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The map label for this gene is dnaA

Identifier: 114330037

GI number: 114330037

Start: 35

End: 1414

Strand: Direct

Name: dnaA

Synonym: Neut_0001

Alternate gene names: 114330037

Gene position: 35-1414 (Clockwise)

Preceding gene: NA

Following gene: 114330038

Centisome position: 0.0

GC content: 45.72

Gene sequence:

>1380_bases
ATGCAGAAAATAGAGACTTTCTGGTATTTCTGTCTTAAGCATTTCAAACAGGAATTGAATGGACAGCAGTTTAATACCTG
GATCAAGCCGCTCAAGCTGGAAATCTGTCCGGATGTGGAAAATACCCTGGTCTTAATTGCTCCCAATCGTTTTGTATTGC
AATGGATCAAGGATAATTTTGTCAACCGCATCGACGAAATGGCACAAGGTCATTTCAATGAAAAAATCCATTTCAAACTG
GAGCTGAAAGATCCAGCCGAGATCAAAACAGCAACAATCAAGGCACCTGAACCGAAAAGCAAGGAAGACAAGAAACCACC
TACAGATAAAGCGCATGGCACCACCGCCAGAAAAACCAATCCCAGCCGGCTCAATCCTGCTTTTACCTTTGACGCCTTTG
TTACCGGGAAGGCCAATCAGCTGGCACGTGCCGGGGCCATTCAGGTAGCAGAACGACCAGGTATTGCCTATAACCCTTTG
TTTATTTACGGGGGGGTAGGATTAGGCAAAACGCATCTGATGCATGCGGTCGGCAATTACGTTATGGAACTGGATGCCGG
GGCCAAAATCCGCTATGTCCATGCTGAAAAATATGTATCGGATGTCGTCAGTGCTTATCAGCACAAGTCATTCGATAAAT
TCAAGCTTTACTATCATTCGCTTGATCTGTTGCTGGTGGATGATGTTCAGTTTTTCAGCGGTAAAAACCGGACACAGGAA
GAATTTTTCTACGCCTTCAACGCATTAATCGAAGCACACAAGCAAGTAATCATAACTTCCGATTGTTATCCGAAGGAGAT
TTCCGGGCTGGAGGAACGTTTGGTATCAAGGTTCGGTTGGGGATTGACCGTGGCGATCGAACCCCCCGAACTCGAAATGC
GCGTAGCCATTCTGCTCAAAAAAGCTTTCATCGAGAAGATCGAACTGGACGAAAGTACCGCCTTTTTCATCGCTAAATAT
ATCCGTTCCAATGTCCGGGAACTGGAAGGCGCACTAAAACGGGTTCTGGCGTATTCACGCTTTACCGGTCATCCGATTTC
CCTTGATCTGGCCAAGGAAGCGTTAAAGGATCTGCTAGCCATACAAAATCGGCAGATTTCAATCGAAAACATTCAGAAAA
CCGTAGCGGATTACTACAAAATAAAAGTAGCCGACATGTACTCAAAGAAACGTGTCAGGGCTATCGCCCGACCCAGACAA
GTTGCAATGGCTATCGCCAAGGAACTAACTCAGTTAAGTCTGCCTGATATAGGCGAAGCTTTCGGTGGAAGAGACCATAC
AACTGTACTGCATGCCCATCGTAAAATCGTAGAACTACGTGCTTCTGATCCCGGAATAAACCGGGATTACAGTACATTGA
TACATATCCTGCGTGGATGA

Upstream 100 bases:

>100_bases
TGCTTTTACACCGCACTTAACTGTTTGTTTTTCCTCTCTAGTTTTTTTCAAGTTTCACCGGAATACTTTTCTAAATCCGG
GTTAATTTCTTCTACTTGTC

Downstream 100 bases:

>100_bases
CGTAATACGCCAATAACCCCTGCATGTTTTGTGGATAACTCGCATAAAATCCTGATTGGAAAATTTTGTTCACAATTCAT
CCACAGGCTATACTCAAATC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQKIETFWYFCLKHFKQELNGQQFNTWIKPLKLEICPDVENTLVLIAPNRFVLQWIKDNFVNRIDEMAQGHFNEKIHFKL
ELKDPAEIKTATIKAPEPKSKEDKKPPTDKAHGTTARKTNPSRLNPAFTFDAFVTGKANQLARAGAIQVAERPGIAYNPL
FIYGGVGLGKTHLMHAVGNYVMELDAGAKIRYVHAEKYVSDVVSAYQHKSFDKFKLYYHSLDLLLVDDVQFFSGKNRTQE
EFFYAFNALIEAHKQVIITSDCYPKEISGLEERLVSRFGWGLTVAIEPPELEMRVAILLKKAFIEKIELDESTAFFIAKY
IRSNVRELEGALKRVLAYSRFTGHPISLDLAKEALKDLLAIQNRQISIENIQKTVADYYKIKVADMYSKKRVRAIARPRQ
VAMAIAKELTQLSLPDIGEAFGGRDHTTVLHAHRKIVELRASDPGINRDYSTLIHILRG

Sequences:

>Translated_459_residues
MQKIETFWYFCLKHFKQELNGQQFNTWIKPLKLEICPDVENTLVLIAPNRFVLQWIKDNFVNRIDEMAQGHFNEKIHFKL
ELKDPAEIKTATIKAPEPKSKEDKKPPTDKAHGTTARKTNPSRLNPAFTFDAFVTGKANQLARAGAIQVAERPGIAYNPL
FIYGGVGLGKTHLMHAVGNYVMELDAGAKIRYVHAEKYVSDVVSAYQHKSFDKFKLYYHSLDLLLVDDVQFFSGKNRTQE
EFFYAFNALIEAHKQVIITSDCYPKEISGLEERLVSRFGWGLTVAIEPPELEMRVAILLKKAFIEKIELDESTAFFIAKY
IRSNVRELEGALKRVLAYSRFTGHPISLDLAKEALKDLLAIQNRQISIENIQKTVADYYKIKVADMYSKKRVRAIARPRQ
VAMAIAKELTQLSLPDIGEAFGGRDHTTVLHAHRKIVELRASDPGINRDYSTLIHILRG
>Mature_459_residues
MQKIETFWYFCLKHFKQELNGQQFNTWIKPLKLEICPDVENTLVLIAPNRFVLQWIKDNFVNRIDEMAQGHFNEKIHFKL
ELKDPAEIKTATIKAPEPKSKEDKKPPTDKAHGTTARKTNPSRLNPAFTFDAFVTGKANQLARAGAIQVAERPGIAYNPL
FIYGGVGLGKTHLMHAVGNYVMELDAGAKIRYVHAEKYVSDVVSAYQHKSFDKFKLYYHSLDLLLVDDVQFFSGKNRTQE
EFFYAFNALIEAHKQVIITSDCYPKEISGLEERLVSRFGWGLTVAIEPPELEMRVAILLKKAFIEKIELDESTAFFIAKY
IRSNVRELEGALKRVLAYSRFTGHPISLDLAKEALKDLLAIQNRQISIENIQKTVADYYKIKVADMYSKKRVRAIARPRQ
VAMAIAKELTQLSLPDIGEAFGGRDHTTVLHAHRKIVELRASDPGINRDYSTLIHILRG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=465, Percent_Identity=53.763440860215, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI226510964, Length=249, Percent_Identity=24.8995983935743, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_NITEC (Q0AK27)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746259.1
- ProteinModelPortal:   Q0AK27
- STRING:   Q0AK27
- GeneID:   4271847
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0001
- NMPDR:   fig|335283.3.peg.338
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   Q0AK27
- ProtClustDB:   PRK00149
- BioCyc:   NEUT335283:NEUT_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52381; Mature: 52381

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIETFWYFCLKHFKQELNGQQFNTWIKPLKLEICPDVENTLVLIAPNRFVLQWIKDNF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEECCCCCCCEEEEECCHHHHHHHHHHH
VNRIDEMAQGHFNEKIHFKLELKDPAEIKTATIKAPEPKSKEDKKPPTDKAHGTTARKTN
HHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
PSRLNPAFTFDAFVTGKANQLARAGAIQVAERPGIAYNPLFIYGGVGLGKTHLMHAVGNY
CCCCCCCEEEEEEEECCHHHHHHHCCCEEECCCCCEECCEEEEECCCCCHHHHHHHHHHH
VMELDAGAKIRYVHAEKYVSDVVSAYQHKSFDKFKLYYHSLDLLLVDDVQFFSGKNRTQE
HEEECCCCEEEEEEHHHHHHHHHHHHHHCCCHHHEEEEEHEEEEEEECHHHHCCCCCCHH
EFFYAFNALIEAHKQVIITSDCYPKEISGLEERLVSRFGWGLTVAIEPPELEMRVAILLK
HHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
KAFIEKIELDESTAFFIAKYIRSNVRELEGALKRVLAYSRFTGHPISLDLAKEALKDLLA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
IQNRQISIENIQKTVADYYKIKVADMYSKKRVRAIARPRQVAMAIAKELTQLSLPDIGEA
HCCCCEEHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FGGRDHTTVLHAHRKIVELRASDPGINRDYSTLIHILRG
HCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MQKIETFWYFCLKHFKQELNGQQFNTWIKPLKLEICPDVENTLVLIAPNRFVLQWIKDNF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEECCCCCCCEEEEECCHHHHHHHHHHH
VNRIDEMAQGHFNEKIHFKLELKDPAEIKTATIKAPEPKSKEDKKPPTDKAHGTTARKTN
HHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
PSRLNPAFTFDAFVTGKANQLARAGAIQVAERPGIAYNPLFIYGGVGLGKTHLMHAVGNY
CCCCCCCEEEEEEEECCHHHHHHHCCCEEECCCCCEECCEEEEECCCCCHHHHHHHHHHH
VMELDAGAKIRYVHAEKYVSDVVSAYQHKSFDKFKLYYHSLDLLLVDDVQFFSGKNRTQE
HEEECCCCEEEEEEHHHHHHHHHHHHHHCCCHHHEEEEEHEEEEEEECHHHHCCCCCCHH
EFFYAFNALIEAHKQVIITSDCYPKEISGLEERLVSRFGWGLTVAIEPPELEMRVAILLK
HHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
KAFIEKIELDESTAFFIAKYIRSNVRELEGALKRVLAYSRFTGHPISLDLAKEALKDLLA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
IQNRQISIENIQKTVADYYKIKVADMYSKKRVRAIARPRQVAMAIAKELTQLSLPDIGEA
HCCCCEEHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FGGRDHTTVLHAHRKIVELRASDPGINRDYSTLIHILRG
HCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA