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The map label for this gene is mutL [H]

Identifier: 113968940

GI number: 113968940

Start: 688666

End: 690600

Strand: Direct

Name: mutL [H]

Synonym: Shewmr4_0596

Alternate gene names: 113968940

Gene position: 688666-690600 (Clockwise)

Preceding gene: 113968939

Following gene: 113968941

Centisome position: 14.63

GC content: 51.73

Gene sequence:

>1935_bases
ATGGGGATCCAGATCCTTCCGCCGCAACTAGCCAACCAAATCGCCGCCGGTGAGGTGGTCGAACGGCCTGCTTCCGTGGT
GAAGGAACTTGTCGAGAACAGCCTAGATGCTGGGGCGACGCGTATCGATATCGAAATCGATAAGGGCGGCAGCAAGCTGA
TTAAGATCCGTGACAATGGTTCGGGGATCCCAAAGGATGAGCTGGCTTTGGCCTTGTCGCGCCATGCCACCTCGAAACTG
CACTCCCTTGACGACCTTGAAGCCATCCTCAGCTTTGGTTTTCGCGGCGAGGCATTGGCGAGTATCAGCTCTGTGTCCCG
CTTAACCTTGACCTCGCGTACGGCCGAGCAAACGGAAGCCTGGCAGGCTTATGCCGAAGGCGTCGACATGGCGGTTAAGG
TCATGCCGGCCGCGCATCCTGTTGGTTCAACTATCGAAGTTGTCGATCTGTTCTTTAATACGCCCGCCCGTAGACGTTTT
CTTAAAAGCGATAAAACCGAATTTACTCATATCGATGAATGGTTAAAACGCATTGCGTTAGTGCGTGGGGATATCCACTT
TACCTTGACCCACAATGGCAAAACCGTACGTAACTATCGTCCGGCGATGAATGAGCCGCAGTATTTGCAGCGATTGACTC
AGGTTGCTGGACGCCAATTTGCCGATGAGGCGTTGCGGGTCGAATGCCAACACGATGACCTACGTTTAAGTGGTTATTTG
CAGTCGCCTTGGTCAACGGTGTTAACCGACACCCATTATTTTTATGTGAATGGCCGCTTAGTGCGCGACCGTTTAGTCAA
TCATGCGGTGCGCCAAGCATTTGCCCAGAAAGCCGAGGTCGAACAGCCGGGTTATGTGTTGATGCTGGATATCGATCCTC
ATCAGGTGGATGTGAACGTGCATCCGGCGAAACACGAAGTGCGCTTTCATCAGAGCCGTTATGTGCATGATTATATTCTG
CAGGCACTGCAATCGGCGCTCGAAGAAGCGGGTGAGCTGGGTTTTGAGCATCCTTTCGAGCCAAGTTCGCCACAGGTTAG
GGATGAGGTCTCTCTCTCCGAATCTGGGACGCAGACACAAACAGAGCATCATGCCTTCGAGCTGCAATCGCCTGAATCTA
AAACGCATTCAACTTGGAATGAAGCTTCACGTGTTGATACTTCTCGCGTCGAGATATCACGGGATTCTCAGCTTACTGAG
CGTACTCGGGACATTGCTAGCGCGCGTCCGTATTCTGGCGTGCAAAGCAATGCCTACGGCAGTATGGCGGTTCCGCGGGA
GTCACGCAGTGGTCCGACAGGGGAAAGTCGTGCCCGAGCCGAGCTTCCTTCTAAGGCGGCAATCGCCAGTTACGGCGAAT
TATTGCAAACGCCATCCTATAGCGTGCAGGACAAGCCGTATCAACCCGTGCTTGCAATGCCCGCCATGCTCAATGGTCAA
TATTGGGTATTAGCGCAAGGGCAAAACCTGAGTCTGTTGCCGATTCAATCTGTGGCGTTAGCGACTCGTAGCCATGAGAT
AGAAACAAAGCTGGCAACCGGCTTGATAGGTCAGCCATTATTGATGCCAGTGTCGATTGCCGCCGATACGGATTGGCCAG
CATTACTCGAAGAACATGAAACACTTATCCGGCAATTAGGATTAGAACTAACAATTCGCTATCAGCAGTTGATAATCAAA
AAAGTGCCCCCATATCTCAGGGATAGCCAGTTAGCGAAGGTGATCCCCGAGTGGTTGCAATCGCTACGTTTTGAAGCGCC
AGCACCTAATGCATTGGCTGTGTGGCTGGCAGAGCAGAGTTTAACTGGATTTACCTCGGCTGCGGATATTTGGGCGGCCT
ATAGTCAGTTAACTGAAGAGAAAAGACAGCAAATTGCCGATAAAGCAGTATCCTTACCTTGGCAATCGTGGCTAGAAGAG
CAAGCAATTGAATAA

Upstream 100 bases:

>100_bases
GTGCCTATGGCCAGCATTAAGCGCGCCAATGGCATGAAGACGGATGTGGTGCAACTCGGACAAACACTCGTCATTCCTGA
GAGTTAATAGGATGAAGTCT

Downstream 100 bases:

>100_bases
AGAATTACAGCCAAAAGTGGTTTTTTTGATGGGACCAACGGCGTCCGGAAAAACCGCTTTAGCACTCGAATTAGCCGAAA
AGCATAATTGCGAGATTATC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKL
HSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKVMPAAHPVGSTIEVVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYIL
QALQSALEEAGELGFEHPFEPSSPQVRDEVSLSESGTQTQTEHHAFELQSPESKTHSTWNEASRVDTSRVEISRDSQLTE
RTRDIASARPYSGVQSNAYGSMAVPRESRSGPTGESRARAELPSKAAIASYGELLQTPSYSVQDKPYQPVLAMPAMLNGQ
YWVLAQGQNLSLLPIQSVALATRSHEIETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQLIIK
KVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYSQLTEEKRQQIADKAVSLPWQSWLEE
QAIE

Sequences:

>Translated_644_residues
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKL
HSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKVMPAAHPVGSTIEVVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYIL
QALQSALEEAGELGFEHPFEPSSPQVRDEVSLSESGTQTQTEHHAFELQSPESKTHSTWNEASRVDTSRVEISRDSQLTE
RTRDIASARPYSGVQSNAYGSMAVPRESRSGPTGESRARAELPSKAAIASYGELLQTPSYSVQDKPYQPVLAMPAMLNGQ
YWVLAQGQNLSLLPIQSVALATRSHEIETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQLIIK
KVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYSQLTEEKRQQIADKAVSLPWQSWLEE
QAIE
>Mature_643_residues
GIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKLH
SLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGVDMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFL
KSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYLQ
SPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYILQ
ALQSALEEAGELGFEHPFEPSSPQVRDEVSLSESGTQTQTEHHAFELQSPESKTHSTWNEASRVDTSRVEISRDSQLTER
TRDIASARPYSGVQSNAYGSMAVPRESRSGPTGESRARAELPSKAAIASYGELLQTPSYSVQDKPYQPVLAMPAMLNGQY
WVLAQGQNLSLLPIQSVALATRSHEIETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQLIIKK
VPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYSQLTEEKRQQIADKAVSLPWQSWLEEQ
AIE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=36.4741641337386, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI4505911, Length=417, Percent_Identity=26.8585131894484, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI189458898, Length=417, Percent_Identity=26.8585131894484, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI189458896, Length=399, Percent_Identity=26.5664160401003, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=27.6470588235294, Blast_Score=131, Evalue=3e-30,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=27.6470588235294, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.063829787234, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310128480, Length=302, Percent_Identity=24.1721854304636, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=25.7575757575758, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=624, Percent_Identity=46.6346153846154, Blast_Score=484, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=35.7142857142857, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=349, Percent_Identity=25.7879656160458, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=318, Percent_Identity=38.3647798742138, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=435, Percent_Identity=25.9770114942529, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=366, Percent_Identity=24.8633879781421, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136968, Length=338, Percent_Identity=36.094674556213, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.0504201680672, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71876; Mature: 71745

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHH
WQAYAEGVDMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
HCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECEE
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNV
CCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEE
HPAKHEVRFHQSRYVHDYILQALQSALEEAGELGFEHPFEPSSPQVRDEVSLSESGTQTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCC
TEHHAFELQSPESKTHSTWNEASRVDTSRVEISRDSQLTERTRDIASARPYSGVQSNAYG
HHHHEEEECCCCCCCCCCHHHHHHCCCHHEEECCCHHHHHHHHHHHCCCCCCCCCCCCCC
SMAVPRESRSGPTGESRARAELPSKAAIASYGELLQTPSYSVQDKPYQPVLAMPAMLNGQ
CCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCHHHCCCC
YWVLAQGQNLSLLPIQSVALATRSHEIETKLATGLIGQPLLMPVSIAADTDWPALLEEHE
EEEEECCCCCEEEEHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
TLIRQLGLELTIRYQQLIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQS
HHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHH
LTGFTSAADIWAAYSQLTEEKRQQIADKAVSLPWQSWLEEQAIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
GIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKDELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCHHHHHH
WQAYAEGVDMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
VRGDIHFTLTHNGKTVRNYRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYL
HCCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECEE
QSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNV
CCCHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEE
HPAKHEVRFHQSRYVHDYILQALQSALEEAGELGFEHPFEPSSPQVRDEVSLSESGTQTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCC
TEHHAFELQSPESKTHSTWNEASRVDTSRVEISRDSQLTERTRDIASARPYSGVQSNAYG
HHHHEEEECCCCCCCCCCHHHHHHCCCHHEEECCCHHHHHHHHHHHCCCCCCCCCCCCCC
SMAVPRESRSGPTGESRARAELPSKAAIASYGELLQTPSYSVQDKPYQPVLAMPAMLNGQ
CCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCHHHCCCC
YWVLAQGQNLSLLPIQSVALATRSHEIETKLATGLIGQPLLMPVSIAADTDWPALLEEHE
EEEEECCCCCEEEEHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
TLIRQLGLELTIRYQQLIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQS
HHHHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHH
LTGFTSAADIWAAYSQLTEEKRQQIADKAVSLPWQSWLEEQAIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA