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The map label for this gene is pth [H]

Identifier: 113969351

GI number: 113969351

Start: 1174571

End: 1175158

Strand: Direct

Name: pth [H]

Synonym: Shewmr4_1007

Alternate gene names: 113969351

Gene position: 1174571-1175158 (Clockwise)

Preceding gene: 113969350

Following gene: 113969352

Centisome position: 24.96

GC content: 48.47

Gene sequence:

>588_bases
ATGAGCGAAATTAAATTAATCGTAGGTCTTGCCAATCCGGGCGCCGAATATGCGCAGACTCGCCATAATGCGGGTGCTTG
GTATGTGGAAGAATTGGCCCGCATCTGTGGCGTCAGCTTAGTGCCGGATAGCAAGTATTTTGGCCTCACCGCCAGAGCCG
TATTGCATGGCAAAGATGTGCGTTTGCTGATCCCAACGACTTATATGAACTTAAGCGGCAAAGCCGTGGGGGCCTTAGCG
AATTTCTTCCGAATTACGCCTGAAGAAATTCTAGTGGCCCACGATGAGTTGGATATGCCGCCCGGTGTGGCTAAATTTAA
ACTCGGTGGCGGTCATGGTGGCCATAACGGTTTAAAAGACATTATTGCTAAACTGGCTAATGATAAAAACTTCTATCGTT
TACGGATTGGGATTGGCCATCCCGGCGATAAGAATAAAGTCAGTGGTTACGTACTGGGTAAGGCGCCAGCCAAAGAACAA
GAGCTGATCAACGCCGCCGTAGATGAAGCCGTACGTTCCACTGAAGTGCTATTTAAAGAGGACATGGTGAAAGCCATGAC
TCGCTTACACTCCTTTAAAGCGGAGTAA

Upstream 100 bases:

>100_bases
TTTTAACGAGCATAAGCGGCATTATTAACTCAAGATGGTCGTCCATGTGCACTTTGCCATCGACCAATTAACACAGTATT
GAGTGCCATTAGTGGGTGTC

Downstream 100 bases:

>100_bases
GCCCTGTGCTCGCGGCCTGCGAAAAGAACAGCGAACACCAGGACAATAGAATTAATTAATGTACTGCCTAAGGGCAGGGT
GACTATAAACTTGCTGGTGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALA
NFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQ
ELINAAVDEAVRSTEVLFKEDMVKAMTRLHSFKAE

Sequences:

>Translated_195_residues
MSEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALA
NFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQ
ELINAAVDEAVRSTEVLFKEDMVKAMTRLHSFKAE
>Mature_194_residues
SEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALAN
FFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQE
LINAAVDEAVRSTEVLFKEDMVKAMTRLHSFKAE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=39.2857142857143, Blast_Score=101, Evalue=5e-22,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=70.8333333333333, Blast_Score=263, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21181; Mature: 21050

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDV
CCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
RLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKD
EEEEEEEEECCCCHHHHHHHHHHHCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCHHH
IIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQELINAAVDEAVRSTEVLFKE
HHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
DMVKAMTRLHSFKAE
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEIKLIVGLANPGAEYAQTRHNAGAWYVEELARICGVSLVPDSKYFGLTARAVLHGKDV
CCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
RLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKD
EEEEEEEEECCCCHHHHHHHHHHHCCHHHHEEECCCCCCCCCCEEEEECCCCCCCCCHHH
IIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQELINAAVDEAVRSTEVLFKE
HHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
DMVKAMTRLHSFKAE
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA