Click here to switch to the map view.

The map label for this gene is tkt1 [H]

Identifier: 113969117

GI number: 113969117

Start: 898768

End: 900762

Strand: Direct

Name: tkt1 [H]

Synonym: Shewmr4_0773

Alternate gene names: 113969117

Gene position: 898768-900762 (Clockwise)

Preceding gene: 113969114

Following gene: 113969118

Centisome position: 19.1

GC content: 50.43

Gene sequence:

>1995_bases
ATGTCTTCCCGTAAAGTACTCGCCAACGCAATCCGTGCGTTAAGTATGGATGCAGTTCAAAAAGCAAACTCAGGCCACCC
TGGCGCCCCAATGGGCATGGCAGATATTGCTGAAGTGCTGTGGAATGATTTCCTTAAGCACAATCCGAACAATCCGAAAT
GGGTAGATAGAGATCGTTTTATCCTCTCTAACGGTCACGGATCTATGCTGATCTACTCTTTATTACACCTGACTGGCTAC
GACCTGCCTATCGATGAACTGAAGCAATTCCGTCAGTTACATTCAAAAACTCCGGGTCACCCAGAATACGGTTACACCCC
AGGTGTTGAAACCACCACTGGCCCATTAGGGGCGGGGATCAGCAACGCTGTGGGTATGGCGATTGCAGAAAAAACCTTAG
CGGCACAGTTTAACCGTGAAGGTCACGAGATTGTTGACCACTACACTTACTGCTTCCTCGGCGATGGCTGCTTGATGGAA
GGTATTTCCCACGAGGCTTGTTCTCTTGCTGGTACCTTAGGCCTAGGCAAACTGATCGCATTTTGGGATGACAACGGCAT
CTCTATCGACGGTCATGTTGAAGGCTGGTTTACCGATGACACGCCAAAACGTTTCGAATCATACGGCTGGCATGTGATTG
CTAACGTTGATGGTCACGATAGCGATGCGATTCGCGCGGCTATCGAAGCGGCAAAAGCGGTGACCGACAAGCCAACCATG
ATCTGCTGCAAAACCATTATCGGTTTTGGTTCTCCAAACAAATCTGGTAGCCACGATTGCCACGGCGCACCATTAGGTGA
TGCCGAAATCGCAGCGGCCCGTGAATTCTTAGGCTGGTCACATGCGCCATTCGAAATCCCTGCCGACGTATACGCAGGTT
GGGATGCTAAAGAAGCCGGTAACGCCCGTGAAGCCGCATGGAACGACAAGTTTGCCGCTTACGCGAAAGCTTACCCAGAA
CTGGCTGCCGAATACGAGCGCCGTGTTCTGAAAGGTGAATTACCAGCAGATTTTGAAGCCAAAGCACAAGCCTTTATCCA
AGAATGCCAAGCGAAAGGCGAAGGCATTGCGAGCCGTAAAGCGTCACAAAACGCGATTGCAGCCTTCGGTGCAGTTCTGC
CTGAACTGTTAGGCGGCAGTGCTGACTTAGCGGGTTCTAACCTGACCCTGTGGGCAGGTTCTAAAGGTATTCAAGAAGAT
CCAGCGGGTAACTACGTGTACTACGGTGTGCGTGAGTTCGGTATGAGCGGCATCATGAACGGTGTGTCACTCCACGGTGG
TTTCATCAACTACGGCGCGACTTTCATGATGTTCATGGAATACGCACGTAACGCAGTACGTATGTCTGCGCTGATGGGCA
TTCAAAACATCTTCGTTTATACCCATGACTCTATCGGTCAAGGTGAAGATGGTCCAACTCACCAACCAGTTGAGCAATTA
GCTAACCTGCGTATGACGCCAAACATGGCGGTATGGCGTCCATGTGACGCGGCTGAAACCGCAGTGGCTTGGAAAGCGGC
TATCGAACGTCGTCATGCACCAACATCGCTAGTATTCAGCCGTCAAAACCTGAAGGCTCAAGTACGTACTGCTGAGCAAT
TAGCGAATGTGGCAAAAGGCGCTTACGTACTGCAAGACTGTGCAGGTACGCCTGAGTACATCCTGATTGCGACCGGTAGT
GAAGTGCAATTAGCGGTAGAAGCTGCAGCTGCGCTGACCGAACAAGGCAAACAAGTTCGCGTTGTTTCTATGCCATCAAA
CACTGAGTTTGATAAGCAAGATGCCGCTTACAAAGAATCTGTACTGCCAAAAGCTGTGACTAAGCGTATCGCTATCGAAG
CGGCCCATACTGACTTCTGGTACAAGTATGTTGGTTTCGAAGGCACTGTTGTTGGCATGACCACTTTCGGTGAGTCTGCG
CCAGGCAACGTGCTGCTGAAGCACTTCGGTTTCACCGTTGAAAATGTGCTGAATGCTGCAAAATCACTAGGCTAA

Upstream 100 bases:

>100_bases
GGGCATTGGAATGCAATTTTCGTTTGCGTCGCTTCGCTATGTAGGGGAAAATATGCGTCCAAATTGCCCGCTAGACCCCA
CAAATTAAGCAGGAGAGAGC

Downstream 100 bases:

>100_bases
TCGCTTAGGTGATGAGATTACCGACAAAAGGTTAAACTTTTGAAAGGTTAATCTGTATAATGCGGCCTGCAATCGTTTGC
AGGCCGTTTTTGTATATGCA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRFILSNGHGSMLIYSLLHLTGY
DLPIDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTM
ICCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWSHAPFEIPADVYAGWDAKEAGNAREAAWNDKFAAYAKAYPE
LAAEYERRVLKGELPADFEAKAQAFIQECQAKGEGIASRKASQNAIAAFGAVLPELLGGSADLAGSNLTLWAGSKGIQED
PAGNYVYYGVREFGMSGIMNGVSLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMAVWRPCDAAETAVAWKAAIERRHAPTSLVFSRQNLKAQVRTAEQLANVAKGAYVLQDCAGTPEYILIATGS
EVQLAVEAAAALTEQGKQVRVVSMPSNTEFDKQDAAYKESVLPKAVTKRIAIEAAHTDFWYKYVGFEGTVVGMTTFGESA
PGNVLLKHFGFTVENVLNAAKSLG

Sequences:

>Translated_664_residues
MSSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRFILSNGHGSMLIYSLLHLTGY
DLPIDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTM
ICCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWSHAPFEIPADVYAGWDAKEAGNAREAAWNDKFAAYAKAYPE
LAAEYERRVLKGELPADFEAKAQAFIQECQAKGEGIASRKASQNAIAAFGAVLPELLGGSADLAGSNLTLWAGSKGIQED
PAGNYVYYGVREFGMSGIMNGVSLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMAVWRPCDAAETAVAWKAAIERRHAPTSLVFSRQNLKAQVRTAEQLANVAKGAYVLQDCAGTPEYILIATGS
EVQLAVEAAAALTEQGKQVRVVSMPSNTEFDKQDAAYKESVLPKAVTKRIAIEAAHTDFWYKYVGFEGTVVGMTTFGESA
PGNVLLKHFGFTVENVLNAAKSLG
>Mature_663_residues
SSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRFILSNGHGSMLIYSLLHLTGYD
LPIDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTMI
CCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWSHAPFEIPADVYAGWDAKEAGNAREAAWNDKFAAYAKAYPEL
AAEYERRVLKGELPADFEAKAQAFIQECQAKGEGIASRKASQNAIAAFGAVLPELLGGSADLAGSNLTLWAGSKGIQEDP
AGNYVYYGVREFGMSGIMNGVSLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQLA
NLRMTPNMAVWRPCDAAETAVAWKAAIERRHAPTSLVFSRQNLKAQVRTAEQLANVAKGAYVLQDCAGTPEYILIATGSE
VQLAVEAAAALTEQGKQVRVVSMPSNTEFDKQDAAYKESVLPKAVTKRIAIEAAHTDFWYKYVGFEGTVVGMTTFGESAP
GNVLLKHFGFTVENVLNAAKSLG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=580, Percent_Identity=25.5172413793103, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI205277463, Length=268, Percent_Identity=33.2089552238806, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI4507521, Length=268, Percent_Identity=33.2089552238806, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI225637459, Length=586, Percent_Identity=22.3549488054608, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=491, Percent_Identity=23.4215885947047, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637461, Length=491, Percent_Identity=23.4215885947047, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=74.8114630467572, Blast_Score=1066, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=66.8174962292609, Blast_Score=958, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=680, Percent_Identity=24.2647058823529, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=48.6526946107784, Blast_Score=589, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=45.5223880597015, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45551847, Length=679, Percent_Identity=25.6259204712813, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550715, Length=679, Percent_Identity=25.6259204712813, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645119, Length=645, Percent_Identity=24.9612403100775, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24666278, Length=691, Percent_Identity=23.8784370477569, Blast_Score=142, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71599; Mature: 71468

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCEE
ILSNGHGSMLIYSLLHLTGYDLPIDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCHHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTM
EECCCCEEECCCCCEEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHH
ICCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWSHAPFEIPADVYAGWDAKEAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHCC
NAREAAWNDKFAAYAKAYPELAAEYERRVLKGELPADFEAKAQAFIQECQAKGEGIASRK
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
ASQNAIAAFGAVLPELLGGSADLAGSNLTLWAGSKGIQEDPAGNYVYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEECHHHHCHHHHCC
GVSLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMAVWRPCDAAETAVAWKAAIERRHAPTSLVFSRQNLKAQVRTAEQLANVAKG
HCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHH
AYVLQDCAGTPEYILIATGSEVQLAVEAAAALTEQGKQVRVVSMPSNTEFDKQDAAYKES
HHHHHHCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPKAVTKRIAIEAAHTDFWYKYVGFEGTVVGMTTFGESAPGNVLLKHFGFTVENVLNAA
HCHHHHHHHHHHEECCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHH
KSLG
HHCC
>Mature Secondary Structure 
SSRKVLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPKWVDRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCEE
ILSNGHGSMLIYSLLHLTGYDLPIDELKQFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNREGHEIVDHYTYCFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCHHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEAAKAVTDKPTM
EECCCCEEECCCCCEEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHH
ICCKTIIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWSHAPFEIPADVYAGWDAKEAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHCC
NAREAAWNDKFAAYAKAYPELAAEYERRVLKGELPADFEAKAQAFIQECQAKGEGIASRK
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
ASQNAIAAFGAVLPELLGGSADLAGSNLTLWAGSKGIQEDPAGNYVYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEECHHHHCHHHHCC
GVSLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMAVWRPCDAAETAVAWKAAIERRHAPTSLVFSRQNLKAQVRTAEQLANVAKG
HCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHH
AYVLQDCAGTPEYILIATGSEVQLAVEAAAALTEQGKQVRVVSMPSNTEFDKQDAAYKES
HHHHHHCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPKAVTKRIAIEAAHTDFWYKYVGFEGTVVGMTTFGESAPGNVLLKHFGFTVENVLNAA
HCHHHHHHHHHHEECCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHH
KSLG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]