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The map label for this gene is acsA [H]

Identifier: 116694780

GI number: 116694780

Start: 944493

End: 946475

Strand: Direct

Name: acsA [H]

Synonym: H16_B0834

Alternate gene names: 116694780

Gene position: 944493-946475 (Clockwise)

Preceding gene: 116694779

Following gene: 116694783

Centisome position: 32.43

GC content: 66.82

Gene sequence:

>1983_bases
ATGACAAGCATTCAATCCGTTGTGCACGAAGGGCGGATGTTCCCGCCATCCCGCCACGCCAGCGCTAAGGCCGCGATTCC
CAGCATGGAGGCCTACCAGGCACTGTGCGACGAAGCCGAGCGTGACTATGAAGGTTTCTGGGCGCGCCACGCGCGCGAGC
TGCTGCACTGGACCAAGCCCTTCACCAAGGTGCTGGACCAAAGCAACGCACCGTTCTACAAGTGGTTCGAAGACGGCGAG
CTCAACGCCTCTTACAACTGCCTGGACCGCAATCTGCAGAACGGCAATGCGGACAAGGTCGCGATCGTGTTCGAGGCCGA
CGACGGCAGCGTGACGCGCGTCACCTACCGCGAGCTGCATGGCAAGGTGTGCCGCTTTGCCAACGGCCTGAAGGCGCTCG
GCATCAGGAAGGGCGACCGCGTGGTGATCTACATGCCGATGTCGGTCGAAGGCGTGGTCGCGATGCAGGCCTGCGCACGC
CTGGGCGCCACGCACTCGGTGGTGTTCGGCGGCTTCTCGGCCAAGTCGCTGCAGGAGCGGCTGGTGGACGTGGGCGCGGT
GGCGCTGATCACCGCCGACGAGCAGATGCGCGGCGGCAAGGCGCTGCCGCTCAAGCCCATCGCCGATGACGCGCTGGCGC
TGGGGGGCTGCGAGGCCGTCAGGAACGTGATCGTCTACCGCCGCACCGGCGGCAAGGTTGCCTGGACCGAAGGCCGCGAC
CGCTGGATGGAAGATGTCAGCGCCGGCCAGCCGGAGACCTGCGAAGCCGAGCCGGTGAGCGCCGAGCACCCGCTGTTCGT
GCTCTACACCTCCGGCTCCACCGGCAAGCCCAAGGGCGTGCAGCACAGCACCGGCGGCTACCTGCTGTGGGCGCTGATGA
CAATGAAGTGGACCTTCGACATCAAGCCCGACGACCTGTTCTGGTGTACCGCGGACATCGGCTGGGTCACCGGCCACACC
TATATTGCCTACGGCCCGCTGGCCGCGGGCGCCACCCAGGTGGTGTTCGAAGGCGTGCCGACCTACCCCAACGCCGGCCG
CTTCTGGGACATGATCGCGCGCCACAAGGTCAGCATCTTCTACACCGCGCCGACCGCGATCCGCTCGCTGATCAAGGCCG
CCGAGGCCGACGAGAAGATCCACCCGAAACAGTACGACCTGTCCAGCCTGCGCCTGCTCGGCACCGTGGGCGAGCCGATC
AACCCCGAAGCCTGGATGTGGTACTACAAGAACATCGGCAACGAGCGCTGCCCGATCGTCGACACCTTCTGGCAGACCGA
GACCGGCGGCCACATGATCACGCCGCTGCCGGGCGCGACGCCGCTGGTGCCGGGTTCGTGCACGCTGCCGCTGCCGGGCA
TCATGGCCGCCATCGTCGACGAGACCGGCCATGACGTGCCCAACGGCAACGGCGGCATCCTGGTGGTCAAGCGTCCGTGG
CCGGCCATGATCCGCACCATCTGGGGCGATCCGGAGCGCTTCAGGAAGAGCTACTTCCCCGAAGAGCTCGGCGGCAAGCT
CTACCTGGCCGGCGACGGCTCGATCCGCGACAAGGACACCGGCTACTTCACCATCATGGGCCGCATCGACGACGTGCTGA
ACGTGTCGGGCCACCGCATGGGGACGATGGAGATCGAGTCCGCGCTGGTGTCCAACCCGCTGGTGGCCGAAGCCGCCGTG
GTGGGCCGCCCCGACGACATGACCGGCGAGGCCATCTGCGCCTTCGTCGTGCTCAAGCGTTCGCGTCCGACTGGCGAAGA
GGCCGTCAAGATCGCGACGGAGCTGCGCAACTGGGTCGGCAAGGAGATCGGCCCGATCGCCAAGCCCAAGGACATCCGCT
TTGGCGACAACCTGCCCAAGACGCGCTCGGGCAAGATCATGCGGCGCCTGCTGCGGTCGCTGGCCAAGGGGGAGGAGATC
ACGCAGGACACCTCGACGCTGGAGAATCCGGCCATCCTGGAGCAGCTTGGCCAGGCACGCTGA

Upstream 100 bases:

>100_bases
GTTCTCCGGCACCACCACCCCGGATTTGGCCGCCTGAGCAGGCGGCTGCTTTGTTTTCAGGCGGCGCTGTCCTGCGCCGC
ATTCCTGTTTCCGAGCTTTC

Downstream 100 bases:

>100_bases
AGATGCGGCGCGACTATGCCCGATTCAGACAAGGTCGGCAATTGTGCAGTGCCGCCGAGCGCTGGCCCAAGGTGACCGCA
GCCCCTTGAGCTTTCCAGAC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MTSIQSVVHEGRMFPPSRHASAKAAIPSMEAYQALCDEAERDYEGFWARHARELLHWTKPFTKVLDQSNAPFYKWFEDGE
LNASYNCLDRNLQNGNADKVAIVFEADDGSVTRVTYRELHGKVCRFANGLKALGIRKGDRVVIYMPMSVEGVVAMQACAR
LGATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKPIADDALALGGCEAVRNVIVYRRTGGKVAWTEGRD
RWMEDVSAGQPETCEAEPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMKWTFDIKPDDLFWCTADIGWVTGHT
YIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPI
NPEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGNGGILVVKRPW
PAMIRTIWGDPERFRKSYFPEELGGKLYLAGDGSIRDKDTGYFTIMGRIDDVLNVSGHRMGTMEIESALVSNPLVAEAAV
VGRPDDMTGEAICAFVVLKRSRPTGEEAVKIATELRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEI
TQDTSTLENPAILEQLGQAR

Sequences:

>Translated_660_residues
MTSIQSVVHEGRMFPPSRHASAKAAIPSMEAYQALCDEAERDYEGFWARHARELLHWTKPFTKVLDQSNAPFYKWFEDGE
LNASYNCLDRNLQNGNADKVAIVFEADDGSVTRVTYRELHGKVCRFANGLKALGIRKGDRVVIYMPMSVEGVVAMQACAR
LGATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKPIADDALALGGCEAVRNVIVYRRTGGKVAWTEGRD
RWMEDVSAGQPETCEAEPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMKWTFDIKPDDLFWCTADIGWVTGHT
YIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPI
NPEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGNGGILVVKRPW
PAMIRTIWGDPERFRKSYFPEELGGKLYLAGDGSIRDKDTGYFTIMGRIDDVLNVSGHRMGTMEIESALVSNPLVAEAAV
VGRPDDMTGEAICAFVVLKRSRPTGEEAVKIATELRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEI
TQDTSTLENPAILEQLGQAR
>Mature_659_residues
TSIQSVVHEGRMFPPSRHASAKAAIPSMEAYQALCDEAERDYEGFWARHARELLHWTKPFTKVLDQSNAPFYKWFEDGEL
NASYNCLDRNLQNGNADKVAIVFEADDGSVTRVTYRELHGKVCRFANGLKALGIRKGDRVVIYMPMSVEGVVAMQACARL
GATHSVVFGGFSAKSLQERLVDVGAVALITADEQMRGGKALPLKPIADDALALGGCEAVRNVIVYRRTGGKVAWTEGRDR
WMEDVSAGQPETCEAEPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMKWTFDIKPDDLFWCTADIGWVTGHTY
IAYGPLAAGATQVVFEGVPTYPNAGRFWDMIARHKVSIFYTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPIN
PEAWMWYYKNIGNERCPIVDTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGNGGILVVKRPWP
AMIRTIWGDPERFRKSYFPEELGGKLYLAGDGSIRDKDTGYFTIMGRIDDVLNVSGHRMGTMEIESALVSNPLVAEAAVV
GRPDDMTGEAICAFVVLKRSRPTGEEAVKIATELRNWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEIT
QDTSTLENPAILEQLGQAR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=684, Percent_Identity=46.1988304093567, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI253970489, Length=697, Percent_Identity=45.19368723099, Blast_Score=581, Evalue=1e-166,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=46.0443037974684, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI13375727, Length=630, Percent_Identity=37.7777777777778, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=28.7593984962406, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=29.3457943925234, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI31982927, Length=655, Percent_Identity=24.7328244274809, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI122937307, Length=533, Percent_Identity=27.9549718574109, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI115511026, Length=550, Percent_Identity=26.1818181818182, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI58082049, Length=520, Percent_Identity=27.3076923076923, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI157311624, Length=520, Percent_Identity=26.5384615384615, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI157311622, Length=520, Percent_Identity=26.5384615384615, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI195947378, Length=450, Percent_Identity=26, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI187761345, Length=398, Percent_Identity=26.1306532663317, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI187761343, Length=398, Percent_Identity=26.1306532663317, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI42544134, Length=324, Percent_Identity=25.3086419753086, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=53.0063291139241, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=639, Percent_Identity=39.1236306729264, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=25.6590509666081, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786810, Length=548, Percent_Identity=22.6277372262774, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI145693145, Length=373, Percent_Identity=24.6648793565684, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=668, Percent_Identity=42.814371257485, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71982997, Length=667, Percent_Identity=42.8785607196402, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17569507, Length=615, Percent_Identity=23.4146341463415, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71985884, Length=603, Percent_Identity=23.8805970149254, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557194, Length=593, Percent_Identity=23.4401349072513, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=563, Percent_Identity=24.866785079929, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=570, Percent_Identity=24.2105263157895, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=570, Percent_Identity=24.2105263157895, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=570, Percent_Identity=23.859649122807, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=141, Percent_Identity=32.6241134751773, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=646, Percent_Identity=47.8328173374613, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6323182, Length=646, Percent_Identity=46.749226006192, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319699, Length=558, Percent_Identity=22.7598566308244, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=47.8454680534918, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=51.067615658363, Blast_Score=547, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24667959, Length=531, Percent_Identity=49.9058380414313, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21355225, Length=660, Percent_Identity=34.5454545454545, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI21355181, Length=535, Percent_Identity=24.2990654205607, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656500, Length=371, Percent_Identity=26.1455525606469, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24581924, Length=563, Percent_Identity=23.8010657193606, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648260, Length=406, Percent_Identity=23.3990147783251, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72562; Mature: 72431

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIQSVVHEGRMFPPSRHASAKAAIPSMEAYQALCDEAERDYEGFWARHARELLHWTKP
CCCHHHHHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTKVLDQSNAPFYKWFEDGELNASYNCLDRNLQNGNADKVAIVFEADDGSVTRVTYRELH
HHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEEHHHHHH
GKVCRFANGLKALGIRKGDRVVIYMPMSVEGVVAMQACARLGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LVDVGAVALITADEQMRGGKALPLKPIADDALALGGCEAVRNVIVYRRTGGKVAWTEGRD
HHHCCEEEEEECCHHHCCCCCCCCCCCCCHHHHHCCHHHHHCEEEEEECCCEEEECCCHH
RWMEDVSAGQPETCEAEPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHEEEHHHHEEEEE
IKPDDLFWCTADIGWVTGHTYIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIARHKVSIF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPINPEAWMWYYKNIGNERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECCCCCCCCCCEEHHHHHCCCCCCCEE
DTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGNGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFRKSYFPEELGGKLYLAGDGSIRDKDTGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSNPLVAEAAVVGRPDDMTGEAICAFVVLKRSRPTGEEAVKIATELRNWVG
EHHHHHHHHHCCCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEITQDTSTLENPAILEQLGQAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCC
>Mature Secondary Structure 
TSIQSVVHEGRMFPPSRHASAKAAIPSMEAYQALCDEAERDYEGFWARHARELLHWTKP
CCHHHHHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTKVLDQSNAPFYKWFEDGELNASYNCLDRNLQNGNADKVAIVFEADDGSVTRVTYRELH
HHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEEHHHHHH
GKVCRFANGLKALGIRKGDRVVIYMPMSVEGVVAMQACARLGATHSVVFGGFSAKSLQER
HHHHHHHCCHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
LVDVGAVALITADEQMRGGKALPLKPIADDALALGGCEAVRNVIVYRRTGGKVAWTEGRD
HHHCCEEEEEECCHHHCCCCCCCCCCCCCHHHHHCCHHHHHCEEEEEECCCEEEECCCHH
RWMEDVSAGQPETCEAEPVSAEHPLFVLYTSGSTGKPKGVQHSTGGYLLWALMTMKWTFD
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHEEEHHHHEEEEE
IKPDDLFWCTADIGWVTGHTYIAYGPLAAGATQVVFEGVPTYPNAGRFWDMIARHKVSIF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAAEADEKIHPKQYDLSSLRLLGTVGEPINPEAWMWYYKNIGNERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEECCCCCCCCCCEEHHHHHCCCCCCCEE
DTFWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGHDVPNGNGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFRKSYFPEELGGKLYLAGDGSIRDKDTGYFTIMGRIDDVLNVSGHRM
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSNPLVAEAAVVGRPDDMTGEAICAFVVLKRSRPTGEEAVKIATELRNWVG
EHHHHHHHHHCCCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEEITQDTSTLENPAILEQLGQAR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1356967 [H]