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The map label for this gene is ccmA [H]

Identifier: 114330094

GI number: 114330094

Start: 62707

End: 63321

Strand: Reverse

Name: ccmA [H]

Synonym: Neut_0063

Alternate gene names: 114330094

Gene position: 63321-62707 (Counterclockwise)

Preceding gene: 114330095

Following gene: 114330093

Centisome position: 2.38

GC content: 54.47

Gene sequence:

>615_bases
GTGCTTCAAGCCATCAATCTGGACTGCGTGCGCGGCGAGCGGCGCCTATTTCATAATTTAAGCTTTCAGCTCAAGGCAGG
CGAGTGCCTGTTGGTGCACGGCGAGAACGGTAGCGGCAAAACCAGTCTTTTGCGCATGCTGGTGGGGCTAACGCCTACGG
CTACCGGCGCAGTTCATTGGCAGGGTAGTCCGATAAAAAAGCTGGGCGATGAGTACCGTCGCGAGCTACTTTATTGTGGC
CATCCTTTGGGTCTTAAAGATGCGCTAAGTGCCACGGAAAACTTAATTTCCAGCATGGAGTTGAATGACGAATCGGTTAC
CCAGGACGTTGTGCACGAAGCCTTACGCCAGGCTGGATTGCAGGGCAGGGAGCATCTATCAGTGCGAGCCTTGTCGCAGG
GGCAAAAGCGCCGTGTAAATTTGGCCAGGCTACTGCTGCAAAAGCGTGCTTTGTGGGTGTTGGATGAACCCCTGACGGCA
TTGGATACCCAAGCCAGCCTATGGGTAGTGGGGCTGATTGACCAGCATCTGAGCAATGGCGGGATCGCAGTTTTGACGAC
GCATCAGGATTTGACCTTGACAGGCACGACGCACGTTATACGGGTAGGCATATGA

Upstream 100 bases:

>100_bases
GCTTAGCCCCGCATGTAACGGACGGTCCGTTGTATGTTGGCGCTTCGCCAAAATACCGATGTCACCTAGTGATTAACGTT
TTTGCGAGCAAAGGTCGACG

Downstream 100 bases:

>100_bases
GCGACACCATTGGCTTATCCGTACTTCGCGGGGTAATACATCGAGATTTAAGGCTCGCCATGCGACGCAAGTCCGATGTG
CTAACACCGCTTTTTTTCTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLQAINLDCVRGERRLFHNLSFQLKAGECLLVHGENGSGKTSLLRMLVGLTPTATGAVHWQGSPIKKLGDEYRRELLYCG
HPLGLKDALSATENLISSMELNDESVTQDVVHEALRQAGLQGREHLSVRALSQGQKRRVNLARLLLQKRALWVLDEPLTA
LDTQASLWVVGLIDQHLSNGGIAVLTTHQDLTLTGTTHVIRVGI

Sequences:

>Translated_204_residues
MLQAINLDCVRGERRLFHNLSFQLKAGECLLVHGENGSGKTSLLRMLVGLTPTATGAVHWQGSPIKKLGDEYRRELLYCG
HPLGLKDALSATENLISSMELNDESVTQDVVHEALRQAGLQGREHLSVRALSQGQKRRVNLARLLLQKRALWVLDEPLTA
LDTQASLWVVGLIDQHLSNGGIAVLTTHQDLTLTGTTHVIRVGI
>Mature_204_residues
MLQAINLDCVRGERRLFHNLSFQLKAGECLLVHGENGSGKTSLLRMLVGLTPTATGAVHWQGSPIKKLGDEYRRELLYCG
HPLGLKDALSATENLISSMELNDESVTQDVVHEALRQAGLQGREHLSVRALSQGQKRRVNLARLLLQKRALWVLDEPLTA
LDTQASLWVVGLIDQHLSNGGIAVLTTHQDLTLTGTTHVIRVGI

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27881501, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI30795238, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI31657092, Length=184, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI116734710, Length=178, Percent_Identity=29.2134831460674, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI153792144, Length=169, Percent_Identity=29.585798816568, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45446740, Length=198, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI47078218, Length=198, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI87082064, Length=193, Percent_Identity=47.6683937823834, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786563, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1786698, Length=204, Percent_Identity=27.9411764705882, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=188, Percent_Identity=30.8510638297872, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789593, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788165, Length=193, Percent_Identity=32.6424870466321, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789891, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787029, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786345, Length=189, Percent_Identity=26.984126984127, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787712, Length=167, Percent_Identity=29.940119760479, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787164, Length=182, Percent_Identity=34.0659340659341, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789991, Length=216, Percent_Identity=27.3148148148148, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788506, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788225, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789032, Length=152, Percent_Identity=30.2631578947368, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI87081709, Length=154, Percent_Identity=27.9220779220779, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787089, Length=201, Percent_Identity=25.8706467661692, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788761, Length=171, Percent_Identity=27.4853801169591, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=177, Percent_Identity=28.2485875706215, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17541710, Length=177, Percent_Identity=31.638418079096, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=200, Percent_Identity=26, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=191, Percent_Identity=29.3193717277487, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=198, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115534520, Length=203, Percent_Identity=28.0788177339901, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321720, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920532, Length=182, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24580930, Length=182, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24666092, Length=182, Percent_Identity=29.6703296703297, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574533, Length=185, Percent_Identity=26.4864864864865, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574150, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007328, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22405; Mature: 22405

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQAINLDCVRGERRLFHNLSFQLKAGECLLVHGENGSGKTSLLRMLVGLTPTATGAVHW
CCEECCCHHHCCHHHHHHCCCEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
QGSPIKKLGDEYRRELLYCGHPLGLKDALSATENLISSMELNDESVTQDVVHEALRQAGL
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
QGREHLSVRALSQGQKRRVNLARLLLQKRALWVLDEPLTALDTQASLWVVGLIDQHLSNG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCEEEEEEHHHHCCCC
GIAVLTTHQDLTLTGTTHVIRVGI
CEEEEEECCCEEEECCEEEEEECC
>Mature Secondary Structure
MLQAINLDCVRGERRLFHNLSFQLKAGECLLVHGENGSGKTSLLRMLVGLTPTATGAVHW
CCEECCCHHHCCHHHHHHCCCEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEE
QGSPIKKLGDEYRRELLYCGHPLGLKDALSATENLISSMELNDESVTQDVVHEALRQAGL
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
QGREHLSVRALSQGQKRRVNLARLLLQKRALWVLDEPLTALDTQASLWVVGLIDQHLSNG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCEEEEEEHHHHCCCC
GIAVLTTHQDLTLTGTTHVIRVGI
CEEEEEECCCEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA