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The map label for this gene is aphA [H]

Identifier: 116696004

GI number: 116696004

Start: 2325210

End: 2326241

Strand: Direct

Name: aphA [H]

Synonym: H16_B2068

Alternate gene names: 116696004

Gene position: 2325210-2326241 (Clockwise)

Preceding gene: 116696003

Following gene: 116696005

Centisome position: 79.84

GC content: 70.35

Gene sequence:

>1032_bases
ATGCTGACGTTTTTCCATCCCGAGCAATTGCTGCACCATCCGCAGAGCTACTACTCGCGCGGCAGGATGCGCTCGCCGCA
GGAGCTGCCTGCGCGGGCGCAGCGGCTGGTCCAGGCGGCAGAGGCGCTTGGCTTCGCGCTCCACGCCCCCGCCGACCACG
GCCTCGCGCCGCTTGCCGCGGTGCACGACCAGCCTTACCTGCAGTTCCTGCAGGACGCCCATGCCAGCTGGCGCGAGCTG
CCGGAGGACTGGGGCGACGAGGTCATGTCCAATATCTTCGTGCGCGAGCCCAACGCCCTGCGCGGCGTGCTGGCGCAGGC
CGCGCGCTATCTCGCCGATGGCAGCTGCCCGGTGGGCCTGAACACCTGGCGCTCGGCCTACTGGTCGGCGCAGAGCGCGG
TGGCCGGGGCCCGGGCGCTGCTGGACGGCGCGCGCCGCGCCTACGCCTTGTGCCGGCCGCCTGGCCATCATGCCCGGCGC
GACGCGGCGGGCGGCTTCTGCTACCTGAACAATGCCGCGATCGCCGCCCAGGCCCTGCGCGCGCGCCTTGGCCGCGTGGC
CATCCTCGATACCGACATGCACCACGGCCAGGGCATCCAGGAGATCTTCTACGACCGGGCCGATGTGCTCTACGTGTCGA
TCCACGGCGACCCGACCAACTTCTATCCGGTGGTCGCGGGCTTCGACGATGAGCACGGCCGCGGCGCCGGCACCGGCCAC
AACCTCAACCTGCCGATGCCGCACCGTTCGCCCGAGTCCGTCTTCTTCGACAAGCTGGACACCGCACGCGGCGCCATCGA
ACGCTTCCAGGCAGACGCGCTGGTGCTGTCGCTCGGCTTCGACATCTACCGCGAGGATCCGCAGTCGCTGGTGGACGTGT
CCACCGCAGGCTTCGGCCGCCTCGGCCGCGCCGTTGCCGCACTGGGCCTGCCCACGCTGGTCGTGCAGGAAGGCGGCTAC
CACCTCGATTCGCTCGCCGCCAATGCAACGGCCTTCTTCGGCGGCATCCAACAGTCAGGGACGGGCGTATGA

Upstream 100 bases:

>100_bases
GCTGTGCATCGCCAGCATCGATGCACGCCAGCGCCAGCAACCACAACCGGCCGCGCAAGCCGCGCAGGCCTGACGCCTTT
CCACGGACATTGCAAACCCC

Downstream 100 bases:

>100_bases
ACGCAATCACGATCAATGGCGAACGCCTGTCGCAAGCGCTGATGGACCTGGCGCGGATCGGCGCCACGCCCAGGGGCGGC
AATGCGCGTCTGGCCCTGAC

Product: histone deacetylase family deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLTFFHPEQLLHHPQSYYSRGRMRSPQELPARAQRLVQAAEALGFALHAPADHGLAPLAAVHDQPYLQFLQDAHASWREL
PEDWGDEVMSNIFVREPNALRGVLAQAARYLADGSCPVGLNTWRSAYWSAQSAVAGARALLDGARRAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALRARLGRVAILDTDMHHGQGIQEIFYDRADVLYVSIHGDPTNFYPVVAGFDDEHGRGAGTGH
NLNLPMPHRSPESVFFDKLDTARGAIERFQADALVLSLGFDIYREDPQSLVDVSTAGFGRLGRAVAALGLPTLVVQEGGY
HLDSLAANATAFFGGIQQSGTGV

Sequences:

>Translated_343_residues
MLTFFHPEQLLHHPQSYYSRGRMRSPQELPARAQRLVQAAEALGFALHAPADHGLAPLAAVHDQPYLQFLQDAHASWREL
PEDWGDEVMSNIFVREPNALRGVLAQAARYLADGSCPVGLNTWRSAYWSAQSAVAGARALLDGARRAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALRARLGRVAILDTDMHHGQGIQEIFYDRADVLYVSIHGDPTNFYPVVAGFDDEHGRGAGTGH
NLNLPMPHRSPESVFFDKLDTARGAIERFQADALVLSLGFDIYREDPQSLVDVSTAGFGRLGRAVAALGLPTLVVQEGGY
HLDSLAANATAFFGGIQQSGTGV
>Mature_343_residues
MLTFFHPEQLLHHPQSYYSRGRMRSPQELPARAQRLVQAAEALGFALHAPADHGLAPLAAVHDQPYLQFLQDAHASWREL
PEDWGDEVMSNIFVREPNALRGVLAQAARYLADGSCPVGLNTWRSAYWSAQSAVAGARALLDGARRAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALRARLGRVAILDTDMHHGQGIQEIFYDRADVLYVSIHGDPTNFYPVVAGFDDEHGRGAGTGH
NLNLPMPHRSPESVFFDKLDTARGAIERFQADALVLSLGFDIYREDPQSLVDVSTAGFGRLGRAVAALGLPTLVVQEGGY
HLDSLAANATAFFGGIQQSGTGV

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=323, Percent_Identity=27.2445820433437, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI20070354, Length=221, Percent_Identity=37.5565610859729, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13128864, Length=227, Percent_Identity=34.3612334801762, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI153085395, Length=215, Percent_Identity=34.4186046511628, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI169234807, Length=234, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI148539870, Length=234, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI17158039, Length=212, Percent_Identity=31.6037735849057, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI30795204, Length=198, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI30795202, Length=198, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI226529806, Length=216, Percent_Identity=35.6481481481481, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073088, Length=192, Percent_Identity=30.7291666666667, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI62750349, Length=212, Percent_Identity=32.5471698113208, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI62750347, Length=212, Percent_Identity=32.5471698113208, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI13128860, Length=315, Percent_Identity=24.4444444444444, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073092, Length=232, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI13128862, Length=238, Percent_Identity=28.9915966386555, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI293336691, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193206283, Length=205, Percent_Identity=36.5853658536585, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17540332, Length=205, Percent_Identity=36.5853658536585, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17540334, Length=205, Percent_Identity=36.5853658536585, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17537347, Length=217, Percent_Identity=33.6405529953917, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193209491, Length=197, Percent_Identity=34.5177664974619, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17508561, Length=262, Percent_Identity=27.8625954198473, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=261, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=213, Percent_Identity=30.5164319248826, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25154020, Length=236, Percent_Identity=27.9661016949153, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=236, Percent_Identity=27.9661016949153, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=223, Percent_Identity=34.0807174887892, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323999, Length=254, Percent_Identity=27.1653543307087, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=206, Percent_Identity=25.7281553398058, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=183, Percent_Identity=25.6830601092896, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281360801, Length=254, Percent_Identity=35.0393700787402, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281360799, Length=254, Percent_Identity=35.0393700787402, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641720, Length=254, Percent_Identity=35.0393700787402, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281360899, Length=249, Percent_Identity=34.136546184739, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24642142, Length=249, Percent_Identity=34.136546184739, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24642146, Length=249, Percent_Identity=34.136546184739, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24642144, Length=249, Percent_Identity=34.136546184739, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24657891, Length=317, Percent_Identity=25.2365930599369, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24644244, Length=307, Percent_Identity=28.3387622149837, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37228; Mature: 37228

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFFHPEQLLHHPQSYYSRGRMRSPQELPARAQRLVQAAEALGFALHAPADHGLAPLAA
CCCEECHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHH
VHDQPYLQFLQDAHASWRELPEDWGDEVMSNIFVREPNALRGVLAQAARYLADGSCPVGL
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCH
NTWRSAYWSAQSAVAGARALLDGARRAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHCCCCCEEEECCHHHHHHHHH
ARLGRVAILDTDMHHGQGIQEIFYDRADVLYVSIHGDPTNFYPVVAGFDDEHGRGAGTGH
HHHCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCC
NLNLPMPHRSPESVFFDKLDTARGAIERFQADALVLSLGFDIYREDPQSLVDVSTAGFGR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCHHHHHHHHHCCHHH
LGRAVAALGLPTLVVQEGGYHLDSLAANATAFFGGIQQSGTGV
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLTFFHPEQLLHHPQSYYSRGRMRSPQELPARAQRLVQAAEALGFALHAPADHGLAPLAA
CCCEECHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHH
VHDQPYLQFLQDAHASWRELPEDWGDEVMSNIFVREPNALRGVLAQAARYLADGSCPVGL
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCH
NTWRSAYWSAQSAVAGARALLDGARRAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALR
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHCCCCCEEEECCHHHHHHHHH
ARLGRVAILDTDMHHGQGIQEIFYDRADVLYVSIHGDPTNFYPVVAGFDDEHGRGAGTGH
HHHCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCC
NLNLPMPHRSPESVFFDKLDTARGAIERFQADALVLSLGFDIYREDPQSLVDVSTAGFGR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCHHHHHHHHHCCHHH
LGRAVAALGLPTLVVQEGGYHLDSLAANATAFFGGIQQSGTGV
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]