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The map label for this gene is pepB [H]

Identifier: 113969076

GI number: 113969076

Start: 852649

End: 853941

Strand: Direct

Name: pepB [H]

Synonym: Shewmr4_0732

Alternate gene names: 113969076

Gene position: 852649-853941 (Clockwise)

Preceding gene: 113969067

Following gene: 113969077

Centisome position: 18.12

GC content: 53.13

Gene sequence:

>1293_bases
ATGAGTGAACTTAAAGTGACTGAAGTGATGAGAGTTGAGTTAACCAAAGATACCCCCGCAGCCCATTGGGGCAAAGCTGA
TGTGACCTTCAATGCCGAAGGCGCATTAGTCCACTTAGGTGGCGGCGATGAGCTGCGCCAAATTCAAATGGCGGCGCGTA
AATTACGTAATCAAGGGATTAACACCGTCGCCTTGGCGGGGTCTCTTTGGGATCTCAATAGCCAATGGGTCTTCGCCCAA
GGTTTTGCCACAGCTAAACCCGGTTATAAGATCCAATGGTGCGGTGATGACGCAGTGCAAGCCGAGTTACAACGTCGCTT
AGAAGTGGCGACATTTGCCCGTCAACTGATCAACGACACCCCTGAAAATCTGTCTCCGGTGAAACTGGCGCAGCAAGCAG
CCAAATGGTTAGCCGATATCGGTGGCGCTAAGGTGAGCTACCGTATCATTGAAGGCGAAGCATTATTAGAAGAGCAATGG
ATTGGTATCCATGCCGTAGGCCGTGGCAGCGAGCGTCCACCAGCGATGTTAGAGCTAGACTTTAACCCGCTGTCAGCCGA
TGCCCCAGTATCTGTTGCCTTAGTCGGTAAAGGGATTACCTTCGACTCAGGCGGTTATAGCATTAAAGCCTCTGAAGGCA
TGCTGGGTATGAAGTGCGATATGGGCGGCGCCGCAACGGTTACCGCAGCACTGGGCCTTGCGATTAAATCGGGCCTGAAC
AAACGCGTTAAGTTATTCCTCTGCTGCGCAGAAAACCTCATTAGCGGCCGCGCCTATAAGCTGGGTGATATCCTCACTTA
CAAAAATGGCGTGACAGTCGAAGTGGTTAACACGGATGCCGAAGGTCGTTTAGTGCTGGCCGATGGTCTGCAAGCGGCTT
CTGCGACGGGTGCACCTTTTATTATCGATGCGGCAACCTTAACTGGCGCAGCTGTGATGGCGGTGGGCTCTAACTACAAC
GCGATTTTCTCGCCTCAGACTGAAGTGTTACAGCTGGCGCAGCAAAAGGCGTCGACAGTGGCCGAGCGTGTATGGCCATT
GCCATTGGATCCTTGGCACAAAGACATGTGCCCATCTGCCTATGCAGATACCGCAAACAGTCGCCCTGTAAAAGGTGGTG
GTGCAGGTGGTGCCTCGAATGCGGCGGGCTTCCTGTGGCGTTTCGTTTCGCCAGAAGCGAAATGGTTACACGTTGATTTA
GCGGCGGCCTTCGAAGATTCGGCTTCTGCACTATGGGGCGCAGGTGCGACCACCAATGGCGTGCTGACCATCAGCGAACT
GATTAAAGGTTAA

Upstream 100 bases:

>100_bases
GGTCGTACTGTGTATACCCCAAAAGCTTGAGGATGCTGATACTCGTCTCCTTAATTGACATGGGTATAAAAGCAAGAACA
AATCAACATAAGGACCCCTC

Downstream 100 bases:

>100_bases
GTTTGCCTTTGCGACTGCAGCTCGCCAGTCGGCTCGCTTTTTTGATTTAAAACCGCCTTCGGGCGGTTTTTTATTGCCTA
AAATTGAGGAATAGGATGTA

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSELKVTEVMRVELTKDTPAAHWGKADVTFNAEGALVHLGGGDELRQIQMAARKLRNQGINTVALAGSLWDLNSQWVFAQ
GFATAKPGYKIQWCGDDAVQAELQRRLEVATFARQLINDTPENLSPVKLAQQAAKWLADIGGAKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLELDFNPLSADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTEVLQLAQQKASTVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AAAFEDSASALWGAGATTNGVLTISELIKG

Sequences:

>Translated_430_residues
MSELKVTEVMRVELTKDTPAAHWGKADVTFNAEGALVHLGGGDELRQIQMAARKLRNQGINTVALAGSLWDLNSQWVFAQ
GFATAKPGYKIQWCGDDAVQAELQRRLEVATFARQLINDTPENLSPVKLAQQAAKWLADIGGAKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLELDFNPLSADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTEVLQLAQQKASTVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AAAFEDSASALWGAGATTNGVLTISELIKG
>Mature_429_residues
SELKVTEVMRVELTKDTPAAHWGKADVTFNAEGALVHLGGGDELRQIQMAARKLRNQGINTVALAGSLWDLNSQWVFAQG
FATAKPGYKIQWCGDDAVQAELQRRLEVATFARQLINDTPENLSPVKLAQQAAKWLADIGGAKVSYRIIEGEALLEEQWI
GIHAVGRGSERPPAMLELDFNPLSADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLNK
RVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYNA
IFSPQTEVLQLAQQKASTVAERVWPLPLDPWHKDMCPSAYADTANSRPVKGGGAGGASNAAGFLWRFVSPEAKWLHVDLA
AAFEDSASALWGAGATTNGVLTISELIKG

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=295, Percent_Identity=37.2881355932203, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI47155554, Length=262, Percent_Identity=39.6946564885496, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI87082123, Length=429, Percent_Identity=50.1165501165501, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1790710, Length=288, Percent_Identity=38.5416666666667, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=37, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221379063, Length=266, Percent_Identity=38.3458646616541, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI221379062, Length=266, Percent_Identity=38.3458646616541, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI21357381, Length=266, Percent_Identity=38.3458646616541, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21355725, Length=295, Percent_Identity=32.2033898305085, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=32.2033898305085, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662227, Length=297, Percent_Identity=28.6195286195286, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI161077148, Length=299, Percent_Identity=30.4347826086957, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20130057, Length=299, Percent_Identity=30.4347826086957, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20129969, Length=295, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355645, Length=296, Percent_Identity=29.0540540540541, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24662223, Length=296, Percent_Identity=29.0540540540541, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129963, Length=297, Percent_Identity=29.2929292929293, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=27.7966101694915, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646701, Length=222, Percent_Identity=30.1801801801802, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646703, Length=222, Percent_Identity=30.1801801801802, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21358201, Length=222, Percent_Identity=30.1801801801802, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 45368; Mature: 45237

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKVTEVMRVELTKDTPAAHWGKADVTFNAEGALVHLGGGDELRQIQMAARKLRNQGI
CCCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCC
NTVALAGSLWDLNSQWVFAQGFATAKPGYKIQWCGDDAVQAELQRRLEVATFARQLINDT
CEEEEECEEECCCCCEEEECCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLADIGGAKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLELD
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEE
FNPLSADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTEVLQLAQQKASTVAERVWPLPLDPWHKDMCPSA
EEEEHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCH
YADTANSRPVKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAAAFEDSASALWGAGATTNG
HHCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCEEEEEEEEEHHCCCCHHHCCCCCCCCC
VLTISELIKG
EEEHHHHHCC
>Mature Secondary Structure 
SELKVTEVMRVELTKDTPAAHWGKADVTFNAEGALVHLGGGDELRQIQMAARKLRNQGI
CCCCEEEEEEEEEECCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCC
NTVALAGSLWDLNSQWVFAQGFATAKPGYKIQWCGDDAVQAELQRRLEVATFARQLINDT
CEEEEECEEECCCCCEEEECCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLADIGGAKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLELD
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEE
FNPLSADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTEVLQLAQQKASTVAERVWPLPLDPWHKDMCPSA
EEEEHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCH
YADTANSRPVKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAAAFEDSASALWGAGATTNG
HHCCCCCCCCCCCCCCCCCCCHHEEEEEECCCCEEEEEEEEEHHCCCCHHHCCCCCCCCC
VLTISELIKG
EEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA