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The map label for this gene is hflC [H]

Identifier: 113968945

GI number: 113968945

Start: 694402

End: 695295

Strand: Direct

Name: hflC [H]

Synonym: Shewmr4_0601

Alternate gene names: 113968945

Gene position: 694402-695295 (Clockwise)

Preceding gene: 113968944

Following gene: 113968946

Centisome position: 14.75

GC content: 44.07

Gene sequence:

>894_bases
ATGGGTAGATTAAGTATTGTTCTGATTGCCATAGTATTAGGCATAGGTCTGTCATCTGTGATGGTGGTTAACGAAGGCGA
GCGTGCGATTGTGGCGCGTTTCGGTGAAATCGTTAAAGACAAGGTTGACGACAAACAAGTGACCCGCGTTTTCGGTCCTG
GCTTGCACTTTAAAGTGCCAGTGATCGATAAGGTGAAGTTGCTCGATGCTCGTATTCAAACCTTAGACGGTGCAGCGGAT
CGTTTCGTGACCTCTGAGAAAAAAGATTTGATGGTCGACTCTTATGTAAAGTGGCGTATTTTCGATTTCGAAAAATACTA
TCTCTCCACTAATGGCGGGATTAAATCGAATGCTGAAACCTTACTGCAACGTAAGATCAACAACGATTTACGTACCGAAT
TTGGTCGTCGCACTATCAAGGAAATCGTATCTGGTAAACGCGATGAGCTGCAAAATGATGCGCTAGAAAACGCCTCTGAA
AGCGCTAAAGACTTAGGTATTGAAGTCGTTGACGTGCGTGTTAAGCAAATCAACCTTCCAGCAAACGTGAGTAACAGTAT
TTACCAACGTATGCGTGCCGAACGTCAAGCGGTTGCTAAAGAGCATAGGGCACAGGGTAAAGAGCAATCTGAAATCATTC
GTGCAACGATTGATGCCAATGTGACAGTGAAGATTGCCGAAGCTGAACGTAAGGCCTTAACCATTCGCGGTGAAGGTGAT
GCATTAGCGGCGAAGATATATTCTGACGCTTACAATAAAGATCCTGAGTTCTTCAGCTTTTTACGTAGCTTAGATGCTTA
CCGTGCAAGTTTCTCCGGTAAATCTGATGTGATGGTGCTAGAACCTGATAGCGAGTTCTTCAAGTATATGAAGAGCACTT
CACCTAAGAAGTAA

Upstream 100 bases:

>100_bases
GAATGTCAATTCTTCATCTATGTCAACGACTCGCATCAGCGAGCCTTTGAGTGGACGTCCGTCTCGCGAGGACCGTGCTC
GCCAAGGGAGGGAGTAATTC

Downstream 100 bases:

>100_bases
GCAGCAAGTTTTGCATTGAAATGGGTCCTGATATCAGGGCCCATTTTTTTTAGCTGCGGGAAAATACAAAATCGCAAAAA
TGAGAGCTTAAACTATATTA

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDDKQVTRVFGPGLHFKVPVIDKVKLLDARIQTLDGAAD
RFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASE
SAKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
ALAAKIYSDAYNKDPEFFSFLRSLDAYRASFSGKSDVMVLEPDSEFFKYMKSTSPKK

Sequences:

>Translated_297_residues
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDDKQVTRVFGPGLHFKVPVIDKVKLLDARIQTLDGAAD
RFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASE
SAKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
ALAAKIYSDAYNKDPEFFSFLRSLDAYRASFSGKSDVMVLEPDSEFFKYMKSTSPKK
>Mature_296_residues
GRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDDKQVTRVFGPGLHFKVPVIDKVKLLDARIQTLDGAADR
FVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAETLLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASES
AKDLGIEVVDVRVKQINLPANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGDA
LAAKIYSDAYNKDPEFFSFLRSLDAYRASFSGKSDVMVLEPDSEFFKYMKSTSPKK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=315, Percent_Identity=52.3809523809524, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1786697, Length=252, Percent_Identity=24.6031746031746, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=205, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17569493, Length=205, Percent_Identity=26.8292682926829, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33361; Mature: 33229

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDDKQVTRVFGPGLHFKVP
CCHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECC
VIDKVKLLDARIQTLDGAADRFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAET
CHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCEEEEEEEEEEEEEEECCCCCCCHHHH
LLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASESAKDLGIEVVDVRVKQINLP
HHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCC
ANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHEECCCEEEEEEECCCEEEEEECCCC
ALAAKIYSDAYNKDPEFFSFLRSLDAYRASFSGKSDVMVLEPDSEFFKYMKSTSPKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRLSIVLIAIVLGIGLSSVMVVNEGERAIVARFGEIVKDKVDDKQVTRVFGPGLHFKVP
CHHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECC
VIDKVKLLDARIQTLDGAADRFVTSEKKDLMVDSYVKWRIFDFEKYYLSTNGGIKSNAET
CHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCEEEEEEEEEEEEEEECCCCCCCHHHH
LLQRKINNDLRTEFGRRTIKEIVSGKRDELQNDALENASESAKDLGIEVVDVRVKQINLP
HHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCC
ANVSNSIYQRMRAERQAVAKEHRAQGKEQSEIIRATIDANVTVKIAEAERKALTIRGEGD
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEHEECCCEEEEEEECCCEEEEEECCCC
ALAAKIYSDAYNKDPEFFSFLRSLDAYRASFSGKSDVMVLEPDSEFFKYMKSTSPKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]