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The map label for this gene is guaD [H]

Identifier: 114330216

GI number: 114330216

Start: 187959

End: 188546

Strand: Reverse

Name: guaD [H]

Synonym: Neut_0187

Alternate gene names: 114330216

Gene position: 188546-187959 (Counterclockwise)

Preceding gene: 114330220

Following gene: 114330211

Centisome position: 7.09

GC content: 53.23

Gene sequence:

>588_bases
ATGAGCATAAGCACTACATTGCACATCAAACTGCCAGCTTTCCTCGTACAGGCAAATATGGAGCCGCGCGTGCTGATTAA
ACCTGAAGCACGCATGAGTTATGTGCTTGAACTAATGCGTATCAATATGGCTACAGATGGTGGCCCTTTTGCCGCAGCGG
TATTCGAGCGCGACAGCGGCTTGCTGATTGCAGCCGGTACCAACCGGGTGGTATCAAGCCACTGTTCCACTGCTCACGCC
GAAATACTTGCGTTATCGCTGGCGCAGGCAAAACTGGGCAGCCACGATTTGAGCGCTGACGGTCTGCCTGCCTGTGAACT
GGTAACCAGTGCCGAACCTTGTGTAATGTGCTTTGGTGCAGTGATCTGGTCCGGCGTACGCAGTTTGGTCTGTGCTGCAC
GCGGTGAGGATGTGGAGGCAATCGGTTTCGACGAAGGCCCTCGACCAGAGAACTGGATTGATGAATTGGAAATTCGCGGT
ATCATCGTGACAACTGATCTGTTGCGTGATACCACCTGCACACTCCTGCGCGACTACGTTGCCTGCAACGGCGTGATTTA
TAACGCACGCTGCGGAATACACAAATGA

Upstream 100 bases:

>100_bases
TCAGACAAAAAAATCAATTTTTATAACAATGAAGATTCGATTGTGCCGAAGTAACACCAAGCGCTACCCGCATTGATCGA
CATTAGTGTAAAGTTGCCCT

Downstream 100 bases:

>100_bases
ACAGCGAGTTACTTACTTTTATCCGGAAGTCCCCTTGCTGCCCAACTCCATTGCCCGTGCTTCGTCTTCCTGCGCAAGAT
ACACCCAATCTACGATCTCC

Product: CMP/dCMP deaminase, zinc-binding

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSISTTLHIKLPAFLVQANMEPRVLIKPEARMSYVLELMRINMATDGGPFAAAVFERDSGLLIAAGTNRVVSSHCSTAHA
EILALSLAQAKLGSHDLSADGLPACELVTSAEPCVMCFGAVIWSGVRSLVCAARGEDVEAIGFDEGPRPENWIDELEIRG
IIVTTDLLRDTTCTLLRDYVACNGVIYNARCGIHK

Sequences:

>Translated_195_residues
MSISTTLHIKLPAFLVQANMEPRVLIKPEARMSYVLELMRINMATDGGPFAAAVFERDSGLLIAAGTNRVVSSHCSTAHA
EILALSLAQAKLGSHDLSADGLPACELVTSAEPCVMCFGAVIWSGVRSLVCAARGEDVEAIGFDEGPRPENWIDELEIRG
IIVTTDLLRDTTCTLLRDYVACNGVIYNARCGIHK
>Mature_194_residues
SISTTLHIKLPAFLVQANMEPRVLIKPEARMSYVLELMRINMATDGGPFAAAVFERDSGLLIAAGTNRVVSSHCSTAHAE
ILALSLAQAKLGSHDLSADGLPACELVTSAEPCVMCFGAVIWSGVRSLVCAARGEDVEAIGFDEGPRPENWIDELEIRGI
IVTTDLLRDTTCTLLRDYVACNGVIYNARCGIHK

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554608, Length=113, Percent_Identity=36.283185840708, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555996, Length=132, Percent_Identity=34.0909090909091, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 20973; Mature: 20842

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISTTLHIKLPAFLVQANMEPRVLIKPEARMSYVLELMRINMATDGGPFAAAVFERDSG
CCCCEEEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
LLIAAGTNRVVSSHCSTAHAEILALSLAQAKLGSHDLSADGLPACELVTSAEPCVMCFGA
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHH
VIWSGVRSLVCAARGEDVEAIGFDEGPRPENWIDELEIRGIIVTTDLLRDTTCTLLRDYV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHH
ACNGVIYNARCGIHK
HHCCEEEECCCCCCC
>Mature Secondary Structure 
SISTTLHIKLPAFLVQANMEPRVLIKPEARMSYVLELMRINMATDGGPFAAAVFERDSG
CCCEEEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
LLIAAGTNRVVSSHCSTAHAEILALSLAQAKLGSHDLSADGLPACELVTSAEPCVMCFGA
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHH
VIWSGVRSLVCAARGEDVEAIGFDEGPRPENWIDELEIRGIIVTTDLLRDTTCTLLRDYV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHH
ACNGVIYNARCGIHK
HHCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]