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The map label for this gene is atoC [H]

Identifier: 113969623

GI number: 113969623

Start: 1487344

End: 1488684

Strand: Direct

Name: atoC [H]

Synonym: Shewmr4_1280

Alternate gene names: 113969623

Gene position: 1487344-1488684 (Clockwise)

Preceding gene: 113969622

Following gene: 113969624

Centisome position: 31.6

GC content: 49.89

Gene sequence:

>1341_bases
ATGTCTGAAGCCAAATTACTCTTAGTCGAAGACGATGCGTCCCTGCGTGAGGCTTTGCTCGATACCTTAATGTTGGCGCA
ATACGACTGCATCGATGTGGCCTCCGGCGAGGAAGCCATTATCGCATTGAAGCAACATCAGTTTGACTTAGTGATCAGCG
ATGTGCAGATGCAGGGCATTGGCGGCTTAGGATTATTAAATTACTTACAGCAGCATCACCCCAAGCTGCCAGTGTTATTG
ATGACGGCGTATGCCACCATTGGCAGTGCGGTCAGTGCAATTAAATTGGGCGCCGTCGATTATTTGGCAAAACCCTTTGC
GCCAGAGGTATTGCTCAACCAAGTTTCCCGCTATTTGCCGCTCAAACAAAGTAGCGATCAACCCGTGGTTGCCGATGAAA
AGAGCCTCGCGCTGCTATCACTGGCACAGCGTGTGGCGGCATCCGATGCTTCTGTGATGATCCTTGGACCAAGCGGCTCG
GGTAAAGAAGTGTTAGCCCGTTATATTCATCAACATAGTAGCCGTGCCAACCAAGCGTTTGTGGCCATCAACTGTGCGGC
CATCCCCGAGAATATGCTCGAGGCGACCTTATTCGGTTATGAAAAAGGGGCTTTTACCGGCGCTTATCAGGCATGCCCTG
GTAAATTTGAACAGGCACAAGGCGGCACCTTATTACTCGATGAAATATCTGAGATGGATTTGGGACTTCAGGCCAAACTG
CTGCGTGTGCTGCAAGAGCGCGAAGTGGAGCGTTTAGGCGGTCGTAAAACCATTAAGTTAGATGTTCGGGTGCTTGCCAC
TTCGAATCGGGATTTAAAGGCCGTGGTTGCCGCTGGGCAATTCCGAGAAGATCTCTATTATCGCATTAACGTGTTTCCAC
TGACGTGGCCTGCACTGAATCAACGCCCTGCGGATATTTTGCCACTAGCTCGGCATTTACTTGCGAAACACGCAAAGGCG
CTAAATGTGCTTGATTTACCTGAGTTTGATGAGGCAGCTTGTCGTCGTTTACTCAGTCACCGCTGGCCAGGTAATGTGCG
CGAGTTGGATAACGTGGTGCAACGCGCGTTAATTTTACGTGCTGGGGCTGTGATTACCGCCAACGATATTATTATCGATG
CCCAAGATGTGCCTCTGTTATCCGATGACGCCGAATATGTCAATGAGCCGGAAGGTTTAGGTGAGGAGTTGAAGGCGCAG
GAACATGTGATCATTCTCGAAACTTTAGCGCAATGCCAAGGTAGTCGTAAGTTGGTTGCCGAAAAACTTGGGATCAGTGC
GCGCACCTTAAGATATAAGATGGCCAGAATGCGCGATATGGGGATTCAATTGCCCAACTAA

Upstream 100 bases:

>100_bases
GGCCAAATCCAATTGAGTTGTATGCCCAATAAAGGTTGTACTGTGTCGCTAACCTTCCCGCAGGCGAAATCGGCTGCAGT
ATTGCCGCTGGAGAAACCCT

Downstream 100 bases:

>100_bases
TTTGTGTTTTGTACCTTGTCTAAAGCCATTGCCACTGGGTTACCCTGTGGCAATTTCATGTCTGACGATTTCTTCACTTC
TTTTTAGCACGGCAAAGTGA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIALKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQSSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRANQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKA
LNVLDLPEFDEAACRRLLSHRWPGNVRELDNVVQRALILRAGAVITANDIIIDAQDVPLLSDDAEYVNEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Sequences:

>Translated_446_residues
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIALKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQSSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRANQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKA
LNVLDLPEFDEAACRRLLSHRWPGNVRELDNVVQRALILRAGAVITANDIIIDAQDVPLLSDDAEYVNEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN
>Mature_445_residues
SEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIALKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLLM
TAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQSSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSG
KEVLARYIHQHSSRANQAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKLL
RVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLAKHAKAL
NVLDLPEFDEAACRRLLSHRWPGNVRELDNVVQRALILRAGAVITANDIIIDAQDVPLLSDDAEYVNEPEGLGEELKAQE
HVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=42, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=39.5505617977528, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790299, Length=385, Percent_Identity=40.7792207792208, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1788905, Length=374, Percent_Identity=42.2459893048128, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082117, Length=309, Percent_Identity=45.9546925566343, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=43.8485804416404, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789233, Length=309, Percent_Identity=41.4239482200647, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI87082152, Length=234, Percent_Identity=47.8632478632479, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081872, Length=302, Percent_Identity=37.7483443708609, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1786524, Length=227, Percent_Identity=46.6960352422907, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787583, Length=318, Percent_Identity=35.5345911949685, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=38.0753138075314, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081858, Length=315, Percent_Identity=29.2063492063492, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=35.5140186915888, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48923; Mature: 48792

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIALKQHQFDLVISDVQMQGI
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCEEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQSSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRANQAF
CCCCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEEEEEEEECCCCC
QRPADILPLARHLLAKHAKALNVLDLPEFDEAACRRLLSHRWPGNVRELDNVVQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGAVITANDIIIDAQDVPLLSDDAEYVNEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEECCCCCCCCCCHHHCCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPN
HHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIALKQHQFDLVISDVQMQGI
CCCEEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCEEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQSSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRANQAF
CCCCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEEEEEEEECCCCC
QRPADILPLARHLLAKHAKALNVLDLPEFDEAACRRLLSHRWPGNVRELDNVVQRALILR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AGAVITANDIIIDAQDVPLLSDDAEYVNEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEECCCCCCCCCCHHHCCCCCCCCHHHHCCCCCHHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPN
HHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]