Click here to switch to the map view.

The map label for this gene is 113969067

Identifier: 113969067

GI number: 113969067

Start: 842865

End: 845372

Strand: Direct

Name: 113969067

Synonym: Shewmr4_0723

Alternate gene names: NA

Gene position: 842865-845372 (Clockwise)

Preceding gene: 113969064

Following gene: 113969076

Centisome position: 17.91

GC content: 51.87

Gene sequence:

>2508_bases
ATGTCGATAAAACTCTCACCACTGGCGTTAGCAATTGCAGGAGCGATGACACTGTCAGCCGTGCCCGCTATGGCAAAAGA
TGCCCCTGTCTATGAAAAAGATGCCATTCTCGTGGTGTATAAAGACAATGCGACGAAGGCGGAGCGCTCGGCGGCTCAGC
GTTTAATTCGTGGCACCTTAACCGATGCCAATGCGGACGGTGTCGATGATAAGTTCCAGCATTTACTCAATGGCAAATTG
GCACGTTTAGCCCTGCGTAAGGGCGCCAATATTGAAGATGCGATTAAGGTGATTAGCCGTCATCCGGCGGTGAAATATGC
CGAACCTAACTATATTCTTAAGGCGATAGGCACGCCTGACGATCCAAGCTTTGCTAGCCTGTGGGGCATGAATAACACGG
GACAAAACGGTGGCACCGTCGATGCGGATATCGATGCACCAGAAGCGTGGGAAATCACTACCGGCAGTTCGGATGTGGTG
ATTGGGGTGATTGACACTGGGGTGGATTACAATCATCCCGATCTACAGACCAACATGTGGGTGAATGGTGGCGAGATCCC
GGGTAACGGTATCGACGATGACGGCAACGGCGTGATCGACGATGTTCATGGTTACAGCGCGGTCAACAATAACGGTAACC
CAATGGACGGTAACGGCCACGGTACACATGTGTCTGGCACTATTGGCGCTAAAGGCAATAACGGCGTGGGTGTCGTTGGG
GTGAACTGGGACGTTAAAATCGCCGCCTGTCAGTTCCTCGATGCCGATGGTTATGGTTCTACCGCAGGCGCGATTGCCTG
TTTGGACTACTTTACCGATCTTAAGGTTAATCATGGCGTGGATATCAAAGCTACCAACAACTCTTGGGGCGGCGGCAGCT
TTAGCCAAGCATTAAAAGATGCGATTGAAGCGGGTGGTGAAGCAGGCATTTTATTTGTTGCAGCAGCAGGTAACGATGCG
GTCGATAACGATGCCAGCCCACATTATCCCTCAAGCTACGATTCGGATGTGGTGTTGTCTATTGCCAGTACCGACCGTAA
TGACCGTATGTCAGATTTCTCCCAGTGGGGCTTAACCAGTGTTGATATGGGCGCGCCTGGCACGGCGATTCTGTCAACCA
TCCCAGGCGGTGGCTATGCCACTTACTCTGGTACCTCAATGGCGACGCCCCACGTGACAGGTGCGGCGGCACTCGTGTGG
TCATTAAATCCAGATCTCTCGCCAGTAGAAATGAAATCCTTACTGATGGCGTCGGGTGATGCGAATGCGGACCTCACTGC
TAAAACCGTGGCAGGTACGCGCCTCAATGTGGCAAATGCCTTAGAGCAGGCAAACCCATCTCCTAGCTATAAGTTTACAG
TATCGCCAGCATCGCAATCGGTGGAAGCGGGTAACACGGCAAGTTATAACTTTAGTGTCGGTAGTGTGGCAGGGTGGGAA
GGTGATGTGGCTCTTAGCGTAGCCGTGTCTCCAGCGCTTGAAGGCGTATCCTTATCAGCCTCAACTGTTTCTGCGGGTGG
TTCATTTACCTTAGATGTTGCGACAACGGCGCAAACTGCTTGGGGTGATTACAGCATCACAGTAACAGGTACCGATGGCA
CCATTGAAAAGTCTAAAGTCGTTTCACTGAATGTGTTCCCTCAGGGATTAAATGACTTTAGCTATGGCAATGAAAACGCT
GTTGCTATCCCTGATAACAACGCTAATGGCGTGGTGAGCACTATCGACGTGACCGACGATGTGCAGATTTTTGGTGTGAC
CGCCGATGTGAATATCAGCCACACTTGGATTGGTGACTTACGTGTCGTGTTAACCTCTCCAGCGGGTACCGAAGTGGTTC
TGCATAACCGTGAGGGCGGCAGCGCCGACAACATCGTTAAGAGCTGGGACTTAAGCGCGTTTGACGGTGAAAATGCCCAG
GGTACTTGGTCATTATCTGTTGACGACAATGCGGGCGCGGACACGGGGACCCTGAATAACTGGGGCTTAGTGATCAGCGG
TTTAGGTGAAGCCTCTCCTGCGGCACCTGTTGCAGGTTTCGAGTATGCGGTTGAAGGCTTAAGCGTTGCCTTTACTAACA
CTAGTACCGATGCAAACGATGATATCGTGAGCTATAGCTGGGATTTTGGTGATGACACAAACTCTAGTGAAATGAACCCA
AGCCATGTGTTTGCTGCCGCTGGTACCTACAGAGTGTCGCTTACCGTGACTGACGCCATGGAGCATAGCAACACTGTGAC
CATGGAAGTGCAAGTGTATGAGCATAGCATCAGTGCTGCTGTGACTCGTGCGTTAGTCTCTCGCCGTGGCAGTGCTATGG
TTGACCTCACATGGGATAGCGCTTTAGGTGAAAGCGTCGCCCTGTACCGTGATGGCGAGTTAGTGGCCACGACTGAAAAC
GATGGTAACTACCGCGATCGCTTCACAACGACGGCATCGAGTGTGACGTACCAAGTGTGTGAAACCACAGGCTCACTCTG
TTCTGCGGCGGTTGTCGCGCAGTTCTAA

Upstream 100 bases:

>100_bases
ACATACTGGATGTTCGTCGCTATTATCCAATCAATTTTGAGCGGAGGCTGCGTAATTGCGGTTCCAGAATTTCAACGTAA
AGGACTATAGGAAGCTCAAT

Downstream 100 bases:

>100_bases
TGAAGCCATAAATTAACAAGGCGACCCTAGGGTCGCCTTTTTTGTTCTCTAGACTCGAAAGCTAAGGTTTTTCTTTCACT
TCCTCAGGCTCGGTTTCGGC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSIKLSPLALAIAGAMTLSAVPAMAKDAPVYEKDAILVVYKDNATKAERSAAQRLIRGTLTDANADGVDDKFQHLLNGKL
ARLALRKGANIEDAIKVISRHPAVKYAEPNYILKAIGTPDDPSFASLWGMNNTGQNGGTVDADIDAPEAWEITTGSSDVV
IGVIDTGVDYNHPDLQTNMWVNGGEIPGNGIDDDGNGVIDDVHGYSAVNNNGNPMDGNGHGTHVSGTIGAKGNNGVGVVG
VNWDVKIAACQFLDADGYGSTAGAIACLDYFTDLKVNHGVDIKATNNSWGGGSFSQALKDAIEAGGEAGILFVAAAGNDA
VDNDASPHYPSSYDSDVVLSIASTDRNDRMSDFSQWGLTSVDMGAPGTAILSTIPGGGYATYSGTSMATPHVTGAAALVW
SLNPDLSPVEMKSLLMASGDANADLTAKTVAGTRLNVANALEQANPSPSYKFTVSPASQSVEAGNTASYNFSVGSVAGWE
GDVALSVAVSPALEGVSLSASTVSAGGSFTLDVATTAQTAWGDYSITVTGTDGTIEKSKVVSLNVFPQGLNDFSYGNENA
VAIPDNNANGVVSTIDVTDDVQIFGVTADVNISHTWIGDLRVVLTSPAGTEVVLHNREGGSADNIVKSWDLSAFDGENAQ
GTWSLSVDDNAGADTGTLNNWGLVISGLGEASPAAPVAGFEYAVEGLSVAFTNTSTDANDDIVSYSWDFGDDTNSSEMNP
SHVFAAAGTYRVSLTVTDAMEHSNTVTMEVQVYEHSISAAVTRALVSRRGSAMVDLTWDSALGESVALYRDGELVATTEN
DGNYRDRFTTTASSVTYQVCETTGSLCSAAVVAQF

Sequences:

>Translated_835_residues
MSIKLSPLALAIAGAMTLSAVPAMAKDAPVYEKDAILVVYKDNATKAERSAAQRLIRGTLTDANADGVDDKFQHLLNGKL
ARLALRKGANIEDAIKVISRHPAVKYAEPNYILKAIGTPDDPSFASLWGMNNTGQNGGTVDADIDAPEAWEITTGSSDVV
IGVIDTGVDYNHPDLQTNMWVNGGEIPGNGIDDDGNGVIDDVHGYSAVNNNGNPMDGNGHGTHVSGTIGAKGNNGVGVVG
VNWDVKIAACQFLDADGYGSTAGAIACLDYFTDLKVNHGVDIKATNNSWGGGSFSQALKDAIEAGGEAGILFVAAAGNDA
VDNDASPHYPSSYDSDVVLSIASTDRNDRMSDFSQWGLTSVDMGAPGTAILSTIPGGGYATYSGTSMATPHVTGAAALVW
SLNPDLSPVEMKSLLMASGDANADLTAKTVAGTRLNVANALEQANPSPSYKFTVSPASQSVEAGNTASYNFSVGSVAGWE
GDVALSVAVSPALEGVSLSASTVSAGGSFTLDVATTAQTAWGDYSITVTGTDGTIEKSKVVSLNVFPQGLNDFSYGNENA
VAIPDNNANGVVSTIDVTDDVQIFGVTADVNISHTWIGDLRVVLTSPAGTEVVLHNREGGSADNIVKSWDLSAFDGENAQ
GTWSLSVDDNAGADTGTLNNWGLVISGLGEASPAAPVAGFEYAVEGLSVAFTNTSTDANDDIVSYSWDFGDDTNSSEMNP
SHVFAAAGTYRVSLTVTDAMEHSNTVTMEVQVYEHSISAAVTRALVSRRGSAMVDLTWDSALGESVALYRDGELVATTEN
DGNYRDRFTTTASSVTYQVCETTGSLCSAAVVAQF
>Mature_834_residues
SIKLSPLALAIAGAMTLSAVPAMAKDAPVYEKDAILVVYKDNATKAERSAAQRLIRGTLTDANADGVDDKFQHLLNGKLA
RLALRKGANIEDAIKVISRHPAVKYAEPNYILKAIGTPDDPSFASLWGMNNTGQNGGTVDADIDAPEAWEITTGSSDVVI
GVIDTGVDYNHPDLQTNMWVNGGEIPGNGIDDDGNGVIDDVHGYSAVNNNGNPMDGNGHGTHVSGTIGAKGNNGVGVVGV
NWDVKIAACQFLDADGYGSTAGAIACLDYFTDLKVNHGVDIKATNNSWGGGSFSQALKDAIEAGGEAGILFVAAAGNDAV
DNDASPHYPSSYDSDVVLSIASTDRNDRMSDFSQWGLTSVDMGAPGTAILSTIPGGGYATYSGTSMATPHVTGAAALVWS
LNPDLSPVEMKSLLMASGDANADLTAKTVAGTRLNVANALEQANPSPSYKFTVSPASQSVEAGNTASYNFSVGSVAGWEG
DVALSVAVSPALEGVSLSASTVSAGGSFTLDVATTAQTAWGDYSITVTGTDGTIEKSKVVSLNVFPQGLNDFSYGNENAV
AIPDNNANGVVSTIDVTDDVQIFGVTADVNISHTWIGDLRVVLTSPAGTEVVLHNREGGSADNIVKSWDLSAFDGENAQG
TWSLSVDDNAGADTGTLNNWGLVISGLGEASPAAPVAGFEYAVEGLSVAFTNTSTDANDDIVSYSWDFGDDTNSSEMNPS
HVFAAAGTYRVSLTVTDAMEHSNTVTMEVQVYEHSISAAVTRALVSRRGSAMVDLTWDSALGESVALYRDGELVATTEND
GNYRDRFTTTASSVTYQVCETTGSLCSAAVVAQF

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI20336244, Length=454, Percent_Identity=25.9911894273128, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI76443679, Length=343, Percent_Identity=25.0728862973761, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=581, Percent_Identity=23.0636833046472, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25141268, Length=326, Percent_Identity=24.5398773006135, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320775, Length=443, Percent_Identity=29.1196388261851, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324576, Length=380, Percent_Identity=30.7894736842105, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319893, Length=361, Percent_Identity=26.8698060941828, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136192, Length=334, Percent_Identity=27.2455089820359, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 86424; Mature: 86293

Theoretical pI: Translated: 4.02; Mature: 4.02

Prosite motif: PS00018 EF_HAND_1 ; PS50093 PKD ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKLSPLALAIAGAMTLSAVPAMAKDAPVYEKDAILVVYKDNATKAERSAAQRLIRGTL
CCEEECHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
TDANADGVDDKFQHLLNGKLARLALRKGANIEDAIKVISRHPAVKYAEPNYILKAIGTPD
CCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCEEEEECCCCC
DPSFASLWGMNNTGQNGGTVDADIDAPEAWEITTGSSDVVIGVIDTGVDYNHPDLQTNMW
CCCHHEECCCCCCCCCCCEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEE
VNGGEIPGNGIDDDGNGVIDDVHGYSAVNNNGNPMDGNGHGTHVSGTIGAKGNNGVGVVG
EECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEE
VNWDVKIAACQFLDADGYGSTAGAIACLDYFTDLKVNHGVDIKATNNSWGGGSFSQALKD
ECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCEECCCEEEEECCCCCCCCHHHHHHHH
AIEAGGEAGILFVAAAGNDAVDNDASPHYPSSYDSDVVLSIASTDRNDRMSDFSQWGLTS
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCE
VDMGAPGTAILSTIPGGGYATYSGTSMATPHVTGAAALVWSLNPDLSPVEMKSLLMASGD
ECCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHEECCC
ANADLTAKTVAGTRLNVANALEQANPSPSYKFTVSPASQSVEAGNTASYNFSVGSVAGWE
CCCCEEEEEECCCEEHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCC
GDVALSVAVSPALEGVSLSASTVSAGGSFTLDVATTAQTAWGDYSITVTGTDGTIEKSKV
CCEEEEEEECCCCCCCEEECEEECCCCEEEEEEEECCEECCCCEEEEEECCCCCCCCCEE
VSLNVFPQGLNDFSYGNENAVAIPDNNANGVVSTIDVTDDVQIFGVTADVNISHTWIGDL
EEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEEEEEEEEECEEEEEEECCE
RVVLTSPAGTEVVLHNREGGSADNIVKSWDLSAFDGENAQGTWSLSVDDNAGADTGTLNN
EEEEECCCCCEEEEECCCCCCHHCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
WGLVISGLGEASPAAPVAGFEYAVEGLSVAFTNTSTDANDDIVSYSWDFGDDTNSSEMNP
CCEEEEECCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCC
SHVFAAAGTYRVSLTVTDAMEHSNTVTMEVQVYEHSISAAVTRALVSRRGSAMVDLTWDS
CEEEEECCEEEEEEEEEEHHCCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECC
ALGESVALYRDGELVATTENDGNYRDRFTTTASSVTYQVCETTGSLCSAAVVAQF
CCCCEEEEEECCEEEEEECCCCCCCCEEEECHHHEEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIKLSPLALAIAGAMTLSAVPAMAKDAPVYEKDAILVVYKDNATKAERSAAQRLIRGTL
CEEECHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
TDANADGVDDKFQHLLNGKLARLALRKGANIEDAIKVISRHPAVKYAEPNYILKAIGTPD
CCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCCEEEEECCCCC
DPSFASLWGMNNTGQNGGTVDADIDAPEAWEITTGSSDVVIGVIDTGVDYNHPDLQTNMW
CCCHHEECCCCCCCCCCCEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEE
VNGGEIPGNGIDDDGNGVIDDVHGYSAVNNNGNPMDGNGHGTHVSGTIGAKGNNGVGVVG
EECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEE
VNWDVKIAACQFLDADGYGSTAGAIACLDYFTDLKVNHGVDIKATNNSWGGGSFSQALKD
ECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHCEECCCEEEEECCCCCCCCHHHHHHHH
AIEAGGEAGILFVAAAGNDAVDNDASPHYPSSYDSDVVLSIASTDRNDRMSDFSQWGLTS
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCE
VDMGAPGTAILSTIPGGGYATYSGTSMATPHVTGAAALVWSLNPDLSPVEMKSLLMASGD
ECCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHEECCC
ANADLTAKTVAGTRLNVANALEQANPSPSYKFTVSPASQSVEAGNTASYNFSVGSVAGWE
CCCCEEEEEECCCEEHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCC
GDVALSVAVSPALEGVSLSASTVSAGGSFTLDVATTAQTAWGDYSITVTGTDGTIEKSKV
CCEEEEEEECCCCCCCEEECEEECCCCEEEEEEEECCEECCCCEEEEEECCCCCCCCCEE
VSLNVFPQGLNDFSYGNENAVAIPDNNANGVVSTIDVTDDVQIFGVTADVNISHTWIGDL
EEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEEEEEEEEECEEEEEEECCE
RVVLTSPAGTEVVLHNREGGSADNIVKSWDLSAFDGENAQGTWSLSVDDNAGADTGTLNN
EEEEECCCCCEEEEECCCCCCHHCEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCC
WGLVISGLGEASPAAPVAGFEYAVEGLSVAFTNTSTDANDDIVSYSWDFGDDTNSSEMNP
CCEEEEECCCCCCCCCCCCHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCC
SHVFAAAGTYRVSLTVTDAMEHSNTVTMEVQVYEHSISAAVTRALVSRRGSAMVDLTWDS
CEEEEECCEEEEEEEEEEHHCCCCEEEEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECC
ALGESVALYRDGELVATTENDGNYRDRFTTTASSVTYQVCETTGSLCSAAVVAQF
CCCCEEEEEECCEEEEEECCCCCCCCEEEECHHHEEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]