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The map label for this gene is glmU

Identifier: 114330306

GI number: 114330306

Start: 289359

End: 290735

Strand: Direct

Name: glmU

Synonym: Neut_0279

Alternate gene names: 114330306

Gene position: 289359-290735 (Clockwise)

Preceding gene: 114330305

Following gene: 114330307

Centisome position: 10.87

GC content: 45.39

Gene sequence:

>1377_bases
GTGTTACAAATTGATGTAGTCATACTGGCAGCTGGGATGGGTAAGAGGATGCGGTCAACTTTACCCAAGGTTTTGCATCC
TTTGGCCGGAAAACCTATTTTATTCCATGTTTTAGATACTGCGCGTATTCTGTCTCCTACAAAAATATGTGTGATTTACG
GGCATGGCGGAGAGCTGGTTCGGCAAACTGTTGGTAATGATCCTAATCTTATCTGGGTAAAACAGACACAGCAGCTGGGG
ACGGGGCATGCAGTAAAGCAAGCTCTGCCTTGCTTGGGGAAGAATGGTATTACGCTGGTTTTATTCGGTGATGTACCGTT
AGTAAAGAGTAATACACTCAAATCCCTGATTGATAAAGCGTGTGAAGATAGCCTGGCTTTGCTGACTGTAGAATTAAATG
ACCCTGCCGGTTATGGGCGTATCATACGCGACCCTAAAACAAATCGTGTCCAAGCAATTGTAGAAGAACAGGATGCCCTG
CCATCGCAGAAGAAAATTCGTGAAATTAACACAGGCATCATGGTTCTTCCGAATATGTATCTGGAGAGCTGGCTCGATAG
GCTAAGTAATGCCAATACTCAGGGCGAATACTACCTTACCGATATTATTGCGATGGCTGTTAATGATGGAGTCCAAATAG
AGACTTCCAGCCCCGCATCTGATTGGGAAGTGGTTGGTGTAAACGACAAGATTCAATTGTCTACCTTGGAGCGCGCCCAT
CAGCAGGATGTTGCAAAGGGGCTTATGGAGCAGGGAGTGATGTTTGCTGATCCTGCGCGCTTTGATGTGCGCGGCCAGCT
GATTTGCGGACATAATGTTGAAATCGACATCAACTGCGTATTTGAAGGTAATGTACGCTTGGGGGATAACGTGAAGATTA
GCGCAAACTGCATACTTAGAAACGTGGCCATCTCGGATGGATCGATTGTCCATCCTTTTAGCATGATAGAAGATACAGAG
GTAGGTAAAAATTGCCGTGTTGGCCCTTATGCTCGCATCCGACCGGGGACACAACTCGACGACGCTGTACATGTTGGAAA
TTTTGTCGAGATTAAAAATAGTCATATAGCTTCTGGGAGCAAGGTTAATCACCTCAGCTATATTGGTGATACTGAAATGG
GCAGACGGGTGAATATTGGTGCTGGTACGATTACTTGTAATTATGACGGAGCCTTTAAACACCAAACGATCATTGAAGAT
GACGTGTTTATTGGCTCTGATTCGCAGTTGATCGCTCCGATAACGGTGGCCAAGGGATCGACAATTGGCGCTGGATCCAC
TATTACGCGTGATACGCCTGAAGGTCAGCTAACATTATCCAGGATTAAACAAATAAGTATTGCCAACTGGAAGCGGCCGA
AAAAAAACAAGGATTGA

Upstream 100 bases:

>100_bases
TCACTGATAATTGTGCAAGAGTGATAGATAATTCTTGGTTTAGCAGATACACCTTTGACTGCATAACCATAAACAAAGCA
TTTCAAGTAAGGATTAACTC

Downstream 100 bases:

>100_bases
TGCTGTTTATACAAGGTAGAGCTGAGTAGAGGATAGGTTATGTGCGGTATTGTAGGTGCAATTGCGAAAAATGATGTTGT
ACCATTTTTATTGGAAGGAT

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELVRQTVGNDPNLIWVKQTQQLG
TGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKACEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDAL
PSQKKIREINTGIMVLPNMYLESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAH
QQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILRNVAISDGSIVHPFSMIEDTE
VGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGSKVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIED
DVFIGSDSQLIAPITVAKGSTIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD

Sequences:

>Translated_458_residues
MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELVRQTVGNDPNLIWVKQTQQLG
TGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKACEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDAL
PSQKKIREINTGIMVLPNMYLESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAH
QQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILRNVAISDGSIVHPFSMIEDTE
VGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGSKVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIED
DVFIGSDSQLIAPITVAKGSTIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD
>Mature_458_residues
MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELVRQTVGNDPNLIWVKQTQQLG
TGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKACEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDAL
PSQKKIREINTGIMVLPNMYLESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAH
QQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILRNVAISDGSIVHPFSMIEDTE
VGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGSKVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIED
DVFIGSDSQLIAPITVAKGSTIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=51.1013215859031, Blast_Score=481, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_NITEC (Q0AJA8)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746528.1
- ProteinModelPortal:   Q0AJA8
- SMR:   Q0AJA8
- STRING:   Q0AJA8
- GeneID:   4272122
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0279
- NMPDR:   fig|335283.3.peg.2234
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q0AJA8
- ProtClustDB:   CLSK643968
- BioCyc:   NEUT335283:NEUT_0279-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49899; Mature: 49899

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 364-364 BINDING 75-75 BINDING 139-139 BINDING 155-155 BINDING 170-170 BINDING 388-388 BINDING 406-406 BINDING 424-424 BINDING 441-441

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELV
CEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCEEEEEECCCHHHH
RQTVGNDPNLIWVKQTQQLGTGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKA
HHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHH
CEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDALPSQKKIREINTGIMVLPNMY
CCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHH
LESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAH
HHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCEEEHHHHHHH
QQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILR
HHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCEEEEEEEEECCEEECCCEEEEEEEEEE
NVAISDGSIVHPFSMIEDTEVGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGS
EEEECCCCEECCHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHCCCCEEEECCCCCCCCC
KVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIEDDVFIGSDSQLIAPITVAKGS
CCCEEEECCCCCCCCEEECCCEEEEECCCCCCCCCEEECCCEEECCCCCEEEEEEEECCC
TIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD
CCCCCCEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLQIDVVILAAGMGKRMRSTLPKVLHPLAGKPILFHVLDTARILSPTKICVIYGHGGELV
CEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCEEEEEECCCHHHH
RQTVGNDPNLIWVKQTQQLGTGHAVKQALPCLGKNGITLVLFGDVPLVKSNTLKSLIDKA
HHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHH
CEDSLALLTVELNDPAGYGRIIRDPKTNRVQAIVEEQDALPSQKKIREINTGIMVLPNMY
CCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHH
LESWLDRLSNANTQGEYYLTDIIAMAVNDGVQIETSSPASDWEVVGVNDKIQLSTLERAH
HHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCEEEHHHHHHH
QQDVAKGLMEQGVMFADPARFDVRGQLICGHNVEIDINCVFEGNVRLGDNVKISANCILR
HHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCEEEEEEEEECCEEECCCEEEEEEEEEE
NVAISDGSIVHPFSMIEDTEVGKNCRVGPYARIRPGTQLDDAVHVGNFVEIKNSHIASGS
EEEECCCCEECCHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHCCCCEEEECCCCCCCCC
KVNHLSYIGDTEMGRRVNIGAGTITCNYDGAFKHQTIIEDDVFIGSDSQLIAPITVAKGS
CCCEEEECCCCCCCCEEECCCEEEEECCCCCCCCCEEECCCEEECCCCCEEEEEEEECCC
TIGAGSTITRDTPEGQLTLSRIKQISIANWKRPKKNKD
CCCCCCEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA