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The map label for this gene is mraY

Identifier: 114330276

GI number: 114330276

Start: 262735

End: 263820

Strand: Reverse

Name: mraY

Synonym: Neut_0249

Alternate gene names: 114330276

Gene position: 263820-262735 (Counterclockwise)

Preceding gene: 114330277

Following gene: 114330275

Centisome position: 9.91

GC content: 49.63

Gene sequence:

>1086_bases
ATGTTATTGGCGCTTTTTCAATGGATTGCGGAAGATATCCGAGCTTTCAATGTATTCAGTTACATCACGCTACGTACCAT
GCTGGCAGCGCTGACTGCATTGAGCATCTCCTTTTTGATCGGTCCGGCCATGATACGCAGCCTGACTACGCGTAAAGTTG
GCCAGTCCGTGCGTAGTGATGGTCCCCAATCTCACCTGACAAAGGCGGGCACTCCGACCATGGGTGGCGCACTAATTCTG
ATGGCAGTTATCATTACGACACTGCTGTGGGCAGATTTGAGTAATCGTTATATCTGGCTCGTACTACTGACAACCTTGGG
TTTTGGTGCAATTGGCTGGGTGGATGATTATCGCAAGGTCGTACAGCATAATTCCAAAGGACTTCCGGCTTCAGCCAAGT
TTTTTTGGCAATCAATCATTGCGTTGCTGGTCGCAGTATATCTTGCCATGACGGCTGAACTTCCTCAGCACACTGATATG
ATCGTACCGTTTTTCAAGGAAGTCGCCATCCCATTGGGATCATTTCTGTTCATCATTTTGACCTATCTGGTTATCGTTGG
CAGCAGTAATGCAGTCAACCTGACGGACGGATTGGATGGCCTGGCTATTATGCCCACGGTCATGATCAGTGGCGCGCTGG
CCATCTTTGCCTATGTTGCCGGCCACGCCATATTTGCCAAATATCTTGGTATTCCACATATTCCCAGCGCAGGTGAACTG
GCTGTTTTCTGTGGTGCGCTGGCTGGCGCCGGTCTGGCATTTTTATGGTTTAACGCCAATCCGGCGGAAGTGTTTATGGG
CGATGTTGGTGCCCTGGCGCTAGGAGCAGCATTGGGAGTGATAACGGTCATTGTTCGCCAGGAAATAGTACTGGTCATCA
TGGGAGGGGTATTCGTCATGGAGGCATTATCGGTCATGATCCAGGTCGCCTCCTTCAAGTTATTCGGCCGGCGTGTTTTC
CGCATGGCACCGTTGCATCATCATTACGAGCTCAAGGGATGGAAGGAAAACCAGGTTGTAGTGAGATTCTGGATTATTAC
CATCATTCTGGTGCTGATCGGCTTATCAACACTGAAACTACGATGA

Upstream 100 bases:

>100_bases
AGCAACTGCAGGATAGATATGTTGAGTAGGAACAAGGTAGATCCTCTGATTAAAACTGTTTTTTGTGTCTGCGACCGGAC
ATTGCAACGGGAACCGTAAA

Downstream 100 bases:

>100_bases
ATTACGCCGACAAAAAAATATTGGTTCTGGGTATGGGTAAAACCGGCATCTCCATGGTCAAGTGGCTTTCCCGTGCCGGA
GCTCGGGTGTCCGTAGCCGA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLLALFQWIAEDIRAFNVFSYITLRTMLAALTALSISFLIGPAMIRSLTTRKVGQSVRSDGPQSHLTKAGTPTMGGALIL
MAVIITTLLWADLSNRYIWLVLLTTLGFGAIGWVDDYRKVVQHNSKGLPASAKFFWQSIIALLVAVYLAMTAELPQHTDM
IVPFFKEVAIPLGSFLFIILTYLVIVGSSNAVNLTDGLDGLAIMPTVMISGALAIFAYVAGHAIFAKYLGIPHIPSAGEL
AVFCGALAGAGLAFLWFNANPAEVFMGDVGALALGAALGVITVIVRQEIVLVIMGGVFVMEALSVMIQVASFKLFGRRVF
RMAPLHHHYELKGWKENQVVVRFWIITIILVLIGLSTLKLR

Sequences:

>Translated_361_residues
MLLALFQWIAEDIRAFNVFSYITLRTMLAALTALSISFLIGPAMIRSLTTRKVGQSVRSDGPQSHLTKAGTPTMGGALIL
MAVIITTLLWADLSNRYIWLVLLTTLGFGAIGWVDDYRKVVQHNSKGLPASAKFFWQSIIALLVAVYLAMTAELPQHTDM
IVPFFKEVAIPLGSFLFIILTYLVIVGSSNAVNLTDGLDGLAIMPTVMISGALAIFAYVAGHAIFAKYLGIPHIPSAGEL
AVFCGALAGAGLAFLWFNANPAEVFMGDVGALALGAALGVITVIVRQEIVLVIMGGVFVMEALSVMIQVASFKLFGRRVF
RMAPLHHHYELKGWKENQVVVRFWIITIILVLIGLSTLKLR
>Mature_361_residues
MLLALFQWIAEDIRAFNVFSYITLRTMLAALTALSISFLIGPAMIRSLTTRKVGQSVRSDGPQSHLTKAGTPTMGGALIL
MAVIITTLLWADLSNRYIWLVLLTTLGFGAIGWVDDYRKVVQHNSKGLPASAKFFWQSIIALLVAVYLAMTAELPQHTDM
IVPFFKEVAIPLGSFLFIILTYLVIVGSSNAVNLTDGLDGLAIMPTVMISGALAIFAYVAGHAIFAKYLGIPHIPSAGEL
AVFCGALAGAGLAFLWFNANPAEVFMGDVGALALGAALGVITVIVRQEIVLVIMGGVFVMEALSVMIQVASFKLFGRRVF
RMAPLHHHYELKGWKENQVVVRFWIITIILVLIGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=358, Percent_Identity=59.4972067039106, Blast_Score=415, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_NITEC (Q0AJD8)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746498.1
- STRING:   Q0AJD8
- GeneID:   4271988
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0249
- NMPDR:   fig|335283.3.peg.2122
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q0AJD8
- ProtClustDB:   PRK00108
- BioCyc:   NEUT335283:NEUT_0249-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 39208; Mature: 39208

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12f99dac)-; HASH(0x12df089c)-; HASH(0x10c54350)-; HASH(0x10c540e0)-; HASH(0x10c54278)-; HASH(0x10c54368)-; HASH(0x9577134)-; HASH(0x1277a9e4)-; HASH(0x10704d2c)-; HASH(0x130fdb54)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLALFQWIAEDIRAFNVFSYITLRTMLAALTALSISFLIGPAMIRSLTTRKVGQSVRSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPQSHLTKAGTPTMGGALILMAVIITTLLWADLSNRYIWLVLLTTLGFGAIGWVDDYRKV
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VQHNSKGLPASAKFFWQSIIALLVAVYLAMTAELPQHTDMIVPFFKEVAIPLGSFLFIIL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TYLVIVGSSNAVNLTDGLDGLAIMPTVMISGALAIFAYVAGHAIFAKYLGIPHIPSAGEL
HHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AVFCGALAGAGLAFLWFNANPAEVFMGDVGALALGAALGVITVIVRQEIVLVIMGGVFVM
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALSVMIQVASFKLFGRRVFRMAPLHHHYELKGWKENQVVVRFWIITIILVLIGLSTLKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCC
R
H
>Mature Secondary Structure
MLLALFQWIAEDIRAFNVFSYITLRTMLAALTALSISFLIGPAMIRSLTTRKVGQSVRSD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPQSHLTKAGTPTMGGALILMAVIITTLLWADLSNRYIWLVLLTTLGFGAIGWVDDYRKV
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VQHNSKGLPASAKFFWQSIIALLVAVYLAMTAELPQHTDMIVPFFKEVAIPLGSFLFIIL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TYLVIVGSSNAVNLTDGLDGLAIMPTVMISGALAIFAYVAGHAIFAKYLGIPHIPSAGEL
HHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AVFCGALAGAGLAFLWFNANPAEVFMGDVGALALGAALGVITVIVRQEIVLVIMGGVFVM
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALSVMIQVASFKLFGRRVFRMAPLHHHYELKGWKENQVVVRFWIITIILVLIGLSTLKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCC
R
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA