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The map label for this gene is 113968883

Identifier: 113968883

GI number: 113968883

Start: 622464

End: 623906

Strand: Direct

Name: 113968883

Synonym: Shewmr4_0539

Alternate gene names: NA

Gene position: 622464-623906 (Clockwise)

Preceding gene: 113968882

Following gene: 113968885

Centisome position: 13.23

GC content: 50.03

Gene sequence:

>1443_bases
ATGCAGATGACATTGCAGTTTTTGGGGGCGACCGAGGAAGTCACTGGGTCGTGCCATTTACTCACAATTGCTGGGCAGCA
GATGCTCCTCGATTGCGGCCTCATCCAAGGCGGTAAGGCTGACGAGTTACGCAATCACGAACGATTTTCCTTTGACCCCC
AAGCCATTTCAGCCGTTGTCTTGAGTCATGCCCATATTGATCATTCGGGACGTTTACCCCTGTTGGTCAAGGCTGGCTAT
ACGGGGCCGATTTATACCCACAAAGCGACTGCCGAGCTGTGTGCCATCATGCTAAAAGATGCTGCCATGTTGCAGGTGCG
GGATACCGAAAGAAACAATAAAAAACGTGCTAAGCATGAGTTAGAACCCTTAGAGCCGCTATTTACCGTGGAAGATGCGG
AGCAGGCCGTCACCCAATTTGTGGCGCTAGAATATGGTCAAGTGACGCAGGTTATTCCCCATGTGGATATCTGCTTATCC
GATGCGGGGCATATTTTAGGCTCGGCACTGGTTGAGCTGTGGTTGGGCGAAGGCAAGGCACAGAAAAAACTGGTATTTAG
TGGCGATCTTGGCCGAGCGGGTATGCCCATCTTACGTAATCCTACCTTAGTCGACACCGCCGATTTAGTGTTAATGGAAA
GCACCTACGGCGATCGTTTCCACCGTAGTTGGACTGATACTCTGGCCGAATTAAAGGCAATTTTTGCCAAGGCAGTGACC
GAGAGCCGCGGTAATATTCTCTTGCCAGCCTTTTCTGTGGGGCGAGCGCAGGAGCTTTTATATCTATTTCATTTATATGC
TAAAGATTGGGACTTATCTCGCTGGAAAGTCTGCCTCGATAGTCCAATGGCGATTGAGGCGACACGGGTGTATGTTAATA
ACTACCCCTTAATGGATGATGATTTTAAGCGTTTTACTCGCCAGCATCCGGGGCAGCATCCCTTACTATCGAATGTCGAA
TTTATTCAAACCACCGAAGAGTCTATCGCGCTAAACGATGTGCATCAGGGCTTGATCATTATTGCGGGTAGTGGCATGTG
TAACGGTGGCCGGATCCGTAGCCATTTGGAGCATAATCTGTGGCGGCCAGAATGTGATGTGATTATCTGTGGTTATCAAG
CACTTGGCACGCCTGGACGCGCCTTGGTCGATGGCGCCGAGGAACTCACTATTCATGGTAATAGCATCAAAGTTGCCGCC
ACATTGCATACGGTCGGTGGCTTATCTGCCCATGCGGATCAGGCCGAGTTGCTACGCTGGTATCGGCATTTTGAAGATCA
GCCACCCTTGGTACTGGTGCATGGCGAGCCTGGAGCGCAGCAGGGATTAGTCGCAGTGATGAATCAAGATCCAAAAACTA
AACCTAAGGCGCTTGCTATTGCCACCCGTGGAGATATGTTGGATTTGAACGCCTTACCAAAATTAGTCTGGGTGACAGCT
TAA

Upstream 100 bases:

>100_bases
TAAAGTTGGTTTTGACCATGGTTTGCTAATTATTCCTTTTTCTTTTAGGAATAAGGGCATAGTCTATCTTTAAAAGAGAT
AAACGTGCTGGAGGTAAGGT

Downstream 100 bases:

>100_bases
GCGATAGTCCACAGCCCGAATAGGGCTGTGGCTAACTGATTGAATTAATCTGAGTTGTTGTCAAACTCAGTATCGTCGAA
TAACTCGAGGCTTGGGTCGA

Product: RNA-metabolizing metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MQMTLQFLGATEEVTGSCHLLTIAGQQMLLDCGLIQGGKADELRNHERFSFDPQAISAVVLSHAHIDHSGRLPLLVKAGY
TGPIYTHKATAELCAIMLKDAAMLQVRDTERNNKKRAKHELEPLEPLFTVEDAEQAVTQFVALEYGQVTQVIPHVDICLS
DAGHILGSALVELWLGEGKAQKKLVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFAKAVT
ESRGNILLPAFSVGRAQELLYLFHLYAKDWDLSRWKVCLDSPMAIEATRVYVNNYPLMDDDFKRFTRQHPGQHPLLSNVE
FIQTTEESIALNDVHQGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGAEELTIHGNSIKVAA
TLHTVGGLSAHADQAELLRWYRHFEDQPPLVLVHGEPGAQQGLVAVMNQDPKTKPKALAIATRGDMLDLNALPKLVWVTA

Sequences:

>Translated_480_residues
MQMTLQFLGATEEVTGSCHLLTIAGQQMLLDCGLIQGGKADELRNHERFSFDPQAISAVVLSHAHIDHSGRLPLLVKAGY
TGPIYTHKATAELCAIMLKDAAMLQVRDTERNNKKRAKHELEPLEPLFTVEDAEQAVTQFVALEYGQVTQVIPHVDICLS
DAGHILGSALVELWLGEGKAQKKLVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFAKAVT
ESRGNILLPAFSVGRAQELLYLFHLYAKDWDLSRWKVCLDSPMAIEATRVYVNNYPLMDDDFKRFTRQHPGQHPLLSNVE
FIQTTEESIALNDVHQGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGAEELTIHGNSIKVAA
TLHTVGGLSAHADQAELLRWYRHFEDQPPLVLVHGEPGAQQGLVAVMNQDPKTKPKALAIATRGDMLDLNALPKLVWVTA
>Mature_480_residues
MQMTLQFLGATEEVTGSCHLLTIAGQQMLLDCGLIQGGKADELRNHERFSFDPQAISAVVLSHAHIDHSGRLPLLVKAGY
TGPIYTHKATAELCAIMLKDAAMLQVRDTERNNKKRAKHELEPLEPLFTVEDAEQAVTQFVALEYGQVTQVIPHVDICLS
DAGHILGSALVELWLGEGKAQKKLVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFAKAVT
ESRGNILLPAFSVGRAQELLYLFHLYAKDWDLSRWKVCLDSPMAIEATRVYVNNYPLMDDDFKRFTRQHPGQHPLLSNVE
FIQTTEESIALNDVHQGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGAEELTIHGNSIKVAA
TLHTVGGLSAHADQAELLRWYRHFEDQPPLVLVHGEPGAQQGLVAVMNQDPKTKPKALAIATRGDMLDLNALPKLVWVTA

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=461, Percent_Identity=26.2472885032538, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI7706427, Length=461, Percent_Identity=25.8134490238612, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI32564696, Length=489, Percent_Identity=25.5623721881391, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32566029, Length=449, Percent_Identity=25.8351893095768, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323307, Length=450, Percent_Identity=24.2222222222222, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24648013, Length=445, Percent_Identity=27.8651685393258, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21358523, Length=457, Percent_Identity=27.1334792122538, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52928; Mature: 52928

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMTLQFLGATEEVTGSCHLLTIAGQQMLLDCGLIQGGKADELRNHERFSFDPQAISAVV
CCEEEEECCCCHHCCCCEEEEEECCCHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
LSHAHIDHSGRLPLLVKAGYTGPIYTHKATAELCAIMLKDAAMLQVRDTERNNKKRAKHE
HHHHCCCCCCCCCEEEECCCCCCCEECHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHC
LEPLEPLFTVEDAEQAVTQFVALEYGQVTQVIPHVDICLSDAGHILGSALVELWLGEGKA
CCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QKKLVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFAKAVT
CCEEEEECCCCCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ESRGNILLPAFSVGRAQELLYLFHLYAKDWDLSRWKVCLDSPMAIEATRVYVNNYPLMDD
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEEEEECCCCCCH
DFKRFTRQHPGQHPLLSNVEFIQTTEESIALNDVHQGLIIIAGSGMCNGGRIRSHLEHNL
HHHHHHHHCCCCCCCCCCCHHEEECCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCC
WRPECDVIICGYQALGTPGRALVDGAEELTIHGNSIKVAATLHTVGGLSAHADQAELLRW
CCCCCCEEEECCHHCCCCCHHHHCCCCEEEEECCEEEEEEEEEHHCCCCCCCCHHHHHHH
YRHFEDQPPLVLVHGEPGAQQGLVAVMNQDPKTKPKALAIATRGDMLDLNALPKLVWVTA
HHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCEEEEEC
>Mature Secondary Structure
MQMTLQFLGATEEVTGSCHLLTIAGQQMLLDCGLIQGGKADELRNHERFSFDPQAISAVV
CCEEEEECCCCHHCCCCEEEEEECCCHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHH
LSHAHIDHSGRLPLLVKAGYTGPIYTHKATAELCAIMLKDAAMLQVRDTERNNKKRAKHE
HHHHCCCCCCCCCEEEECCCCCCCEECHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHC
LEPLEPLFTVEDAEQAVTQFVALEYGQVTQVIPHVDICLSDAGHILGSALVELWLGEGKA
CCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QKKLVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGDRFHRSWTDTLAELKAIFAKAVT
CCEEEEECCCCCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ESRGNILLPAFSVGRAQELLYLFHLYAKDWDLSRWKVCLDSPMAIEATRVYVNNYPLMDD
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEEEEECCCCCCH
DFKRFTRQHPGQHPLLSNVEFIQTTEESIALNDVHQGLIIIAGSGMCNGGRIRSHLEHNL
HHHHHHHHCCCCCCCCCCCHHEEECCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCC
WRPECDVIICGYQALGTPGRALVDGAEELTIHGNSIKVAATLHTVGGLSAHADQAELLRW
CCCCCCEEEECCHHCCCCCHHHHCCCCEEEEECCEEEEEEEEEHHCCCCCCCCHHHHHHH
YRHFEDQPPLVLVHGEPGAQQGLVAVMNQDPKTKPKALAIATRGDMLDLNALPKLVWVTA
HHHHCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA