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The map label for this gene is uvrD [H]

Identifier: 113968817

GI number: 113968817

Start: 537637

End: 539805

Strand: Direct

Name: uvrD [H]

Synonym: Shewmr4_0473

Alternate gene names: 113968817

Gene position: 537637-539805 (Clockwise)

Preceding gene: 113968813

Following gene: 113968818

Centisome position: 11.42

GC content: 52.88

Gene sequence:

>2169_bases
ATGGACGTATCTTCTTTACTAGACGGCCTGAATGATAAACAGCGCGAGGCTGTCGCGGCACCGCAATCCAGCATGTTAGT
GCTTGCGGGCGCAGGCAGTGGCAAAACGCGAGTATTAACCCACCGTATCGCGTGGTTAATGCAGGTCGAACAGCAGAGCC
CTTACTCAATTTTAGCCGTGACGTTTACCAATAAAGCCGCAGCCGAGATGCGTGAGCGGGTGGAGAAGGTCGCTGGCACC
AATATGGGGCGGATGTGGATTGGTACCTTCCACGGGTTAGCGCATCGTCTGTTACGCACTCACTTCCAAGATGCGGGACT
ACCGCAAAGCTTCCAAATTCTCGATTCGGACGATCAGGTGCGTTTGCTGAAACGCATCCTTAAAAGTTTGAATCTGGATG
AAAAACAATATCCTCCCCGTCAGGCGCAGGCCTATATCAATGGCAAGAAAGACCAAGGATTACGGCCCAAGCATATTGAT
GCGGGTGGTTTCCCGATTGAGCAAAACCTGCTGAAGATTTATCAGGTTTATCAAGAGTCTTGCGACCGCGCAGGTTTAGT
CGACTTTGCCGAAATCCTGCTGCGTGCCCACGAGCTGTGGCTCAATAAACCGCATCTGCTGGCGCATTATCAGGAGCGTT
TTAAGCATATTCTGGTGGACGAGTTCCAGGATACCAACGCCATCCAATATGCGTGGATCCGTGTGTTGGCCGGCCAAACT
GCCAACGTGATGATAGTGGGTGACGATGACCAATCCATTTACGGTTGGCGCGGCGCTCAGGTTGAAAACCTGCACCGGTT
CCTGCGGGATTTTCCGACTGCGACTACGATTCGCCTCGAGCAAAATTATCGCTCCAAGGGCAATATTTTGAAGGCGTCGA
ACGCCCTTATCGCCAATAACCCTGAGCGTTTAGGTAAAGAGCTGTGGACCGACGAAGCCGATGGTGAGCCGATTTCCCTC
TACTGCGCCTTTAACGAAATGGACGAGGCGCGCTTTATTGTCGGTCGTATCAATGATTGGTACGAAAAAGGCGGCAATTT
AAGTGACTGCGCGATTTTATATCGCTCAAACGCTCAGTCGCGCGTGCTCGAAGAAGCCTTATTACACAAAGGCTTAGCCT
ATCGTATTTACGGTGGCCTGCGCTTCTTCGAACGCCAAGAGATTAAAGATGCTATGGGTTATATGCGTCTTATCAGCAAT
AAAAATGACGATGCCGCCTTCGAGCGCGTGGTCAATACGCCGCCCCGTGGCATTGGCGATCGCACCTTAGATATTCTGCG
TTCGACCGCCCGTCAGCAAGAGCTTACGTTATGGCAGGCTTGTTTACGTTTGCTGGATGAAAAGGTGCTGGCTGGCCGCG
CCGCCTCTGCGGTACGTGGCTTTATGGATCTTATCGTCACCCTGCAGGAAGAAACTCAGGACATGGCGCTGTACCGGATG
ACAGACACAGTGATCCAAGCCTCTGGGCTTAAGGCCATGTACGAGGCGGAAAAAGGCGAGAAGGCCCACGCCCGTATCGA
AAACTTAGAGGAACTCGTTACTGCGGCGCGTACCTTCGAAATGCCAGAGGAGCTTGAGGATATGGGCGAGCTGAATGCCT
TCTTATCCCATGCAGCCCTAGAGGCGGGCGAAGGTCAGGCCGATGCCTTTACCGATGCCGTACAGTTAATGACACTGCAC
TCGGCCAAGGGGCTTGAGTTTACTATGGTGTTTATGGCGGGCGTCGAGGAGGGGATTTTCCCGAGTAAGATGGCGCTCGA
AGAGGGCGACAGACTCGATGAGGAACGCCGCCTCTGTTACGTGGGCATGACCCGCGCGATGGAAAAACTCTATATCACCT
ATGCCGAATCCCGCCGTATTTATGGTCGCGAGGATTATGCCCGCCCATCGCGCTTTATTAAGGAAATTCCGCCGCAATAT
GTGGACGAAATTCGCTTAAAAGCGCAGGTGTCAACGCCGATGGCGAATAATCGCTTCAGTACGCAAAAGTCGGCGGTCGC
CAACGATACTGGCTTTAGCGTCGGCCAAAGGGTGCATCATCCAAAATTTGGTGACGGCAAAGTGACTAACTTCGAAGGCA
GTGGCGCACAGGCGCGGGTGCAGGTGAATTTTAGTGATTTTGGCAGTAAGTGGCTGGTGGTGGCCTACGCGCGTTTAGAG
GCGCGTTGA

Upstream 100 bases:

>100_bases
TCTCCTTATGGCTTTCGTCTCGTAGCTCTTGTCTTGTGGATCAGGCGCGCAGGTGGGATTTCTTCTGTTATACTGCCCCC
TCGATTTTTTGGAGGCGAGA

Downstream 100 bases:

>100_bases
TTGACGCCAATGTCATGATTTTGTGACAGCTTGAGTCTGCACAAATTCGCTTAAAAGGTGGCTAGGGTATATGATGCTTA
GCCTAGCAACCGAGATAAAA

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MDVSSLLDGLNDKQREAVAAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYSILAVTFTNKAAAEMRERVEKVAGT
NMGRMWIGTFHGLAHRLLRTHFQDAGLPQSFQILDSDDQVRLLKRILKSLNLDEKQYPPRQAQAYINGKKDQGLRPKHID
AGGFPIEQNLLKIYQVYQESCDRAGLVDFAEILLRAHELWLNKPHLLAHYQERFKHILVDEFQDTNAIQYAWIRVLAGQT
ANVMIVGDDDQSIYGWRGAQVENLHRFLRDFPTATTIRLEQNYRSKGNILKASNALIANNPERLGKELWTDEADGEPISL
YCAFNEMDEARFIVGRINDWYEKGGNLSDCAILYRSNAQSRVLEEALLHKGLAYRIYGGLRFFERQEIKDAMGYMRLISN
KNDDAAFERVVNTPPRGIGDRTLDILRSTARQQELTLWQACLRLLDEKVLAGRAASAVRGFMDLIVTLQEETQDMALYRM
TDTVIQASGLKAMYEAEKGEKAHARIENLEELVTAARTFEMPEELEDMGELNAFLSHAALEAGEGQADAFTDAVQLMTLH
SAKGLEFTMVFMAGVEEGIFPSKMALEEGDRLDEERRLCYVGMTRAMEKLYITYAESRRIYGREDYARPSRFIKEIPPQY
VDEIRLKAQVSTPMANNRFSTQKSAVANDTGFSVGQRVHHPKFGDGKVTNFEGSGAQARVQVNFSDFGSKWLVVAYARLE
AR

Sequences:

>Translated_722_residues
MDVSSLLDGLNDKQREAVAAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYSILAVTFTNKAAAEMRERVEKVAGT
NMGRMWIGTFHGLAHRLLRTHFQDAGLPQSFQILDSDDQVRLLKRILKSLNLDEKQYPPRQAQAYINGKKDQGLRPKHID
AGGFPIEQNLLKIYQVYQESCDRAGLVDFAEILLRAHELWLNKPHLLAHYQERFKHILVDEFQDTNAIQYAWIRVLAGQT
ANVMIVGDDDQSIYGWRGAQVENLHRFLRDFPTATTIRLEQNYRSKGNILKASNALIANNPERLGKELWTDEADGEPISL
YCAFNEMDEARFIVGRINDWYEKGGNLSDCAILYRSNAQSRVLEEALLHKGLAYRIYGGLRFFERQEIKDAMGYMRLISN
KNDDAAFERVVNTPPRGIGDRTLDILRSTARQQELTLWQACLRLLDEKVLAGRAASAVRGFMDLIVTLQEETQDMALYRM
TDTVIQASGLKAMYEAEKGEKAHARIENLEELVTAARTFEMPEELEDMGELNAFLSHAALEAGEGQADAFTDAVQLMTLH
SAKGLEFTMVFMAGVEEGIFPSKMALEEGDRLDEERRLCYVGMTRAMEKLYITYAESRRIYGREDYARPSRFIKEIPPQY
VDEIRLKAQVSTPMANNRFSTQKSAVANDTGFSVGQRVHHPKFGDGKVTNFEGSGAQARVQVNFSDFGSKWLVVAYARLE
AR
>Mature_722_residues
MDVSSLLDGLNDKQREAVAAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYSILAVTFTNKAAAEMRERVEKVAGT
NMGRMWIGTFHGLAHRLLRTHFQDAGLPQSFQILDSDDQVRLLKRILKSLNLDEKQYPPRQAQAYINGKKDQGLRPKHID
AGGFPIEQNLLKIYQVYQESCDRAGLVDFAEILLRAHELWLNKPHLLAHYQERFKHILVDEFQDTNAIQYAWIRVLAGQT
ANVMIVGDDDQSIYGWRGAQVENLHRFLRDFPTATTIRLEQNYRSKGNILKASNALIANNPERLGKELWTDEADGEPISL
YCAFNEMDEARFIVGRINDWYEKGGNLSDCAILYRSNAQSRVLEEALLHKGLAYRIYGGLRFFERQEIKDAMGYMRLISN
KNDDAAFERVVNTPPRGIGDRTLDILRSTARQQELTLWQACLRLLDEKVLAGRAASAVRGFMDLIVTLQEETQDMALYRM
TDTVIQASGLKAMYEAEKGEKAHARIENLEELVTAARTFEMPEELEDMGELNAFLSHAALEAGEGQADAFTDAVQLMTLH
SAKGLEFTMVFMAGVEEGIFPSKMALEEGDRLDEERRLCYVGMTRAMEKLYITYAESRRIYGREDYARPSRFIKEIPPQY
VDEIRLKAQVSTPMANNRFSTQKSAVANDTGFSVGQRVHHPKFGDGKVTNFEGSGAQARVQVNFSDFGSKWLVVAYARLE
AR

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=721, Percent_Identity=71.2898751733703, Blast_Score=1077, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=673, Percent_Identity=35.9583952451709, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1787196, Length=90, Percent_Identity=44.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=804, Percent_Identity=26.7412935323383, Blast_Score=199, Evalue=1e-51,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81718; Mature: 81718

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSSLLDGLNDKQREAVAAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYSILAV
CCHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TFTNKAAAEMRERVEKVAGTNMGRMWIGTFHGLAHRLLRTHFQDAGLPQSFQILDSDDQV
EECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
RLLKRILKSLNLDEKQYPPRQAQAYINGKKDQGLRPKHIDAGGFPIEQNLLKIYQVYQES
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
CDRAGLVDFAEILLRAHELWLNKPHLLAHYQERFKHILVDEFQDTNAIQYAWIRVLAGQT
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ANVMIVGDDDQSIYGWRGAQVENLHRFLRDFPTATTIRLEQNYRSKGNILKASNALIANN
CEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCEEECC
PERLGKELWTDEADGEPISLYCAFNEMDEARFIVGRINDWYEKGGNLSDCAILYRSNAQS
HHHHHHHHCCCCCCCCCEEEEEEECCCCCHHEEHHCCHHHHHCCCCCCCEEEEEECCCHH
RVLEEALLHKGLAYRIYGGLRFFERQEIKDAMGYMRLISNKNDDAAFERVVNTPPRGIGD
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCH
RTLDILRSTARQQELTLWQACLRLLDEKVLAGRAASAVRGFMDLIVTLQEETQDMALYRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDTVIQASGLKAMYEAEKGEKAHARIENLEELVTAARTFEMPEELEDMGELNAFLSHAAL
HHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGEGQADAFTDAVQLMTLHSAKGLEFTMVFMAGVEEGIFPSKMALEEGDRLDEERRLCY
HCCCCCHHHHHHHHHHHHHHCCCCCEEEEHEEHHHHCCCCCCHHHHHCCCCCCHHHHEEH
VGMTRAMEKLYITYAESRRIYGREDYARPSRFIKEIPPQYVDEIRLKAQVSTPMANNRFS
HHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHEECCCCCCCCCC
TQKSAVANDTGFSVGQRVHHPKFGDGKVTNFEGSGAQARVQVNFSDFGSKWLVVAYARLE
CHHHHHCCCCCCHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEHHCCCCCEEEEEEEHHC
AR
CC
>Mature Secondary Structure
MDVSSLLDGLNDKQREAVAAPQSSMLVLAGAGSGKTRVLTHRIAWLMQVEQQSPYSILAV
CCHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TFTNKAAAEMRERVEKVAGTNMGRMWIGTFHGLAHRLLRTHFQDAGLPQSFQILDSDDQV
EECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHH
RLLKRILKSLNLDEKQYPPRQAQAYINGKKDQGLRPKHIDAGGFPIEQNLLKIYQVYQES
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
CDRAGLVDFAEILLRAHELWLNKPHLLAHYQERFKHILVDEFQDTNAIQYAWIRVLAGQT
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
ANVMIVGDDDQSIYGWRGAQVENLHRFLRDFPTATTIRLEQNYRSKGNILKASNALIANN
CEEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCEEECC
PERLGKELWTDEADGEPISLYCAFNEMDEARFIVGRINDWYEKGGNLSDCAILYRSNAQS
HHHHHHHHCCCCCCCCCEEEEEEECCCCCHHEEHHCCHHHHHCCCCCCCEEEEEECCCHH
RVLEEALLHKGLAYRIYGGLRFFERQEIKDAMGYMRLISNKNDDAAFERVVNTPPRGIGD
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCH
RTLDILRSTARQQELTLWQACLRLLDEKVLAGRAASAVRGFMDLIVTLQEETQDMALYRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDTVIQASGLKAMYEAEKGEKAHARIENLEELVTAARTFEMPEELEDMGELNAFLSHAAL
HHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EAGEGQADAFTDAVQLMTLHSAKGLEFTMVFMAGVEEGIFPSKMALEEGDRLDEERRLCY
HCCCCCHHHHHHHHHHHHHHCCCCCEEEEHEEHHHHCCCCCCHHHHHCCCCCCHHHHEEH
VGMTRAMEKLYITYAESRRIYGREDYARPSRFIKEIPPQYVDEIRLKAQVSTPMANNRFS
HHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHEECCCCCCCCCC
TQKSAVANDTGFSVGQRVHHPKFGDGKVTNFEGSGAQARVQVNFSDFGSKWLVVAYARLE
CHHHHHCCCCCCHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEHHCCCCCEEEEEEEHHC
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]