Click here to switch to the map view.

The map label for this gene is lldD [H]

Identifier: 116695753

GI number: 116695753

Start: 2053730

End: 2054905

Strand: Direct

Name: lldD [H]

Synonym: H16_B1817

Alternate gene names: 116695753

Gene position: 2053730-2054905 (Clockwise)

Preceding gene: 116695749

Following gene: 116695754

Centisome position: 70.51

GC content: 69.05

Gene sequence:

>1176_bases
GTGCTTTCGCTGAACGACCTTGAACCGCTCGCCCGCCGCCGCCTGCCCCGGCCGCTGTACGCCTACGTCAGCGGTGCGGT
GGAGGACAGCGTCTCGCTGGCGGAGAATCGCCGCGCCTTCACCGAGATCGCGTTGCGGCCACGCGTGCTTGCCGGCGTGG
CCACGCGCGAACTGGACTTCGAGCTGTTCGGCAGGCGCTATGCCGCCCCCTTCGGCGTTGCACCCATGGGCATCGCCGCG
TTGTTCGCTTACCGCGGCGATATCGTGCTCGCGCAGGCCGCGCAGCAGGCCGCGGTGCCGGCGATCATGAGCGGTTCATC
GCTGATCCGGCTGGAAGAAGTGATGGCAGCCGCGCCCGGCACCTGGTTCCAGGCCTACCTGCCCGGCGACGTGGCGCAGA
TCGACGGGCTGTTGTCGCGCGTCGAGGCGGCAGGCGTATCGACGCTGGTGATCACCGTCGATACGCCCGTTGCGGGCAAT
CGCGAGAACAACGTGCGCGCCGGCTTCTCGACACCGCTGCGGCCAAGCCTGCGCTTGGCATGGCAAGGCATCACGCATCC
GCGCTGGCTGCTCGGCACTTTTGCGCGCACGCTGCTGCGGCACGGCATGCCGCACTTCGAGAACGCCTATGCGCACCGCG
GCGCGCCTATCCTGTCATCGCGCGTGCTGCGCGACTTCTCCGACCGCGCGCATTTCACCTGGACGCACCTTGAAGCCATC
CGCCGGCGCTGGCAAGGCACGCTGGTGGTCAAGGGCATCCTGACCGCGGAAGACGCCTTGCTGGCGCGTCGGCACGGTGT
GGACGGGGTCATCGTTTCGAACCACGGCGGCCGGCAACTCGACGGCGCCATCGCGCCGCTGCGCGTCCTGCCTGAGATCG
TGCACGCCGTGCCCGACCTGCCGGTGATGCTCGACAGCGGCGTATGCCGCGGCACCGACGTAATCAAGGCGCTCGCGCTC
GGCGCGCGTTGCGTCTTTGTCGGCCGGCCGTTCGCCTATGCGGCGACGGTCGGGTCCACCCCCGGCGTGGCGCACGCCAT
CGACTTGTTGCAGGCCGAGATCTCGCGCGATATGGCAATGCTCGGCCTGACCCGGCTGGCAGACATCGGCCCTGCCTGCA
TCCGGCCTGCCGCTTCACTACCCCACATGCCCCCTCACCCGGAGACTTATCGATGA

Upstream 100 bases:

>100_bases
AGAAAACGCCGCTGACCGCGCCACAGATGCCGTCGGCACCGCTTCCGCGCCGCGCGTGACGACTGCAAGCGCAAGCGGCG
CAGGTACCTTGCGCCGCCAA

Downstream 100 bases:

>100_bases
GCACGCTTCACGGCTTTCGCATCCACCCCAAGCCGGCGCCGACTGCCAGCAACGCGCTGCTGGAACGCTACCGCAGCTTC
CCGGTGGCCAATGTCAGCGA

Product: L-lactate cytochrome c reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLSLNDLEPLARRRLPRPLYAYVSGAVEDSVSLAENRRAFTEIALRPRVLAGVATRELDFELFGRRYAAPFGVAPMGIAA
LFAYRGDIVLAQAAQQAAVPAIMSGSSLIRLEEVMAAAPGTWFQAYLPGDVAQIDGLLSRVEAAGVSTLVITVDTPVAGN
RENNVRAGFSTPLRPSLRLAWQGITHPRWLLGTFARTLLRHGMPHFENAYAHRGAPILSSRVLRDFSDRAHFTWTHLEAI
RRRWQGTLVVKGILTAEDALLARRHGVDGVIVSNHGGRQLDGAIAPLRVLPEIVHAVPDLPVMLDSGVCRGTDVIKALAL
GARCVFVGRPFAYAATVGSTPGVAHAIDLLQAEISRDMAMLGLTRLADIGPACIRPAASLPHMPPHPETYR

Sequences:

>Translated_391_residues
MLSLNDLEPLARRRLPRPLYAYVSGAVEDSVSLAENRRAFTEIALRPRVLAGVATRELDFELFGRRYAAPFGVAPMGIAA
LFAYRGDIVLAQAAQQAAVPAIMSGSSLIRLEEVMAAAPGTWFQAYLPGDVAQIDGLLSRVEAAGVSTLVITVDTPVAGN
RENNVRAGFSTPLRPSLRLAWQGITHPRWLLGTFARTLLRHGMPHFENAYAHRGAPILSSRVLRDFSDRAHFTWTHLEAI
RRRWQGTLVVKGILTAEDALLARRHGVDGVIVSNHGGRQLDGAIAPLRVLPEIVHAVPDLPVMLDSGVCRGTDVIKALAL
GARCVFVGRPFAYAATVGSTPGVAHAIDLLQAEISRDMAMLGLTRLADIGPACIRPAASLPHMPPHPETYR
>Mature_391_residues
MLSLNDLEPLARRRLPRPLYAYVSGAVEDSVSLAENRRAFTEIALRPRVLAGVATRELDFELFGRRYAAPFGVAPMGIAA
LFAYRGDIVLAQAAQQAAVPAIMSGSSLIRLEEVMAAAPGTWFQAYLPGDVAQIDGLLSRVEAAGVSTLVITVDTPVAGN
RENNVRAGFSTPLRPSLRLAWQGITHPRWLLGTFARTLLRHGMPHFENAYAHRGAPILSSRVLRDFSDRAHFTWTHLEAI
RRRWQGTLVVKGILTAEDALLARRHGVDGVIVSNHGGRQLDGAIAPLRVLPEIVHAVPDLPVMLDSGVCRGTDVIKALAL
GARCVFVGRPFAYAATVGSTPGVAHAIDLLQAEISRDMAMLGLTRLADIGPACIRPAASLPHMPPHPETYR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=373, Percent_Identity=35.9249329758713, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI7705393, Length=373, Percent_Identity=35.9249329758713, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI11068137, Length=378, Percent_Identity=33.3333333333333, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1790033, Length=370, Percent_Identity=36.4864864864865, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI193208036, Length=376, Percent_Identity=32.1808510638298, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566217, Length=311, Percent_Identity=29.5819935691318, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323587, Length=384, Percent_Identity=33.0729166666667, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI78707188, Length=377, Percent_Identity=35.0132625994695, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363140, Length=377, Percent_Identity=35.0132625994695, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI78707190, Length=377, Percent_Identity=35.0132625994695, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42273; Mature: 42273

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLNDLEPLARRRLPRPLYAYVSGAVEDSVSLAENRRAFTEIALRPRVLAGVATRELDF
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCH
ELFGRRYAAPFGVAPMGIAALFAYRGDIVLAQAAQQAAVPAIMSGSSLIRLEEVMAAAPG
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHCCHHHCCCCHHHHHHHHHHCCC
TWFQAYLPGDVAQIDGLLSRVEAAGVSTLVITVDTPVAGNRENNVRAGFSTPLRPSLRLA
CEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCHHHE
WQGITHPRWLLGTFARTLLRHGMPHFENAYAHRGAPILSSRVLRDFSDRAHFTWTHLEAI
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHH
RRRWQGTLVVKGILTAEDALLARRHGVDGVIVSNHGGRQLDGAIAPLRVLPEIVHAVPDL
HHHHCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
PVMLDSGVCRGTDVIKALALGARCVFVGRPFAYAATVGSTPGVAHAIDLLQAEISRDMAM
CEEECCCCCCHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LGLTRLADIGPACIRPAASLPHMPPHPETYR
HHHHHHHHCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSLNDLEPLARRRLPRPLYAYVSGAVEDSVSLAENRRAFTEIALRPRVLAGVATRELDF
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCH
ELFGRRYAAPFGVAPMGIAALFAYRGDIVLAQAAQQAAVPAIMSGSSLIRLEEVMAAAPG
HHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHCCHHHCCCCHHHHHHHHHHCCC
TWFQAYLPGDVAQIDGLLSRVEAAGVSTLVITVDTPVAGNRENNVRAGFSTPLRPSLRLA
CEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCHHHE
WQGITHPRWLLGTFARTLLRHGMPHFENAYAHRGAPILSSRVLRDFSDRAHFTWTHLEAI
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHH
RRRWQGTLVVKGILTAEDALLARRHGVDGVIVSNHGGRQLDGAIAPLRVLPEIVHAVPDL
HHHHCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCC
PVMLDSGVCRGTDVIKALALGARCVFVGRPFAYAATVGSTPGVAHAIDLLQAEISRDMAM
CEEECCCCCCHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LGLTRLADIGPACIRPAASLPHMPPHPETYR
HHHHHHHHCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]