| Definition | Shewanella sp. MR-4 chromosome, complete genome. |
|---|---|
| Accession | NC_008321 |
| Length | 4,706,287 |
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The map label for this gene is topB [H]
Identifier: 113969775
GI number: 113969775
Start: 1675222
End: 1677342
Strand: Direct
Name: topB [H]
Synonym: Shewmr4_1433
Alternate gene names: 113969775
Gene position: 1675222-1677342 (Clockwise)
Preceding gene: 113969772
Following gene: 113969777
Centisome position: 35.6
GC content: 51.34
Gene sequence:
>2121_bases ATGATCCTCTATATTGCTGAAAAACCAAGCCTAGGGCGTGCAATCGCCGATGTGCTGCCTAAACCCCACAAAAAAGGTGA CGGGTTTATCGAAGACGCAAACGGTAACTGTGTGTCTTGGTGTGTCGGGCACTTGCTCGAACAGGCTGAGCCCGATGCCT ATAATCCCGAGTTTAAATCGTGGAAGTTTGAGCATTTACCCATAGTGCCAGAGAAGTGGCAGCTTAAACCTAAGGCCGCG ACCCGCAGCCAACTCACAGTACTTAAAAAGCTGGTGAAGCAGGCCGATACTTTAGTGAATGCGGGTGATCCCGACAGGGA AGGGCAGTTATTGGTTGATGAAGTGATCGCCTATTTGGGCGTGACGGGCGATAAATTACAGCAAACGCAGCGACTCCTTA TCAGCGACTTAAACCCGCAGGCGGTGAAACGTGCCTTGTCACAACTCCGCAGTAATCGTGAGTTTATTCCTTTGTCGACC TCGGCACTTGCCAGAAGCCGCGCCGATTGGCTCTATGGCATGAATATGACGCGGGCCTACACTATTCAAGGGAAAAAGGT TGGCTATCAGGGCGTACTATCGGTCGGCCGAGTACAGACCCCGCTGCTTGGGCTTATCGTGCGCCGCGATGAGGAAATCG CAAATTTTCAATCTAAGCCTTTTTATGAGGTTCTGGCCCACTTAGTGACGGACAAAGATCAGGCTTTCACGGCGAAGTGG CAACCCAGTGAAGCCTGTTTACCCTATATGGATGAGGAAGGGCGCGTGCTCGCTAAGGGCCTAGCACAAAATGTGGTGCG TCGGATCACCGATAAACCCGCCAAAGTGACCCAGTTAAGCACTAAGGATAAGCAGCAGAATCCGCCTTTACCCTATAGTT TATCGGCGCTGCAAATAGATGCCGCCAAGCGCTTCGGTATGAGCGCCAAGGACGTGCTCGATACCTGCCAGAGCTTATAC GAGCGCCATAAGCTAATCACTTATCCACGCTCAGACAGTCGTTATTTGCCCACCGAGCAGCATGGGCTTGCAAGTGGGGT ATTAGCGGCCATTACGGGCGGTGCGCCCGAGTTAGTCGCACATGCTGAGGCGCCCAATCCTCGGCTTAAATCTAAGGCGT GGGATGATAAAAAAGTCGATGCTCACCACGCCATTATTCCAACGGAAAAACAGCCCAATCTAGCTGGTTTAAGCCAGCGG GAAAGGCAGCTTTATCTGCATATTGCTCGCCAGTATTTGGCGCAGTTTTACCCTGCCTATTGCTACAGTGAAACCGCGGT CGAAGTGACGATCGAAGGTGGCCTTTTTAAAACTAAGGCAAAACAGGATAAGTCTCTCGGTTGGAAACAACTGTTTGCCA GAGAAGAGAACGAACGAAAGGACGCATCATCCGCAGCGAGTTTTGCGCAAGGCGACAAGGACACAGAGGAAGGGGAATAT CTTGGTCAGTTACCGCCTCTTACCTTAGGACAAGTTCTTCATTGTCACCAAGGTGAATTAGTCGAGAAGCAAACTCAACC TCCCAAAGCCTTTACCGATGCTACCTTGCTGAGTGCGATGACGGGGATTAACCGTTATGTGACTGACCCAGAGATCCGCA AAATTTTAAAGGAAACCGATGGCTTAGGTACGGAAGCGACTCGCGCAGGCATTATTGAACTGCTGTTTAAACGGGGCTTT ATTCAGCGTCAGGGCAAGTCGATTGTGGCCACGGAGGTGGGCAAGGGCTTAATTAATAGTTTACCCCTTAGCGCCACGAC ACCCGATATGACGGCGCTGTGGGAGGCAAGTCTAAACGGTATCTGCCATAAAGAAATCTCATATCAAGGCTTTATGCAAC CACTGCTGGGGACGCTAAATAACTTAATTGAAAATGCGGGCGCTCAATTACCCTCAGCCCTCAATGGCTTAAAAGGGCAG GGCTTTAAGCGTGCAGCAACGAAAAAGTCCGGCTATCGAAAAGCTGGAGCCAAAGGGGCAGGATGGAAAAAATCCGGCAC TAAAAACGCGGCAGTGGGAAGCTCGGCCGCTAAAACTACCGCGGCTAAATCGACGGTCTCGACATCCGGTACGCCTACTA CGCCTAGACGGCGAGCGAGCAAAGCGCCCGCCCAAGCTTGA
Upstream 100 bases:
>100_bases AGAGCGAGTTAAATCGGCCCTTGAGGTAAAACGGCGGTTTGCACTCTTGTCCGCTTTGGGCTAAATTACACTGTAATTAT ATCCAGTATTTAATGTAGAT
Downstream 100 bases:
>100_bases TGACACAAATGTAATCAAACTGTCGCTAATGCTCGCGATCTAGTAACGATATTTAATATATTCCGCGATATTTAATTGCC GCCAATCACGATATTTAGCG
Product: DNA topoisomerase III
Products: NA
Alternate protein names: DNA topoisomerase III [H]
Number of amino acids: Translated: 706; Mature: 706
Protein sequence:
>706_residues MILYIAEKPSLGRAIADVLPKPHKKGDGFIEDANGNCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPEKWQLKPKAA TRSQLTVLKKLVKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLST SALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIANFQSKPFYEVLAHLVTDKDQAFTAKW QPSEACLPYMDEEGRVLAKGLAQNVVRRITDKPAKVTQLSTKDKQQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLY ERHKLITYPRSDSRYLPTEQHGLASGVLAAITGGAPELVAHAEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLAGLSQR ERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKAKQDKSLGWKQLFAREENERKDASSAASFAQGDKDTEEGEY LGQLPPLTLGQVLHCHQGELVEKQTQPPKAFTDATLLSAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGF IQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKEISYQGFMQPLLGTLNNLIENAGAQLPSALNGLKGQ GFKRAATKKSGYRKAGAKGAGWKKSGTKNAAVGSSAAKTTAAKSTVSTSGTPTTPRRRASKAPAQA
Sequences:
>Translated_706_residues MILYIAEKPSLGRAIADVLPKPHKKGDGFIEDANGNCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPEKWQLKPKAA TRSQLTVLKKLVKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLST SALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIANFQSKPFYEVLAHLVTDKDQAFTAKW QPSEACLPYMDEEGRVLAKGLAQNVVRRITDKPAKVTQLSTKDKQQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLY ERHKLITYPRSDSRYLPTEQHGLASGVLAAITGGAPELVAHAEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLAGLSQR ERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKAKQDKSLGWKQLFAREENERKDASSAASFAQGDKDTEEGEY LGQLPPLTLGQVLHCHQGELVEKQTQPPKAFTDATLLSAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGF IQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKEISYQGFMQPLLGTLNNLIENAGAQLPSALNGLKGQ GFKRAATKKSGYRKAGAKGAGWKKSGTKNAAVGSSAAKTTAAKSTVSTSGTPTTPRRRASKAPAQA >Mature_706_residues MILYIAEKPSLGRAIADVLPKPHKKGDGFIEDANGNCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPEKWQLKPKAA TRSQLTVLKKLVKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLST SALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIANFQSKPFYEVLAHLVTDKDQAFTAKW QPSEACLPYMDEEGRVLAKGLAQNVVRRITDKPAKVTQLSTKDKQQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLY ERHKLITYPRSDSRYLPTEQHGLASGVLAAITGGAPELVAHAEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLAGLSQR ERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKAKQDKSLGWKQLFAREENERKDASSAASFAQGDKDTEEGEY LGQLPPLTLGQVLHCHQGELVEKQTQPPKAFTDATLLSAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGF IQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKEISYQGFMQPLLGTLNNLIENAGAQLPSALNGLKGQ GFKRAATKKSGYRKAGAKGAGWKKSGTKNAAVGSSAAKTTAAKSTVSTSGTPTTPRRRASKAPAQA
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI4507635, Length=638, Percent_Identity=23.1974921630094, Blast_Score=89, Evalue=1e-17, Organism=Escherichia coli, GI1788061, Length=677, Percent_Identity=55.6868537666174, Blast_Score=746, Evalue=0.0, Organism=Escherichia coli, GI1787529, Length=551, Percent_Identity=24.3194192377495, Blast_Score=105, Evalue=1e-23, Organism=Caenorhabditis elegans, GI32563869, Length=647, Percent_Identity=23.8021638330757, Blast_Score=105, Evalue=1e-22, Organism=Drosophila melanogaster, GI24585251, Length=536, Percent_Identity=24.0671641791045, Blast_Score=100, Evalue=4e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR005738 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 77389; Mature: 77389
Theoretical pI: Translated: 9.88; Mature: 9.88
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILYIAEKPSLGRAIADVLPKPHKKGDGFIEDANGNCVSWCVGHLLEQAEPDAYNPEFKS CEEEEECCCCHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC WKFEHLPIVPEKWQLKPKAATRSQLTVLKKLVKQADTLVNAGDPDREGQLLVDEVIAYLG CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC VTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAY CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCEEE TIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIANFQSKPFYEVLAHLVTDKDQAFTAKW EECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCCCCEEECC QPSEACLPYMDEEGRVLAKGLAQNVVRRITDKPAKVTQLSTKDKQQNPPLPYSLSALQID CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEECHHEEEH AAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASGVLAAITGGAPELVA HHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHE HAEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLAGLSQRERQLYLHIARQYLAQFYPAY ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH CYSETAVEVTIEGGLFKTKAKQDKSLGWKQLFAREENERKDASSAASFAQGDKDTEEGEY HCCCCEEEEEECCCEEECCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHH LGQLPPLTLGQVLHCHQGELVEKQTQPPKAFTDATLLSAMTGINRYVTDPEIRKILKETD HCCCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC GLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNG CCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC ICHKEISYQGFMQPLLGTLNNLIENAGAQLPSALNGLKGQGFKRAATKKSGYRKAGAKGA HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCHHCCCCCC GWKKSGTKNAAVGSSAAKTTAAKSTVSTSGTPTTPRRRASKAPAQA CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC >Mature Secondary Structure MILYIAEKPSLGRAIADVLPKPHKKGDGFIEDANGNCVSWCVGHLLEQAEPDAYNPEFKS CEEEEECCCCHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC WKFEHLPIVPEKWQLKPKAATRSQLTVLKKLVKQADTLVNAGDPDREGQLLVDEVIAYLG CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC VTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAY CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCCEEE TIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIANFQSKPFYEVLAHLVTDKDQAFTAKW EECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHCCCCCCEEECC QPSEACLPYMDEEGRVLAKGLAQNVVRRITDKPAKVTQLSTKDKQQNPPLPYSLSALQID CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEECHHEEEH AAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASGVLAAITGGAPELVA HHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHE HAEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLAGLSQRERQLYLHIARQYLAQFYPAY ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH CYSETAVEVTIEGGLFKTKAKQDKSLGWKQLFAREENERKDASSAASFAQGDKDTEEGEY HCCCCEEEEEECCCEEECCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHH LGQLPPLTLGQVLHCHQGELVEKQTQPPKAFTDATLLSAMTGINRYVTDPEIRKILKETD HCCCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC GLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNG CCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC ICHKEISYQGFMQPLLGTLNNLIENAGAQLPSALNGLKGQGFKRAATKKSGYRKAGAKGA HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCHHCCCCCC GWKKSGTKNAAVGSSAAKTTAAKSTVSTSGTPTTPRRRASKAPAQA CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2553698; 9097039; 9278503; 10574789 [H]