Click here to switch to the map view.

The map label for this gene is dapL [H]

Identifier: 114330255

GI number: 114330255

Start: 242034

End: 243239

Strand: Direct

Name: dapL [H]

Synonym: Neut_0228

Alternate gene names: 114330255

Gene position: 242034-243239 (Clockwise)

Preceding gene: 114330253

Following gene: 114330256

Centisome position: 9.1

GC content: 48.84

Gene sequence:

>1206_bases
ATGAACCCTTTACTGGAAAGCCTTCAGTTATACCCGTTTCAAAAACTTACCAGACTATTTGAGAATCTCGTGCTGAGTGA
TGCCTCTCTGACCCCCATTGGTTTGCATATTGGAGAACCAAGACACGATACGCCCGAGTTTATCAGACAAGAGTTAGTGA
ATAATCTTGAAGGGCTGGCACATTATCCCACAGTACTTGGAACCAGCCAGCTGCGGATCAGCATTGCGAGCTGGCTAACA
CAGCGCTATCGCTTGGCTGCTATCAATCCAGATACCGAAGTTATCCCGGTCAATGGCAGTCGGGAAGCATTATTTTCATT
TGCCCAGGCGGTTATTGATGCCGATGCGCGCGAGGTTATGCAACCTGTAGTGGTTTGCCAAAATCCTTTTTATCAAATCT
ACGAAGGTGCTGCATTGCTGGCTGGTGCCGAACCCTATTTTTTGAATCAGCTTCCAGAAAATGGTTTTTCAGTGGATGCC
GCTCAGTTGCCTGATTCGGTGTGGAAACGTACTCAGCTGACTTATATCTGTTCACCCAATAATCCGACTGGTAAGGTGCT
AACACTAGATGAATGGCAACTTCTGTTTAATTTGTCTGATCGTTATGGATTTGTAATTGCAGCGGATGAATGCTATTCAG
AAATCTATTTCAATGAGGATCACCCTCCTCTGGGGGCGTTGGAGGCGGCAGAGAAGTTAGGCCGCAATGGTTTTCCCCGG
CTGGTTGTGTTCAGCAGTCTTTCCAAGCGCTCCAATGTGCCGGGCATGCGTTCTGGTTTTGTGGCAGGGGATGCTGCCAT
TCTCAAAAAGTTTTTGCTTTACCGGACGTATCATGGCAGTGCCATGAATCCGGCTGTGCAGGCAGCCAGCACTGTTGCAT
GGGGTGATGAGCAGCACGTGGTTGAAAACCGGCGACTGTATCGTGAAAAATTTGCCGGTGCCATGCGTATACTGAGCGAT
ACCTTGCCTGTTAGCATGCCGGATGCCGGGTTTTATTTATGGTTAAAGGTGCCTGTCAGTGGTATCGAATTTTCCGGGCG
TTTATATCGGGAAGGAAGTGTTACTGTACTGCCTGGCAGTTATCTGGCACGAGAGGCACACGGCCTTAACCCTGGTGAGC
ATTTTGTACGGATTGCGCTGGTTGCGCCGGTGGCAGAGTGCATGGAGGCAATGGAGCGAATCAAGGATATCGCTAGAAAG
TTCTGA

Upstream 100 bases:

>100_bases
GGTCAACGTTGCCAGTGCCCTTTATAATTGGTGCTTAACATTTTTACTGCCTCCCTAACCTGCTCCACAAGCACCACATT
TGTGGATAATCCTGAAAAGT

Downstream 100 bases:

>100_bases
TCTGATTATTTTTTAGTTAGGAGTCACATGGAGCAATTACAAGCTGTCATCGAAGATGCTTTTGAAAGGCGTGCTGAAAT
TACCCCTCGTAATGTTGAGG

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNPLLESLQLYPFQKLTRLFENLVLSDASLTPIGLHIGEPRHDTPEFIRQELVNNLEGLAHYPTVLGTSQLRISIASWLT
QRYRLAAINPDTEVIPVNGSREALFSFAQAVIDADAREVMQPVVVCQNPFYQIYEGAALLAGAEPYFLNQLPENGFSVDA
AQLPDSVWKRTQLTYICSPNNPTGKVLTLDEWQLLFNLSDRYGFVIAADECYSEIYFNEDHPPLGALEAAEKLGRNGFPR
LVVFSSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASTVAWGDEQHVVENRRLYREKFAGAMRILSD
TLPVSMPDAGFYLWLKVPVSGIEFSGRLYREGSVTVLPGSYLAREAHGLNPGEHFVRIALVAPVAECMEAMERIKDIARK
F

Sequences:

>Translated_401_residues
MNPLLESLQLYPFQKLTRLFENLVLSDASLTPIGLHIGEPRHDTPEFIRQELVNNLEGLAHYPTVLGTSQLRISIASWLT
QRYRLAAINPDTEVIPVNGSREALFSFAQAVIDADAREVMQPVVVCQNPFYQIYEGAALLAGAEPYFLNQLPENGFSVDA
AQLPDSVWKRTQLTYICSPNNPTGKVLTLDEWQLLFNLSDRYGFVIAADECYSEIYFNEDHPPLGALEAAEKLGRNGFPR
LVVFSSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASTVAWGDEQHVVENRRLYREKFAGAMRILSD
TLPVSMPDAGFYLWLKVPVSGIEFSGRLYREGSVTVLPGSYLAREAHGLNPGEHFVRIALVAPVAECMEAMERIKDIARK
F
>Mature_401_residues
MNPLLESLQLYPFQKLTRLFENLVLSDASLTPIGLHIGEPRHDTPEFIRQELVNNLEGLAHYPTVLGTSQLRISIASWLT
QRYRLAAINPDTEVIPVNGSREALFSFAQAVIDADAREVMQPVVVCQNPFYQIYEGAALLAGAEPYFLNQLPENGFSVDA
AQLPDSVWKRTQLTYICSPNNPTGKVLTLDEWQLLFNLSDRYGFVIAADECYSEIYFNEDHPPLGALEAAEKLGRNGFPR
LVVFSSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASTVAWGDEQHVVENRRLYREKFAGAMRILSD
TLPVSMPDAGFYLWLKVPVSGIEFSGRLYREGSVTVLPGSYLAREAHGLNPGEHFVRIALVAPVAECMEAMERIKDIARK
F

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=315, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI169881279, Length=315, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI56713256, Length=324, Percent_Identity=21.6049382716049, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI56713254, Length=324, Percent_Identity=21.6049382716049, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI169881281, Length=243, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=25.7294429708223, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786816, Length=414, Percent_Identity=23.1884057971014, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790797, Length=390, Percent_Identity=24.1025641025641, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44701; Mature: 44701

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLESLQLYPFQKLTRLFENLVLSDASLTPIGLHIGEPRHDTPEFIRQELVNNLEGLA
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HYPTVLGTSQLRISIASWLTQRYRLAAINPDTEVIPVNGSREALFSFAQAVIDADAREVM
HCCHHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCHHHHH
QPVVVCQNPFYQIYEGAALLAGAEPYFLNQLPENGFSVDAAQLPDSVWKRTQLTYICSPN
HHHHHHCCCHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHCCHHHHHCEEEEEEECCC
NPTGKVLTLDEWQLLFNLSDRYGFVIAADECYSEIYFNEDHPPLGALEAAEKLGRNGFPR
CCCCEEEEECCEEEEEEECCCCEEEEECHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCC
LVVFSSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASTVAWGDEQHV
EEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
VENRRLYREKFAGAMRILSDTLPVSMPDAGFYLWLKVPVSGIEFSGRLYREGSVTVLPGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEECCEEEECCCEEEECCH
YLAREAHGLNPGEHFVRIALVAPVAECMEAMERIKDIARKF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPLLESLQLYPFQKLTRLFENLVLSDASLTPIGLHIGEPRHDTPEFIRQELVNNLEGLA
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HYPTVLGTSQLRISIASWLTQRYRLAAINPDTEVIPVNGSREALFSFAQAVIDADAREVM
HCCHHHCCHHHHHHHHHHHHHHEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCHHHHH
QPVVVCQNPFYQIYEGAALLAGAEPYFLNQLPENGFSVDAAQLPDSVWKRTQLTYICSPN
HHHHHHCCCHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHCCHHHHHCEEEEEEECCC
NPTGKVLTLDEWQLLFNLSDRYGFVIAADECYSEIYFNEDHPPLGALEAAEKLGRNGFPR
CCCCEEEEECCEEEEEEECCCCEEEEECHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCC
LVVFSSLSKRSNVPGMRSGFVAGDAAILKKFLLYRTYHGSAMNPAVQAASTVAWGDEQHV
EEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
VENRRLYREKFAGAMRILSDTLPVSMPDAGFYLWLKVPVSGIEFSGRLYREGSVTVLPGS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEECCEEEECCCEEEECCH
YLAREAHGLNPGEHFVRIALVAPVAECMEAMERIKDIARKF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]