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The map label for this gene is cusS [H]

Identifier: 114330072

GI number: 114330072

Start: 40449

End: 41783

Strand: Reverse

Name: cusS [H]

Synonym: Neut_0039

Alternate gene names: 114330072

Gene position: 41783-40449 (Counterclockwise)

Preceding gene: 114330073

Following gene: 114330070

Centisome position: 1.57

GC content: 51.46

Gene sequence:

>1335_bases
ATGTTGAGTTGCTCAAACTCAATTCGAGGCCGACTTTCACGTTGGCTCGCGATACATACCTTGGTAAGTGTAGGACTGAT
CTGTACAGCTGTTTATCTTGCTATTAGTTCGAACTTCGCGACCCGCCAGACTGAGCTGTTGGCGGAAAAGAAGAGGGCAA
TTCAGCATTTAGCGACGGAAAGCGTATCTAAAGATAGCTCGGAATCGTTGCAACATCAGCTCTTGGATTTCTTCCACGGC
CATCCAGAGCTTTCGTTAGTCCTGCAGAGTAGCAGTGTGACCAATACGTTTGGAAAGAGACCGTTAAACGCTGAGGCAAA
GATGTTTCGACAGCTGACGTTTACGCTGCCGGAACATGCGTTATCGACCGGACCGATCCAGGCGCAACTGAGCATGGACA
TCACTTCCGACGTTCGCTTTCTCAGGCGCTTGGCATTGGCCCTATTTATTTGCGCAATTTTAGGCGCAGTGCTCGCGTCA
TTAGGTGCCGCATGGTTGGTTCGCAGGGCCCTGGCCCCGATCGATGCATTGAGTAGCCAGGTCGTAAAGCTGTCTCCGGA
GCGGCTTGGCGAGCGGCTTGAAGCGAAGGACTCTGCAGTAGAAATTCGCCCCTTGATTGCCCAGTTCAACGCGTTACTCG
AGCGTATCGAGGGTGCCTATGCTCAGATGGAGGAGTTTAATGCCAATCTGGCACATGAGTTAAGGACGCCGTTAGCAACG
CTGATTGGTGAAACCGAGCTGGCATTAAGCTCTAAACGCTATGAGCGCTCGCTTGAAGAAATGCTTGTTTCTAACCTGGA
AGATCTACACAGAATGGAAAGAGTCATAAGCGACATATTGCTCCTCGCGCGGGCCGATGGCGGTACGAGGATCAAGACAG
AACCGACCAACAGTATTGCCATTACCATCCGGGAGGTAATGGATTATCACGAAGCCCAAGCCGAAGAAGCTGATGTGAAA
TTACTGCTAGTGGGCGACGCCTCAGCCATGATTAGCCGTACGCTTTTTCAACGCGCCGTGTCGAATCTGATATCAAACGC
GATCCGGCATGCCGACCCGTTTAGCGACGTGCTGATTGTAGTAGAAACAGCAGGCGAAGAAGTGCGGATCGCAGTTTGTA
ATCTTGGCACTCCTGTTGAACAAGAGCACCTGGTAAGGTGTTTTGAGCGGTTCGTCAGATTACCGGCAGGGCGAGTGTCT
AGCGATCAAGATCATTTTGGGCTGGGGTTAGCAATCGTTGCCGCGATAGCTCGAATGCACAGCGGCAAAACGTTCGCCCG
GTCGGTTGATCGATTGGTCACGATGGGATTTACAGTGGCTAGACCAATACATTAG

Upstream 100 bases:

>100_bases
CTGTCCGACGGTTACGCGCAAAAGTGGATGGCCCGTTCGAGAGCAAACTCATACACACCGTGCGCGGTATGGGCTATGTG
ATTGAGGCTCGGGATCAAGA

Downstream 100 bases:

>100_bases
CTTCGGTTTGCGTGTGAGGATATTAAACGCTCCACACATGGATATGACCGGCTGGAACATTGGAAAAAAAACCGCGCACA
AATGTAGCCGTGCGCGGTGA

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLSCSNSIRGRLSRWLAIHTLVSVGLICTAVYLAISSNFATRQTELLAEKKRAIQHLATESVSKDSSESLQHQLLDFFHG
HPELSLVLQSSSVTNTFGKRPLNAEAKMFRQLTFTLPEHALSTGPIQAQLSMDITSDVRFLRRLALALFICAILGAVLAS
LGAAWLVRRALAPIDALSSQVVKLSPERLGERLEAKDSAVEIRPLIAQFNALLERIEGAYAQMEEFNANLAHELRTPLAT
LIGETELALSSKRYERSLEEMLVSNLEDLHRMERVISDILLLARADGGTRIKTEPTNSIAITIREVMDYHEAQAEEADVK
LLLVGDASAMISRTLFQRAVSNLISNAIRHADPFSDVLIVVETAGEEVRIAVCNLGTPVEQEHLVRCFERFVRLPAGRVS
SDQDHFGLGLAIVAAIARMHSGKTFARSVDRLVTMGFTVARPIH

Sequences:

>Translated_444_residues
MLSCSNSIRGRLSRWLAIHTLVSVGLICTAVYLAISSNFATRQTELLAEKKRAIQHLATESVSKDSSESLQHQLLDFFHG
HPELSLVLQSSSVTNTFGKRPLNAEAKMFRQLTFTLPEHALSTGPIQAQLSMDITSDVRFLRRLALALFICAILGAVLAS
LGAAWLVRRALAPIDALSSQVVKLSPERLGERLEAKDSAVEIRPLIAQFNALLERIEGAYAQMEEFNANLAHELRTPLAT
LIGETELALSSKRYERSLEEMLVSNLEDLHRMERVISDILLLARADGGTRIKTEPTNSIAITIREVMDYHEAQAEEADVK
LLLVGDASAMISRTLFQRAVSNLISNAIRHADPFSDVLIVVETAGEEVRIAVCNLGTPVEQEHLVRCFERFVRLPAGRVS
SDQDHFGLGLAIVAAIARMHSGKTFARSVDRLVTMGFTVARPIH
>Mature_444_residues
MLSCSNSIRGRLSRWLAIHTLVSVGLICTAVYLAISSNFATRQTELLAEKKRAIQHLATESVSKDSSESLQHQLLDFFHG
HPELSLVLQSSSVTNTFGKRPLNAEAKMFRQLTFTLPEHALSTGPIQAQLSMDITSDVRFLRRLALALFICAILGAVLAS
LGAAWLVRRALAPIDALSSQVVKLSPERLGERLEAKDSAVEIRPLIAQFNALLERIEGAYAQMEEFNANLAHELRTPLAT
LIGETELALSSKRYERSLEEMLVSNLEDLHRMERVISDILLLARADGGTRIKTEPTNSIAITIREVMDYHEAQAEEADVK
LLLVGDASAMISRTLFQRAVSNLISNAIRHADPFSDVLIVVETAGEEVRIAVCNLGTPVEQEHLVRCFERFVRLPAGRVS
SDQDHFGLGLAIVAAIARMHSGKTFARSVDRLVTMGFTVARPIH

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=311, Percent_Identity=35.048231511254, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1788279, Length=419, Percent_Identity=24.582338902148, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789403, Length=262, Percent_Identity=31.2977099236641, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=314, Percent_Identity=26.1146496815287, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=29.7872340425532, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=26.0536398467433, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.9406392694064, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=305, Percent_Identity=24.9180327868852, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48959; Mature: 48959

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSCSNSIRGRLSRWLAIHTLVSVGLICTAVYLAISSNFATRQTELLAEKKRAIQHLATE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SVSKDSSESLQHQLLDFFHGHPELSLVLQSSSVTNTFGKRPLNAEAKMFRQLTFTLPEHA
HHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHCHHHH
LSTGPIQAQLSMDITSDVRFLRRLALALFICAILGAVLASLGAAWLVRRALAPIDALSSQ
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VVKLSPERLGERLEAKDSAVEIRPLIAQFNALLERIEGAYAQMEEFNANLAHELRTPLAT
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LIGETELALSSKRYERSLEEMLVSNLEDLHRMERVISDILLLARADGGTRIKTEPTNSIA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCE
ITIREVMDYHEAQAEEADVKLLLVGDASAMISRTLFQRAVSNLISNAIRHADPFSDVLIV
EEHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEE
VETAGEEVRIAVCNLGTPVEQEHLVRCFERFVRLPAGRVSSDQDHFGLGLAIVAAIARMH
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
SGKTFARSVDRLVTMGFTVARPIH
CCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSCSNSIRGRLSRWLAIHTLVSVGLICTAVYLAISSNFATRQTELLAEKKRAIQHLATE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SVSKDSSESLQHQLLDFFHGHPELSLVLQSSSVTNTFGKRPLNAEAKMFRQLTFTLPEHA
HHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHCHHHH
LSTGPIQAQLSMDITSDVRFLRRLALALFICAILGAVLASLGAAWLVRRALAPIDALSSQ
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VVKLSPERLGERLEAKDSAVEIRPLIAQFNALLERIEGAYAQMEEFNANLAHELRTPLAT
HHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LIGETELALSSKRYERSLEEMLVSNLEDLHRMERVISDILLLARADGGTRIKTEPTNSIA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCE
ITIREVMDYHEAQAEEADVKLLLVGDASAMISRTLFQRAVSNLISNAIRHADPFSDVLIV
EEHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEE
VETAGEEVRIAVCNLGTPVEQEHLVRCFERFVRLPAGRVSSDQDHFGLGLAIVAAIARMH
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
SGKTFARSVDRLVTMGFTVARPIH
CCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]