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The map label for this gene is serS

Identifier: 114330290

GI number: 114330290

Start: 275209

End: 276522

Strand: Direct

Name: serS

Synonym: Neut_0263

Alternate gene names: 114330290

Gene position: 275209-276522 (Clockwise)

Preceding gene: 114330289

Following gene: 114330291

Centisome position: 10.34

GC content: 46.73

Gene sequence:

>1314_bases
ATGTTAGATATCCAGCAATTACGTAGCGACCTACAAAATATTACTACTTGTCTAGCCCAAAGAGGTTACAACTTTCCTGT
GTCCGATTTTGAGAATCTGGAAAGCCAACGTAAATCCATACAAACCCTGACTCAAACATTACAGGCAAAACGTAATTCAG
CTTCTAAGCAAATTGGTATCGCCAAACAGCAGGGAGAAGATGTCAGTACGATCATGGCTGAAATAGCGAATATGGGAGAT
GCGTTAAAGCAGGCGGAAAATCAGTTCGAATCTATTCAAACCAAACTACAGCAATTGTTGATGGAAATTCCCAATCTGCC
TCATAACAGCGTTCCGACAGGCAAGAATGCAGATGGCAATCTTGAAATAAGGCGCTGGGGAACGCCCAAGAATTTTGATT
TTACAGTCAAGGATCATGTCAGCATCGGTGAGCATCTTGGGTTGATTGATTTTGAAACCGCGGCAAAGCTGAGCGGGGCA
CGCTTCTGCCTGCTGAAAGGCGGGGTGGCGCGGCTGCATCGCGCGCTGGCGCAATTTATGCTCGATGCCCATACGCAAGA
AAATGGCTACAACGAGGTCTATGTGCCTTATCTAGTTAATGCGGACTGTTTGCGCGGAACTGGACAGCTACCCAAATTCG
AACAAGATCTCTTTTCTGTACTGACCAACGCACAGGATGAAACAGATAATGTAGATAAAACAGGCATGGTTGGCCTGCAC
CTCATTCCTACTGCCGAAGTCCCTCTTGCCAATATCGTTCGCAATACGATTGTTCCTCTTGAGCAGCTTCCGCTTAAGTT
TGTCGCTCATACTCCGTGTTTCCGTTCCGAGGCGGGAAGTTACGGTAAGGATACACGCGGATTAATCCGTCAGCATCAAT
TTGATAAGGTCGAACTGGTACAAATCACCCATCCGGAAAAATCTTACGAAGCATTGGAATCGCTGGTAGGTCATGCCGAG
AAAATTCTCCAAAAGCTGGAGCTGCCTTATAGGATCATGTTGTTGTGTACAGGAGATATGGGATTCTCTGCCGCCAAGAC
TTACGACATTGAAGTATGGCTACCCGCACAACAAACCTACCGGGAGATATCATCGTGTAGTAATTGTGAAGCGTTCCAGG
CGCGACGCATGCAAGCACGCTTCCGTAAGGGGCAAGATAAACCGGAACTGCTGCATACACTTAATGGCTCTGGACTAGCA
GTAGGACGAACGCTGGTGGCCATCTTGGAAAATTATCAGAATGAAGATGGCAGTGTTACTATCCCGGAAATTTTGCAGAC
TTATATGGGCGGCATCAAGCGGATCAGCCTATAA

Upstream 100 bases:

>100_bases
AGATTAGCCGCAATCCTGCCGGTTAAGATGCCGGAGCAACTTTCCGCAATAACAAATTTTATATCGACCCAGCCTACTGG
CTGCCGTGGAGTCCGTTCAC

Downstream 100 bases:

>100_bases
TGTATGCATGTTCGTCTGTATTAACTACTAGAAATGGAGGATTCTGATGCAAAATGACAATCATGATGCCACCCATACTG
ATAAGGATGTTACCCAACTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLDIQQLRSDLQNITTCLAQRGYNFPVSDFENLESQRKSIQTLTQTLQAKRNSASKQIGIAKQQGEDVSTIMAEIANMGD
ALKQAENQFESIQTKLQQLLMEIPNLPHNSVPTGKNADGNLEIRRWGTPKNFDFTVKDHVSIGEHLGLIDFETAAKLSGA
RFCLLKGGVARLHRALAQFMLDAHTQENGYNEVYVPYLVNADCLRGTGQLPKFEQDLFSVLTNAQDETDNVDKTGMVGLH
LIPTAEVPLANIVRNTIVPLEQLPLKFVAHTPCFRSEAGSYGKDTRGLIRQHQFDKVELVQITHPEKSYEALESLVGHAE
KILQKLELPYRIMLLCTGDMGFSAAKTYDIEVWLPAQQTYREISSCSNCEAFQARRMQARFRKGQDKPELLHTLNGSGLA
VGRTLVAILENYQNEDGSVTIPEILQTYMGGIKRISL

Sequences:

>Translated_437_residues
MLDIQQLRSDLQNITTCLAQRGYNFPVSDFENLESQRKSIQTLTQTLQAKRNSASKQIGIAKQQGEDVSTIMAEIANMGD
ALKQAENQFESIQTKLQQLLMEIPNLPHNSVPTGKNADGNLEIRRWGTPKNFDFTVKDHVSIGEHLGLIDFETAAKLSGA
RFCLLKGGVARLHRALAQFMLDAHTQENGYNEVYVPYLVNADCLRGTGQLPKFEQDLFSVLTNAQDETDNVDKTGMVGLH
LIPTAEVPLANIVRNTIVPLEQLPLKFVAHTPCFRSEAGSYGKDTRGLIRQHQFDKVELVQITHPEKSYEALESLVGHAE
KILQKLELPYRIMLLCTGDMGFSAAKTYDIEVWLPAQQTYREISSCSNCEAFQARRMQARFRKGQDKPELLHTLNGSGLA
VGRTLVAILENYQNEDGSVTIPEILQTYMGGIKRISL
>Mature_437_residues
MLDIQQLRSDLQNITTCLAQRGYNFPVSDFENLESQRKSIQTLTQTLQAKRNSASKQIGIAKQQGEDVSTIMAEIANMGD
ALKQAENQFESIQTKLQQLLMEIPNLPHNSVPTGKNADGNLEIRRWGTPKNFDFTVKDHVSIGEHLGLIDFETAAKLSGA
RFCLLKGGVARLHRALAQFMLDAHTQENGYNEVYVPYLVNADCLRGTGQLPKFEQDLFSVLTNAQDETDNVDKTGMVGLH
LIPTAEVPLANIVRNTIVPLEQLPLKFVAHTPCFRSEAGSYGKDTRGLIRQHQFDKVELVQITHPEKSYEALESLVGHAE
KILQKLELPYRIMLLCTGDMGFSAAKTYDIEVWLPAQQTYREISSCSNCEAFQARRMQARFRKGQDKPELLHTLNGSGLA
VGRTLVAILENYQNEDGSVTIPEILQTYMGGIKRISL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=339, Percent_Identity=36.283185840708, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI8923421, Length=404, Percent_Identity=31.4356435643564, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=32.7327327327327, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=56.1926605504587, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539260, Length=338, Percent_Identity=32.5443786982249, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=345, Percent_Identity=27.536231884058, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=421, Percent_Identity=31.1163895486936, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=411, Percent_Identity=31.1435523114355, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24581334, Length=358, Percent_Identity=33.2402234636872, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17737985, Length=343, Percent_Identity=31.7784256559767, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_NITEC (Q0AJC4)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746512.1
- ProteinModelPortal:   Q0AJC4
- SMR:   Q0AJC4
- STRING:   Q0AJC4
- GeneID:   4272002
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0263
- NMPDR:   fig|335283.3.peg.2136
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q0AJC4
- ProtClustDB:   PRK05431
- BioCyc:   NEUT335283:NEUT_0263-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48847; Mature: 48847

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 298-298 BINDING 397-397

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQQLRSDLQNITTCLAQRGYNFPVSDFENLESQRKSIQTLTQTLQAKRNSASKQIGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKQQGEDVSTIMAEIANMGDALKQAENQFESIQTKLQQLLMEIPNLPHNSVPTGKNADGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LEIRRWGTPKNFDFTVKDHVSIGEHLGLIDFETAAKLSGARFCLLKGGVARLHRALAQFM
EEEEECCCCCCCCEEECCCCCHHHHCCCEEHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
LDAHTQENGYNEVYVPYLVNADCLRGTGQLPKFEQDLFSVLTNAQDETDNVDKTGMVGLH
HHHHHCCCCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
LIPTAEVPLANIVRNTIVPLEQLPLKFVAHTPCFRSEAGSYGKDTRGLIRQHQFDKVELV
ECCCCCCCHHHHHHHHCCCHHHCCHHHHHCCCCHHHCCCCCCCHHHHHHHHCCCCCEEEE
QITHPEKSYEALESLVGHAEKILQKLELPYRIMLLCTGDMGFSAAKTYDIEVWLPAQQTY
EEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECHHHHH
REISSCSNCEAFQARRMQARFRKGQDKPELLHTLNGSGLAVGRTLVAILENYQNEDGSVT
HHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEE
IPEILQTYMGGIKRISL
HHHHHHHHHCHHHCCCC
>Mature Secondary Structure
MLDIQQLRSDLQNITTCLAQRGYNFPVSDFENLESQRKSIQTLTQTLQAKRNSASKQIGI
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKQQGEDVSTIMAEIANMGDALKQAENQFESIQTKLQQLLMEIPNLPHNSVPTGKNADGN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LEIRRWGTPKNFDFTVKDHVSIGEHLGLIDFETAAKLSGARFCLLKGGVARLHRALAQFM
EEEEECCCCCCCCEEECCCCCHHHHCCCEEHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
LDAHTQENGYNEVYVPYLVNADCLRGTGQLPKFEQDLFSVLTNAQDETDNVDKTGMVGLH
HHHHHCCCCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
LIPTAEVPLANIVRNTIVPLEQLPLKFVAHTPCFRSEAGSYGKDTRGLIRQHQFDKVELV
ECCCCCCCHHHHHHHHCCCHHHCCHHHHHCCCCHHHCCCCCCCHHHHHHHHCCCCCEEEE
QITHPEKSYEALESLVGHAEKILQKLELPYRIMLLCTGDMGFSAAKTYDIEVWLPAQQTY
EEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECHHHHH
REISSCSNCEAFQARRMQARFRKGQDKPELLHTLNGSGLAVGRTLVAILENYQNEDGSVT
HHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEE
IPEILQTYMGGIKRISL
HHHHHHHHHCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA