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The map label for this gene is bkdA1 [H]

Identifier: 116696169

GI number: 116696169

Start: 2532117

End: 2533202

Strand: Direct

Name: bkdA1 [H]

Synonym: H16_B2233

Alternate gene names: 116696169

Gene position: 2532117-2533202 (Clockwise)

Preceding gene: 116696168

Following gene: 116696170

Centisome position: 86.94

GC content: 70.72

Gene sequence:

>1086_bases
ATGTCCACGGTTGCGCGCTTTGAGATCGGCTACACCCGCTACCTTGCCCCGCCGGGCGACACCTCCTCCCCCACTTCTCC
TCCCCCACCCCTTGCCAGCAACCCCGACGCGCTGCTGCCGCTGTACCAGGCGATGGTGCTGACGCGCCAGTTCGACCTGA
AAGCGATTGCGCTGCAGCGCACCGGCAAGATCGGCACCTTTGCCTCGGCCCTCGGCCAGGAAGCCATCGGCGTGGGCGTG
GCCTTTGCGATGCGGCCCGAAGACGTGCTGGTGCCCTCGTACCGCGACCACGCGGCGCAGTTTGTGCGGGGCGTCACGAT
GGCCGAGAGCCTGCTCTACTGGGGCGGCGACGAACGCGGCAGCGGCTTTGCGGCGGCGCCGCATGACTTTGCCAACTGCG
TGCCGATCGGCACCCAGGTCTGCCACGCGGCCGGCGCCGCCTATGCGTTCCAGCTGCGCGGCGAGCCGCGCGTGGCGGTC
TGCCTGCTGGGCGACGGCGGCACCTCCAAGGGCGATTTCTATGAGGGCATGAACATGGCCGGCGCGTGGCACGCGCCGCT
GGTGATCGTGATCAACAACAACCAGTGGGCAATCTCGATGCCGCGCAGCGGCCAGACCGCGGCGCAGACGCTGGCGCAGA
AGGCCATTGCCGCCGGCATCCCCGGTGAGCAGGTCGACGGCAACGACGTGGTCGCGGTGCGGCACCGCGTCGGCGAGGCC
ATCGCGCGCGCGCGCGACGGCGGCGGCCCGGCGCTGATCGAGGCCATCACCTATCGCCTGGGCGACCACACCACCGCCGA
CGACGCCTCGCGCTACCGCGACGAGGCCAGCGTCAAGGCGCACTGGCAGGAAGAGCCGCTGCTGCGGCTGCGCACGCACC
TGCTGGCGCTGCACGCGTGGGACGCGGCGCGCGAGGAAGCGCTGGTCAAGGCCTGCTCACAGCAGGTGGCGCAGGCCGTG
GAGACTTACCTGGCCGTGCCGCAGCCGGACCCGGCCGCGATGTTCGACTGCCTGTACGCAACCATGCCGGCCGAATTGCA
GGCGCAGCTGGAGATTGCCCGGCGCTTCCTGGCGCCGCACGGATAA

Upstream 100 bases:

>100_bases
CGGCAGGGATCACAACGCGATCATTGCTGCGGATAGCTGCGAAGATCCTCGCGGCCGTCCCAGCGGATCCTGTCGAGACA
ACCGCATCGAGAGACCTGCC

Downstream 100 bases:

>100_bases
CCAGCAAACCCTGCGCCTTCACCTGGCGACCACAGCGAGCGAACCATGGCGGAAATCAATCTGGTCGAAGCAGTCAACCT
GGCGCTGGCCCATGCGCTCG

Product: 2-oxoisovalerate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSTVARFEIGYTRYLAPPGDTSSPTSPPPPLASNPDALLPLYQAMVLTRQFDLKAIALQRTGKIGTFASALGQEAIGVGV
AFAMRPEDVLVPSYRDHAAQFVRGVTMAESLLYWGGDERGSGFAAAPHDFANCVPIGTQVCHAAGAAYAFQLRGEPRVAV
CLLGDGGTSKGDFYEGMNMAGAWHAPLVIVINNNQWAISMPRSGQTAAQTLAQKAIAAGIPGEQVDGNDVVAVRHRVGEA
IARARDGGGPALIEAITYRLGDHTTADDASRYRDEASVKAHWQEEPLLRLRTHLLALHAWDAAREEALVKACSQQVAQAV
ETYLAVPQPDPAAMFDCLYATMPAELQAQLEIARRFLAPHG

Sequences:

>Translated_361_residues
MSTVARFEIGYTRYLAPPGDTSSPTSPPPPLASNPDALLPLYQAMVLTRQFDLKAIALQRTGKIGTFASALGQEAIGVGV
AFAMRPEDVLVPSYRDHAAQFVRGVTMAESLLYWGGDERGSGFAAAPHDFANCVPIGTQVCHAAGAAYAFQLRGEPRVAV
CLLGDGGTSKGDFYEGMNMAGAWHAPLVIVINNNQWAISMPRSGQTAAQTLAQKAIAAGIPGEQVDGNDVVAVRHRVGEA
IARARDGGGPALIEAITYRLGDHTTADDASRYRDEASVKAHWQEEPLLRLRTHLLALHAWDAAREEALVKACSQQVAQAV
ETYLAVPQPDPAAMFDCLYATMPAELQAQLEIARRFLAPHG
>Mature_360_residues
STVARFEIGYTRYLAPPGDTSSPTSPPPPLASNPDALLPLYQAMVLTRQFDLKAIALQRTGKIGTFASALGQEAIGVGVA
FAMRPEDVLVPSYRDHAAQFVRGVTMAESLLYWGGDERGSGFAAAPHDFANCVPIGTQVCHAAGAAYAFQLRGEPRVAVC
LLGDGGTSKGDFYEGMNMAGAWHAPLVIVINNNQWAISMPRSGQTAAQTLAQKAIAAGIPGEQVDGNDVVAVRHRVGEAI
ARARDGGGPALIEAITYRLGDHTTADDASRYRDEASVKAHWQEEPLLRLRTHLLALHAWDAAREEALVKACSQQVAQAVE
TYLAVPQPDPAAMFDCLYATMPAELQAQLEIARRFLAPHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=337, Percent_Identity=34.1246290801187, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI258645172, Length=337, Percent_Identity=34.1246290801187, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=27.9141104294479, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI291084742, Length=326, Percent_Identity=27.9141104294479, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI291084744, Length=333, Percent_Identity=27.6276276276276, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4885543, Length=266, Percent_Identity=30.4511278195489, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI291084757, Length=321, Percent_Identity=24.9221183800623, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563357, Length=334, Percent_Identity=32.0359281437126, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI86563355, Length=334, Percent_Identity=32.0359281437126, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI32564172, Length=332, Percent_Identity=27.710843373494, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17536047, Length=332, Percent_Identity=27.710843373494, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=343, Percent_Identity=29.4460641399417, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355903, Length=333, Percent_Identity=28.5285285285285, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24639748, Length=324, Percent_Identity=29.9382716049383, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24639740, Length=313, Percent_Identity=28.7539936102236, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24639744, Length=313, Percent_Identity=28.7539936102236, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28571106, Length=313, Percent_Identity=28.7539936102236, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24639746, Length=295, Percent_Identity=29.1525423728814, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38569; Mature: 38438

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVARFEIGYTRYLAPPGDTSSPTSPPPPLASNPDALLPLYQAMVLTRQFDLKAIALQR
CCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHH
TGKIGTFASALGQEAIGVGVAFAMRPEDVLVPSYRDHAAQFVRGVTMAESLLYWGGDERG
CCCCHHHHHHHCHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGFAAAPHDFANCVPIGTQVCHAAGAAYAFQLRGEPRVAVCLLGDGGTSKGDFYEGMNMA
CCCCCCCHHHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCC
GAWHAPLVIVINNNQWAISMPRSGQTAAQTLAQKAIAAGIPGEQVDGNDVVAVRHRVGEA
CCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
IARARDGGGPALIEAITYRLGDHTTADDASRYRDEASVKAHWQEEPLLRLRTHLLALHAW
HHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHH
DAAREEALVKACSQQVAQAVETYLAVPQPDPAAMFDCLYATMPAELQAQLEIARRFLAPH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
G
C
>Mature Secondary Structure 
STVARFEIGYTRYLAPPGDTSSPTSPPPPLASNPDALLPLYQAMVLTRQFDLKAIALQR
CCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHH
TGKIGTFASALGQEAIGVGVAFAMRPEDVLVPSYRDHAAQFVRGVTMAESLLYWGGDERG
CCCCHHHHHHHCHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGFAAAPHDFANCVPIGTQVCHAAGAAYAFQLRGEPRVAVCLLGDGGTSKGDFYEGMNMA
CCCCCCCHHHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCC
GAWHAPLVIVINNNQWAISMPRSGQTAAQTLAQKAIAAGIPGEQVDGNDVVAVRHRVGEA
CCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHH
IARARDGGGPALIEAITYRLGDHTTADDASRYRDEASVKAHWQEEPLLRLRTHLLALHAW
HHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHH
DAAREEALVKACSQQVAQAVETYLAVPQPDPAAMFDCLYATMPAELQAQLEIARRFLAPH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA