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The map label for this gene is glmS [H]

Identifier: 114330307

GI number: 114330307

Start: 290775

End: 292622

Strand: Direct

Name: glmS [H]

Synonym: Neut_0280

Alternate gene names: 114330307

Gene position: 290775-292622 (Clockwise)

Preceding gene: 114330306

Following gene: 114330308

Centisome position: 10.93

GC content: 46.81

Gene sequence:

>1848_bases
ATGTGCGGTATTGTAGGTGCAATTGCGAAAAATGATGTTGTACCATTTTTATTGGAAGGATTATCCAGGCTTGAGTACCG
TGGTTATGACTCGGCAGGAATCGTAGTTGCAGATGGTACGTTGCATAGATTGCGGACAACGGGCCGTGTTTCTGAGCTGA
GCAAGCTGGTTCATGCCGGAGGAACATCAGGACTTACCGGTATTGCGCATACTCGTTGGGCAACGCATGGGGCGCCTTCT
GAGCGGAATGCTCACCCGCATTTTTCTGGTGATCAAAGAAAAATTGCTGTTGTACATAATGGTATTATCGAAAATCACGA
AACTCTCCGGCAACGTTTAGAACAGGAGGGATTTAAATTTCTGTCAGATACCGACACCGAAGTAATTGCTCATTTGATTT
CGCTTTATCTTCGTAAGACCGATGATTTGCTGGATGCTGTCTGCCATTCCCTTGAGGAGTTGCAGGGCGCATATGCTATC
GCCGTTATGGAAGAGGCGCGTCAGGATCGCATTGTCGTTGCCAGAAATGGGGCTCCACTCTTGCTCGGGATAGATGATGG
TGGACTTTACGCTGCTTCTGATGCCTCTGCACTGGTACAGATTACGCAGCGGATTGTGTATCTTGAAGAAGGAGATGTGG
CGGAGTTGTCCAGTGATGGATATCGTATTTTGAATTGCCTGAATACGGTAAACGGCTGTGAAGTCACTCGTGAAGTAATT
GAGAGCAGCTTGACGCGGGATGCGGTGGAGCTAGGTTCATATTCGCATTTTATGCAAAAGGAGATCTTTGAGCAGCCGGT
TGCTGTGGCAAATACCCTGGAAATGGTATTGAATGTACAATCAGTGTCTCCTCAATTATTTGGCAGTGAAGCACAAACGA
TTTTTGCCCAGACTCGGGGAATATTGATACTCGCTTGCGGGACCAGCTATCATGCTGGTCTGGTTGCAAAATACTGGTTG
GAAACAATTGCAAGACTTCCTTGTAATGTCGAGATTGCCAGTGAATATCGATATCGCAATCCAATTGCTGATCCAGCTAC
GCTGGTTATTGGTATTTCTCAATCTGGTGAAACTGCGGATACTCTGGCTGCGCTAAGTTATGCTAAGTCATTAGGCCATC
GCTACAATTTAGCAATTTGTAACGTGCCGGAAAGTGCCCTGATTAGGCAAACTAATCTGCGCTTCCTGACTCGTGCCGGC
CCTGAAATTGGAGTTGCCTCCACAAAAGCTTTCACTACGCAGCTGGCAGTTTTGCTGTTGTTTACAGCAGTGCTTGCAAA
GATACGCAACAAATTGCCGACTGAAGACGAACAGAAAATGATTGCCGCATTACGGCATTTGCCAGTTGCGATACAGCGTA
CGCTTCAAAGTGAGCTGGAAATTAAAAAATGGGCAGGAGATTTTTCCCAGAAACACCATGCTCTGTTTCTGGGGCGCGGC
GTACACTACCCAATCGCATTGGAGGGGGCGCTGAAGCTTAAGGAGATTTCGTATATTCATGCTGAAGCTTATGCCGCAGG
TGAACTCAAGCACGGCCCTCTTGCGCTTGTAGACAGTGGAATGCCTGTAGTTGCCATAGCTCCGAATGATGTGTTGCTGG
AAAAGCTGAAATCCAATTTGCATGAAGTGCGTGCACGCGGAGGAGAGTTGTACGTCTTTGCAGATGCAGATTCACGTATT
GAGGAGAGTGAAGGGGTGCATATTATTCGCATGGATGAATATGGAGGTGTACTTAGTCCCATTTTGCATACTATTCCGTT
ACAGCTATTGGCTTATCACGTGGCTTTGCAAAAGGGTACCGATGTTGATAAACCCAGAAATCTGGCAAAATCCGTTACGG
TTGAGTAA

Upstream 100 bases:

>100_bases
ATCCAGGATTAAACAAATAAGTATTGCCAACTGGAAGCGGCCGAAAAAAAACAAGGATTGATGCTGTTTATACAAGGTAG
AGCTGAGTAGAGGATAGGTT

Downstream 100 bases:

>100_bases
TTGAGCTGCTTTGATTTTCAGCTTGCGATTAAAGTATCCAAGTACTCTCTGGCCCGACCAACAAGGCACACGGCTGCGGC
ATGCTTTATACAATGATGCT

Product: glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MCGIVGAIAKNDVVPFLLEGLSRLEYRGYDSAGIVVADGTLHRLRTTGRVSELSKLVHAGGTSGLTGIAHTRWATHGAPS
ERNAHPHFSGDQRKIAVVHNGIIENHETLRQRLEQEGFKFLSDTDTEVIAHLISLYLRKTDDLLDAVCHSLEELQGAYAI
AVMEEARQDRIVVARNGAPLLLGIDDGGLYAASDASALVQITQRIVYLEEGDVAELSSDGYRILNCLNTVNGCEVTREVI
ESSLTRDAVELGSYSHFMQKEIFEQPVAVANTLEMVLNVQSVSPQLFGSEAQTIFAQTRGILILACGTSYHAGLVAKYWL
ETIARLPCNVEIASEYRYRNPIADPATLVIGISQSGETADTLAALSYAKSLGHRYNLAICNVPESALIRQTNLRFLTRAG
PEIGVASTKAFTTQLAVLLLFTAVLAKIRNKLPTEDEQKMIAALRHLPVAIQRTLQSELEIKKWAGDFSQKHHALFLGRG
VHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDSGMPVVAIAPNDVLLEKLKSNLHEVRARGGELYVFADADSRI
EESEGVHIIRMDEYGGVLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE

Sequences:

>Translated_615_residues
MCGIVGAIAKNDVVPFLLEGLSRLEYRGYDSAGIVVADGTLHRLRTTGRVSELSKLVHAGGTSGLTGIAHTRWATHGAPS
ERNAHPHFSGDQRKIAVVHNGIIENHETLRQRLEQEGFKFLSDTDTEVIAHLISLYLRKTDDLLDAVCHSLEELQGAYAI
AVMEEARQDRIVVARNGAPLLLGIDDGGLYAASDASALVQITQRIVYLEEGDVAELSSDGYRILNCLNTVNGCEVTREVI
ESSLTRDAVELGSYSHFMQKEIFEQPVAVANTLEMVLNVQSVSPQLFGSEAQTIFAQTRGILILACGTSYHAGLVAKYWL
ETIARLPCNVEIASEYRYRNPIADPATLVIGISQSGETADTLAALSYAKSLGHRYNLAICNVPESALIRQTNLRFLTRAG
PEIGVASTKAFTTQLAVLLLFTAVLAKIRNKLPTEDEQKMIAALRHLPVAIQRTLQSELEIKKWAGDFSQKHHALFLGRG
VHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDSGMPVVAIAPNDVLLEKLKSNLHEVRARGGELYVFADADSRI
EESEGVHIIRMDEYGGVLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE
>Mature_615_residues
MCGIVGAIAKNDVVPFLLEGLSRLEYRGYDSAGIVVADGTLHRLRTTGRVSELSKLVHAGGTSGLTGIAHTRWATHGAPS
ERNAHPHFSGDQRKIAVVHNGIIENHETLRQRLEQEGFKFLSDTDTEVIAHLISLYLRKTDDLLDAVCHSLEELQGAYAI
AVMEEARQDRIVVARNGAPLLLGIDDGGLYAASDASALVQITQRIVYLEEGDVAELSSDGYRILNCLNTVNGCEVTREVI
ESSLTRDAVELGSYSHFMQKEIFEQPVAVANTLEMVLNVQSVSPQLFGSEAQTIFAQTRGILILACGTSYHAGLVAKYWL
ETIARLPCNVEIASEYRYRNPIADPATLVIGISQSGETADTLAALSYAKSLGHRYNLAICNVPESALIRQTNLRFLTRAG
PEIGVASTKAFTTQLAVLLLFTAVLAKIRNKLPTEDEQKMIAALRHLPVAIQRTLQSELEIKKWAGDFSQKHHALFLGRG
VHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDSGMPVVAIAPNDVLLEKLKSNLHEVRARGGELYVFADADSRI
EESEGVHIIRMDEYGGVLSPILHTIPLQLLAYHVALQKGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=37.1345029239766, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=36.0058309037901, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=55.7536466774716, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI87082251, Length=309, Percent_Identity=22.9773462783171, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=30.635838150289, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=39.0697674418605, Blast_Score=272, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=38.3720930232558, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=38.3720930232558, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=455, Percent_Identity=36.2637362637363, Blast_Score=266, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=31.1627906976744, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=35.609756097561, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323958, Length=172, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.4825581395349, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573187, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659598, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67119; Mature: 67119

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIAKNDVVPFLLEGLSRLEYRGYDSAGIVVADGTLHRLRTTGRVSELSKLVHAG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHCC
GTSGLTGIAHTRWATHGAPSERNAHPHFSGDQRKIAVVHNGIIENHETLRQRLEQEGFKF
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHHHHHHHHHHCCHH
LSDTDTEVIAHLISLYLRKTDDLLDAVCHSLEELQGAYAIAVMEEARQDRIVVARNGAPL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCEEEEECCCEE
LLGIDDGGLYAASDASALVQITQRIVYLEEGDVAELSSDGYRILNCLNTVNGCEVTREVI
EEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ESSLTRDAVELGSYSHFMQKEIFEQPVAVANTLEMVLNVQSVSPQLFGSEAQTIFAQTRG
HHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCC
ILILACGTSYHAGLVAKYWLETIARLPCNVEIASEYRYRNPIADPATLVIGISQSGETAD
EEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCEEEEEECCCCCHHH
TLAALSYAKSLGHRYNLAICNVPESALIRQTNLRFLTRAGPEIGVASTKAFTTQLAVLLL
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHHH
FTAVLAKIRNKLPTEDEQKMIAALRHLPVAIQRTLQSELEIKKWAGDFSQKHHALFLGRG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
VHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDSGMPVVAIAPNDVLLEKLKSNL
CCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHH
HEVRARGGELYVFADADSRIEESEGVHIIRMDEYGGVLSPILHTIPLQLLAYHVALQKGT
HHHHHCCCEEEEEECCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DVDKPRNLAKSVTVE
CCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAIAKNDVVPFLLEGLSRLEYRGYDSAGIVVADGTLHRLRTTGRVSELSKLVHAG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCHHHHHHHHHCC
GTSGLTGIAHTRWATHGAPSERNAHPHFSGDQRKIAVVHNGIIENHETLRQRLEQEGFKF
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHHHHHHHHHHCCHH
LSDTDTEVIAHLISLYLRKTDDLLDAVCHSLEELQGAYAIAVMEEARQDRIVVARNGAPL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHCCCCEEEEECCCEE
LLGIDDGGLYAASDASALVQITQRIVYLEEGDVAELSSDGYRILNCLNTVNGCEVTREVI
EEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHH
ESSLTRDAVELGSYSHFMQKEIFEQPVAVANTLEMVLNVQSVSPQLFGSEAQTIFAQTRG
HHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCC
ILILACGTSYHAGLVAKYWLETIARLPCNVEIASEYRYRNPIADPATLVIGISQSGETAD
EEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCEEEEEECCCCCHHH
TLAALSYAKSLGHRYNLAICNVPESALIRQTNLRFLTRAGPEIGVASTKAFTTQLAVLLL
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHHHHHH
FTAVLAKIRNKLPTEDEQKMIAALRHLPVAIQRTLQSELEIKKWAGDFSQKHHALFLGRG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
VHYPIALEGALKLKEISYIHAEAYAAGELKHGPLALVDSGMPVVAIAPNDVLLEKLKSNL
CCCCEEECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHH
HEVRARGGELYVFADADSRIEESEGVHIIRMDEYGGVLSPILHTIPLQLLAYHVALQKGT
HHHHHCCCEEEEEECCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DVDKPRNLAKSVTVE
CCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]