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The map label for this gene is apt

Identifier: 114330289

GI number: 114330289

Start: 274490

End: 275014

Strand: Direct

Name: apt

Synonym: Neut_0262

Alternate gene names: 114330289

Gene position: 274490-275014 (Clockwise)

Preceding gene: 114330288

Following gene: 114330290

Centisome position: 10.32

GC content: 46.1

Gene sequence:

>525_bases
ATGTCTATCAAATCACGTATCCGTACTATCCCACACTACCCTCGCGAAGGGATTATGTTCCGGGATATCACCACTCTTCT
GAAAGATCCAGTCGGATTGCGTATAACTATTGATGAGATTGCCGAGCGTTATCGGGCTGAAAAAATCGACAAAGTTGTCG
GAATAGAATCTCGTGGTTTTATCTTTGCCGCACCGGTTGCTTATGCGCTGGGGGCCGGATTTGTTCCCATCCGCAAGCAA
GGTAAATTGCCGGCAGAAACCATCAGCTGTGATTACCAACTGGAATATGGTTACGATAAGATTGAAATCCATGCGGATGC
AATCGATAAAGACGACCGTGTGCTAATGATCGATGATCTAATTGCAACAGGTGGAACGATGGAAGCAGCGATCAAGCTGG
TTCAGGAGATGGGCGGAAAAATAATCGAATGCTGTTTTGTGATTGATTTACCTGGTGTCGGTGGAAGTACACGGCTGCGC
CAACAAGACCATCCACTGTATTCTCTGTGCAGTTTTGATGATTGA

Upstream 100 bases:

>100_bases
GCAACGCCTGAAACACAAACAGCCAAGTTAAAAGCCAACAAACTGCATCATCCTGTCAATCCTGGCTGCTGACTCCGATA
CTGCTATCACTCTTGTTAAT

Downstream 100 bases:

>100_bases
ATCTGCTGGCGGCATCCTCGTCTCTGGATTAAACACGTATACAGATATCTAATTTCTGTTCAAACAGAATCGTTGCAATG
CTAATATCCGCAGCAGATTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MSIKSRIRTIPHYPREGIMFRDITTLLKDPVGLRITIDEIAERYRAEKIDKVVGIESRGFIFAAPVAYALGAGFVPIRKQ
GKLPAETISCDYQLEYGYDKIEIHADAIDKDDRVLMIDDLIATGGTMEAAIKLVQEMGGKIIECCFVIDLPGVGGSTRLR
QQDHPLYSLCSFDD

Sequences:

>Translated_174_residues
MSIKSRIRTIPHYPREGIMFRDITTLLKDPVGLRITIDEIAERYRAEKIDKVVGIESRGFIFAAPVAYALGAGFVPIRKQ
GKLPAETISCDYQLEYGYDKIEIHADAIDKDDRVLMIDDLIATGGTMEAAIKLVQEMGGKIIECCFVIDLPGVGGSTRLR
QQDHPLYSLCSFDD
>Mature_173_residues
SIKSRIRTIPHYPREGIMFRDITTLLKDPVGLRITIDEIAERYRAEKIDKVVGIESRGFIFAAPVAYALGAGFVPIRKQG
KLPAETISCDYQLEYGYDKIEIHADAIDKDDRVLMIDDLIATGGTMEAAIKLVQEMGGKIIECCFVIDLPGVGGSTRLRQ
QDHPLYSLCSFDD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=40.2298850574713, Blast_Score=143, Evalue=8e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44.8, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=53.5294117647059, Blast_Score=194, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17509087, Length=174, Percent_Identity=43.6781609195402, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=38.728323699422, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=35.4651162790698, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17136334, Length=168, Percent_Identity=43.452380952381, Blast_Score=136, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NITEC (Q0AJC5)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746511.1
- ProteinModelPortal:   Q0AJC5
- SMR:   Q0AJC5
- STRING:   Q0AJC5
- GeneID:   4272001
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0262
- NMPDR:   fig|335283.3.peg.2135
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q0AJC5
- ProtClustDB:   PRK02304
- BioCyc:   NEUT335283:NEUT_0262-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19410; Mature: 19279

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKSRIRTIPHYPREGIMFRDITTLLKDPVGLRITIDEIAERYRAEKIDKVVGIESRGF
CCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCC
IFAAPVAYALGAGFVPIRKQGKLPAETISCDYQLEYGYDKIEIHADAIDKDDRVLMIDDL
EEECHHHHHHCCCCCEECCCCCCCHHHEEEEEEEECCCCEEEEEECCCCCCCCEEEEECH
IATGGTMEAAIKLVQEMGGKIIECCFVIDLPGVGGSTRLRQQDHPLYSLCSFDD
HHCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
SIKSRIRTIPHYPREGIMFRDITTLLKDPVGLRITIDEIAERYRAEKIDKVVGIESRGF
CHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCC
IFAAPVAYALGAGFVPIRKQGKLPAETISCDYQLEYGYDKIEIHADAIDKDDRVLMIDDL
EEECHHHHHHCCCCCEECCCCCCCHHHEEEEEEEECCCCEEEEEECCCCCCCCEEEEECH
IATGGTMEAAIKLVQEMGGKIIECCFVIDLPGVGGSTRLRQQDHPLYSLCSFDD
HHCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA