDTKPVRHAADDHGPGNQFIPDFTQSRMDEPGIGLGNDGRRVLVYTDLKSLKPYPDQRKPERELEI
HLTGHMERFIWSFDGKKYSDAREPILFHHGERLRWIFVNDTMMDHTMHLHGMWMYLENGAGAYLPRKHTVLVKPAERISV
AITADAPGPWAFHCHLLLHMETGMFRVVETLDAVPGTEP
>Mature_599_residues
MKDSISRRAFLKKSGTLGTLTALDGMLPTYAWSNFLSAVTPAMQLSGDVINLTIARTPFRIDHRTTTATTVNGTVPGPLL
RLREGQDVTLNVTNRLDETSSIHWHGILLPPEMDGVPGVSFPGIEPGTTFSYRFTIRQYGTYWFHSHSGGQEQAGVYAPM
IIDPLEPDPIQYDREYVIMLSDWSFSSVDAMIGKLKKQPGYFNFQKRTLGDFIKDVMQDGWLPAFDNYLMWARMRMDPTD
LADVTGYAYTYLMNGLTSAANWTGIFRPGERVRLRFIQAGAMTFQDIRIPGLRMTVVQADGQNVQPVEVDEFRIGPAETY
DIIVEPKEDRAYTIFAETLDRSGFARGTLAPRPGMTAEIPPRRSRPLLTMADMGMRHMNAESHGDHESHDAARGEPTKGM
QLDDTHGEHDRPGHLDTKPVRHAADDHGPGNQFIPDFTQSRMDEPGIGLGNDGRRVLVYTDLKSLKPYPDQRKPERELEI
HLTGHMERFIWSFDGKKYSDAREPILFHHGERLRWIFVNDTMMDHTMHLHGMWMYLENGAGAYLPRKHTVLVKPAERISV
AITADAPGPWAFHCHLLLHMETGMFRVVETLDAVPGTEP

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=355, Percent_Identity=25.0704225352113, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321067, Length=559, Percent_Identity=22.8980322003578, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=300, Percent_Identity=24.6666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323703, Length=264, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650186, Length=573, Percent_Identity=22.6876090750436, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859919, Length=273, Percent_Identity=27.8388278388278, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574104, Length=144, Percent_Identity=37.5, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360167, Length=290, Percent_Identity=27.2413793103448, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24585842, Length=290, Percent_Identity=27.2413793103448, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221329998, Length=290, Percent_Identity=27.2413793103448, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221330000, Length=290, Percent_Identity=27.2413793103448, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67625; Mature: 67625

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDSISRRAFLKKSGTLGTLTALDGMLPTYAWSNFLSAVTPAMQLSGDVINLTIARTPFR
CCCCHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHCHHHHCCCCEEEEEEEECCEE
IDHRTTTATTVNGTVPGPLLRLREGQDVTLNVTNRLDETSSIHWHGILLPPEMDGVPGVS
ECCCCEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
FPGIEPGTTFSYRFTIRQYGTYWFHSHSGGQEQAGVYAPMIIDPLEPDPIQYDREYVIML
CCCCCCCCEEEEEEEEEECCEEEEECCCCCCCCCCEECCEEECCCCCCCCCCCCEEEEEE
SDWSFSSVDAMIGKLKKQPGYFNFQKRTLGDFIKDVMQDGWLPAFDNYLMWARMRMDPTD
ECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHH
LADVTGYAYTYLMNGLTSAANWTGIFRPGERVRLRFIQAGAMTFQDIRIPGLRMTVVQAD
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEEECCCEEEEEECCCEEEEEEECC
GQNVQPVEVDEFRIGPAETYDIIVEPKEDRAYTIFAETLDRSGFARGTLAPRPGMTAEIP
CCCCCCEECCCEECCCCCCEEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCC
PRRSRPLLTMADMGMRHMNAESHGDHESHDAARGEPTKGMQLDDTHGEHDRPGHLDTKPV
CCCCCCEEEHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHH
RHAADDHGPGNQFIPDFTQSRMDEPGIGLGNDGRRVLVYTDLKSLKPYPDQRKPERELEI
HHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECHHHCCCCCCCCCCCCEEEE
HLTGHMERFIWSFDGKKYSDAREPILFHHGERLRWIFVNDTMMDHTMHLHGMWMYLENGA
EEEECCEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCEEEEEEEEEEEECCC
GAYLPRKHTVLVKPAERISVAITADAPGPWAFHCHLLLHMETGMFRVVETLDAVPGTEP
CCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKDSISRRAFLKKSGTLGTLTALDGMLPTYAWSNFLSAVTPAMQLSGDVINLTIARTPFR
CCCCHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHCHHHHCCCCEEEEEEEECCEE
IDHRTTTATTVNGTVPGPLLRLREGQDVTLNVTNRLDETSSIHWHGILLPPEMDGVPGVS
ECCCCEEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
FPGIEPGTTFSYRFTIRQYGTYWFHSHSGGQEQAGVYAPMIIDPLEPDPIQYDREYVIML
CCCCCCCCEEEEEEEEEECCEEEEECCCCCCCCCCEECCEEECCCCCCCCCCCCEEEEEE
SDWSFSSVDAMIGKLKKQPGYFNFQKRTLGDFIKDVMQDGWLPAFDNYLMWARMRMDPTD
ECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHH
LADVTGYAYTYLMNGLTSAANWTGIFRPGERVRLRFIQAGAMTFQDIRIPGLRMTVVQAD
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEEECCCEEEEEECCCEEEEEEECC
GQNVQPVEVDEFRIGPAETYDIIVEPKEDRAYTIFAETLDRSGFARGTLAPRPGMTAEIP
CCCCCCEECCCEECCCCCCEEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCC
PRRSRPLLTMADMGMRHMNAESHGDHESHDAARGEPTKGMQLDDTHGEHDRPGHLDTKPV
CCCCCCEEEHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHH
RHAADDHGPGNQFIPDFTQSRMDEPGIGLGNDGRRVLVYTDLKSLKPYPDQRKPERELEI
HHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECHHHCCCCCCCCCCCCEEEE
HLTGHMERFIWSFDGKKYSDAREPILFHHGERLRWIFVNDTMMDHTMHLHGMWMYLENGA
EEEECCEEEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCCCCEEEEEEEEEEEECCC
GAYLPRKHTVLVKPAERISVAITADAPGPWAFHCHLLLHMETGMFRVVETLDAVPGTEP
CCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]