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The map label for this gene is lon [H]

Identifier: 114330230

GI number: 114330230

Start: 204252

End: 206675

Strand: Reverse

Name: lon [H]

Synonym: Neut_0201

Alternate gene names: 114330230

Gene position: 206675-204252 (Counterclockwise)

Preceding gene: 114330231

Following gene: 114330229

Centisome position: 7.77

GC content: 44.39

Gene sequence:

>2424_bases
ATGACATCAGATATTCTCGACACCCAAGAACAAAACGAGCTTGATTTACCACTGCTCCCACTGCGTGATGTGGTGGTCTT
TCCACACATGGTTATTCCATTATTTGTGGGACGTCCAAAGTCTATCAAGGCTTTAGAAGCTGCGACAGAAGCTGGAAAAA
ATATTCTGCTAGTTGCTCAGAAATCAGCCTCTAAAGATGACCCTTCTCCCCAAGACCTTTATAAAGTTTGCTGTGTTTCA
AGCATTTTGCAAATGCTGAAACTCCCCGATGGAACAGTCAAGGTATTGGTAGAAGGAAGTTATCGGGCAGAAATTGAATC
TTTTAATGATTCCGAAGCCTATTTTTCTGGAAAGGCTATACCAGTCACGATTGATGAGATCGATACGTCAGAAATTGAAG
CATTACGACGCGCTCTTCTTTCCCAATTTGACCAATATGTCAAATTAAACAAAAAAATCCCATCAGAAATTCTTGCTTCC
CTGACAGGAATTGATGAGGTCGGACGATTAGCTGATACGATCGCTGCTTATCTTCCCTTGAGACTGGAGCAAAAACAGGA
AATTCTGGAAATTTTTGAAGTTCAGCCACGTTTAGAACGTTTACTTGGCCTTCTGGAAGCCGAACTGGATATCCTCCAGG
TAGAAAAGCGCATTCGCGGTAGAGTCAAGCGCCAGATGGAAAAAAGCCAGCGGGACTATTACCTGAATGAACAGGTTAAA
GCTATTCAGAAAGAACTGGGCGAAGGCGAAGATGGTACTGACCTTGAAGAAATTGAAAGAAAAATAAAGGCAGCTTCCTT
GCCTAAAGAAGCATTAGCCAAGGCAGAGTCTGAGCTGAAAAAACTGCGCCTGATGTCTCCTATGTCAGCCGAAGCAACTG
TTGTACGAAATTATATTGACACGCTGGTTGCATTGCCCTGGAAGCAGAAAACCAAAATCAGCAAAGAATTAAAGATTGCC
GAATCCATCCTGAATGAAGATCATTATGGTTTGGAGAAAGTAAAGGAAAGGATAGTTGAATACCTTGCAGTACAACAGCG
GGTTGCCAAATCCAAGGCTCCCATTCTTTGCCTTGTCGGCCCGCCTGGAGTAGGTAAAACTTCACTAGGTCGATCTATAG
CTCGCGCGACAAACCGTAAATTTGTTCGTATGTCTCTCGGAGGCATGCGAGATGAAGCTGAGATCCGTGGGCATCGTCGA
ACTTACATCGGTTCGATGCCCGGAAAGATTTTGCAAAGTATGACAAAAATCGGTGTCAAAAACCCACTGTTTCTGTTAGA
TGAAGTTGACAAAATGGGAATGGATTTTCGTGGCGACCCTTCTTCTGCCTTGCTGGAAGTACTTGATCCGGAGCAAAACA
ATACATTTGTTGATCACTACATCGAAGTTGAATACGACTTATCGGATGTCATGTTCGTTGCTACCGCAAACACACTGAAC
ATTCCTCCCGCACTCCTTGATCGAATGGAAGTTATTCGACTTTCAGGCTATACCGAAGATGAGAAACTAAATATTGCAAA
ACGATATCTTCTACCCAAGCAAATGAAGGATCATGGTTTAAGCGAGGGGGAGTTGTCTGTTTCTGAATCTGCATTACGTG
ACATTGTCCGCTACTACACCCGAGAAGCGGGAGTGCGTTCAATGGAAAGAGAAATCTCCAAGATTTGCAGGAAAGTCGTC
AAAATTTTGCTGGTTAAAAAAAATAAGGAAAAGATTATTATCAACTCCCGCAACCTCGATAAATATCTTGGAGTGCGCCG
TTACGCTTATGGCATGGCTGACGAAAAAAATCAGGTTGGACAGGTTACGGGACTGGCTTGGACGGAGGTAGGCGGTGAGT
TGCTGAGAATTGAGGCGGTAGTGCTACTAGGCAAAGGGAAGACGATTACGACCGGTAAACTGGGTGAAGTCATGCAGGAA
TCCATTCAGGCAGCCCTGTCTGTTGTTCGAAGCCGCTCAATCGTTCTGGGAATATCAGATGATTTTTATCTGAAGAACGA
TATTCATATTCACTTGCCTGAAGGGGCCACGCCTAAAGATGGGCCGAGTGCAGGTATTGGTATTTGTCTGGCTATGGTTT
CTGCATTGACCGGAGTCCCGGTGCGAGCATCCGTTGCGATGACCGGGGAAATTACACTAAGAGGCGAAATTCTTCCAATC
GGTGGGCTCAAGGAGAAACTCCTGGCTGCTCATCGTGGTGGAATAAGCACGGTGTTGATCCCGGAAGATAATGTCAAGGA
TTTGAGTGAGATTCCTGGAAACATTAAAAACAAACTGGATATCAAGCCAGTAAAATGGATTGACCAGGTGCTAGAAATTG
CTCTGGAATATAAGCCTGATGCGATACCGTCAGCTATCCCTGGTCAAGTCATTGCATCCACACCTAAAGATAGCGTTACA
AGAGCTTCTTCAATCAAGCATTGA

Upstream 100 bases:

>100_bases
ATTCTTTTAAGAGTTTGTTTTTAGCACACTGCGGGTACCTGTTTTTCACAGGTGTCACCATATCTTATCCTATCCATGTT
TTCTGCAGGATGTAAATGAC

Downstream 100 bases:

>100_bases
TTATTTGGATACACATAACGGGAGAGCTTCAATAAAATTTTAAAGTATCTTCCTTTAAAGCTGCTATTTTATAAATAGAT
TCGGCTTTATTTTCCGCAGA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MTSDILDTQEQNELDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAATEAGKNILLVAQKSASKDDPSPQDLYKVCCVS
SILQMLKLPDGTVKVLVEGSYRAEIESFNDSEAYFSGKAIPVTIDEIDTSEIEALRRALLSQFDQYVKLNKKIPSEILAS
LTGIDEVGRLADTIAAYLPLRLEQKQEILEIFEVQPRLERLLGLLEAELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVK
AIQKELGEGEDGTDLEEIERKIKAASLPKEALAKAESELKKLRLMSPMSAEATVVRNYIDTLVALPWKQKTKISKELKIA
ESILNEDHYGLEKVKERIVEYLAVQQRVAKSKAPILCLVGPPGVGKTSLGRSIARATNRKFVRMSLGGMRDEAEIRGHRR
TYIGSMPGKILQSMTKIGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNTFVDHYIEVEYDLSDVMFVATANTLN
IPPALLDRMEVIRLSGYTEDEKLNIAKRYLLPKQMKDHGLSEGELSVSESALRDIVRYYTREAGVRSMEREISKICRKVV
KILLVKKNKEKIIINSRNLDKYLGVRRYAYGMADEKNQVGQVTGLAWTEVGGELLRIEAVVLLGKGKTITTGKLGEVMQE
SIQAALSVVRSRSIVLGISDDFYLKNDIHIHLPEGATPKDGPSAGIGICLAMVSALTGVPVRASVAMTGEITLRGEILPI
GGLKEKLLAAHRGGISTVLIPEDNVKDLSEIPGNIKNKLDIKPVKWIDQVLEIALEYKPDAIPSAIPGQVIASTPKDSVT
RASSIKH

Sequences:

>Translated_807_residues
MTSDILDTQEQNELDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAATEAGKNILLVAQKSASKDDPSPQDLYKVCCVS
SILQMLKLPDGTVKVLVEGSYRAEIESFNDSEAYFSGKAIPVTIDEIDTSEIEALRRALLSQFDQYVKLNKKIPSEILAS
LTGIDEVGRLADTIAAYLPLRLEQKQEILEIFEVQPRLERLLGLLEAELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVK
AIQKELGEGEDGTDLEEIERKIKAASLPKEALAKAESELKKLRLMSPMSAEATVVRNYIDTLVALPWKQKTKISKELKIA
ESILNEDHYGLEKVKERIVEYLAVQQRVAKSKAPILCLVGPPGVGKTSLGRSIARATNRKFVRMSLGGMRDEAEIRGHRR
TYIGSMPGKILQSMTKIGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNTFVDHYIEVEYDLSDVMFVATANTLN
IPPALLDRMEVIRLSGYTEDEKLNIAKRYLLPKQMKDHGLSEGELSVSESALRDIVRYYTREAGVRSMEREISKICRKVV
KILLVKKNKEKIIINSRNLDKYLGVRRYAYGMADEKNQVGQVTGLAWTEVGGELLRIEAVVLLGKGKTITTGKLGEVMQE
SIQAALSVVRSRSIVLGISDDFYLKNDIHIHLPEGATPKDGPSAGIGICLAMVSALTGVPVRASVAMTGEITLRGEILPI
GGLKEKLLAAHRGGISTVLIPEDNVKDLSEIPGNIKNKLDIKPVKWIDQVLEIALEYKPDAIPSAIPGQVIASTPKDSVT
RASSIKH
>Mature_806_residues
TSDILDTQEQNELDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAATEAGKNILLVAQKSASKDDPSPQDLYKVCCVSS
ILQMLKLPDGTVKVLVEGSYRAEIESFNDSEAYFSGKAIPVTIDEIDTSEIEALRRALLSQFDQYVKLNKKIPSEILASL
TGIDEVGRLADTIAAYLPLRLEQKQEILEIFEVQPRLERLLGLLEAELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVKA
IQKELGEGEDGTDLEEIERKIKAASLPKEALAKAESELKKLRLMSPMSAEATVVRNYIDTLVALPWKQKTKISKELKIAE
SILNEDHYGLEKVKERIVEYLAVQQRVAKSKAPILCLVGPPGVGKTSLGRSIARATNRKFVRMSLGGMRDEAEIRGHRRT
YIGSMPGKILQSMTKIGVKNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNTFVDHYIEVEYDLSDVMFVATANTLNI
PPALLDRMEVIRLSGYTEDEKLNIAKRYLLPKQMKDHGLSEGELSVSESALRDIVRYYTREAGVRSMEREISKICRKVVK
ILLVKKNKEKIIINSRNLDKYLGVRRYAYGMADEKNQVGQVTGLAWTEVGGELLRIEAVVLLGKGKTITTGKLGEVMQES
IQAALSVVRSRSIVLGISDDFYLKNDIHIHLPEGATPKDGPSAGIGICLAMVSALTGVPVRASVAMTGEITLRGEILPIG
GLKEKLLAAHRGGISTVLIPEDNVKDLSEIPGNIKNKLDIKPVKWIDQVLEIALEYKPDAIPSAIPGQVIASTPKDSVTR
ASSIKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=44.6808510638298, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI21396489, Length=663, Percent_Identity=40.422322775264, Blast_Score=504, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=778, Percent_Identity=67.0951156812339, Blast_Score=1048, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=694, Percent_Identity=38.6167146974063, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=40.7407407407407, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=711, Percent_Identity=39.803094233474, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.6774193548387, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=604, Percent_Identity=45.1986754966887, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89566; Mature: 89435

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDILDTQEQNELDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAATEAGKNILLVAQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEE
KSASKDDPSPQDLYKVCCVSSILQMLKLPDGTVKVLVEGSYRAEIESFNDSEAYFSGKAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCEECCCEE
PVTIDEIDTSEIEALRRALLSQFDQYVKLNKKIPSEILASLTGIDEVGRLADTIAAYLPL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCH
RLEQKQEILEIFEVQPRLERLLGLLEAELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AIQKELGEGEDGTDLEEIERKIKAASLPKEALAKAESELKKLRLMSPMSAEATVVRNYID
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TLVALPWKQKTKISKELKIAESILNEDHYGLEKVKERIVEYLAVQQRVAKSKAPILCLVG
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPGVGKTSLGRSIARATNRKFVRMSLGGMRDEAEIRGHRRTYIGSMPGKILQSMTKIGVK
CCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCC
NPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNTFVDHYIEVEYDLSDVMFVATANTLN
CCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKLNIAKRYLLPKQMKDHGLSEGELSVSESALRDIVRYYT
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
REAGVRSMEREISKICRKVVKILLVKKNKEKIIINSRNLDKYLGVRRYAYGMADEKNQVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
QVTGLAWTEVGGELLRIEAVVLLGKGKTITTGKLGEVMQESIQAALSVVRSRSIVLGISD
HHCCCHHHHHCCCEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEECCC
DFYLKNDIHIHLPEGATPKDGPSAGIGICLAMVSALTGVPVRASVAMTGEITLRGEILPI
CEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEEEEC
GGLKEKLLAAHRGGISTVLIPEDNVKDLSEIPGNIKNKLDIKPVKWIDQVLEIALEYKPD
CCHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AIPSAIPGQVIASTPKDSVTRASSIKH
CCCCCCCCCCEECCCCHHHHHHHCCCC
>Mature Secondary Structure 
TSDILDTQEQNELDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAATEAGKNILLVAQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEE
KSASKDDPSPQDLYKVCCVSSILQMLKLPDGTVKVLVEGSYRAEIESFNDSEAYFSGKAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCCEECCCEE
PVTIDEIDTSEIEALRRALLSQFDQYVKLNKKIPSEILASLTGIDEVGRLADTIAAYLPL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHCH
RLEQKQEILEIFEVQPRLERLLGLLEAELDILQVEKRIRGRVKRQMEKSQRDYYLNEQVK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AIQKELGEGEDGTDLEEIERKIKAASLPKEALAKAESELKKLRLMSPMSAEATVVRNYID
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TLVALPWKQKTKISKELKIAESILNEDHYGLEKVKERIVEYLAVQQRVAKSKAPILCLVG
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPGVGKTSLGRSIARATNRKFVRMSLGGMRDEAEIRGHRRTYIGSMPGKILQSMTKIGVK
CCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCC
NPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNNTFVDHYIEVEYDLSDVMFVATANTLN
CCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKLNIAKRYLLPKQMKDHGLSEGELSVSESALRDIVRYYT
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
REAGVRSMEREISKICRKVVKILLVKKNKEKIIINSRNLDKYLGVRRYAYGMADEKNQVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
QVTGLAWTEVGGELLRIEAVVLLGKGKTITTGKLGEVMQESIQAALSVVRSRSIVLGISD
HHCCCHHHHHCCCEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEECCC
DFYLKNDIHIHLPEGATPKDGPSAGIGICLAMVSALTGVPVRASVAMTGEITLRGEILPI
CEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEEEEC
GGLKEKLLAAHRGGISTVLIPEDNVKDLSEIPGNIKNKLDIKPVKWIDQVLEIALEYKPD
CCHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AIPSAIPGQVIASTPKDSVTRASSIKH
CCCCCCCCCCEECCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]