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The map label for this gene is epd [H]

Identifier: 113969118

GI number: 113969118

Start: 900891

End: 901907

Strand: Direct

Name: epd [H]

Synonym: Shewmr4_0774

Alternate gene names: 113969118

Gene position: 900891-901907 (Clockwise)

Preceding gene: 113969117

Following gene: 113969119

Centisome position: 19.14

GC content: 49.36

Gene sequence:

>1017_bases
ATGATCCGAGTCGCAATCAATGGTTATGGTCGTATTGGCCGCTCAATTCTTCGCGCTTTATATGAGTCCGGAAAACGTCA
GCAAATACAAATTGTCGCAATCAACGAGTTGGCTAAGCCCGAAGCCATTGTTCACCTGACCCAGTACGACACTACCCACG
GTCGGTTTCAGCCCAGAGTCAAATTAGTCGATGATCAGATGCTGATCGGCGATGACGTCATCAAAATTCTCCATGAACCG
GATCCTGCTAAGTTGCCTTGGCACGAGATGGATATCGATATCGTCTATGAAGCGACTGGCGCCATCTTAGATCGCAACAG
CTGCGAGGCCCATATCCACGCAGGCGCCAAACAGGTCTTAATCAGTCACCCTTCTTCTGCCGATGTTGATGGCACTATCG
TTTACGGTGTGAACCAAGACTTACTGCGCGCCGAGCATACCGTGGTCTCCAACGCCTCTTGTACGACCAACTGTATCGTG
CCCGTTATCGATGTACTGGATAAACACTTTGGTGTGAAAAGTGGCGCGATTACCACTATCCATTCGGCGATGAACGATCA
GCAAGTGATTGATGCTTATCATGATGACTTACGCCGCACCCGAGCTGCGGGCCAGTCTATCATCCCAGTCGACACTAAAC
TTGCACGCGGCATCGAGCGAATTTTGCCGCACATGAAAGACAAGTTTGAGGCGATTTCGGTGCGCGTTCCCACGATCAAC
GTTACCGCTATCGATCTTTCGGTAACATTAGATAAAACAGTGGATATTGCGACCGTCAATCAAGTGTTAGAATTGGCCGC
CAATGGACGATTTAACGGTATCTTAGGCTATACTGATGAGCCGCTCGTATCCTGTGATTTTAACCATGATCCGCGCTCAA
GTATTGTCGATGGCACCCAAACTCGGGTGAGCGCAGGGCAGTTGGTTAAACTGTTGCTGTGGTGCGATAACGAGTGGGGC
TTTGCAAATCGTATGCTAGATACCAGTTTGGCGATGATTGCAGCTAAACAAAGCTGA

Upstream 100 bases:

>100_bases
AGGTTAAACTTTTGAAAGGTTAATCTGTATAATGCGGCCTGCAATCGTTTGCAGGCCGTTTTTGTATATGCAGTATTGTT
AAGAGGAAATAAAGACCTCA

Downstream 100 bases:

>100_bases
AGATAAGAATTTATACCAATGGGTTAAGCCTAGTGGCCAATTCGACGGGATGTCGAGTGCCGAGTAGCTATCTAAGCTAA
CCGATTGATGCAAAACCAGT

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIVHLTQYDTTHGRFQPRVKLVDDQMLIGDDVIKILHEP
DPAKLPWHEMDIDIVYEATGAILDRNSCEAHIHAGAKQVLISHPSSADVDGTIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDKHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLDKTVDIATVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQTRVSAGQLVKLLLWCDNEWG
FANRMLDTSLAMIAAKQS

Sequences:

>Translated_338_residues
MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIVHLTQYDTTHGRFQPRVKLVDDQMLIGDDVIKILHEP
DPAKLPWHEMDIDIVYEATGAILDRNSCEAHIHAGAKQVLISHPSSADVDGTIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDKHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLDKTVDIATVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQTRVSAGQLVKLLLWCDNEWG
FANRMLDTSLAMIAAKQS
>Mature_338_residues
MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIVHLTQYDTTHGRFQPRVKLVDDQMLIGDDVIKILHEP
DPAKLPWHEMDIDIVYEATGAILDRNSCEAHIHAGAKQVLISHPSSADVDGTIVYGVNQDLLRAEHTVVSNASCTTNCIV
PVIDVLDKHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLDKTVDIATVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQTRVSAGQLVKLLLWCDNEWG
FANRMLDTSLAMIAAKQS

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=38.1656804733728, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI7657116, Length=329, Percent_Identity=36.4741641337386, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1789295, Length=331, Percent_Identity=65.8610271903323, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=40.0611620795107, Blast_Score=258, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17534677, Length=332, Percent_Identity=39.1566265060241, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17534679, Length=332, Percent_Identity=38.855421686747, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI32566163, Length=341, Percent_Identity=38.1231671554252, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17568413, Length=341, Percent_Identity=38.1231671554252, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322468, Length=329, Percent_Identity=37.9939209726444, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6321631, Length=329, Percent_Identity=37.6899696048632, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322409, Length=329, Percent_Identity=37.9939209726444, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI17933600, Length=329, Percent_Identity=37.6899696048632, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI18110149, Length=329, Percent_Identity=37.6899696048632, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI85725000, Length=329, Percent_Identity=37.6899696048632, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI22023983, Length=329, Percent_Identity=37.6899696048632, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=34.0361445783133, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 37210; Mature: 37210

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIVHLTQYDTTHGRFQPRV
CEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCE
KLVDDQMLIGDDVIKILHEPDPAKLPWHEMDIDIVYEATGAILDRNSCEAHIHAGAKQVL
EEECCCEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCEEECCCCEEEE
ISHPSSADVDGTIVYGVNQDLLRAEHTVVSNASCTTNCIVPVIDVLDKHFGVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEEE
VTAIDLSVTLDKTVDIATVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCCCCCHHHCCCCH
TRVSAGQLVKLLLWCDNEWGFANRMLDTSLAMIAAKQS
HHCCHHHHEEEEEEECCCCCHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIVHLTQYDTTHGRFQPRV
CEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCE
KLVDDQMLIGDDVIKILHEPDPAKLPWHEMDIDIVYEATGAILDRNSCEAHIHAGAKQVL
EEECCCEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCEEECCCCEEEE
ISHPSSADVDGTIVYGVNQDLLRAEHTVVSNASCTTNCIVPVIDVLDKHFGVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEEE
VTAIDLSVTLDKTVDIATVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCCCCCHHHCCCCH
TRVSAGQLVKLLLWCDNEWGFANRMLDTSLAMIAAKQS
HHCCHHHHEEEEEEECCCCCHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA