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The map label for this gene is kguD [H]

Identifier: 116695749

GI number: 116695749

Start: 2049451

End: 2050440

Strand: Direct

Name: kguD [H]

Synonym: H16_B1813

Alternate gene names: 116695749

Gene position: 2049451-2050440 (Clockwise)

Preceding gene: 116695748

Following gene: 116695753

Centisome position: 70.37

GC content: 70.1

Gene sequence:

>990_bases
ATGCGCAAGAATGTCCTGGTGTTCCGCCCGATTCCTGATGACCTGCTCGCCAGGATCGAATCGGAGCACGATGTGATCGT
GGCCGACCCGCGCCAGCCGGCACAACTGCCTGCCTTCCGCGCCGCGCTGGCAAACGCCCATGGCCTGATCGGCTCCAGCG
TGAAGCTGGGCGCAGCGGAACTGGCCGAAGCGGGCCAGTTGGAGGTGATCTCGAGTATTTCGGTCGGAGTCGACAACTAC
GACCTTCCCTGCCTGCACCGGCGCGGCATCACCCTGTGCCACACGCCCGGCGTACTCACCGAGACCACCGCCGACACTGT
CTTCGCGCTCATCATGGCCACGAGCCGCCGCCTGGTCGAGCTTGCGGCGCATGTGCGCGAAGGCCGCTGGGCCGCCAACA
TCGGCGAGGGCCTGTTCGGCTGGGACGTGCACGGCAAGACCCTGGCGATCCTGGGCTTCGGACGCATCGGCCAGGCCGTG
GCGCGACGCGCGGCGCTCGGCTTCGGCATGGAGGTGCTCTACGTCAACGAGACCGCGGCGGAACCGCGTGACCTGGTGGG
ACGCGCCACCCGGACGGATCTCGACGATGCCTTGCAGCGAGCCGATATCGTCGCCGTCACGCTGCCCCTGACCGACAGCA
CGCGTGGCCTGATGGGCCTGCGCGAGTTCGCGCTGATGAAGCCGGGCGCCATCTTCGTCAACGGCGCCCGCGGCCAGATC
GTGCAGGAAGACGCGCTGCTCGCGGCGCTCGACAGCGGCCACCTGCGCGCGGCCGGGCTGGACGTCTTCGCCACCGAGCC
ACTGCCGCAGGATTCACCGCTGCGCAGCCATCCCAGGGTGACAGCCCTGCCCCATATCGGCTCGGCCACGCATGAGACCC
GGCGCGCCATGGCCGAACTCGCCACGCGCAACCTGCTGGACGCGCTCGCCGGGCGGCAGCCCGCCGCGCGCTTCGACCTC
GCGGCCTTTGCCGCCCGGGCAGCCGCCTGA

Upstream 100 bases:

>100_bases
TCGGCGCCCGCGCGGTGCAGGTGCGCGGCGATACCGAAGGCCTGCCGACCCATGCCCAGCTGGCGGCCGCCAGTTTGTGA
AGCCACTGCAAGGATTACCC

Downstream 100 bases:

>100_bases
TACGGACACGCTGCCTCACTTCCGCAGGTTGGTCCTGGCCACCAGTACCTTCATCACCGCGTTGTCTGCCGCGATCATCG
CCTTGAAGGTCGCCGCGTCG

Product: putative 2-ketogluconate-6-phosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRKNVLVFRPIPDDLLARIESEHDVIVADPRQPAQLPAFRAALANAHGLIGSSVKLGAAELAEAGQLEVISSISVGVDNY
DLPCLHRRGITLCHTPGVLTETTADTVFALIMATSRRLVELAAHVREGRWAANIGEGLFGWDVHGKTLAILGFGRIGQAV
ARRAALGFGMEVLYVNETAAEPRDLVGRATRTDLDDALQRADIVAVTLPLTDSTRGLMGLREFALMKPGAIFVNGARGQI
VQEDALLAALDSGHLRAAGLDVFATEPLPQDSPLRSHPRVTALPHIGSATHETRRAMAELATRNLLDALAGRQPAARFDL
AAFAARAAA

Sequences:

>Translated_329_residues
MRKNVLVFRPIPDDLLARIESEHDVIVADPRQPAQLPAFRAALANAHGLIGSSVKLGAAELAEAGQLEVISSISVGVDNY
DLPCLHRRGITLCHTPGVLTETTADTVFALIMATSRRLVELAAHVREGRWAANIGEGLFGWDVHGKTLAILGFGRIGQAV
ARRAALGFGMEVLYVNETAAEPRDLVGRATRTDLDDALQRADIVAVTLPLTDSTRGLMGLREFALMKPGAIFVNGARGQI
VQEDALLAALDSGHLRAAGLDVFATEPLPQDSPLRSHPRVTALPHIGSATHETRRAMAELATRNLLDALAGRQPAARFDL
AAFAARAAA
>Mature_329_residues
MRKNVLVFRPIPDDLLARIESEHDVIVADPRQPAQLPAFRAALANAHGLIGSSVKLGAAELAEAGQLEVISSISVGVDNY
DLPCLHRRGITLCHTPGVLTETTADTVFALIMATSRRLVELAAHVREGRWAANIGEGLFGWDVHGKTLAILGFGRIGQAV
ARRAALGFGMEVLYVNETAAEPRDLVGRATRTDLDDALQRADIVAVTLPLTDSTRGLMGLREFALMKPGAIFVNGARGQI
VQEDALLAALDSGHLRAAGLDVFATEPLPQDSPLRSHPRVTALPHIGSATHETRRAMAELATRNLLDALAGRQPAARFDL
AAFAARAAA

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=317, Percent_Identity=39.1167192429022, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI23308577, Length=273, Percent_Identity=34.7985347985348, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=32.7205882352941, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=32.7205882352941, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=32.3636363636364, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=32.3636363636364, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=30.9090909090909, Blast_Score=114, Evalue=9e-26,
Organism=Escherichia coli, GI87082289, Length=312, Percent_Identity=48.3974358974359, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=33.8912133891213, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=38.1944444444444, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=34.7490347490347, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=30.4029304029304, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=231, Percent_Identity=35.0649350649351, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=267, Percent_Identity=29.5880149812734, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=267, Percent_Identity=28.8389513108614, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=34.1176470588235, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=26.8382352941176, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=180, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574286, Length=305, Percent_Identity=34.0983606557377, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=39.2156862745098, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45551003, Length=266, Percent_Identity=39.4736842105263, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=39.3258426966292, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=39.3258426966292, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552429, Length=266, Percent_Identity=39.4736842105263, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574284, Length=266, Percent_Identity=39.4736842105263, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=36.046511627907, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=33.5793357933579, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=32.3529411764706, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=32.3529411764706, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=32.3529411764706, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=32.3529411764706, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=32.3529411764706, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35048; Mature: 35048

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKNVLVFRPIPDDLLARIESEHDVIVADPRQPAQLPAFRAALANAHGLIGSSVKLGAAE
CCCCEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
LAEAGQLEVISSISVGVDNYDLPCLHRRGITLCHTPGVLTETTADTVFALIMATSRRLVE
HHCCCCEEEEHHEECCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LAAHVREGRWAANIGEGLFGWDVHGKTLAILGFGRIGQAVARRAALGFGMEVLYVNETAA
HHHHHHCCCEEECCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCC
EPRDLVGRATRTDLDDALQRADIVAVTLPLTDSTRGLMGLREFALMKPGAIFVNGARGQI
CHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCE
VQEDALLAALDSGHLRAAGLDVFATEPLPQDSPLRSHPRVTALPHIGSATHETRRAMAEL
ECCCHHEEEECCCCEEEECCEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
ATRNLLDALAGRQPAARFDLAAFAARAAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKNVLVFRPIPDDLLARIESEHDVIVADPRQPAQLPAFRAALANAHGLIGSSVKLGAAE
CCCCEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
LAEAGQLEVISSISVGVDNYDLPCLHRRGITLCHTPGVLTETTADTVFALIMATSRRLVE
HHCCCCEEEEHHEECCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LAAHVREGRWAANIGEGLFGWDVHGKTLAILGFGRIGQAVARRAALGFGMEVLYVNETAA
HHHHHHCCCEEECCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCC
EPRDLVGRATRTDLDDALQRADIVAVTLPLTDSTRGLMGLREFALMKPGAIFVNGARGQI
CHHHHHCCCCCCCHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCE
VQEDALLAALDSGHLRAAGLDVFATEPLPQDSPLRSHPRVTALPHIGSATHETRRAMAEL
ECCCHHEEEECCCCEEEECCEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
ATRNLLDALAGRQPAARFDLAAFAARAAA
HHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA