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The map label for this gene is edd2 [H]

Identifier: 116696503

GI number: 116696503

Start: 2895964

End: 2897820

Strand: Direct

Name: edd2 [H]

Synonym: H16_B2567

Alternate gene names: 116696503

Gene position: 2895964-2897820 (Clockwise)

Preceding gene: 116696497

Following gene: 116696506

Centisome position: 99.43

GC content: 70.38

Gene sequence:

>1857_bases
ATGCCACGTCATCCAGTGCTCGAGCGGGTCACCGCCCGCATCGTCTCCCGCAGCGCCGCCTCGCGCCAGGCGTACCTTGA
CCGCACCCACGCCATGGCCGGGCAGAAGGTCGAACGCGCGCAGCTTTCCTGTACCAACCTGGCCCATGCGGTGGCTGCCA
TGCCGGACGCCGCGAAGATCCGGCTGAAGGCCGACGAGCGGCCCAACCTGGCGATCGTCTCGGCCTACAACGACATGCTG
TCGGCGCACCAGCCGCTGGCGGCTTTCCCTCAGTGGCTCAAGGAAGCGGCGCTCGAGGCCGGCGGCACCGCGCAGTTTGC
CGGCGGCACGCCCGCGATGTGCGACGGCGTCACGCAGGGCCAGGACGGCATGGACCTGTCGCTGTTCTCGCGCGATGTGA
TTGCGCTGGCCACGGCGGTGGCGCTGTCGCATCAGATGTTCGATGCCGCGCTGTACCTGGGCGTGTGCGACAAGATCGTG
CCCGGGCTGGTGATGGGCGCGCTGTCGTTCGGCCACCTGCCGGCCGTGTTCGTGCCGGGCGGGCCGATGACCACCGGCAT
CAGCAACGACGAAAAGGCGCACACGCGCCAGCTCTACGCCGAAGGCAAGATCGGCCGCAAGGAACTGCTCGAGGCCGAGA
CCCGCTCCTACCACGGCCCCGGCACCTGCACCTTCTACGGCACCGCCAATTCCAACCAGATGCTGATGGAGATGATGGGC
CTGCACCTGCCGGGCACGGCCTTCGTCAACCCCAACACACCGCTGCGCGAGGCGCTCACGCGCGAGGCCGCGCGCCAGGC
GCTGAAGCTGGTGCACGGCGGCGAGCGCTATACGCCGGTGGCCGAGGTGCTGGACGAGCGCGCCTTCGTCAACGGCATCG
TCGGGCTGCTGGCCACCGGCGGCTCCACCAACCACACGCTGCACCTGATCGCGATGGCGCGCGTGGCCGGCATCGTGCTG
GGCTGGGACGACTTTGACGAGCTCTCGGCCGTGGTGCCGCTGCTGGCGCGCGTGTACCCGAACGGCAAGGCCGACGTGAA
CCAGTTCCAGGCCGCAGGCGGGCTGCCCGTGGTGATCCGCGGGCTGCTGTCGCTGGGCCTGGTGCATGACGACGTGACCA
CCATCGTCGGCCGCGGGCTGCAGGACTACACGCGCGAACCCGTGCTGCGCGACGGCAAGCTGACCTGGATCGACGGCCCG
GCCGCGCCGCTCGACGACAGCATCGTGCGCGCCGCCGACGCGCCCTTTGCGCCGGACGGCGGCATCAAGGTGCTGGACGG
CAGGCTAGGCCGCGCGGTGATCAAGACCTCTGCGGTCAAGGCCGAGCACCAGGTGGTGGAGGCACCGGCGATGGTGTTCG
AGCATCAGGACGATGTGCTGCACGCATTCAAGCGCGGCGAGCTGGAGCGAGACTTCGTTGCGGTGCTACCGTGGCAGGGC
CCGGCCTCGTGCGGCATGCCCGAGCTGCACAAGCTCACGCCCACGCTGACGGTGCTGCAGGACCGCGGCTTCCATGTGGC
GCTGGTGACCGACGGGCGCATGTCGGGCGCGTCGGGCAAGGTGCCGGCGGCTATTCACGTCTGCCCCGAGGCGCTGCGCG
GGGGCGCGATCGGGCGCGTGCGCAGCGGCGACATGATGCGCGTGGATGCGCCCGCGGGCGTGCTCGAGGTGCTGGTGCCG
GATGACGAATGGCAGGCGCGCGCGCCTGCCCGTCCGGACCTCAGCGCCAATCGCCACGGCGTGGGCCGCGACCTGTTCGC
CACCTTCCGCCGCCATGTCAGCACCGCGGAAAGCGGCGCCTGCACGCTGTTTTCGGACGAGGACGACGACGACAACAACG
CACCCGTGCTCGGCTAG

Upstream 100 bases:

>100_bases
CGGAGCGCGAAGCGTACCCGTTTCTGCGTGTGCTGCGCAGTGGATCGTGCGGTACGCGGCAAAGTGCGCTAGGCTGAAAG
CTCCCCCGCAGGAGAACCCC

Downstream 100 bases:

>100_bases
CCCAGGTGCTGCACCGGCCGGCGCGACGCCGCGCCGGCCGGGTGCGGCGCGCTCGCCGATGGCGCGCTGTCGGCCACCTT
CACCGCACCCGGCACCGAGG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MPRHPVLERVTARIVSRSAASRQAYLDRTHAMAGQKVERAQLSCTNLAHAVAAMPDAAKIRLKADERPNLAIVSAYNDML
SAHQPLAAFPQWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDAALYLGVCDKIV
PGLVMGALSFGHLPAVFVPGGPMTTGISNDEKAHTRQLYAEGKIGRKELLEAETRSYHGPGTCTFYGTANSNQMLMEMMG
LHLPGTAFVNPNTPLREALTREAARQALKLVHGGERYTPVAEVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVL
GWDDFDELSAVVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLVHDDVTTIVGRGLQDYTREPVLRDGKLTWIDGP
AAPLDDSIVRAADAPFAPDGGIKVLDGRLGRAVIKTSAVKAEHQVVEAPAMVFEHQDDVLHAFKRGELERDFVAVLPWQG
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALRGGAIGRVRSGDMMRVDAPAGVLEVLVP
DDEWQARAPARPDLSANRHGVGRDLFATFRRHVSTAESGACTLFSDEDDDDNNAPVLG

Sequences:

>Translated_618_residues
MPRHPVLERVTARIVSRSAASRQAYLDRTHAMAGQKVERAQLSCTNLAHAVAAMPDAAKIRLKADERPNLAIVSAYNDML
SAHQPLAAFPQWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDAALYLGVCDKIV
PGLVMGALSFGHLPAVFVPGGPMTTGISNDEKAHTRQLYAEGKIGRKELLEAETRSYHGPGTCTFYGTANSNQMLMEMMG
LHLPGTAFVNPNTPLREALTREAARQALKLVHGGERYTPVAEVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVL
GWDDFDELSAVVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLVHDDVTTIVGRGLQDYTREPVLRDGKLTWIDGP
AAPLDDSIVRAADAPFAPDGGIKVLDGRLGRAVIKTSAVKAEHQVVEAPAMVFEHQDDVLHAFKRGELERDFVAVLPWQG
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALRGGAIGRVRSGDMMRVDAPAGVLEVLVP
DDEWQARAPARPDLSANRHGVGRDLFATFRRHVSTAESGACTLFSDEDDDDNNAPVLG
>Mature_617_residues
PRHPVLERVTARIVSRSAASRQAYLDRTHAMAGQKVERAQLSCTNLAHAVAAMPDAAKIRLKADERPNLAIVSAYNDMLS
AHQPLAAFPQWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDAALYLGVCDKIVP
GLVMGALSFGHLPAVFVPGGPMTTGISNDEKAHTRQLYAEGKIGRKELLEAETRSYHGPGTCTFYGTANSNQMLMEMMGL
HLPGTAFVNPNTPLREALTREAARQALKLVHGGERYTPVAEVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVLG
WDDFDELSAVVPLLARVYPNGKADVNQFQAAGGLPVVIRGLLSLGLVHDDVTTIVGRGLQDYTREPVLRDGKLTWIDGPA
APLDDSIVRAADAPFAPDGGIKVLDGRLGRAVIKTSAVKAEHQVVEAPAMVFEHQDDVLHAFKRGELERDFVAVLPWQGP
ASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALRGGAIGRVRSGDMMRVDAPAGVLEVLVPD
DEWQARAPARPDLSANRHGVGRDLFATFRRHVSTAESGACTLFSDEDDDDNNAPVLG

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=59.1362126245847, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=547, Percent_Identity=29.6160877513711, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI2367371, Length=470, Percent_Identity=31.063829787234, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1786464, Length=470, Percent_Identity=29.3617021276596, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=537, Percent_Identity=30.5400372439479, Blast_Score=186, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65838; Mature: 65707

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHPVLERVTARIVSRSAASRQAYLDRTHAMAGQKVERAQLSCTNLAHAVAAMPDAAKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEE
RLKADERPNLAIVSAYNDMLSAHQPLAAFPQWLKEAALEAGGTAQFAGGTPAMCDGVTQG
EEECCCCCCEEEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCC
QDGMDLSLFSRDVIALATAVALSHQMFDAALYLGVCDKIVPGLVMGALSFGHLPAVFVPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGISNDEKAHTRQLYAEGKIGRKELLEAETRSYHGPGTCTFYGTANSNQMLMEMMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHC
LHLPGTAFVNPNTPLREALTREAARQALKLVHGGERYTPVAEVLDERAFVNGIVGLLATG
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSTNHTLHLIAMARVAGIVLGWDDFDELSAVVPLLARVYPNGKADVNQFQAAGGLPVVIR
CCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHH
GLLSLGLVHDDVTTIVGRGLQDYTREPVLRDGKLTWIDGPAAPLDDSIVRAADAPFAPDG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCC
GIKVLDGRLGRAVIKTSAVKAEHQVVEAPAMVFEHQDDVLHAFKRGELERDFVAVLPWQG
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCC
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALRGGAIGRV
CCCCCCCHHHHHCCHHEEEECCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCCEE
RSGDMMRVDAPAGVLEVLVPDDEWQARAPARPDLSANRHGVGRDLFATFRRHVSTAESGA
CCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
CTLFSDEDDDDNNAPVLG
EEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PRHPVLERVTARIVSRSAASRQAYLDRTHAMAGQKVERAQLSCTNLAHAVAAMPDAAKI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEE
RLKADERPNLAIVSAYNDMLSAHQPLAAFPQWLKEAALEAGGTAQFAGGTPAMCDGVTQG
EEECCCCCCEEEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCC
QDGMDLSLFSRDVIALATAVALSHQMFDAALYLGVCDKIVPGLVMGALSFGHLPAVFVPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGISNDEKAHTRQLYAEGKIGRKELLEAETRSYHGPGTCTFYGTANSNQMLMEMMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHC
LHLPGTAFVNPNTPLREALTREAARQALKLVHGGERYTPVAEVLDERAFVNGIVGLLATG
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSTNHTLHLIAMARVAGIVLGWDDFDELSAVVPLLARVYPNGKADVNQFQAAGGLPVVIR
CCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHH
GLLSLGLVHDDVTTIVGRGLQDYTREPVLRDGKLTWIDGPAAPLDDSIVRAADAPFAPDG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCC
GIKVLDGRLGRAVIKTSAVKAEHQVVEAPAMVFEHQDDVLHAFKRGELERDFVAVLPWQG
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCC
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALRGGAIGRV
CCCCCCCHHHHHCCHHEEEECCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCCEE
RSGDMMRVDAPAGVLEVLVPDDEWQARAPARPDLSANRHGVGRDLFATFRRHVSTAESGA
CCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
CTLFSDEDDDDNNAPVLG
EEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]