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The map label for this gene is pcaR [H]

Identifier: 116695769

GI number: 116695769

Start: 2072358

End: 2073182

Strand: Direct

Name: pcaR [H]

Synonym: H16_B1833

Alternate gene names: 116695769

Gene position: 2072358-2073182 (Clockwise)

Preceding gene: 116695768

Following gene: 116695780

Centisome position: 71.15

GC content: 65.7

Gene sequence:

>825_bases
GTGGATTCAGGTAATGAAGGCAACGGGCTGCGCACAAGGCGCGAGCGTTCGTCCCTGTTCGTCGGTTCGGTGGAAAAGGC
CTTCCAGGTGCTGGAAGCCTTCCACGGCCCGGACCGCCGCCTGATGTCGATGGCGGAAATCGCCCGGGCGGCCGATCTCG
ACCGCAGCGCCACCCAGCGGCTGGTGCACACACTGGAACAGCTGGGCTACATCCGGCGCCTGCCCGATTCGGCGATGTAT
GGGCTTGCGCCGAAGGCACTGGGCCTGTCGTACAACTACCTGCGCTCCAACGACCTGGTCGAGCGCGCATCGCCCTACCT
GCTCGATATCAGCCGCACGCTGGGAGAAACCGCCAACCTGCAGGAACTCGACGGGCACGAAATCGTGTTCCTGGCCCGCT
TCCCCGGGCAGCACCTGATCAACGTCGATTTCGGGGTCGGGTACCGGCTCCCGGCCGTGTACACCGCGTCCGGGATTGCG
ATCCTGTCGAAGCTGCCCGAAGCGCAGCGCCTGGAGGTGGTGCGGGCGACCGCACTGAACCCCATCACGCCGTTCACTGA
AACCGACCCCGACAAGCTGATGACGGCGATCCGCGAGGCCGGTGAACGCGGCTATGCCGTGGCCATGAACCAGACCGTGG
TCGGCGACATCTCCGTCGCAGCCGCAATCACCGACCACCGCGGGCTGCCGGTCGGGGCCATCAATATCTCAGTCCCGTCC
ACGCGCTGGACGCTGGAAACCGCCCAGGCCAAGCTGGCCCCGCATGTGCAAGTGGCGGCCATGTCGATCTCGCAGGCAAA
GCGGATGAGTTTCCAGACGGCATGA

Upstream 100 bases:

>100_bases
GCAGCCAGGCTGGACGCTGCCGCGCTCTCGGACGACCATGCCGCGCGGCTGGCCGCACTGTAAGCCATGAAAACAATGAC
AAGGACGAGCAGGAGGTTGT

Downstream 100 bases:

>100_bases
GCGATGCCGGAAACGCCGCCGGCTTCGCTCAGATGGCCCGGCCTCCGTCAACGGGCATGTCGATGCCGGTAAGGAAGCGG
GCACCCGGGCTTGCCAGGAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MDSGNEGNGLRTRRERSSLFVGSVEKAFQVLEAFHGPDRRLMSMAEIARAADLDRSATQRLVHTLEQLGYIRRLPDSAMY
GLAPKALGLSYNYLRSNDLVERASPYLLDISRTLGETANLQELDGHEIVFLARFPGQHLINVDFGVGYRLPAVYTASGIA
ILSKLPEAQRLEVVRATALNPITPFTETDPDKLMTAIREAGERGYAVAMNQTVVGDISVAAAITDHRGLPVGAINISVPS
TRWTLETAQAKLAPHVQVAAMSISQAKRMSFQTA

Sequences:

>Translated_274_residues
MDSGNEGNGLRTRRERSSLFVGSVEKAFQVLEAFHGPDRRLMSMAEIARAADLDRSATQRLVHTLEQLGYIRRLPDSAMY
GLAPKALGLSYNYLRSNDLVERASPYLLDISRTLGETANLQELDGHEIVFLARFPGQHLINVDFGVGYRLPAVYTASGIA
ILSKLPEAQRLEVVRATALNPITPFTETDPDKLMTAIREAGERGYAVAMNQTVVGDISVAAAITDHRGLPVGAINISVPS
TRWTLETAQAKLAPHVQVAAMSISQAKRMSFQTA
>Mature_274_residues
MDSGNEGNGLRTRRERSSLFVGSVEKAFQVLEAFHGPDRRLMSMAEIARAADLDRSATQRLVHTLEQLGYIRRLPDSAMY
GLAPKALGLSYNYLRSNDLVERASPYLLDISRTLGETANLQELDGHEIVFLARFPGQHLINVDFGVGYRLPAVYTASGIA
ILSKLPEAQRLEVVRATALNPITPFTETDPDKLMTAIREAGERGYAVAMNQTVVGDISVAAAITDHRGLPVGAINISVPS
TRWTLETAQAKLAPHVQVAAMSISQAKRMSFQTA

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=248, Percent_Identity=27.8225806451613, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082359, Length=205, Percent_Identity=28.2926829268293, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786715, Length=202, Percent_Identity=28.7128712871287, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788131, Length=244, Percent_Identity=25.8196721311475, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693096, Length=232, Percent_Identity=26.7241379310345, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29919; Mature: 29919

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGNEGNGLRTRRERSSLFVGSVEKAFQVLEAFHGPDRRLMSMAEIARAADLDRSATQR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHH
LVHTLEQLGYIRRLPDSAMYGLAPKALGLSYNYLRSNDLVERASPYLLDISRTLGETANL
HHHHHHHHHHHHHCCCHHHHCCCHHHHCCEEHHHCCCCHHHHCCCCEEEEHHHHCCCCCC
QELDGHEIVFLARFPGQHLINVDFGVGYRLPAVYTASGIAILSKLPEAQRLEVVRATALN
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCC
PITPFTETDPDKLMTAIREAGERGYAVAMNQTVVGDISVAAAITDHRGLPVGAINISVPS
CCCCCCCCCHHHHHHHHHHCCCCCEEEEECCEEEECHHEEEEEECCCCCEEEEEEEECCC
TRWTLETAQAKLAPHVQVAAMSISQAKRMSFQTA
CEEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDSGNEGNGLRTRRERSSLFVGSVEKAFQVLEAFHGPDRRLMSMAEIARAADLDRSATQR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHH
LVHTLEQLGYIRRLPDSAMYGLAPKALGLSYNYLRSNDLVERASPYLLDISRTLGETANL
HHHHHHHHHHHHHCCCHHHHCCCHHHHCCEEHHHCCCCHHHHCCCCEEEEHHHHCCCCCC
QELDGHEIVFLARFPGQHLINVDFGVGYRLPAVYTASGIAILSKLPEAQRLEVVRATALN
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCC
PITPFTETDPDKLMTAIREAGERGYAVAMNQTVVGDISVAAAITDHRGLPVGAINISVPS
CCCCCCCCCHHHHHHHHHHCCCCCEEEEECCEEEECHHEEEEEECCCCCEEEEEEEECCC
TRWTLETAQAKLAPHVQVAAMSISQAKRMSFQTA
CEEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]