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The map label for this gene is kynU [H]

Identifier: 113968639

GI number: 113968639

Start: 314761

End: 315885

Strand: Direct

Name: kynU [H]

Synonym: Shewmr4_0295

Alternate gene names: 113968639

Gene position: 314761-315885 (Clockwise)

Preceding gene: 113968638

Following gene: 113968643

Centisome position: 6.69

GC content: 52.71

Gene sequence:

>1125_bases
ATGCTGCTAAATGTAAAACAAGACTTTTGCCTCGCAGGCCCAGGCTATCTGCTCAACCATTCCGTGGGGCGGCCACTTAA
ATCGACCGAGCAGGCGTTTAAGCAGGCATTTTTTGCGCCTTGGCAGGAGTCTGGCCGCGAGCCTTGGGGCCAATGGTTGG
GCGTCATCGATAACTTTACCGCGGCGCTGGCGAGCCTTTTTAATGGTCAGCCGCAGGACTTTTGCCCGCAGGTGAATCTA
TCGAGCGCCTTGACCAAAATTGTGATATCCCTCGATAGATTAACGCGAGATGGCGGCGCCGTGGTGCTGATGAGCGAGAT
TGATTTTCCCAGCATGGGGTTTGCCCTGAAAAAGGCATTGCCCGCAAGCTGTGAACTGCGCTTTATTCCCAAGGGTTTAG
ATGTCACCGACCCCAATGTGTGGGACGCGCATATTTGTGCCGATGTCGATTTAGTCTTTGTCAGCCATGCCTATTCTAAT
ACTGGTCAGCAGGCGCCATTGGCGCAGATCATTCCCCTTGCCCGTGAGCGTGGCTGCTTGAGTCTCGTGGATGTGGCGCA
ATCGGCTGGGATTTTACCGCTGGATTTAGCCAAGCTACAGCCGGACTTTATGATTGGTTCGAGTGTGAAATGGTTATGCT
CAGGCCCAGGGGCTGCGTATCTGTGGGTCAATCCGGCTATTTTGCCCCAGTGTCAGCCGCAGGATGTGGGTTGGTTTAGC
CATGAAAATCCCTTCGAGTTTGATATCCATGATTTCCGCTATCACCCAACTGCGCTGCGGTTTTGGGGCGGTACACCTTC
TATCGCGCCCTATGCGATTGCCGCTCACAGCATTGAATATTTTGCCAATATTGGTTCACAGGTGATGCGTGAACATAACT
TGCAGTTGATGGATACGGTCGTCCAAACATTGGAATGTGATTTGGTCTCGCCACGGGAAGTCGATAAGCGCAGTGGCACC
TTGATCCTGCAATTTGGCGAGCGACAAGCACCCATCATGGCGGCGTTGGCGGAGGCGAATATCAGTGTCGATGCCCGCAG
TTTAGGAATGCGCGTATCGCCGCATATCTATAACGATGAGGCCGATATCGCGAAATTGCTGGAGGTGATAAAAGCCCATC
GTTAA

Upstream 100 bases:

>100_bases
CTCGAGCGCTTAAGGGATAGACGCGCCGCGGTGTTGCGACACGATATTCGCACCCGTTATCACGATCTGAAAAAACTCAA
AGACAGTTTAAGGTAAGGCC

Downstream 100 bases:

>100_bases
CGGATTGAACAGGGCTTGCTCGGAACGGCTATGAATGGGGTGCGCTAAGGCGACCTAGTTGCACCCCTATGCTTAAATAC
TGTAGTTATAGCGGCAGAAC

Product: aminotransferase, class V

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVISLDRLTRDGGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSN
TGQQAPLAQIIPLARERGCLSLVDVAQSAGILPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFS
HENPFEFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIEYFANIGSQVMREHNLQLMDTVVQTLECDLVSPREVDKRSGT
LILQFGERQAPIMAALAEANISVDARSLGMRVSPHIYNDEADIAKLLEVIKAHR

Sequences:

>Translated_374_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVISLDRLTRDGGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSN
TGQQAPLAQIIPLARERGCLSLVDVAQSAGILPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFS
HENPFEFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIEYFANIGSQVMREHNLQLMDTVVQTLECDLVSPREVDKRSGT
LILQFGERQAPIMAALAEANISVDARSLGMRVSPHIYNDEADIAKLLEVIKAHR
>Mature_374_residues
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFTAALASLFNGQPQDFCPQVNL
SSALTKIVISLDRLTRDGGAVVLMSEIDFPSMGFALKKALPASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSN
TGQQAPLAQIIPLARERGCLSLVDVAQSAGILPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFS
HENPFEFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIEYFANIGSQVMREHNLQLMDTVVQTLECDLVSPREVDKRSGT
LILQFGERQAPIMAALAEANISVDARSLGMRVSPHIYNDEADIAKLLEVIKAHR

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17550466, Length=395, Percent_Identity=22.2784810126582, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 41170; Mature: 41170

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00591 GLYCOSYL_HYDROL_F10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFT
CEECCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AALASLFNGQPQDFCPQVNLSSALTKIVISLDRLTRDGGAVVLMSEIDFPSMGFALKKAL
HHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCC
PASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNTGQQAPLAQIIPLARERGCL
CCCCEEEEECCCCCCCCCCCCCHHHHCCEEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCH
SLVDVAQSAGILPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFS
HHHHHHHHCCCCEEHHHHCCCCEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
HENPFEFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIEYFANIGSQVMREHNLQLMDTV
CCCCEEECHHHCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQTLECDLVSPREVDKRSGTLILQFGERQAPIMAALAEANISVDARSLGMRVSPHIYNDE
HHHHHCCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHCCCEECCCEECCH
ADIAKLLEVIKAHR
HHHHHHHHHHHCCC
>Mature Secondary Structure
MLLNVKQDFCLAGPGYLLNHSVGRPLKSTEQAFKQAFFAPWQESGREPWGQWLGVIDNFT
CEECCCCCCEECCCCHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
AALASLFNGQPQDFCPQVNLSSALTKIVISLDRLTRDGGAVVLMSEIDFPSMGFALKKAL
HHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCC
PASCELRFIPKGLDVTDPNVWDAHICADVDLVFVSHAYSNTGQQAPLAQIIPLARERGCL
CCCCEEEEECCCCCCCCCCCCCHHHHCCEEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCH
SLVDVAQSAGILPLDLAKLQPDFMIGSSVKWLCSGPGAAYLWVNPAILPQCQPQDVGWFS
HHHHHHHHCCCCEEHHHHCCCCEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCC
HENPFEFDIHDFRYHPTALRFWGGTPSIAPYAIAAHSIEYFANIGSQVMREHNLQLMDTV
CCCCEEECHHHCEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQTLECDLVSPREVDKRSGTLILQFGERQAPIMAALAEANISVDARSLGMRVSPHIYNDE
HHHHHCCCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHCCCEECCCEECCH
ADIAKLLEVIKAHR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]