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The map label for this gene is vipA [H]

Identifier: 114330253

GI number: 114330253

Start: 239762

End: 241036

Strand: Direct

Name: vipA [H]

Synonym: Neut_0226

Alternate gene names: 114330253

Gene position: 239762-241036 (Clockwise)

Preceding gene: 114330252

Following gene: 114330255

Centisome position: 9.01

GC content: 46.43

Gene sequence:

>1275_bases
ATGCAACTCCAGGATATCAAACTTGCCATTATCGGGCTTGGATATGTCGGCCTTCCACTGGCTGCTGAGTTTGGCCGCAA
GCGTCCTGTGACCGGGTTCGATATTAACCAGCAGCGTATTGATGAGCTTAAAAATGGCAATGACTTTACGCTGGAAGTCA
CGCAGGAAGAACTTGCAGCGGCAAAGCATTTGACTTTTACCACCAATATAGACGATTTACGCACCTGTAATTGCTACATT
ATTACCGTTCCCACACCAATTGATGATCACAAGCGCCCTGATCTTATGCCACTTATCAAAGCCAGCGAGACTGTCGGTAA
GGTATTGAGAAAAGGAGATATTGTTATTTATGAATCTACTGTCTACCCTGGTTGTACCGAAGAAGATTGTGTGCCTGTGC
TGGAGCGTGTTTCTGGCCTGAAATTTAACCGGGATTTCTACTGTGGCTACAGTCCAGAGCGCATCAACCCAGGTGACAAG
GAACATCGTGTCACGACTATCAAAAAGGTTACCTCGGGCTCCACTCCGGAAATCGCTGATCTGGTAGATAGCTTATACAA
CGAAATTATTACTGTAGGCACACACAAAGCGGAAAGTATCAAGGTGGCTGAAGCTGCCAAGGTGATCGAAAACACCCAGC
GTGATCTGAATATTGCTCTTATCAACGAGCTGGCGTTGATTTTCAACAAAATGAATATTGATACTGAAGCCGTACTCAAA
GCAGCGGGCAGTAAGTGGAATTTTCTGCCGTTTCGTCCCGGTCTGGTGGGTGGACATTGTATTGGGGTGGATCCGTATTA
CCTGACACATAAAGCGCAGGCAATTGGCTATCATCCGGAAATTATTCTTGCTGGACGGCGACTAAATGACAGCATGGGAG
CCTATGTTGTTGCTCAGCTGGTTAAAGCCATGACCAAAAAACGTCTTCAGGTAGATGGCGCCAAGGTATTGGTCATGGGA
CTTACCTTCAAGGAAAACTGTCCGGATCTGCGTAATACCCGAGTGGTGGATATCGTGACCGAACTCAAGGATTACAACTG
CGTAGTGGATGTATACGATCCATGGTTGTCTTCTGAAGAGGCACAACACGAATACAGTATCAAGCTGATTGAAGCACCCG
AATCCGGTAATTATGATGCTATTATCCTGGCTGTGGCACATCGGCAGTTCAAGGATATGGGGGCTTCCTCTATCCGTGCA
CTGGGGAAACCCAATGCTGTTCTATATGATTTGAAGTATGTGCTTAATCCACAGGAATCAGATCTGAGGCTGTAA

Upstream 100 bases:

>100_bases
TCGTCGAACAATTCGATTACAGGCCCGCCACGTCGGTCGAACAGGGAATAGCCAGCTTTGTGACGTGGTATCGCAATTAC
TTCAATTTGTAGGAGACAAC

Downstream 100 bases:

>100_bases
ATAAGATTACTTTCGCAGATCCTGGTTCTGATTGATCCGGGCAGAAAACAGGCTGGCAGATGCAATCACGAGTCCTCCCG
CCCAGTCTCTACTTGTCAGA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MQLQDIKLAIIGLGYVGLPLAAEFGRKRPVTGFDINQQRIDELKNGNDFTLEVTQEELAAAKHLTFTTNIDDLRTCNCYI
ITVPTPIDDHKRPDLMPLIKASETVGKVLRKGDIVIYESTVYPGCTEEDCVPVLERVSGLKFNRDFYCGYSPERINPGDK
EHRVTTIKKVTSGSTPEIADLVDSLYNEIITVGTHKAESIKVAEAAKVIENTQRDLNIALINELALIFNKMNIDTEAVLK
AAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDSMGAYVVAQLVKAMTKKRLQVDGAKVLVMG
LTFKENCPDLRNTRVVDIVTELKDYNCVVDVYDPWLSSEEAQHEYSIKLIEAPESGNYDAIILAVAHRQFKDMGASSIRA
LGKPNAVLYDLKYVLNPQESDLRL

Sequences:

>Translated_424_residues
MQLQDIKLAIIGLGYVGLPLAAEFGRKRPVTGFDINQQRIDELKNGNDFTLEVTQEELAAAKHLTFTTNIDDLRTCNCYI
ITVPTPIDDHKRPDLMPLIKASETVGKVLRKGDIVIYESTVYPGCTEEDCVPVLERVSGLKFNRDFYCGYSPERINPGDK
EHRVTTIKKVTSGSTPEIADLVDSLYNEIITVGTHKAESIKVAEAAKVIENTQRDLNIALINELALIFNKMNIDTEAVLK
AAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDSMGAYVVAQLVKAMTKKRLQVDGAKVLVMG
LTFKENCPDLRNTRVVDIVTELKDYNCVVDVYDPWLSSEEAQHEYSIKLIEAPESGNYDAIILAVAHRQFKDMGASSIRA
LGKPNAVLYDLKYVLNPQESDLRL
>Mature_424_residues
MQLQDIKLAIIGLGYVGLPLAAEFGRKRPVTGFDINQQRIDELKNGNDFTLEVTQEELAAAKHLTFTTNIDDLRTCNCYI
ITVPTPIDDHKRPDLMPLIKASETVGKVLRKGDIVIYESTVYPGCTEEDCVPVLERVSGLKFNRDFYCGYSPERINPGDK
EHRVTTIKKVTSGSTPEIADLVDSLYNEIITVGTHKAESIKVAEAAKVIENTQRDLNIALINELALIFNKMNIDTEAVLK
AAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDSMGAYVVAQLVKAMTKKRLQVDGAKVLVMG
LTFKENCPDLRNTRVVDIVTELKDYNCVVDVYDPWLSSEEAQHEYSIKLIEAPESGNYDAIILAVAHRQFKDMGASSIRA
LGKPNAVLYDLKYVLNPQESDLRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=29.9019607843137, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=388, Percent_Identity=25.5154639175258, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47211; Mature: 47211

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQDIKLAIIGLGYVGLPLAAEFGRKRPVTGFDINQQRIDELKNGNDFTLEVTQEELAA
CCCCCEEEEEEECCHHCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHHH
AKHLTFTTNIDDLRTCNCYIITVPTPIDDHKRPDLMPLIKASETVGKVLRKGDIVIYEST
HHEEEEECCCCCCEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
VYPGCTEEDCVPVLERVSGLKFNRDFYCGYSPERINPGDKEHRVTTIKKVTSGSTPEIAD
CCCCCCCHHHHHHHHHHHCCEECCEEECCCCCCCCCCCCCHHHEEEEEHHCCCCCCHHHH
LVDSLYNEIITVGTHKAESIKVAEAAKVIENTQRDLNIALINELALIFNKMNIDTEAVLK
HHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
AAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDSMGAYVVAQL
HCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCCCCHHHHHHHHH
VKAMTKKRLQVDGAKVLVMGLTFKENCPDLRNTRVVDIVTELKDYNCVVDVYDPWLSSEE
HHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEEHHHCCCCEEEEECCCCCCCCC
AQHEYSIKLIEAPESGNYDAIILAVAHRQFKDMGASSIRALGKPNAVLYDLKYVLNPQES
CCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCC
DLRL
CCCC
>Mature Secondary Structure
MQLQDIKLAIIGLGYVGLPLAAEFGRKRPVTGFDINQQRIDELKNGNDFTLEVTQEELAA
CCCCCEEEEEEECCHHCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHHH
AKHLTFTTNIDDLRTCNCYIITVPTPIDDHKRPDLMPLIKASETVGKVLRKGDIVIYEST
HHEEEEECCCCCCEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
VYPGCTEEDCVPVLERVSGLKFNRDFYCGYSPERINPGDKEHRVTTIKKVTSGSTPEIAD
CCCCCCCHHHHHHHHHHHCCEECCEEECCCCCCCCCCCCCHHHEEEEEHHCCCCCCHHHH
LVDSLYNEIITVGTHKAESIKVAEAAKVIENTQRDLNIALINELALIFNKMNIDTEAVLK
HHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
AAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDSMGAYVVAQL
HCCCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCCCCHHHHHHHHH
VKAMTKKRLQVDGAKVLVMGLTFKENCPDLRNTRVVDIVTELKDYNCVVDVYDPWLSSEE
HHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEEHHHCCCCEEEEECCCCCCCCC
AQHEYSIKLIEAPESGNYDAIILAVAHRQFKDMGASSIRALGKPNAVLYDLKYVLNPQES
CCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCC
DLRL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]