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The map label for this gene is serA5 [H]

Identifier: 116694787

GI number: 116694787

Start: 952890

End: 953819

Strand: Direct

Name: serA5 [H]

Synonym: H16_B0841

Alternate gene names: 116694787

Gene position: 952890-953819 (Clockwise)

Preceding gene: 116694786

Following gene: 116694789

Centisome position: 32.72

GC content: 70.75

Gene sequence:

>930_bases
ATGGCCATCCTCGTTCACCTGCCGTCGTTCATGGCGGTTCCCATCACTGCCGCGCTGCGCGAAGCCGCGCCGGACATCAC
CGTGTGGAACGGCCGCGAGGCCGCCGTCGCGGAACAGGTCGAAGCCATCATCGCCTGGGGCCTGAAGCCCGGCGTGCTGC
CGGCCTACCCGAAGCTGCGGCTGGTCTGCGCTGCCACCGCGGGCGTCGACAAGCTGCTGGCGGCGCCGGACCTGCCGCCT
GGCATGCCGGTCACGCGCATCGTCGATCCCGGCCAGCAGGCCGGCATCGCCCACTACGTGCTGGCGATGGCGCTGCGCCA
TACCCGCGCGCTCGGCCGGTACGCCGAACAGCAGCGCCGCGGCGAATGGAAGCGCCACCCGGGGCGCGATGTGTCGCGCT
GCCGCGTGGGTGTGCTGGGGCTGGGCGAGATCGGCAGCGAGGTGGCGCGCATGTTTGCCGCCATCGGCTACCCGGTCAGC
GGCTGGAGCCGCAGCGCCAAGCATCTGCCCGGCGTGACCGACTTCACCGGCGACGACGGGCTGGATGCCATGCTCGCGCA
CAGCGACATCCTGGTCTGCACGCTGCCGCTGACGCCGCGCACCGAGGGCATGCTGAACCGCCAGACGCTGTCGCGGCTGC
CCAAGGGGGCGTTCCTGATCAACGTCGGGCGTGGCGAGCATGTGGTCGAGCCAGACCTGGTCGCACTGATCGACGAAGGC
CACCTTGCCGGCGCGGCGCTTGATGTGTTCGCCAAGGAGCCGCCCTCGGCGGACGATCCGGTCTGGAACCATCCCCGCAT
CGAGGCCACGCCGCATATCGCGGCCGACCCCTCGTACGAACTGGTGGCGCGGCAATGCATCGAGAACCTGCGGCGCGCGC
GCGACGGGCGTGAACTGTTGAACCAGGTGGACCGGCAAGCGGGCTACTGA

Upstream 100 bases:

>100_bases
AGCAGGCGCGCCAGGCCACCAAGGGCAAGGGCTCCAACCTGGCCTGGCCGGGCCTGCTGCGCCGCCTCGACCGCATCAAC
CCTGACTACCGCAACTGACC

Downstream 100 bases:

>100_bases
GCGCCCGGCGTGCCGGTCCGTCCGGGTGGCTATGTCACGCTTACATCCGCGGTTCCCGCCGCCACCTCCAGCAGCCGCGT
GCTCGCCGTGGCAGGTAGCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAILVHLPSFMAVPITAALREAAPDITVWNGREAAVAEQVEAIIAWGLKPGVLPAYPKLRLVCAATAGVDKLLAAPDLPP
GMPVTRIVDPGQQAGIAHYVLAMALRHTRALGRYAEQQRRGEWKRHPGRDVSRCRVGVLGLGEIGSEVARMFAAIGYPVS
GWSRSAKHLPGVTDFTGDDGLDAMLAHSDILVCTLPLTPRTEGMLNRQTLSRLPKGAFLINVGRGEHVVEPDLVALIDEG
HLAGAALDVFAKEPPSADDPVWNHPRIEATPHIAADPSYELVARQCIENLRRARDGRELLNQVDRQAGY

Sequences:

>Translated_309_residues
MAILVHLPSFMAVPITAALREAAPDITVWNGREAAVAEQVEAIIAWGLKPGVLPAYPKLRLVCAATAGVDKLLAAPDLPP
GMPVTRIVDPGQQAGIAHYVLAMALRHTRALGRYAEQQRRGEWKRHPGRDVSRCRVGVLGLGEIGSEVARMFAAIGYPVS
GWSRSAKHLPGVTDFTGDDGLDAMLAHSDILVCTLPLTPRTEGMLNRQTLSRLPKGAFLINVGRGEHVVEPDLVALIDEG
HLAGAALDVFAKEPPSADDPVWNHPRIEATPHIAADPSYELVARQCIENLRRARDGRELLNQVDRQAGY
>Mature_308_residues
AILVHLPSFMAVPITAALREAAPDITVWNGREAAVAEQVEAIIAWGLKPGVLPAYPKLRLVCAATAGVDKLLAAPDLPPG
MPVTRIVDPGQQAGIAHYVLAMALRHTRALGRYAEQQRRGEWKRHPGRDVSRCRVGVLGLGEIGSEVARMFAAIGYPVSG
WSRSAKHLPGVTDFTGDDGLDAMLAHSDILVCTLPLTPRTEGMLNRQTLSRLPKGAFLINVGRGEHVVEPDLVALIDEGH
LAGAALDVFAKEPPSADDPVWNHPRIEATPHIAADPSYELVARQCIENLRRARDGRELLNQVDRQAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=28.1021897810219, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI6912396, Length=224, Percent_Identity=25.4464285714286, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557497, Length=275, Percent_Identity=28, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI61743967, Length=275, Percent_Identity=28, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081824, Length=314, Percent_Identity=35.3503184713376, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082289, Length=291, Percent_Identity=27.8350515463918, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789279, Length=269, Percent_Identity=28.2527881040892, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=32.8301886792453, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=193, Percent_Identity=29.5336787564767, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322116, Length=193, Percent_Identity=29.0155440414508, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=223, Percent_Identity=24.6636771300448, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=27.7056277056277, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=25.2873563218391, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=24.0458015267176, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=24.0458015267176, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=24.0458015267176, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=24.0458015267176, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=24.0458015267176, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585516, Length=273, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571528, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33379; Mature: 33248

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVHLPSFMAVPITAALREAAPDITVWNGREAAVAEQVEAIIAWGLKPGVLPAYPKLR
CEEEEECCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LVCAATAGVDKLLAAPDLPPGMPVTRIVDPGQQAGIAHYVLAMALRHTRALGRYAEQQRR
EEEEHHHCHHHHHHCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEWKRHPGRDVSRCRVGVLGLGEIGSEVARMFAAIGYPVSGWSRSAKHLPGVTDFTGDDG
CCHHCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCC
LDAMLAHSDILVCTLPLTPRTEGMLNRQTLSRLPKGAFLINVGRGEHVVEPDLVALIDEG
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCC
HLAGAALDVFAKEPPSADDPVWNHPRIEATPHIAADPSYELVARQCIENLRRARDGRELL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NQVDRQAGY
HHHHHHCCC
>Mature Secondary Structure 
AILVHLPSFMAVPITAALREAAPDITVWNGREAAVAEQVEAIIAWGLKPGVLPAYPKLR
EEEEECCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LVCAATAGVDKLLAAPDLPPGMPVTRIVDPGQQAGIAHYVLAMALRHTRALGRYAEQQRR
EEEEHHHCHHHHHHCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEWKRHPGRDVSRCRVGVLGLGEIGSEVARMFAAIGYPVSGWSRSAKHLPGVTDFTGDDG
CCHHCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCC
LDAMLAHSDILVCTLPLTPRTEGMLNRQTLSRLPKGAFLINVGRGEHVVEPDLVALIDEG
HHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEECCC
HLAGAALDVFAKEPPSADDPVWNHPRIEATPHIAADPSYELVARQCIENLRRARDGRELL
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NQVDRQAGY
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]