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The map label for this gene is lysA [H]

Identifier: 113968735

GI number: 113968735

Start: 438992

End: 440236

Strand: Direct

Name: lysA [H]

Synonym: Shewmr4_0391

Alternate gene names: 113968735

Gene position: 438992-440236 (Clockwise)

Preceding gene: 113968733

Following gene: 113968736

Centisome position: 9.33

GC content: 51.65

Gene sequence:

>1245_bases
TTGGATCACTTTCTCTACCAAGACAATACCCTGTACGCCGAAGGCTGTCGGGTCAATGATTTAGCCCAGCAGTATGGCAC
GCCATTGTATATCTATTCCCGTGCGACGCTCGAACGTCACTGGCATGCGTTTAACAATGCGGTGGCCGACCATCCACATT
TAGTGTGTTACGCGGTGAAAGCCAACTCGAACTTAGCCGTGCTAAACGTCTTGGCTCGTTTAGGCAGTGGTTTTGATATT
GTCTCGGGCGGAGAGTTAGCGCGGGTGATTGAAGCCGGTGGCGACCCGGCCAAAGTGGTATTTTCGGGCGTGGGTAAAAC
CGTTGCCGAAATGGAACAGGCACTTAACCTCGGTATTTATTGCTTTAATGTCGAATCGAGCGCCGAGCTTGAGCAGTTAA
ATCAGGTCGCGGGCCGCTTAGGTAAAATTGCTCCCGTGTCATTGCGGGTGAATCCCGATGTCGATGCCGGTACGCATCCT
TATATTTCGACGGGCCTTAAAGAGAACAAATTTGGTATCGCTATGGATGAGGCCGAAGTTGTATTCGCCCGTGCCCATGC
GCTGCCACATTTACAGGTAAAAGGGGTCGATTGCCACATTGGTTCACAACTGACTGAGATCCAGCCTTTCCTCGATGCGA
TGGACAGAATGTTAGCCCTTATCGACCGTTTGGCCGAGCAAGGCATTGTGATTGAACACTTCGATGTGGGTGGTGGTTTA
GGGGTGACCTATGATGATGAAACCCCGCCACATCCTGATGTTTACGCCGCAGCCCTGCTCGCGCGTTTAGGCGATCGCAA
GCTCAAGTTAATTTTCGAGCCGGGTCGTGCCATTGCCGCTAACGCGGGTATTTTCGTCACGCAGGTGCTGTACCTTAAAG
AAAACAGCGATAAACGTTTTGCGATTGTCGACGGCGCGATGAACGACTTAATTCGTCCCGCACTCTATAGCGCTTGGCAA
AATATCATTCCGGTAAATCCAAGGGATGAACAAGCGCAAGTATTTGATATCGTAGGGCCTGTGTGCGAAACCGGTGACTT
TTTAGGTAAAGACAGAGCACTTGCGATTGCGGCAGGGGATTTATTGGTTGTGCGCTCGAGCGGTGCCTACGGTTTTGCCA
TGGCCTCTAACTATAACACTCGTCCCCGTGCGGCCGAGGTGATGGTCGATGGTGACAAGGCTTATCTGGTGCGTGAGCGA
GAAAAATTAGCGCAGCTCTGGCAAGGTGAGCAACTCCTGCCGTAA

Upstream 100 bases:

>100_bases
TGAGGCAACCCCTGCCGAGCCGGCGGAGCCTCAAGCTGAAACTGAAAAAACACAATAATAATCAGCATAATTACAACAAA
GCGCAGTAAGGAATCGGACA

Downstream 100 bases:

>100_bases
ACTAGAAAATTATATTGATTCAGGCGCTTGGCTAGTTAATGGCGGCGCCTAGGCTTAAAGGATAAGTATCTTGATCCAAT
TCACTAAGATGCACGGACTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNQVAGRLGKIAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP

Sequences:

>Translated_414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNQVAGRLGKIAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP
>Mature_414_residues
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVKANSNLAVLNVLARLGSGFDI
VSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIYCFNVESSAELEQLNQVAGRLGKIAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMDEAEVVFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFAIVDGAMNDLIRPALYSAWQ
NIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGDLLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVRER
EKLAQLWQGEQLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=363, Percent_Identity=26.4462809917355, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI22538418, Length=355, Percent_Identity=26.1971830985915, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361583, Length=355, Percent_Identity=26.1971830985915, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI16506287, Length=348, Percent_Identity=24.4252873563218, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789203, Length=435, Percent_Identity=31.7241379310345, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=352, Percent_Identity=23.5795454545455, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=382, Percent_Identity=24.869109947644, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=25.4385964912281, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586474, Length=367, Percent_Identity=24.5231607629428, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45117; Mature: 45117

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNVESSAELEQLNQVAGRLGKIAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMDEAEV
EEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
EEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCCCCCCCCCEEEEEECC
LLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVREREKLAQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYQDNTLYAEGCRVNDLAQQYGTPLYIYSRATLERHWHAFNNAVADHPHLVCYAVK
CCCEEECCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEE
ANSNLAVLNVLARLGSGFDIVSGGELARVIEAGGDPAKVVFSGVGKTVAEMEQALNLGIY
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCEE
CFNVESSAELEQLNQVAGRLGKIAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMDEAEV
EEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHE
VFARAHALPHLQVKGVDCHIGSQLTEIQPFLDAMDRMLALIDRLAEQGIVIEHFDVGGGL
EEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GVTYDDETPPHPDVYAAALLARLGDRKLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCEE
AIVDGAMNDLIRPALYSAWQNIIPVNPRDEQAQVFDIVGPVCETGDFLGKDRALAIAAGD
EEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHCCCCCCCCCCEEEEEECC
LLVVRSSGAYGFAMASNYNTRPRAAEVMVDGDKAYLVREREKLAQLWQGEQLLP
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]