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The map label for this gene is czcR [H]

Identifier: 114330073

GI number: 114330073

Start: 41777

End: 42472

Strand: Reverse

Name: czcR [H]

Synonym: Neut_0040

Alternate gene names: 114330073

Gene position: 42472-41777 (Counterclockwise)

Preceding gene: 114330074

Following gene: 114330072

Centisome position: 1.6

GC content: 51.01

Gene sequence:

>696_bases
ATGAAAGTTCTTGTGGTCGAAGATGAAAAAAAGCTTGCGGATTACTTACGTCGGGCGTTGACGGAGCATGGCTATGTGGT
TGATGTTGCTGGCGACGGCAGGGAAGGTCTATATTTCGCACAGGAAACCCCATACGATCTTATCCTCCTTGATGTAATGT
TGCCGGGTATGGATGGTTTTCAATTGTTACGCGAATTGCGCAAAAAGAGTCGTGTGCCAGTGATAATGCTCAGCGCAAGA
GACCGGGTTGAAGACCGGGTTAGAGGGTTGGAGGATGGCGCTGATGACTACCTTCCCAAGCCCTTCTCGCTGACCGAGCT
CATGGCTCGGATCTTTGCGCTGGCTCGTAGGAACGATCCCGCAAACTTGGCTGAGGCCCACACGAATATCGTTCGCGTAG
CCGATCTAGAACTAGATCTTCAGCGCCGACGCGTCTATCGGAACGAGCAACCGATCAGCTTGACTTTGAAAGAGTTCGCT
TTGCTCCAGCTGTTCATGCGTAAGTGTGGCCAAGTCTTATCGCGGCAGACTTTAGCGGAACAGGTATGGGATATTAACTT
CAACAATAATACTAACGTAGTTGAAGCGGCTGTCCGACGGTTACGCGCAAAAGTGGATGGCCCGTTCGAGAGCAAACTCA
TACACACCGTGCGCGGTATGGGCTATGTGATTGAGGCTCGGGATCAAGAATGTTGA

Upstream 100 bases:

>100_bases
GTGCGTTAGGAACGAGCTGCTAGTTACGACAGCAGATGCGGTGTCGCCTCACGCGCCACTGTGCGCTCAGCCCTTATCCC
ATGGAGGAATCACACCCGCA

Downstream 100 bases:

>100_bases
GTTGCTCAAACTCAATTCGAGGCCGACTTTCACGTTGGCTCGCGATACATACCTTGGTAAGTGTAGGACTGATCTGTACA
GCTGTTTATCTTGCTATTAG

Product: two component heavy metal response transcriptional regulator, winged helix family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKVLVVEDEKKLADYLRRALTEHGYVVDVAGDGREGLYFAQETPYDLILLDVMLPGMDGFQLLRELRKKSRVPVIMLSAR
DRVEDRVRGLEDGADDYLPKPFSLTELMARIFALARRNDPANLAEAHTNIVRVADLELDLQRRRVYRNEQPISLTLKEFA
LLQLFMRKCGQVLSRQTLAEQVWDINFNNNTNVVEAAVRRLRAKVDGPFESKLIHTVRGMGYVIEARDQEC

Sequences:

>Translated_231_residues
MKVLVVEDEKKLADYLRRALTEHGYVVDVAGDGREGLYFAQETPYDLILLDVMLPGMDGFQLLRELRKKSRVPVIMLSAR
DRVEDRVRGLEDGADDYLPKPFSLTELMARIFALARRNDPANLAEAHTNIVRVADLELDLQRRRVYRNEQPISLTLKEFA
LLQLFMRKCGQVLSRQTLAEQVWDINFNNNTNVVEAAVRRLRAKVDGPFESKLIHTVRGMGYVIEARDQEC
>Mature_231_residues
MKVLVVEDEKKLADYLRRALTEHGYVVDVAGDGREGLYFAQETPYDLILLDVMLPGMDGFQLLRELRKKSRVPVIMLSAR
DRVEDRVRGLEDGADDYLPKPFSLTELMARIFALARRNDPANLAEAHTNIVRVADLELDLQRRRVYRNEQPISLTLKEFA
LLQLFMRKCGQVLSRQTLAEQVWDINFNNNTNVVEAAVRRLRAKVDGPFESKLIHTVRGMGYVIEARDQEC

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=48.1981981981982, Blast_Score=227, Evalue=5e-61,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=49.3506493506493, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=40.8888888888889, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=39.3013100436681, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=35.0877192982456, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=37.8260869565217, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=37.8378378378378, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.2422907488987, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=35.6521739130435, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=36.8888888888889, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=36.4035087719298, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.8854625550661, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=31.0924369747899, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=36.9369369369369, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=35.6521739130435, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=35.2380952380952, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=33.6134453781513, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI48994928, Length=115, Percent_Identity=37.3913043478261, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26560; Mature: 26560

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVVEDEKKLADYLRRALTEHGYVVDVAGDGREGLYFAQETPYDLILLDVMLPGMDGF
CEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEEEHHCCCCCHH
QLLRELRKKSRVPVIMLSARDRVEDRVRGLEDGADDYLPKPFSLTELMARIFALARRNDP
HHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCC
ANLAEAHTNIVRVADLELDLQRRRVYRNEQPISLTLKEFALLQLFMRKCGQVLSRQTLAE
CHHHHHHHCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVWDINFNNNTNVVEAAVRRLRAKVDGPFESKLIHTVRGMGYVIEARDQEC
HHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MKVLVVEDEKKLADYLRRALTEHGYVVDVAGDGREGLYFAQETPYDLILLDVMLPGMDGF
CEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEEEHHCCCCCHH
QLLRELRKKSRVPVIMLSARDRVEDRVRGLEDGADDYLPKPFSLTELMARIFALARRNDP
HHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCC
ANLAEAHTNIVRVADLELDLQRRRVYRNEQPISLTLKEFALLQLFMRKCGQVLSRQTLAE
CHHHHHHHCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVWDINFNNNTNVVEAAVRRLRAKVDGPFESKLIHTVRGMGYVIEARDQEC
HHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]