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The map label for this gene is hflK [H]

Identifier: 113968944

GI number: 113968944

Start: 693253

End: 694398

Strand: Direct

Name: hflK [H]

Synonym: Shewmr4_0600

Alternate gene names: 113968944

Gene position: 693253-694398 (Clockwise)

Preceding gene: 113968943

Following gene: 113968945

Centisome position: 14.73

GC content: 47.56

Gene sequence:

>1146_bases
ATGGCTTGGAACGAGCCCGGTAACAAGGGTAATGATCCTTGGGGAAATAAAGGTGGTAACGACAAAGGACCACCGGACCT
TGATGAGGTTTTTCGTAATCTTTCAAAACGCTTTGGCGGCAAAGGCAATGGCTCATCAGGCCAGAACTTTAGTTCGTTTA
GCGTAATCATCATTCTTGCCATCGCTTTTGTTGTTTGGGGACTCTCGGGTTTTTACACCATTAAAGAAGCTGAGCGTGGT
GTCGCGCTGCGTTTTGGTCAGCATATTGGTGAAGTGGGCCCAGGTCTGCATTGGAAAGCCACTTTTATCGACCAGATTTA
CCCTGTTGATGTGCAATCTGTCCGCTCTATTCCTGCCTCAGGCAGTATGTTGACCTCAGATGAAAACGTCGTAAAGGTAG
AGTTGGACGTACAGTATCGTATTTTAGATGCGTACTCTTATCTGTTCAGTGCAGTTGATGCCAATGCCAGCTTACGTGAA
GCCACAGACAGTGCGCTGCGTTATGTCATCGGCCACAACAAAATGGACGATATTCTAACCACGGGTCGTGATGCCATTCG
TCGTGATACTTGGAAAGAGTTAGAGCGCATAATTGAGCCGTACAAATTAGGCTTAGCCATTGTTGACGTTAACTTTTTGC
CAGCTCGTCCACCTGAAGAAGTGAAAGATGCTTTCGATGATGCGATTGCGGCTCAAGAAGACGAACAGCGCTTTATCCGT
GAAGCAGAAGCTTATGCCCGTGAAGTTGAGCCTAAAGCGCGCGGTGAAGTCGAGCGTATGGCACAACAAGCCAATGCCTA
TAAAGAACGTGAAGTTCTTGAGGCTCGCGGTAAAGTGGCTCGTTTCGAGTTGTTGTTACCTGAGTACCAAGCGGCACCTG
AAGTGACCCGTAAGCGTTTGTATCTTGATGCAATGCAGCAGGTGATGACAGATACCAATAAAGTACTGATCGACACAAAG
AACAGTGGCAACTTAATGTATTTGCCCTTAGACAAGTTAATGAAAGAGAAGCCTGTGACTATGCCAGAGGCTGAGAATAA
GTCTCAGCAGAATGTCAATTCTTCATCTATGTCAACGACTCGCATCAGCGAGCCTTTGAGTGGACGTCCGTCTCGCGAGG
ACCGTGCTCGCCAAGGGAGGGAGTAA

Upstream 100 bases:

>100_bases
ACAGAGTCAGGGTGAGTTAGAAACCTTTATCTTCGATCCGTCGATAGAAAAGGCTGTTTGTTAATAATCTAATTTATTTC
ATCCACTTATGGAGTGCTAA

Downstream 100 bases:

>100_bases
TTCATGGGTAGATTAAGTATTGTTCTGATTGCCATAGTATTAGGCATAGGTCTGTCATCTGTGATGGTGGTTAACGAAGG
CGAGCGTGCGATTGTGGCGC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MAWNEPGNKGNDPWGNKGGNDKGPPDLDEVFRNLSKRFGGKGNGSSGQNFSSFSVIIILAIAFVVWGLSGFYTIKEAERG
VALRFGQHIGEVGPGLHWKATFIDQIYPVDVQSVRSIPASGSMLTSDENVVKVELDVQYRILDAYSYLFSAVDANASLRE
ATDSALRYVIGHNKMDDILTTGRDAIRRDTWKELERIIEPYKLGLAIVDVNFLPARPPEEVKDAFDDAIAAQEDEQRFIR
EAEAYAREVEPKARGEVERMAQQANAYKEREVLEARGKVARFELLLPEYQAAPEVTRKRLYLDAMQQVMTDTNKVLIDTK
NSGNLMYLPLDKLMKEKPVTMPEAENKSQQNVNSSSMSTTRISEPLSGRPSREDRARQGRE

Sequences:

>Translated_381_residues
MAWNEPGNKGNDPWGNKGGNDKGPPDLDEVFRNLSKRFGGKGNGSSGQNFSSFSVIIILAIAFVVWGLSGFYTIKEAERG
VALRFGQHIGEVGPGLHWKATFIDQIYPVDVQSVRSIPASGSMLTSDENVVKVELDVQYRILDAYSYLFSAVDANASLRE
ATDSALRYVIGHNKMDDILTTGRDAIRRDTWKELERIIEPYKLGLAIVDVNFLPARPPEEVKDAFDDAIAAQEDEQRFIR
EAEAYAREVEPKARGEVERMAQQANAYKEREVLEARGKVARFELLLPEYQAAPEVTRKRLYLDAMQQVMTDTNKVLIDTK
NSGNLMYLPLDKLMKEKPVTMPEAENKSQQNVNSSSMSTTRISEPLSGRPSREDRARQGRE
>Mature_380_residues
AWNEPGNKGNDPWGNKGGNDKGPPDLDEVFRNLSKRFGGKGNGSSGQNFSSFSVIIILAIAFVVWGLSGFYTIKEAERGV
ALRFGQHIGEVGPGLHWKATFIDQIYPVDVQSVRSIPASGSMLTSDENVVKVELDVQYRILDAYSYLFSAVDANASLREA
TDSALRYVIGHNKMDDILTTGRDAIRRDTWKELERIIEPYKLGLAIVDVNFLPARPPEEVKDAFDDAIAAQEDEQRFIRE
AEAYAREVEPKARGEVERMAQQANAYKEREVLEARGKVARFELLLPEYQAAPEVTRKRLYLDAMQQVMTDTNKVLIDTKN
SGNLMYLPLDKLMKEKPVTMPEAENKSQQNVNSSSMSTTRISEPLSGRPSREDRARQGRE

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=361, Percent_Identity=54.5706371191136, Blast_Score=359, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: NA

Molecular weight: Translated: 42738; Mature: 42606

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGNKGNDPWGNKGGNDKGPPDLDEVFRNLSKRFGGKGNGSSGQNFSSFSVIIILA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IAFVVWGLSGFYTIKEAERGVALRFGQHIGEVGPGLHWKATFIDQIYPVDVQSVRSIPAS
HHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCHHHHHCCCCC
GSMLTSDENVVKVELDVQYRILDAYSYLFSAVDANASLREATDSALRYVIGHNKMDDILT
CCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TGRDAIRRDTWKELERIIEPYKLGLAIVDVNFLPARPPEEVKDAFDDAIAAQEDEQRFIR
HCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHH
EAEAYAREVEPKARGEVERMAQQANAYKEREVLEARGKVARFELLLPEYQAAPEVTRKRL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHH
YLDAMQQVMTDTNKVLIDTKNSGNLMYLPLDKLMKEKPVTMPEAENKSQQNVNSSSMSTT
HHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHCCCCHHCCHH
RISEPLSGRPSREDRARQGRE
HHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
AWNEPGNKGNDPWGNKGGNDKGPPDLDEVFRNLSKRFGGKGNGSSGQNFSSFSVIIILA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IAFVVWGLSGFYTIKEAERGVALRFGQHIGEVGPGLHWKATFIDQIYPVDVQSVRSIPAS
HHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCHHHHHCCCCC
GSMLTSDENVVKVELDVQYRILDAYSYLFSAVDANASLREATDSALRYVIGHNKMDDILT
CCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TGRDAIRRDTWKELERIIEPYKLGLAIVDVNFLPARPPEEVKDAFDDAIAAQEDEQRFIR
HCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHH
EAEAYAREVEPKARGEVERMAQQANAYKEREVLEARGKVARFELLLPEYQAAPEVTRKRL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHH
YLDAMQQVMTDTNKVLIDTKNSGNLMYLPLDKLMKEKPVTMPEAENKSQQNVNSSSMSTT
HHHHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHCCCCHHCCHH
RISEPLSGRPSREDRARQGRE
HHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]